1RK8
 
 | | Structure of the cytosolic protein PYM bound to the Mago-Y14 core of the exon junction complex | | 分子名称: | CALCIUM ION, CG8781-PA protein, Mago nashi protein, ... | | 著者 | Bono, F, Ebert, J, Guettler, T, Izaurralde, E, Conti, E. | | 登録日 | 2003-11-21 | | 公開日 | 2004-04-13 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Molecular insights into the interaction of PYM with
the Mago-Y14 core of the exon junction complex
EMBO Rep., 5, 2004
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2X1G
 | | Crystal structure of Importin13 - Mago-Y14 complex | | 分子名称: | CADMUS, PROTEIN MAGO NASHI, RNA-BINDING PROTEIN 8A | | 著者 | Bono, F, Cook, A.G, Gruenwald, M, Ebert, J, Conti, E. | | 登録日 | 2009-12-23 | | 公開日 | 2010-02-16 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (3.35 Å) | | 主引用文献 | Nuclear Import Mechanism of the Ejc Component Mago- Y14 Revealed by Structural Studies of Importin 13.
Mol.Cell, 37, 2010
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2X19
 | | Crystal structure of Importin13 - RanGTP complex | | 分子名称: | GTP-BINDING NUCLEAR PROTEIN GSP1/CNR1, GUANOSINE-5'-TRIPHOSPHATE, IMPORTIN-13, ... | | 著者 | Bono, F, Cook, A.G, Gruenwald, M, Ebert, J, Conti, E. | | 登録日 | 2009-12-23 | | 公開日 | 2010-02-16 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Nuclear Import Mechanism of the Ejc Component Mago- Y14 Revealed by Structural Studies of Importin 13.
Mol.Cell, 37, 2010
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2J0S
 | | The crystal structure of the Exon Junction Complex at 2.2 A resolution | | 分子名称: | 5'-R(*UP*UP*UP*UP*UP*UP*UP*UP*UP*UP *UP*UP*UP*UP*U)-3', ATP-DEPENDENT RNA HELICASE DDX48, MAGNESIUM ION, ... | | 著者 | Bono, F, Ebert, J, Lorentzen, E, Conti, E. | | 登録日 | 2006-08-04 | | 公開日 | 2006-09-06 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.21 Å) | | 主引用文献 | The Crystal Structure of the Exon Junction Complex Reveals How It Mantains a Stable Grip on Mrna
Cell(Cambridge,Mass.), 126, 2006
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2J0Q
 | | The crystal structure of the Exon Junction Complex at 3.2 A resolution | | 分子名称: | 5'-R(*UP*UP*UP*UP*UP*UP*UP*UP*UP*UP*UP*UP*UP*UP*U)-3', ATP-DEPENDENT RNA HELICASE DDX48, MAGNESIUM ION, ... | | 著者 | Bono, F, Ebert, J, Lorentzen, E, Conti, E. | | 登録日 | 2006-08-04 | | 公開日 | 2006-08-30 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | The Crystal Structure of the Exon Junction Complex Reveals How It Maintains a Stable Grip on Mrna.
Cell(Cambridge,Mass.), 126, 2006
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2J0U
 | | The crystal structure of eIF4AIII-Barentsz complex at 3.0 A resolution | | 分子名称: | ATP-DEPENDENT RNA HELICASE DDX48, PROTEIN CASC3 | | 著者 | Bono, F, Ebert, J, Lorentzen, E, Conti, E. | | 登録日 | 2006-08-04 | | 公開日 | 2006-09-06 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | The Crystal Structure of the Exon Junction Complex Reveals How It Mantains a Stable Grip on Mrna
Cell(Cambridge,Mass.), 126, 2006
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6F0E
 | | Structure of yeast Sec14p with a picolinamide compound | | 分子名称: | SEC14 cytosolic factor, ~{N}-(1,3-benzodioxol-5-ylmethyl)-5-bromanyl-3-fluoranyl-pyridine-2-carboxamide | | 著者 | Hong, Z, Johnen, P, Schaaf, G, Bono, F. | | 登録日 | 2017-11-20 | | 公開日 | 2018-01-17 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Target Identification and Mechanism of Action of Picolinamide and Benzamide Chemotypes with Antifungal Properties.
Cell Chem Biol, 25, 2018
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5L7Z
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5L80
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6HU6
 | | Structure of ARF1 RNA | | 分子名称: | AMMONIUM ION, RNA (19-MER), RNA (5'-R(*CP*UP*GP*GP*UP*AP*CP*UP*C)-3'), ... | | 著者 | Emmerich, C, Lazzaretti, D, Bandholz-Cajamarca, L, Bono, F. | | 登録日 | 2018-10-05 | | 公開日 | 2018-11-21 | | 最終更新日 | 2024-05-15 | | 実験手法 | X-RAY DIFFRACTION (1.904 Å) | | 主引用文献 | The crystal structure of Staufen1 in complex with a physiological RNA sheds light on substrate selectivity.
Life Sci Alliance, 1, 2018
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6HTU
 | | Structure of hStau1 dsRBD3-4 in complex with ARF1 RNA | | 分子名称: | Double-stranded RNA-binding protein Staufen homolog 1, RNA (19-MER) | | 著者 | Emmerich, C, Lazzaretti, D, Bandholz-Cajamarca, L, Bono, F. | | 登録日 | 2018-10-04 | | 公開日 | 2018-11-21 | | 最終更新日 | 2024-05-15 | | 実験手法 | X-RAY DIFFRACTION (2.888 Å) | | 主引用文献 | The crystal structure of Staufen1 in complex with a physiological RNA sheds light on substrate selectivity.
Life Sci Alliance, 1, 2018
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4BTU
 | | Factor Xa in complex with the dual thrombin-FXa inhibitor 57. | | 分子名称: | 5-Chloro-thiophene-2-carboxylic acid [(S)-2-[2-chloro-5-fluoro-3-(2-oxo-piperidin-1-yl)-benzenesulfonylamino]-3-(4-methyl-piperazin-1-yl)-3-oxo-propyl]-amide, CALCIUM ION, COAGULATION FACTOR X HEAVY CHAIN, ... | | 著者 | Meneyrol, J, Follmann, M, Lassalle, G, Wehner, V, Barre, G, Rousseaux, T, Altenburger, J.M, Petit, F, Bocskei, Z, Stehlin-Gaon, C, Schreuder, H, Alet, N, Herault, J.-P, Millet, L, Dol, F, Hasbrand, C, Schaeffer, P, Sadoun, F, Klieber, S, Briot, C, Bono, F, Herbert, J.-M. | | 登録日 | 2013-06-19 | | 公開日 | 2013-12-18 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.37 Å) | | 主引用文献 | 5-Chlorothiophene-2-Carboxylic Acid [(S)-2-[2-Methyl-3-(2-Oxopyrrolidin-1-Yl)Benzenesulfonylamino]-3-(4-Methylpiperazin-1-Yl)-3-Oxopropyl]Amide (Sar107375), a Selective and Potent Orally Active Dual Thrombin and Factor Xa Inhibitor.
J.Med.Chem., 56, 2013
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4BTI
 | | factor Xa in complex with the dual thrombin-FXa inhibitor 58. | | 分子名称: | 5-Chloro-thiophene-2-carboxylic acid [(S)-2-[2-difluoromethoxy-3-(2-oxo-piperidin-1-yl)-benzenesulfonylamino]-3-((S)-3-dimethylamino-pyrrolidin-1-yl)-3-oxo-propyl]-amide, CALCIUM ION, COAGULATION FACTOR X HEAVY CHAIN, ... | | 著者 | Meneyrol, J, Follmann, M, Lassalle, G, Wehner, V, Barre, G, Rousseaux, T, Altenburger, J.M, Petit, F, Bocskei, Z, Stehlin-Gaon, C, Schreuder, H, Alet, N, Herault, J.-P, Millet, L, Dol, F, Hasbrand, C, Schaeffer, P, Sadoun, F, Klieber, S, Briot, C, Bono, F, Herbert, J.-M. | | 登録日 | 2013-06-18 | | 公開日 | 2013-12-25 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | 5-Chlorothiophene-2-Carboxylic Acid [(S)-2-[2-Methyl-3-(2-Oxopyrrolidin-1-Yl)Benzenesulfonylamino]-3-(4-Methylpiperazin-1-Yl)-3-Oxopropyl]Amide (Sar107375), a Selective and Potent Orally Active Dual Thrombin and Factor Xa Inhibitor.
J.Med.Chem., 56, 2013
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4BTT
 | | factor Xa in complex with the dual thrombin-FXa inhibitor 31. | | 分子名称: | CALCIUM ION, COAGULATION FACTOR X, COAGULATION FACTOR X LIGHT CHAIN, ... | | 著者 | Meneyrol, J, Follmann, M, Lassalle, G, Wehner, V, Barre, G, Rousseaux, T, Altenburger, J.M, Petit, F, Bocskei, Z, Stehlin-Gaon, C, Schreuder, H, Alet, N, Herault, J.-P, Millet, L, Dol, F, Hasbrand, C, Schaeffer, P, Sadoun, F, Klieber, S, Briot, C, Bono, F, Herbert, J.-M. | | 登録日 | 2013-06-19 | | 公開日 | 2013-12-18 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (2.59 Å) | | 主引用文献 | 5-Chlorothiophene-2-Carboxylic Acid [(S)-2-[2-Methyl-3-(2-Oxopyrrolidin-1-Yl)Benzenesulfonylamino]-3-(4-Methylpiperazin-1-Yl)-3-Oxopropyl]Amide (Sar107375), a Selective and Potent Orally Active Dual Thrombin and Factor Xa Inhibitor.
