7QUO
 
 | | FimH lectin domain in complex with oligomannose-6 | | Descriptor: | FimH, NICKEL (II) ION, SULFATE ION, ... | | Authors: | Bouckaert, J, Bourenkov, G.P. | | Deposit date: | 2022-01-18 | | Release date: | 2023-02-01 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Structural insights into a cooperative switch between one and two FimH bacterial adhesins binding pauci- and high-mannose type N-glycan receptors
J.Biol.Chem., 299, 2023
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8BY3
 | | FimH lectin domain in complex with oligomannose-6 | | Descriptor: | NICKEL (II) ION, SULFATE ION, Type 1 fimbrin D-mannose specific adhesin, ... | | Authors: | Bouckaert, J, Bourenkov, G.P. | | Deposit date: | 2022-12-11 | | Release date: | 2023-04-12 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (3.186 Å) | | Cite: | Structural insights into a cooperative switch between one and two FimH bacterial adhesins binding pauci- and high-mannose type N-glycan receptors.
J.Biol.Chem., 299, 2023
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1QDO
 | | MAN(APLHA1-3)MAN(ALPHA1-O)METHYL CONCANAVALIN A COMPLEX | | Descriptor: | CALCIUM ION, MANGANESE (II) ION, PROTEIN (CONCANAVALIN A), ... | | Authors: | Bouckaert, J, Loris, R, Wyns, L. | | Deposit date: | 1999-05-24 | | Release date: | 1999-10-14 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | The crystal structures of Man(alpha1-3)Man(alpha1-O)Me and Man(alpha1-6)Man(alpha1-O)Me in complex with concanavalin A.
J.Biol.Chem., 274, 1999
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8BVD
 | | FimH lectin domain in complex with mannose C-linked to quinoline | | Descriptor: | (2R,3S,4R,5S,6R)-2-(hydroxymethyl)-6-[(E)-3-quinolin-6-ylprop-2-enyl]oxane-3,4,5-triol, Type 1 fimbrin D-mannose specific adhesin | | Authors: | Bouckaert, J, Bridot, C. | | Deposit date: | 2022-12-03 | | Release date: | 2023-02-15 | | Last modified: | 2023-03-08 | | Method: | X-RAY DIFFRACTION (2.995 Å) | | Cite: | Insightful Improvement in the Design of Potent Uropathogenic E. coli FimH Antagonists.
Pharmaceutics, 15, 2023
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2ENR
 | | CO-CRYSTALS OF DEMETALLIZED CONCANAVALIN A WITH CADMIUM HAVING A CADMIUM ION BOUND IN BOTH THE S1 SITE AND THE S2 SITE | | Descriptor: | CADMIUM ION, CONCANAVALIN A | | Authors: | Bouckaert, J, Loris, R, Wyns, L. | | Deposit date: | 1998-07-14 | | Release date: | 1999-02-16 | | Last modified: | 2024-05-22 | | Method: | X-RAY DIFFRACTION (2.35 Å) | | Cite: | Zinc/calcium- and cadmium/cadmium-substituted concanavalin A: interplay of metal binding, pH and molecular packing.
Acta Crystallogr.,Sect.D, 56, 2000
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1APN
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1UWF
 | | 1.7 A resolution structure of the receptor binding domain of the FimH adhesin from uropathogenic E. coli | | Descriptor: | FIMH PROTEIN, GLYCEROL, butyl alpha-D-mannopyranoside | | Authors: | Bouckaert, J, Berglund, J, Genst, E.D, Cools, L, Hung, C.-S, Wuhrer, M, Zavialov, A, Langermann, S, Hultgren, S, Wyns, L, Oscarson, S, Knight, S.D, De Greve, H. | | Deposit date: | 2004-02-05 | | Release date: | 2005-02-16 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (1.69 Å) | | Cite: | Receptor Binding Studies Disclose a Novel Class of High-Affinity Inhibitors of the Escherichia Coli Fimh Adhesin.
Mol.Microbiol., 55, 2005
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1TR7
 | | FimH adhesin receptor binding domain from uropathogenic E. coli | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, CACODYLATE ION, FimH protein, ... | | Authors: | Bouckaert, J, Berglund, J, Schembri, M, De Genst, E, Cools, L, Wuhrer, M, Hung, C.S, Pinkner, J, Slattegard, R, Zavialov, A, Choudhury, D, Langermann, S, Hultgren, S.J, Wyns, L, Klemm, P, Oscarson, S, Knight, S.D, De Greve, H. | | Deposit date: | 2004-06-21 | | Release date: | 2005-05-03 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Receptor binding studies disclose a novel class of high-affinity inhibitors of the Escherichia coli FimH adhesin
Mol.Microbiol., 55, 2005
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5FWR
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5FX3
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5FS5
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1CES
 | | CRYSTALS OF DEMETALLIZED CONCANAVALIN A SOAKED WITH ZINC HAVE A ZINC ION BOUND IN THE S1 SITE | | Descriptor: | CONCANAVALIN A, ZINC ION | | Authors: | Bouckaert, J, Loris, R, Poortmans, F, Wyns, L. | | Deposit date: | 1996-02-15 | | Release date: | 1997-02-15 | | Last modified: | 2024-05-22 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Sequential structural changes upon zinc and calcium binding to metal-free concanavalin A.
J.Biol.Chem., 271, 1996
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1ENS
 | | CRYSTALS OF DEMETALLIZED CONCANAVALIN A SOAKED WITH COBALT HAVING A COBALT ION BOUND IN THE S1 SITE | | Descriptor: | COBALT (II) ION, CONCANAVALIN A | | Authors: | Bouckaert, J, Loris, R, Poortmans, F, Wyns, L. | | Deposit date: | 1996-03-20 | | Release date: | 1996-08-17 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Sequential structural changes upon zinc and calcium binding to metal-free concanavalin A.
J.Biol.Chem., 271, 1996
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1ONA
 | | CO-CRYSTALS OF CONCANAVALIN A WITH METHYL-3,6-DI-O-(ALPHA-D-MANNOPYRANOSYL)-ALPHA-D-MANNOPYRANOSIDE | | Descriptor: | CALCIUM ION, CONCANAVALIN A, MANGANESE (II) ION, ... | | Authors: | Bouckaert, J, Maes, D, Poortmans, F, Wyns, L, Loris, R. | | Deposit date: | 1996-07-07 | | Release date: | 1997-09-17 | | Last modified: | 2024-05-22 | | Method: | X-RAY DIFFRACTION (2.35 Å) | | Cite: | A structure of the complex between concanavalin A and methyl-3,6-di-O-(alpha-D-mannopyranosyl)-alpha-D-mannopyranoside reveals two binding modes.
J.Biol.Chem., 271, 1996
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1ENQ
 | | CO-CRYSTALS OF DEMETALLIZED CONCANAVALIN A WITH ZINC HAVING A ZINC ION BOUND IN THE S1 SITE | | Descriptor: | CONCANAVALIN A, ZINC ION | | Authors: | Bouckaert, J, Loris, R, Poortmans, F, Wyns, L. | | Deposit date: | 1996-03-20 | | Release date: | 1996-08-17 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Sequential structural changes upon zinc and calcium binding to metal-free concanavalin A.
J.Biol.Chem., 271, 1996
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1ENR
 | | CO-CRYSTALS OF DEMETALLIZED CONCANAVALIN A WITH ZINC AND CALCIUM HAVING A ZINC ION BOUND IN THE S1 SITE AND A CALCIUM ION BOUND IN THE S2 SITE | | Descriptor: | CALCIUM ION, CONCANAVALIN A, ZINC ION | | Authors: | Bouckaert, J, Loris, R, Poortmans, F, Wyns, L. | | Deposit date: | 1996-03-20 | | Release date: | 1996-08-17 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.83 Å) | | Cite: | Sequential structural changes upon zinc and calcium binding to metal-free concanavalin A.
J.Biol.Chem., 271, 1996
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1QDC
 | | MAN(APLHA1-6)MAN(ALPHA1-O)METHYL CONCANAVALIN A COMPLEX | | Descriptor: | CALCIUM ION, CHLORIDE ION, MANGANESE (II) ION, ... | | Authors: | Bouckaert, J, Loris, R, Wyns, L. | | Deposit date: | 1998-07-14 | | Release date: | 1999-10-14 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | The crystal structures of Man(alpha1-3)Man(alpha1-O)Me and Man(alpha1-6)Man(alpha1-O)Me in complex with concanavalin A.
