1QP4
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![BU of 1qp4 by Molmil](/molmil-images/mine/1qp4) | PURINE REPRESSOR-HYPOXANTHINE-PALINDROMIC OPERATOR COMPLEX | Descriptor: | DNA (5'-D(*TP*AP*CP*GP*CP*AP*AP*TP*CP*GP*AP*TP*TP*GP*CP*GP*T)-3'), HYPOXANTHINE, PROTEIN (PURINE NUCLEOTIDE SYNTHESIS REPRESSOR) | Authors: | Glasfeld, A, Koehler, A.N, Schumacher, M.A, Brennan, R.G. | Deposit date: | 1999-06-01 | Release date: | 1999-06-07 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | The role of lysine 55 in determining the specificity of the purine repressor for its operators through minor groove interactions. J.Mol.Biol., 291, 1999
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1QP0
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![BU of 1qp0 by Molmil](/molmil-images/mine/1qp0) | PURINE REPRESSOR-HYPOXANTHINE-PALINDROMIC OPERATOR COMPLEX | Descriptor: | DNA (5'-D(*TP*AP*CP*GP*CP*AP*AP*CP*CP*GP*GP*TP*TP*GP*CP*GP*T)-3'), HYPOXANTHINE, PROTEIN (PURINE NUCLEOTIDE SYNTHESIS REPRESSOR) | Authors: | Glasfeld, A, Koehler, A.N, Schumacher, M.A, Brennan, R.G. | Deposit date: | 1999-06-01 | Release date: | 1999-06-07 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | The role of lysine 55 in determining the specificity of the purine repressor for its operators through minor groove interactions. J.Mol.Biol., 291, 1999
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1QP7
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![BU of 1qp7 by Molmil](/molmil-images/mine/1qp7) | PURINE REPRESSOR MUTANT-HYPOXANTHINE-PALINDROMIC OPERATOR COMPLEX | Descriptor: | DNA (5'-D(*TP*AP*CP*GP*CP*AP*AP*CP*CP*GP*GP*TP*TP*GP*CP*GP*T)-3'), HYPOXANTHINE, PROTEIN (PURINE NUCLEOTIDE SYNTHESIS REPRESSOR) | Authors: | Glasfeld, A, Koehler, A.N, Schumacher, M.A, Brennan, R.G. | Deposit date: | 1999-06-01 | Release date: | 1999-06-04 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | The role of lysine 55 in determining the specificity of the purine repressor for its operators through minor groove interactions. J.Mol.Biol., 291, 1999
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1QPZ
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![BU of 1qpz by Molmil](/molmil-images/mine/1qpz) | PURINE REPRESSOR-HYPOXANTHINE-PALINDROMIC OPERATOR COMPLEX | Descriptor: | DNA (5'-D(*TP*AP*CP*GP*CP*AP*AP*AP*CP*GP*TP*TP*TP*GP*CP*GP*T)-3'), HYPOXANTHINE, PROTEIN (PURINE NUCLEOTIDE SYNTHESIS REPRESSOR) | Authors: | Glasfeld, A, Koehler, A.N, Schumacher, M.A, Brennan, R.G. | Deposit date: | 1999-06-01 | Release date: | 1999-06-07 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | The role of lysine 55 in determining the specificity of the purine repressor for its operators through minor groove interactions. J.Mol.Biol., 291, 1999
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1QQA
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![BU of 1qqa by Molmil](/molmil-images/mine/1qqa) | PURINE REPRESSOR MUTANT-HYPOXANTHINE-PALINDROMIC OPERATOR COMPLEX | Descriptor: | DNA (5'-D(*TP*AP*CP*GP*CP*AP*AP*GP*CP*GP*CP*TP*TP*GP*CP*GP*T)-3'), HYPOXANTHINE, PROTEIN (PURINE NUCLEOTIDE SYNTHESIS REPRESSOR) | Authors: | Glasfeld, A, Koehler, A.N, Schumacher, M.A, Brennan, R.G. | Deposit date: | 1999-06-01 | Release date: | 1999-06-09 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | The role of lysine 55 in determining the specificity of the purine repressor for its operators through minor groove interactions. J.Mol.Biol., 291, 1999
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2NZU
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![BU of 2nzu by Molmil](/molmil-images/mine/2nzu) | Structural mechanism for the fine-tuning of CcpA function by the small molecule effectors G6P and FBP | Descriptor: | 6-O-phosphono-beta-D-glucopyranose, Catabolite control protein, Phosphocarrier protein HPr, ... | Authors: | Schumacher, M.A, Hillen, W, Brennan, R.G. | Deposit date: | 2006-11-25 | Release date: | 2007-05-01 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural Mechanism for the Fine-tuning of CcpA Function by The Small Molecule Effectors Glucose 6-Phosphate and Fructose 1,6-Bisphosphate. J.Mol.Biol., 368, 2007
