1UPF

STRUCTURE OF THE URACIL PHOSPHORIBOSYLTRANSFERASE, MUTANT C128V BOUND TO THE DRUG 5-FLUOROURACIL

Summary for 1UPF

Entry DOI	10.2210/pdb1upf/pdb
Descriptor	URACIL PHOSPHORIBOSYLTRANSFERASE, SULFATE ION, 5-FLUOROURACIL, ... (4 entities in total)
Functional Keywords	transferase, glycosyltransferase, phosphoribosyltransferase
Biological source	Toxoplasma gondii
Total number of polymer chains	4
Total formula weight	103845.11
Authors	Schumacher, M.A.,Carter, D.,Scott, D.,Roos, D.,Ullman, B.,Brennan, R.G. (deposition date: 1998-06-17, release date: 1999-06-22, Last modification date: 2024-02-14)
Primary citation	Schumacher, M.A.,Carter, D.,Scott, D.M.,Roos, D.S.,Ullman, B.,Brennan, R.G. Crystal structures of Toxoplasma gondii uracil phosphoribosyltransferase reveal the atomic basis of pyrimidine discrimination and prodrug binding. EMBO J., 17:3219-3232, 1998 Cited by PubMed: 9628859 DOI: 10.1093/emboj/17.12.3219 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation