1UPF
STRUCTURE OF THE URACIL PHOSPHORIBOSYLTRANSFERASE, MUTANT C128V BOUND TO THE DRUG 5-FLUOROURACIL
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | D, C, B, A | URACIL PHOSPHORIBOSYLTRANSFERASE | polymer | 224 | 25543.0 | 4 | UniProt (Q26998) Pfam (PF14681) In PDB | Toxoplasma gondii | UPRTASE |
| 2 | D, C, B, A | SULFATE ION | non-polymer | 96.1 | 12 | Chemie (SO4) | |||
| 3 | D, C, B, A | 5-FLUOROURACIL | non-polymer | 130.1 | 4 | Chemie (URF) | |||
| 4 | water | water | 18.0 | 207 | Chemie (HOH) |
Sequence modifications
D, C, B, A: 21 - 244 (UniProt: Q26998)
| PDB | External Database | Details |
|---|---|---|
| Gln 84 | Glu 84 | conflict |
| Val 128 | Cys 128 | engineered mutation |
| Glu 157 | Asp 157 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 102172.0 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 1673.1 | |
| All* | Total formula weight | 103845.1 |
