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PDB: 166 件
5EZ8
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BU of 5ez8 by Molmil
A de novo designed heptameric coiled coil CC-Hept-I-C-I
分子名称: CC-Hept-I-C-I
著者Burton, A.J, Brady, R.L, Woolfson, D.N.
登録日2015-11-26
公開日2016-07-06
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Installing hydrolytic activity into a completely de novo protein framework.
Nat.Chem., 8, 2016
1T2D
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BU of 1t2d by Molmil
Plasmodium falciparum lactate dehydrogenase complexed with NAD+ and oxalate
分子名称: GLYCEROL, L-lactate dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ...
著者Cameron, A, Read, J, Tranter, R, Winter, V.J, Sessions, R.B, Brady, R.L, Vivas, L, Easton, A, Kendrick, H, Croft, S.L, Barros, D, Lavandera, J.L, Martin, J.J, Risco, F, Garcia-Ochoa, S, Gamo, F.J, Sanz, L, Leon, L, Ruiz, J.R, Gabarro, R, Mallo, A, De Las Heras, F.G.
登録日2004-04-21
公開日2004-05-11
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (1.1 Å)
主引用文献Identification and Activity of a Series of Azole-based Compounds with Lactate Dehydrogenase-directed Anti-malarial Activity.
J.Biol.Chem., 279, 2004
1T2F
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BU of 1t2f by Molmil
Human B lactate dehydrogenase complexed with NAD+ and 4-hydroxy-1,2,5-oxadiazole-3-carboxylic acid
分子名称: 4-HYDROXY-1,2,5-OXADIAZOLE-3-CARBOXYLIC ACID, L-lactate dehydrogenase B chain, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
著者Cameron, A, Read, J, Tranter, R, Winter, V.J, Sessions, R.B, Brady, R.L, Vivas, L, Easton, A, Kendrick, H, Croft, S.L, Barros, D, Lavandera, J.L, Martin, J.J, Risco, F, Garcia-Ochoa, S, Gamo, F.J, Sanz, L, Leon, L, Ruiz, J.R, Gabarro, R, Mallo, A, De Las Heras, F.G.
登録日2004-04-21
公開日2004-05-11
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Identification and Activity of a Series of Azole-based Compounds with Lactate Dehydrogenase-directed Anti-malarial Activity.
J.Biol.Chem., 279, 2004
5EZA
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BU of 5eza by Molmil
A de novo designed heptameric coiled coil CC-Hept-I18C-L22H
分子名称: CC-Hept-C-H-I, GLYCEROL
著者Burton, A.J, Brady, R.L, Woolfson, D.N.
登録日2015-11-26
公開日2016-07-06
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.76 Å)
主引用文献Installing hydrolytic activity into a completely de novo protein framework.
Nat.Chem., 8, 2016
5EZE
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BU of 5eze by Molmil
A de novo designed heptameric coiled coil CC-Hept-I18betaMeCys-L22H-I25E
分子名称: CC-Hept-bMeCys-His-Glu, GLYCEROL
著者Burton, A.J, Brady, R.L, Woolfson, D.N.
登録日2015-11-26
公開日2016-07-06
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Installing hydrolytic activity into a completely de novo protein framework.
Nat.Chem., 8, 2016
5EZ9
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BU of 5ez9 by Molmil
A de novo designed heptameric coiled coil CC-Hept-I-H-I
分子名称: CC-Hept-L22H, HEXANE-1,6-DIOL
著者Burton, A.J, Brady, R.L, Woolfson, D.N.
登録日2015-11-26
公開日2016-07-06
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Installing hydrolytic activity into a completely de novo protein framework.
Nat.Chem., 8, 2016
5EZC
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BU of 5ezc by Molmil
A de novo designed heptameric coiled coil CC-Hept-I18C-L22H-I25E
分子名称: CC-Hept-C-H-E
著者Burton, A.J, Brady, R.L, Woolfson, D.N.
登録日2015-11-26
公開日2016-07-06
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Installing hydrolytic activity into a completely de novo protein framework.
Nat.Chem., 8, 2016
5F2Y
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BU of 5f2y by Molmil
A de novo designed heptameric coiled coil CC-Hept-homoCys-H-E
分子名称: CC-Hept-hCys-H-E
著者Burton, A.J, Brady, R.L, Woolfson, D.N.
登録日2015-12-02
公開日2016-07-06
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Installing hydrolytic activity into a completely de novo protein framework.