J.Med.Chem., 56, 2013
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7ZGB
 | | Structure of yeast Sec14p with NPPM112 | | 分子名称: | 4-fluoranyl-~{N}-[(4-pyrrolidin-1-ylphenyl)methyl]benzamide, SEC14 cytosolic factor | | 著者 | Hong, Z, Johnen, P, Schaaf, G, Bono, F. | | 登録日 | 2022-04-03 | | 公開日 | 2023-01-25 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Mechanisms by which small molecules of diverse chemotypes arrest Sec14 lipid transfer activity.
J.Biol.Chem., 299, 2023
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7ZGA
 | | Structure of yeast Sec14p with ergoline | | 分子名称: | SEC14 cytosolic factor, ~{O}9-methyl ~{O}4-[2,2,2-tris(chloranyl)ethyl] (5~{a}~{S},6~{a}~{S},9~{R},10~{a}~{S})-7-methyl-3-nitro-5,5~{a},6,6~{a},8,9,10,10~{a}-octahydroindolo[4,3-fg]quinoline-4,9-dicarboxylate | | 著者 | Hong, Z, Johnen, P, Schaaf, G, Bono, F. | | 登録日 | 2022-04-03 | | 公開日 | 2023-01-25 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.302 Å) | | 主引用文献 | Mechanisms by which small molecules of diverse chemotypes arrest Sec14 lipid transfer activity.
J.Biol.Chem., 299, 2023
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7ZG9
 | | Structure of yeast Sec14p with himbacine | | 分子名称: | Himbacine, SEC14 cytosolic factor | | 著者 | Hong, Z, Johnen, P, Schaaf, G, Bono, F. | | 登録日 | 2022-04-03 | | 公開日 | 2023-01-25 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.764 Å) | | 主引用文献 | Mechanisms by which small molecules of diverse chemotypes arrest Sec14 lipid transfer activity.
J.Biol.Chem., 299, 2023
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7ZGD
 | | Structure of yeast Sec14p with NPPM244 | | 分子名称: | (4-bromanyl-3-nitro-phenyl)-[4-(2-fluorophenyl)piperazin-1-yl]methanone, SEC14 cytosolic factor | | 著者 | Hong, Z, Johnen, P, Schaaf, G, Bono, F. | | 登録日 | 2022-04-03 | | 公開日 | 2023-01-25 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.08 Å) | | 主引用文献 | Mechanisms by which small molecules of diverse chemotypes arrest Sec14 lipid transfer activity.
J.Biol.Chem., 299, 2023
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7ZGC
 | | Structure of yeast Sec14p with NPPM481 | | 分子名称: | (4-chloranyl-3-nitro-phenyl)-[4-(2-fluorophenyl)piperazin-1-yl]methanone, PHOSPHATE ION, SEC14 cytosolic factor | | 著者 | Hong, Z, Johnen, P, Schaaf, G, Bono, F. | | 登録日 | 2022-04-03 | | 公開日 | 2023-01-25 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.236 Å) | | 主引用文献 | Mechanisms by which small molecules of diverse chemotypes arrest Sec14 lipid transfer activity.
J.Biol.Chem., 299, 2023
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2XWU
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2XB2
 | | Crystal structure of the core Mago-Y14-eIF4AIII-Barentsz-UPF3b assembly shows how the EJC is bridged to the NMD machinery | | 分子名称: | EUKARYOTIC INITIATION FACTOR 4A-III, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | | 著者 | Buchwald, G, Ebert, J, Basquin, C, Sauliere, J, Jayachandran, U, Bono, F, Le Hir, H, Conti, E. | | 登録日 | 2010-04-03 | | 公開日 | 2010-05-12 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | | 主引用文献 | Insights Into the Recruitment of the Nmd Machinery from the Crystal Structure of a Core Ejc-Upf3B Complex.
Proc.Natl.Acad.Sci.USA, 107, 2010
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3ZKV
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4AXG
 | | Structure of eIF4E-Cup complex | | 分子名称: | EUKARYOTIC TRANSLATION INITIATION FACTOR 4E, PROTEIN CUP | | 著者 | Kinkelin, K, Veith, K, Gruenwald, M, Bono, F. | | 登録日 | 2012-06-12 | | 公開日 | 2012-08-29 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Crystal Structure of a Minimal Eif4E-Cup Complex Revelas a General Mechanism of Eif4E Regulation in Translational Repression
RNA, 18, 2012
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3ZJY
 | | Crystal Structure of Importin 13 - RanGTP - eIF1A complex | | 分子名称: | EUKARYOTIC TRANSLATION INITIATION FACTOR 1A, X-CHROMOSOMAL, GTP-BINDING NUCLEAR PROTEIN RAN, ... | | 著者 | Gruenwald, M, Lazzaretti, D, Bono, F. | | 登録日 | 2013-01-21 | | 公開日 | 2013-04-10 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | | 主引用文献 | Structural Basis for the Nuclear Export Activity of Importin13.
Embo J., 32, 2013
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