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PDB: 478 results

5JIO
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BU of 5jio by Molmil
Structure of Mycobacterium thermoresistibile trehalose-6-phosphate synthase ternary complex with ADP and Glucose-6-phosphate.
Descriptor: 1,2-ETHANEDIOL, 6-O-phosphono-alpha-D-glucopyranose, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Mendes, V, Verma, N, Blaszczyk, M, Blundell, T.L.
Deposit date:2016-04-22
Release date:2017-05-10
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.711 Å)
Cite:Mycobacterial OtsA Structures Unveil Substrate Preference Mechanism and Allosteric Regulation by 2-Oxoglutarate and 2-Phosphoglycerate.
Mbio, 10, 2019
5K5C
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BU of 5k5c by Molmil
Structure of Mycobacterium thermoresistibile trehalose-6-phosphate synthase in a complex with Trehalose.
Descriptor: 1,2-ETHANEDIOL, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, Alpha,alpha-trehalose-phosphate synthase, ...
Authors:Mendes, V, Verma, N, Blaszczyk, M, Blundell, T.L.
Deposit date:2016-05-23
Release date:2017-06-07
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.848 Å)
Cite:Mycobacterial OtsA Structures Unveil Substrate Preference Mechanism and Allosteric Regulation by 2-Oxoglutarate and 2-Phosphoglycerate.
Mbio, 10, 2019
5LUQ
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BU of 5luq by Molmil
Crystal Structure of Human DNA-dependent Protein Kinase Catalytic Subunit (DNA-PKcs)
Descriptor: C-terminal fragment of KU80 (KU80ct194), DNA-dependent protein kinase catalytic subunit,DNA-dependent Protein Kinase Catalytic Subunit,DNA-dependent protein kinase catalytic subunit
Authors:Sibanda, B.L, Chirgadze, D.Y, Ascher, D.B, Blundell, T.L.
Deposit date:2016-09-09
Release date:2017-02-15
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (4.3 Å)
Cite:DNA-PKcs structure suggests an allosteric mechanism modulating DNA double-strand break repair.
Science, 355, 2017
4G5Y
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BU of 4g5y by Molmil
Crystal Structure of Mycobacterium tuberculosis Pantothenate synthetase in a ternary complex with ATP and N,N-DIMETHYLTHIOPHENE-3-SULFONAMIDE
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, ETHANOL, GLYCEROL, ...
Authors:Ciulli, A, Silvestre, H.L, Blundell, T.L, Abell, C.
Deposit date:2012-07-18
Release date:2013-07-03
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Integrated biophysical approach to fragment screening and validation for fragment-based lead discovery.
Proc.Natl.Acad.Sci.USA, 110, 2013
4H7Y
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BU of 4h7y by Molmil
Crystal structure of the tetratricopeptide repeat (TPR) motif of human dual specificity protein kinase Mps1
Descriptor: Dual specificity protein kinase TTK
Authors:Bolanos-Garcia, V.M, Chirgadze, D.Y, Blundell, T.L.
Deposit date:2012-09-21
Release date:2012-12-12
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural and functional insights into the role of the N-terminal Mps1 TPR domain in the SAC (spindle assembly checkpoint).
Biochem.J., 448, 2012
1YJQ
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BU of 1yjq by Molmil
Crystal structure of ketopantoate reductase in complex with NADP+
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 2-dehydropantoate 2-reductase, ACETATE ION, ...
Authors:Lobley, C.M.C, Ciulli, A, Whitney, H.M, Williams, G, Smith, A.G, Abell, C, Blundell, T.L.
Deposit date:2005-01-15
Release date:2005-06-28
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:The crystal structure of Escherichia coli ketopantoate reductase with NADP+ bound.
Biochemistry, 44, 2005
1YON
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BU of 1yon by Molmil
Escherichia coli ketopantoate reductase in complex with 2-monophosphoadenosine-5'-diphosphate
Descriptor: 2-dehydropantoate 2-reductase, [(2R,3R,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3-HYDROXY-4-(PHOSPHONOOXY)TETRAHYDROFURAN-2-YL]METHYL [(2R,3S,4R,5R)-3,4,5-TRIHYDROXYTETRAHYDROFURAN-2-YL]METHYL DIHYDROGEN DIPHOSPHATE
Authors:Ciulli, A, Lobley, C.M.C, Tuck, K.L, Williams, G, Smith, A.G, Blundell, T.L, Abell, C.
Deposit date:2005-01-28
Release date:2006-04-18
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:pH-tuneable binding of 2'-phospho-ADP-ribose to ketopantoate reductase: a structural and calorimetric study.
Acta Crystallogr.,Sect.D, 63, 2007
1XOD
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BU of 1xod by Molmil
Crystal structure of X. tropicalis Spred1 EVH-1 domain
Descriptor: GLYCEROL, Spred1
Authors:Harmer, N.J, Sivak, J.M, Amaya, E, Blundell, T.L.
Deposit date:2004-10-06
Release date:2005-01-25
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:1.15A Crystal structure of the X. tropicalis Spred1 EVH1 domain suggests a fourth distinct peptide-binding mechanism within the EVH1 family
Febs Lett., 579, 2005
1YYH
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BU of 1yyh by Molmil
Crystal structure of the human Notch 1 ankyrin domain
Descriptor: Notch 1, ankyrin domain
Authors:Ehebauer, M.T, Chirgadze, D.Y, Hayward, P, Martinez-Arias, A, Blundell, T.L.
Deposit date:2005-02-25
Release date:2005-08-16
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.901 Å)
Cite:High-resolution crystal structure of the human Notch 1 ankyrin domain
Biochem.J., 392, 2005
4G5F
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BU of 4g5f by Molmil
Pantothenate synthetase in complex with racemate (2S)-2,3-DIHYDRO-1,4-BENZODIOXINE-2-CARBOXYLIC ACID and (2R)-2,3-DIHYDRO-1,4-BENZODIOXINE-2-CARBOXYLIC ACID
Descriptor: (2R)-2,3-dihydro-1,4-benzodioxine-2-carboxylic acid, (2S)-2,3-dihydro-1,4-benzodioxine-2-carboxylic acid, 1,2-ETHANEDIOL, ...
Authors:Silvestre, H.L, Blundell, T.L, Abell, C, Ciulli, A.
Deposit date:2012-07-17
Release date:2013-07-17
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.33 Å)
Cite:Integrated biophysical approach to fragment screening and validation for fragment-based lead discovery.
Proc.Natl.Acad.Sci.USA, 110, 2013
4FZJ
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BU of 4fzj by Molmil
Pantothenate synthetase in complex with 1,3-DIMETHYL-1H-THIENO[2,3-C]PYRAZOLE-5-CARBOXYLIC ACID
Descriptor: 1,2-ETHANEDIOL, 1,3-dimethyl-1H-thieno[2,3-c]pyrazole-5-carboxylic acid, ETHANOL, ...
Authors:Silvestre, H.L, Blundell, T.L, Abell, C, Ciulli, A.
Deposit date:2012-07-06
Release date:2013-06-26
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:Integrated biophysical approach to fragment screening and validation for fragment-based lead discovery.
Proc.Natl.Acad.Sci.USA, 110, 2013
4H7X
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BU of 4h7x by Molmil
Crystal structure of the tetratricopeptide repeat (TPR) motif of human dual specificity protein kinase Mps1
Descriptor: Dual specificity protein kinase TTK, LEAD (II) ION
Authors:Bolanos-Garcia, V.M, Chirgadze, D.Y, Blundell, T.L.
Deposit date:2012-09-21
Release date:2012-12-12
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural and functional insights into the role of the N-terminal Mps1 TPR domain in the SAC (spindle assembly checkpoint).
Biochem.J., 448, 2012
1Z56
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BU of 1z56 by Molmil
Co-Crystal Structure of Lif1p-Lig4p
Descriptor: DNA ligase IV, Ligase interacting factor 1
Authors:Dore, A.S, Furnham, N, Davies, O.R, Sibanda, B.L, Chirgadze, D.Y, Jackson, S.P, Pellegrini, L, Blundell, T.L.
Deposit date:2005-03-17
Release date:2006-01-31
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (3.92 Å)
Cite:Structure of an Xrcc4-DNA ligase IV yeast ortholog complex reveals a novel BRCT interaction mode.
DNA REPAIR, 5, 2006
4B3D
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BU of 4b3d by Molmil
Humanised monomeric RadA in complex with 5-methyl indole
Descriptor: 5-METHYL INDOLE, DNA REPAIR AND RECOMBINATION PROTEIN RADA, PHOSPHATE ION
Authors:Scott, D.E, Ehebauer, M.T, Pukala, T, Marsh, M, Blundell, T.L, Venkitaraman, A.R, Abell, C, Hyvonen, M.
Deposit date:2012-07-23
Release date:2013-02-06
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.589 Å)
Cite:Using a Fragment-Based Approach to Target Protein-Protein Interactions.
Chembiochem, 14, 2013
4B3B
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BU of 4b3b by Molmil
Humanised monomeric RadA in complex with FHTA tetrapeptide
Descriptor: DNA REPAIR AND RECOMBINATION PROTEIN RADA, FHTA TETRAPEPTIDE, PHOSPHATE ION
Authors:Scott, D.E, Ehebauer, M.T, Pukala, T, Marsh, M, Blundell, T.L, Venkitaraman, A.R, Abell, C, Hyvonen, M.
Deposit date:2012-07-23
Release date:2013-02-27
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (1.193 Å)
Cite:Using a Fragment-Based Approach to Target Protein-Protein Interactions.
Chembiochem, 14, 2013
4B2P
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BU of 4b2p by Molmil
RadA C-terminal ATPase domain from Pyrococcus furiosus bound to GTP
Descriptor: DNA REPAIR AND RECOMBINATION PROTEIN RADA, GLYCEROL, GUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Marsh, M.E, Ehebauer, M.T, Scott, D, Abell, C, Blundell, T.L, Hyvonen, M.
Deposit date:2012-07-17
Release date:2013-07-24
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:ATP Half-Sites in Rada and Rad51 Recombinases Bind Nucleotides
FEBS Open Bio, 6, 2016
1E0O
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BU of 1e0o by Molmil
CRYSTAL STRUCTURE OF A TERNARY FGF1-FGFR2-HEPARIN COMPLEX
Descriptor: 2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, FIBROBLAST GROWTH FACTOR 1, FIBROBLAST GROWTH FACTOR RECEPTOR 2, ...
Authors:Pellegrini, L, Burke, D.F, von Delft, F, Mulloy, B, Blundell, T.L.
Deposit date:2000-04-03
Release date:2000-10-23
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal Structure of Fibroblast Growth Factor Receptor Ectodomain Bound to Ligand and Heparin
Nature, 407, 2000
4A6X
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BU of 4a6x by Molmil
RadA C-terminal ATPase domain from Pyrococcus furiosus bound to ATP
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, DNA REPAIR AND RECOMBINATION PROTEIN RADA, MAGNESIUM ION
Authors:Marsh, M.E, Ehebauer, M.T, Scott, D, Abell, C, Blundell, T.L, Hyvonen, M.
Deposit date:2011-11-10
Release date:2012-11-21
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.548 Å)
Cite:ATP Half-Sites in Rada and Rad51 Recombinases Bind Nucleotides
FEBS Open Bio, 6, 2016
4A6P
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BU of 4a6p by Molmil
RadA C-terminal ATPase domain from Pyrococcus furiosus
Descriptor: DNA REPAIR AND RECOMBINATION PROTEIN RADA, PHOSPHATE ION
Authors:Marsh, M.E, Ehebauer, M.T, Scott, D, Abell, C, Blundell, T.L, Hyvonen, M.