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2NZV
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![BU of 2nzv by Molmil](/molmil-images/mine/2nzv) | Structural mechanism for the fine-tuning of CcpA function by the small molecule effectors G6P and FBP | Descriptor: | 1,6-di-O-phosphono-beta-D-fructofuranose, Catabolite control protein, Phosphocarrier protein HPr, ... | Authors: | Schumacher, M.A, Hillen, W, Brennan, R.G. | Deposit date: | 2006-11-25 | Release date: | 2007-05-01 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structural Mechanism for the Fine-tuning of CcpA Function by The Small Molecule Effectors Glucose 6-Phosphate and Fructose 1,6-Bisphosphate. J.Mol.Biol., 368, 2007
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2OEN
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![BU of 2oen by Molmil](/molmil-images/mine/2oen) | Structural mechanism for the fine-tuning of CcpA function by the small molecule effectors glucose-6-phosphate and fructose-1,6-bisphosphate | Descriptor: | Catabolite control protein, Phosphocarrier protein HPr | Authors: | Schumacher, M.A, Seidel, G, Hillen, W, Brennan, R.G. | Deposit date: | 2006-12-30 | Release date: | 2007-05-01 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (3.17 Å) | Cite: | Structural Mechanism for the Fine-tuning of CcpA Function by The Small Molecule Effectors Glucose 6-Phosphate and Fructose 1,6-Bisphosphate. J.Mol.Biol., 368, 2007
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1DBR
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![BU of 1dbr by Molmil](/molmil-images/mine/1dbr) | HYPOXANTHINE GUANINE XANTHINE | Descriptor: | HYPOXANTHINE GUANINE XANTHINE PHOSPHORIBOSYLTRANSFERASE, MAGNESIUM ION | Authors: | Schumacher, M.A, Carter, D, Roos, D, Ullman, B, Brennan, R.G. | Deposit date: | 1996-02-13 | Release date: | 1997-12-03 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystal structures of Toxoplasma gondii HGXPRTase reveal the catalytic role of a long flexible loop. Nat.Struct.Biol., 3, 1996
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1EXI
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![BU of 1exi by Molmil](/molmil-images/mine/1exi) | CRYSTAL STRUCTURE OF TRANSCRIPTION ACTIVATOR BMRR, FROM B. SUBTILIS, BOUND TO 21 BASE PAIR BMR OPERATOR AND TPSB | Descriptor: | DNA (5'-D(*AP*CP*CP*CP*TP*CP*CP*CP*CP*TP*TP*AP*GP*GP*GP*GP*AP*GP*GP*GP*T)-3'), MULTIDRUG-EFFLUX TRANSPORTER REGULATOR, TETRAPHENYLANTIMONIUM ION, ... | Authors: | Zheleznova-Heldwein, E.E, Brennan, R.G. | Deposit date: | 2000-05-02 | Release date: | 2001-01-24 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (3.12 Å) | Cite: | Crystal structure of the transcription activator BmrR bound to DNA and a drug. Nature, 409, 2001
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1DBQ
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![BU of 1dbq by Molmil](/molmil-images/mine/1dbq) | DNA-BINDING REGULATORY PROTEIN | Descriptor: | MAGNESIUM ION, PURINE REPRESSOR | Authors: | Schumacher, M.A, Choi, K.Y, Lu, F, Zalkin, H, Brennan, R.G. | Deposit date: | 1996-02-13 | Release date: | 1996-12-07 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Mechanism of corepressor-mediated specific DNA binding by the purine repressor. Cell(Cambridge,Mass.), 83, 1995
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1EXJ
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![BU of 1exj by Molmil](/molmil-images/mine/1exj) | CRYSTAL STRUCTURE OF TRANSCRIPTION ACTIVATOR BMRR, FROM B. SUBTILIS, BOUND TO 21 BASE PAIR BMR OPERATOR AND TPP | Descriptor: | DNA (5'-D(*AP*CP*CP*CP*TP*CP*CP*CP*CP*TP*TP*AP*GP*GP*GP*GP*AP*GP*GP*GP*T)-3'), MULTIDRUG-EFFLUX TRANSPORTER REGULATOR, SODIUM ION, ... | Authors: | Zheleznova-Heldwein, E.E, Brennan, R.G. | Deposit date: | 2000-05-02 | Release date: | 2001-01-24 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Crystal structure of the transcription activator BmrR bound to DNA and a drug. Nature, 409, 2001