Nat.Chem., 8, 2016
1T2C
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BU of 1t2c by Molmil
Plasmodium falciparum lactate dehydrogenase complexed with NADH
分子名称: 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, GLYCEROL, L-lactate dehydrogenase
著者Cameron, A, Read, J, Tranter, R, Winter, V.J, Sessions, R.B, Brady, R.L, Vivas, L, Easton, A, Kendrick, H, Croft, S.L, Barros, D, Lavandera, J.L, Martin, J.J, Risco, F, Garcia-Ochoa, S, Gamo, F.J, Sanz, L, Leon, L, Ruiz, J.R, Gabarro, R, Mallo, A, De Las Heras, F.G.
登録日2004-04-21
公開日2004-05-11
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.01 Å)
主引用文献Identification and Activity of a Series of Azole-based Compounds with Lactate Dehydrogenase-directed Anti-malarial Activity.
J.Biol.Chem., 279, 2004
1CET
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BU of 1cet by Molmil
CHLOROQUINE BINDS IN THE COFACTOR BINDING SITE OF PLASMODIUM FALCIPARUM LACTATE DEHYDROGENASE.
分子名称: N4-(7-CHLORO-QUINOLIN-4-YL)-N1,N1-DIETHYL-PENTANE-1,4-DIAMINE, PROTEIN (L-LACTATE DEHYDROGENASE)
著者Read, J.A, Wilkinson, K.W, Tranter, R, Sessions, R.B, Brady, R.L.
登録日1999-03-10
公開日1999-03-19
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Chloroquine binds in the cofactor binding site of Plasmodium falciparum lactate dehydrogenase.
J.Biol.Chem., 274, 1999
1CEQ
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BU of 1ceq by Molmil
CHLOROQUINE BINDS IN THE COFACTOR BINDING SITE OF PLASMODIUM FALCIPARUM LACTATE DEHYDROGENASE.
分子名称: PROTEIN (L-LACTATE DEHYDROGENASE)
著者Read, J.A, Wilkinson, K.W, Tranter, R, Sessions, R.B, Brady, R.L.
登録日1999-03-10
公開日1999-03-19
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Chloroquine binds in the cofactor binding site of Plasmodium falciparum lactate dehydrogenase.
J.Biol.Chem., 274, 1999
1CLO
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BU of 1clo by Molmil
ANTI-CARCINOEMBRYONIC ANTIGEN MONOCLONAL ANTIBODY A5B7
分子名称: A5B7 MONOCLONAL ANTIBODY
著者Banfield, M.J, King, D.J, Mountain, A, Brady, R.L.
登録日1996-05-01
公開日1997-05-15
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献VL:VH domain rotations in engineered antibodies: crystal structures of the Fab fragments from two murine antitumor antibodies and their engineered human constructs.
Proteins, 29, 1997
3R3K
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BU of 3r3k by Molmil
Crystal structure of a parallel 6-helix coiled coil
分子名称: 1,2-ETHANEDIOL, CChex-Phi22 helix, CHLORIDE ION, ...
著者Zaccai, N.R, Chi, B.H.C, Woolfson, D.N, Brady, R.L.
登録日2011-03-16
公開日2011-11-16
最終更新日2011-11-30
実験手法X-RAY DIFFRACTION (2.2009 Å)
主引用文献A de novo peptide hexamer with a mutable channel.
Nat.Chem.Biol., 7, 2011
3R8Q
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BU of 3r8q by Molmil
Structure of Fibronectin domain 12-14
分子名称: Fibronectin
著者Zaccai, N.R, Agnew, C, Brady, R.L.
登録日2011-03-24
公開日2012-04-11
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structure of Fibronectin domain 12-14
To be Published
3R9B
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BU of 3r9b by Molmil
Crystal structure of Mycobacterium smegmatis CYP164A2 in ligand free state
分子名称: 1,2-ETHANEDIOL, CYTOCHROME P450 164A2, DODECANE, ...
著者Agnew, C.R.J, Warrilow, A.G.S, Kelly, S.L, Brady, R.L.
登録日2011-03-25
公開日2012-04-04
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (1.89 Å)
主引用文献An enlarged, adaptable active site in CYP164 family P450 enzymes, the sole P450 in Mycobacterium leprae.
Antimicrob.Agents Chemother., 56, 2012
3PR7
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BU of 3pr7 by Molmil
Multi-functional and mechanosensitive receptor binding activity of the Moraxella catarrhalis adhesin UspA1
分子名称: UspA1
著者Agnew, C.R.J, Zaccai, N.R, Conners, R, Brady, R.L.
登録日2010-11-29
公開日2011-09-07
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.94 Å)
主引用文献Correlation of in situ mechanosensitive responses of the Moraxella catarrhalis adhesin UspA1 with fibronectin and receptor CEACAM1 binding.