Deposit date:2011-11-08
Release date:2012-11-14
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.498 Å)
Cite:ATP Half-Sites in Rada and Rad51 Recombinases Bind Nucleotides
FEBS Open Bio, 6, 2016
4CJM
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BU of 4cjm by Molmil
Crystal structure of human FGF18
Descriptor: FIBROBLAST GROWTH FACTOR 18, SULFATE ION
Authors:Brown, A, Adam, L.E, Blundell, T.L.
Deposit date:2013-12-21
Release date:2014-04-09
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The Crystal Structure of Fibroblast Growth Factor 18 (Fgf18)
Protein Cell, 5, 2014
1AW8
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BU of 1aw8 by Molmil
PYRUVOYL DEPENDENT ASPARTATE DECARBOXYLASE
Descriptor: L-ASPARTATE-ALPHA-DECARBOXYLASE
Authors:Albert, A, Dhanaraj, V, Genschel, U, Khan, G, Ramjee, M.K, Pulido, R, Sybanda, B.L, von Delf, F, Witty, M, Blundell, T.L, Smith, A.G, Abell, C.
Deposit date:1997-10-12
Release date:1998-04-29
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of aspartate decarboxylase at 2.2 A resolution provides evidence for an ester in protein self-processing.
Nat.Struct.Biol., 5, 1998
4B33
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BU of 4b33 by Molmil
Humanised monomeric RadA in complex with napht-2-ol
Descriptor: 1-NAPHTHOL, DNA REPAIR AND RECOMBINATION PROTEIN RADA, PHOSPHATE ION
Authors:Scott, D.E, Ehebauer, M.T, Pukala, T, Marsh, M, Blundell, T.L, Venkitaraman, A.R, Abell, C, Hyvonen, M.
Deposit date:2012-07-20
Release date:2013-02-06
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.499 Å)
Cite:Using a Fragment-Based Approach to Target Protein-Protein Interactions.
Chembiochem, 14, 2013
4B34
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BU of 4b34 by Molmil
Humanised monomeric RadA in complex with 2-amino benzothiazole
Descriptor: 1,3-benzothiazol-2-amine, DNA REPAIR AND RECOMBINATION PROTEIN RADA, PHOSPHATE ION
Authors:Scott, D.E, Ehebauer, M.T, Pukala, T, Marsh, M, Blundell, T.L, Venkitaraman, A.R, Abell, C, Hyvonen, M.
Deposit date:2012-07-20
Release date:2013-02-06
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Using a Fragment-Based Approach to Target Protein-Protein Interactions.
Chembiochem, 14, 2013
4AZD
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BU of 4azd by Molmil
T57V mutant of aspartate decarboxylase
Descriptor: ASPARTATE 1-DECARBOXYLASE, MALONATE ION
Authors:Webb, M.E, Yorke, B.A, Kershaw, T, Lovelock, S, Lobley, C.M.C, Kilkenny, M.L, Smith, A.G, Blundell, T.L, Pearson, A.R, Abell, C.
Deposit date:2012-06-25
Release date:2012-07-25
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:Threonine 57 is Required for the Post-Translational Activation of Escherichia Coli Aspartate Alpha-Decarboxylase
Acta Crystallogr.,Sect.D, 70, 2014
4B2L
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BU of 4b2l by Molmil
Humanised monomeric RadA in complex with L-methylester tryptophan
Descriptor: DNA REPAIR AND RECOMBINATION PROTEIN RADA, PHOSPHATE ION, methyl L-tryptophanate
Authors:Scott, D.E, Ehebauer, M.T, Pukala, T, Marsh, M, Blundell, T.L, Venkitaraman, A.R, Abell, C, Hyvonen, M.
Deposit date:2012-07-16
Release date:2013-02-06
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Using a Fragment-Based Approach to Target Protein-Protein Interactions.
Chembiochem, 14, 2013

227561

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