4BTU
Factor Xa in complex with the dual thrombin-FXa inhibitor 57.
Summary for 4BTU
Entry DOI | 10.2210/pdb4btu/pdb |
Related | 4BTI 4BTT |
Descriptor | COAGULATION FACTOR X LIGHT CHAIN, COAGULATION FACTOR X HEAVY CHAIN, CALCIUM ION, ... (5 entities in total) |
Functional Keywords | hydrolase, sar107375, factor xa inhibitor, thrombin inhibitor, chlorothiophene p1 fragment, s3 subsite, microsomes stability, oral antithrombotic, dual inhibitor, iv antithrombotic |
Biological source | HOMO SAPIENS (HUMAN) More |
Total number of polymer chains | 4 |
Total formula weight | 79489.86 |
Authors | Meneyrol, J.,Follmann, M.,Lassalle, G.,Wehner, V.,Barre, G.,Rousseaux, T.,Altenburger, J.M.,Petit, F.,Bocskei, Z.,Stehlin-Gaon, C.,Schreuder, H.,Alet, N.,Herault, J.-P.,Millet, L.,Dol, F.,Hasbrand, C.,Schaeffer, P.,Sadoun, F.,Klieber, S.,Briot, C.,Bono, F.,Herbert, J.-M. (deposition date: 2013-06-19, release date: 2013-12-18, Last modification date: 2024-05-01) |
Primary citation | Meneyrol, J.,Follmann, M.,Lassalle, G.,Wehner, V.,Barre, G.,Rousseaux, T.,Altenburger, J.,Petit, F.,Bocskei, Z.,Schreuder, H.,Alet, N.,Herault, J.,Millet, L.,Dol, F.,Florian, P.,Schaeffer, P.,Sadoun, F.,Klieber, S.,Briot, C.,Bono, F.,Herbert, J. 5-Chlorothiophene-2-Carboxylic Acid [(S)-2-[2-Methyl-3-(2-Oxopyrrolidin-1-Yl)Benzenesulfonylamino]-3-(4-Methylpiperazin-1-Yl)-3-Oxopropyl]Amide (Sar107375), a Selective and Potent Orally Active Dual Thrombin and Factor Xa Inhibitor. J.Med.Chem., 56:9441-, 2013 Cited by PubMed: 24175584DOI: 10.1021/JM4005835 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.37 Å) |
Structure validation
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