Proc.Natl.Acad.Sci.USA, 108, 2011
3RA3
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BU of 3ra3 by Molmil
Crystal structure of a section of a de novo design gigaDalton protein fibre
分子名称: SODIUM ION, p1c, p2f
著者Zaccai, N.R, Sharp, T.H, Bruning, M, Woolfson, D.N, Brady, R.L.
登録日2011-03-27
公開日2012-08-08
最終更新日2013-06-19
実験手法X-RAY DIFFRACTION (2.31 Å)
主引用文献Cryo-transmission electron microscopy structure of a gigadalton peptide fiber of de novo design
Proc.Natl.Acad.Sci.USA, 109, 2012
3R47
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BU of 3r47 by Molmil
Crystal structure of a 6-helix coiled coil CC-hex-H24
分子名称: BROMIDE ION, coiled coil helix L24H
著者Zaccai, N.R, Chi, B.H.C, Woolfson, D.N, Brady, R.L.
登録日2011-03-17
公開日2011-11-16
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.5002 Å)
主引用文献A de novo peptide hexamer with a mutable channel.
Nat.Chem.Biol., 7, 2011
3R9C
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BU of 3r9c by Molmil
Crystal structure of Mycobacterium smegmatis CYP164A2 with Econazole bound
分子名称: 1,2-ETHANEDIOL, 1-[(2R)-2-[(4-chlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole, Cytochrome P450 164A2, ...
著者Agnew, C.R.J, Kelly, S.L, Brady, R.L.
登録日2011-03-25
公開日2012-03-28
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.14 Å)
主引用文献An enlarged, adaptable active site in CYP164 family P450 enzymes, the sole P450 in Mycobacterium leprae.
Antimicrob.Agents Chemother., 56, 2012
3R46
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BU of 3r46 by Molmil
Crystal structure of a parallel 6-helix coiled coil CC-hex-D24
分子名称: CHLORIDE ION, GLYCEROL, SODIUM ION, ...
著者Zaccai, N.R, Chi, B.H.C, Woolfson, D.N, Brady, R.L.
登録日2011-03-17
公開日2011-11-16
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.751 Å)
主引用文献A de novo peptide hexamer with a mutable channel.
Nat.Chem.Biol., 7, 2011
3R4A
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BU of 3r4a by Molmil
Crystal structure of the 4-helix coiled coil CC-tet
分子名称: coiled coil helix CC-tet
著者Zaccai, N.R, Chi, B.H.C, Woolfson, D.N, Brady, R.L.
登録日2011-03-17
公開日2011-11-16
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.0701 Å)
主引用文献A de novo peptide hexamer with a mutable channel.
Nat.Chem.Biol., 7, 2011
3R48
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BU of 3r48 by Molmil
Crystal structure of a hetero-hexamer coiled coil
分子名称: GLYCEROL, coiled coil helix W22-L24H, coiled coil helix Y15-L24D
著者Zaccai, N.R, Chi, B.H.C, Woolfson, D.N, Brady, R.L.
登録日2011-03-17
公開日2011-11-16
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.0011 Å)
主引用文献A de novo peptide hexamer with a mutable channel.
Nat.Chem.Biol., 7, 2011
3R4H
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BU of 3r4h by Molmil
Crystal structure of the 4-helix coiled coil CC-Tet-phi22
分子名称: coiled coil helix CC-Tet-phi22
著者Zaccai, N.R, Chi, B.H.C, Woolfson, D.N, Brady, R.L.
登録日2011-03-17
公開日2011-11-16
最終更新日2019-07-17
実験手法X-RAY DIFFRACTION (2.7003 Å)
主引用文献A de novo peptide hexamer with a mutable channel.
Nat.Chem.Biol., 7, 2011
1EB2
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BU of 1eb2 by Molmil
Trypsin inhibitor complex (BPO)
分子名称: 3-[(Z)-AMINO(IMINO)METHYL]-N-[2-(4-BENZOYL-1-PIPERIDINYL)-2-OXO-1-PHENYLETHYL]BENZAMIDE, CALCIUM ION, SULFATE ION, ...
著者Wilkinson, K.W, Young, S.C, Liebeschuetz, J.W, Brady, R.L.
登録日2001-07-18
公開日2002-02-11
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Pro_Select: Combining Structure-Based Drug Design and Array-Based Chemistry for Rapid Lead Discovery. 2. The Development of a Series of Highly Potent and Selective Factor Xa Inhibitors
J.Med.Chem., 45, 2002
1A7B
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BU of 1a7b by Molmil
ENGINEERING A MISFOLDED FORM OF CD2
分子名称: CD2
著者Murray, A.J, Head, J.G, Barker, J.J, Brady, R.L.
登録日1998-03-10
公開日1998-06-17
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Engineering an intertwined form of CD2 for stability and assembly.
Nat.Struct.Biol., 5, 1998

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