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1DH3
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![BU of 1dh3 by Molmil](/molmil-images/mine/1dh3) | |
1RKW
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![BU of 1rkw by Molmil](/molmil-images/mine/1rkw) | CRYSTAL STRUCTURE OF THE MULTIDRUG BINDING TRANSCRIPTIONAL REPRESSOR QACR BOUND TO PENTAMADINE | Descriptor: | 1,5-BIS(4-AMIDINOPHENOXY)PENTANE, SULFATE ION, Transcriptional regulator qacR | Authors: | Murray, D.S, Schumacher, M.A, Brennan, R.G. | Deposit date: | 2003-11-23 | Release date: | 2004-06-01 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.62 Å) | Cite: | Crystal structures of QacR-diamidine complexes reveal additional multidrug-binding modes and a novel mechanism of drug charge neutralization. J.Biol.Chem., 279, 2004
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1SDK
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![BU of 1sdk by Molmil](/molmil-images/mine/1sdk) | CROSS-LINKED, CARBONMONOXY HEMOGLOBIN A | Descriptor: | 1,3,5-BENZENETRICARBOXYLIC ACID, CARBON MONOXIDE, HEMOGLOBIN A, ... | Authors: | Schumacher, M.A, Dixon, M.M, Kluger, R, Jones, R.T, Brennan, R.G. | Deposit date: | 1996-02-26 | Release date: | 1996-08-01 | Last modified: | 2024-06-05 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Allosteric transition intermediates modelled by crosslinked haemoglobins. Nature, 375, 1995
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1RZR
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![BU of 1rzr by Molmil](/molmil-images/mine/1rzr) | crystal structure of transcriptional regulator-phosphoprotein-DNA complex | Descriptor: | 5'-D(*CP*TP*GP*AP*AP*AP*GP*CP*GP*CP*TP*AP*AP*CP*AP*G)-3', 5'-D(*CP*TP*GP*TP*TP*AP*GP*CP*GP*CP*TP*TP*TP*CP*AP*G)-3', Glucose-resistance amylase regulator, ... | Authors: | Schumacher, M.A, Allen, G.S, Brennan, R.G. | Deposit date: | 2003-12-27 | Release date: | 2004-10-12 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural basis for allosteric control of the transcription regulator CcpA by the phosphoprotein HPr-Ser46-P. Cell(Cambridge,Mass.), 118, 2004
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1RPW
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![BU of 1rpw by Molmil](/molmil-images/mine/1rpw) | Crystal Structure Of The Multidrug Binding Protein Qacr Bound To The Diamidine Hexamidine | Descriptor: | 4,4'[1,6-HEXANEDIYLBIS(OXY)]BISBENZENECARBOXIMIDAMIDE, SULFATE ION, Transcriptional regulator qacR | Authors: | Murray, D.S, Schumacher, M.A, Brennan, R.G. | Deposit date: | 2003-12-03 | Release date: | 2004-06-01 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Crystal structures of QacR-diamidine complexes reveal additional multidrug-binding modes and a novel mechanism of drug charge neutralization. J.Biol.Chem., 279, 2004
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1SXI
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![BU of 1sxi by Molmil](/molmil-images/mine/1sxi) | Structure of apo transcription regulator B. megaterium | Descriptor: | Glucose-resistance amylase regulator, MAGNESIUM ION | Authors: | Schumacher, M.A, Allen, G.S, Diel, M, Seidel, G, Hillen, W, Brennan, R.G. | Deposit date: | 2004-03-30 | Release date: | 2004-10-19 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structural studies on the apo transcription factor form B. megaterium Cell(Cambridge,Mass.), 118, 2004
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1SXG
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![BU of 1sxg by Molmil](/molmil-images/mine/1sxg) | Structural studies on the apo transcription factor form B. megaterium | Descriptor: | 2-PHENYLAMINO-ETHANESULFONIC ACID, Glucose-resistance amylase regulator | Authors: | Schumacher, M.A, Allen, G.S, Diel, M, Seidel, G, Hillen, W, Brennan, R.G. | Deposit date: | 2004-03-30 | Release date: | 2004-10-19 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Structural studies on the apo transcription factor form B. megaterium Cell(Cambridge,Mass.), 118, 2004