J.Biol.Chem., 274, 1999
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3ENR
 | | ZINC-CALCIUM CONCANAVALIN A AT PH 6.15 | | Descriptor: | CALCIUM ION, Concanavalin-A, ZINC ION | | Authors: | Bouckaert, J, Loris, R, Wyns, L. | | Deposit date: | 1999-02-11 | | Release date: | 2000-09-18 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Zinc/calcium- and cadmium/cadmium-substituted concanavalin A: interplay of metal binding, pH and molecular packing.
Acta Crystallogr.,Sect.D, 56, 2000
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1DQ0
 | | Locked, metal-free concanavalin A, a minor species in solution | | Descriptor: | Concanavalin-Br | | Authors: | Bouckaert, J, Dewallef, Y, Poortmans, F, Wyns, L, Loris, R. | | Deposit date: | 1999-12-29 | | Release date: | 2000-01-19 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | The structural features of concanavalin A governing non-proline peptide isomerization
J.Biol.Chem., 275, 2000
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1DQ4
 | | A transient unlocked concanavalin A structure with MN2+ bound in the transition metal ion binding site S1 and an empty calcium binding site S2 | | Descriptor: | Concanavalin-Br, MANGANESE (II) ION | | Authors: | Bouckaert, J, Dewallef, Y, Poortmans, F, Wyns, L, Loris, R. | | Deposit date: | 1999-12-30 | | Release date: | 2000-01-19 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | The structural features of concanavalin A governing non-proline peptide isomerization
J.Biol.Chem., 275, 2000
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1DQ1
 | | Calcium;Calcium concanavalin A | | Descriptor: | CALCIUM ION, Concanavalin-Br | | Authors: | Bouckaert, J, Dewallef, Y, Poortmans, F, Wyns, L, Loris, R. | | Deposit date: | 1999-12-29 | | Release date: | 2000-01-19 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | The structural features of concanavalin A governing non-proline peptide isomerization
J.Biol.Chem., 275, 2000
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1DQ6
 | | Manganese;Manganese concanavalin A at pH 7.0 | | Descriptor: | Concanavalin-A, MANGANESE (II) ION | | Authors: | Bouckaert, J, Dewallef, Y, Poortmans, F, Wyns, L, Loris, R. | | Deposit date: | 1999-12-30 | | Release date: | 2000-01-19 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | The structural features of concanavalin A governing non-proline peptide isomerization
J.Biol.Chem., 275, 2000
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1DQ2
 | | Unlocked metal-free concanavalin A | | Descriptor: | ACETIC ACID, Concanavalin-Br | | Authors: | Bouckaert, J, Dewallef, Y, Poortmans, F, Wyns, L, Loris, R. | | Deposit date: | 1999-12-29 | | Release date: | 2000-01-19 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | The structural features of concanavalin A governing non-proline peptide isomerization
J.Biol.Chem., 275, 2000
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1DQ5
 | | Manganese;Manganese concanavalin A at pH 5.0 | | Descriptor: | Concanavalin-Br, MANGANESE (II) ION | | Authors: | Bouckaert, J, Dewallef, Y, Poortmans, F, Wyns, L, Loris, R. | | Deposit date: | 1999-12-30 | | Release date: | 2000-01-19 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | The structural features of concanavalin A governing non-proline peptide isomerization
J.Biol.Chem., 275, 2000
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4AV4
 | | FimH lectin domain co-crystal with a alpha-D-mannoside O-linked to a propynyl pyridine | | Descriptor: | 3-(pyridin-3-yl)prop-2-yn-1-yl alpha-D-mannopyranoside, FIMH | | Authors: | Bouckaert, J, Touaibia, M, Roos, G, Shiao, T.C, Wang, Q, Papadopoulos, A, Roy, R. | | Deposit date: | 2012-05-23 | | Release date: | 2012-06-27 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | The Tyrosine Gate as a Potential Entropic Lever in the Receptor-Binding Site of the Bacterial Adhesin Fimh.
Biochemistry, 51, 2012
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