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1QCD
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![BU of 1qcd by Molmil](/molmil-images/mine/1qcd) | CRYSTAL STRUCTURES OF ADENINE PHOSPHORIBOSYLTRANSFERASE FROM LEISHMANIA DONOVANI | Descriptor: | ADENINE PHOSPHORIBOSYLTRANSFERASE, SULFATE ION | Authors: | Phillips, C.L, Ullman, B, Brennan, R.G, Hill, C.P. | Deposit date: | 1999-05-01 | Release date: | 1999-07-21 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.48 Å) | Cite: | Crystal structures of adenine phosphoribosyltransferase from Leishmania donovani. EMBO J., 18, 1999
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1SXH
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![BU of 1sxh by Molmil](/molmil-images/mine/1sxh) | apo structure of B. megaterium transcription regulator | Descriptor: | Glucose-resistance amylase regulator | Authors: | Schumacher, M.A, Allen, G.S, Diel, M, Seidel, G, Hillen, W, Brennan, R.G. | Deposit date: | 2004-03-30 | Release date: | 2004-10-19 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Structural studies on the apo transcription factor form B. megaterium Cell(Cambridge,Mass.), 118, 2004
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1UPF
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![BU of 1upf by Molmil](/molmil-images/mine/1upf) | STRUCTURE OF THE URACIL PHOSPHORIBOSYLTRANSFERASE, MUTANT C128V BOUND TO THE DRUG 5-FLUOROURACIL | Descriptor: | 5-FLUOROURACIL, SULFATE ION, URACIL PHOSPHORIBOSYLTRANSFERASE | Authors: | Schumacher, M.A, Carter, D, Scott, D, Roos, D, Ullman, B, Brennan, R.G. | Deposit date: | 1998-06-17 | Release date: | 1999-06-22 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal structures of Toxoplasma gondii uracil phosphoribosyltransferase reveal the atomic basis of pyrimidine discrimination and prodrug binding. EMBO J., 17, 1998
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1SDL
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![BU of 1sdl by Molmil](/molmil-images/mine/1sdl) | CROSS-LINKED, CARBONMONOXY HEMOGLOBIN A | Descriptor: | 1,3,5-BENZENETRICARBOXYLIC ACID, CARBON MONOXIDE, HEMOGLOBIN A, ... | Authors: | Schumacher, M.A, Dixon, M.M, Kluger, R, Jones, R.T, Brennan, R.G. | Deposit date: | 1996-02-26 | Release date: | 1996-08-01 | Last modified: | 2024-06-05 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Allosteric transition intermediates modelled by crosslinked haemoglobins. Nature, 375, 1995
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1UPU
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![BU of 1upu by Molmil](/molmil-images/mine/1upu) | STRUCTURE OF THE URACIL PHOSPHORIBOSYLTRANSFERASE, MUTANT C128V, BOUND TO PRODUCT URIDINE-1-MONOPHOSPHATE (UMP) | Descriptor: | PHOSPHATE ION, URACIL PHOSPHORIBOSYLTRANSFERASE, URIDINE-5'-MONOPHOSPHATE | Authors: | Schumacher, M.A, Carter, D, Scott, D, Roos, D, Ullman, B, Brennan, R.G. | Deposit date: | 1998-04-16 | Release date: | 1999-05-11 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal structures of Toxoplasma gondii uracil phosphoribosyltransferase reveal the atomic basis of pyrimidine discrimination and prodrug binding. EMBO J., 17, 1998
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1VPW
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![BU of 1vpw by Molmil](/molmil-images/mine/1vpw) | STRUCTURE OF THE PURR MUTANT, L54M, BOUND TO HYPOXANTHINE AND PURF OPERATOR DNA | Descriptor: | DNA (5'-D(*TP*AP*CP*GP*CP*AP*AP*AP*CP*GP*TP*TP*TP*GP*CP*GP*T )-3'), HYPOXANTHINE, PURINE REPRESSOR | Authors: | Arvidson, D.N, Lu, F, Faber, C, Zalkin, H, Brennan, R.G. | Deposit date: | 1998-02-27 | Release date: | 1998-06-17 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | The structure of PurR mutant L54M shows an alternative route to DNA kinking. Nat.Struct.Biol., 5, 1998
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