3IQA
| Crystal Structure of BlaC covalently bound with Doripenem | Descriptor: | (2S,3R,4S)-2-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-3-methyl-4-({(3S,5S)-5-[(sulfamoylamino)methyl]pyrrolidin-3-yl}sulfanyl)-3,4-dihydro-2H-pyrrole-5-carboxylic acid, Beta-lactamase, PHOSPHATE ION | Authors: | Tremblay, L.W, Blanchard, J.S. | Deposit date: | 2009-08-19 | Release date: | 2010-04-14 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Biochemical and structural characterization of Mycobacterium tuberculosis beta-lactamase with the carbapenems ertapenem and doripenem. Biochemistry, 49, 2010
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3HT5
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1BXG
| PHENYLALANINE DEHYDROGENASE STRUCTURE IN TERNARY COMPLEX WITH NAD+ AND BETA-PHENYLPROPIONATE | Descriptor: | HYDROCINNAMIC ACID, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, PHENYLALANINE DEHYDROGENASE, ... | Authors: | Vanhooke, J.L, Thoden, J.B, Brunhuber, N.M.W, Blanchard, J.L, Holden, H.M. | Deposit date: | 1998-10-02 | Release date: | 1999-05-18 | Last modified: | 2024-06-05 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Phenylalanine dehydrogenase from Rhodococcus sp. M4: high-resolution X-ray analyses of inhibitory ternary complexes reveal key features in the oxidative deamination mechanism. Biochemistry, 38, 1999
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2PR2
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1TDT
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1S7N
| Ribosomal L7/L12 alpha-N-protein acetyltransferase in complex with Coenzyme A (CoA free sulfhydryl) | Descriptor: | COENZYME A, acetyl transferase | Authors: | Vetting, M.W, de Carvalho, L.P, Roderick, S.L, Blanchard, J.S. | Deposit date: | 2004-01-29 | Release date: | 2005-03-15 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | A novel dimeric structure of the RimL Nalpha-acetyltransferase from Salmonella typhimurium. J.Biol.Chem., 280, 2005
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1DIH
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1S7L
| RimL- Ribosomal L7/L12 alpha-N-protein acetyltransferase in complex with Coenzyme A (CoA-Cys134 Disulfide) | Descriptor: | COENZYME A, SULFATE ION, acetyl transferase | Authors: | Vetting, M.W, de Carvalho, L.P, Roderick, S.L, Blanchard, J.S. | Deposit date: | 2004-01-29 | Release date: | 2005-03-15 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | A novel dimeric structure of the RimL Nalpha-acetyltransferase from Salmonella typhimurium. J.Biol.Chem., 280, 2005
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2C27
| The Structure of Mycothiol Synthase in Complex with des- AcetylMycothiol and CoenzymeA. | Descriptor: | (1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside, ACETYL COENZYME *A, COENZYME A, ... | Authors: | Vetting, M.W, Yu, M, Rendle, P.M, Blanchard, J.S. | Deposit date: | 2005-09-26 | Release date: | 2005-12-01 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | The Substrate-Induced Conformational Change of Mycobacterium Tuberculosis Mycothiol Synthase. J.Biol.Chem., 281, 2006
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1S7F
| RimL- Ribosomal L7/L12 alpha-N-protein acetyltransferase crystal form I (apo) | Descriptor: | CHLORIDE ION, MALONIC ACID, acetyl transferase | Authors: | Vetting, M.W, de Carvalho, L.P, Roderick, S.L, Blanchard, J.S. | Deposit date: | 2004-01-29 | Release date: | 2005-03-15 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | A novel dimeric structure of the RimL Nalpha-acetyltransferase from Salmonella typhimurium. J.Biol.Chem., 280, 2005
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2GKJ
| Crystal structure of diaminopimelate epimerase in complex with an irreversible inhibitor DL-AZIDAP | Descriptor: | (2R,6S)-2,6-DIAMINO-2-METHYLHEPTANEDIOIC ACID, ACETIC ACID, Diaminopimelate epimerase | Authors: | Pillai, B, Cherney, M.M, Diaper, C.M, Sutherland, A, Blanchard, J.S, Vederas, J.C, James, M.N. | Deposit date: | 2006-04-02 | Release date: | 2006-05-16 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structural insights into stereochemical inversion by diaminopimelate epimerase: An antibacterial drug target. Proc.Natl.Acad.Sci.Usa, 103, 2006
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1S7K
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2GKE
| Crystal structure of diaminopimelate epimerase in complex with an irreversible inhibitor LL-AziDAP | Descriptor: | (2S,6S)-2,6-DIAMINO-2-METHYLHEPTANEDIOIC ACID, ACETIC ACID, Diaminopimelate epimerase, ... | Authors: | Pillai, B, Cherney, M.M, Diaper, C.M, Sutherland, A, Blanchard, J.S, Vederas, J.C, James, M.N. | Deposit date: | 2006-04-01 | Release date: | 2006-05-16 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.35 Å) | Cite: | Structural insights into stereochemical inversion by diaminopimelate epimerase: An antibacterial drug target. Proc.Natl.Acad.Sci.Usa, 103, 2006
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2JEV
| Crystal structure of human spermine,spermidine acetyltransferase in complex with a bisubstrate analog (N1-acetylspermine-S-CoA). | Descriptor: | (3R)-27-AMINO-3-HYDROXY-2,2-DIMETHYL-4,8,14-TRIOXO-12-THIA-5,9,15,19,24-PENTAAZAHEPTACOS-1-YL [(2S,3R,4S,5S)-5-(6-AMINO-9H-PURIN-9-YL)-4-HYDROXY-3-(PHOSPHONOOXY)TETRAHYDROFURAN-2-YL]METHYL DIHYDROGEN DIPHOSPHATE, DIAMINE ACETYLTRANSFERASE 1 | Authors: | Hegde, S.S, Chandler, J, Vetting, M.W, Yu, M, Blanchard, J.S. | Deposit date: | 2007-01-23 | Release date: | 2007-06-05 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Mechanistic and Structural Analysis of Human Spermidine/Spermine N(1)-Acetyltransferase. Biochemistry, 46, 2007
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2CNM
| RimI - Ribosomal S18 N-alpha-protein acetyltransferase in complex with a bisubstrate inhibitor (Cterm-Arg-Arg-Phe-Tyr-Arg-Ala-N-alpha- acetyl-S-CoA). | Descriptor: | 30S RIBOSOMAL PROTEIN S18, COENZYME A, MODIFICATION OF 30S RIBOSOMAL SUBUNIT PROTEIN S18 | Authors: | Vetting, M.W, Yu, M, Bareich, D.C, Blanchard, J.S. | Deposit date: | 2006-05-22 | Release date: | 2007-05-22 | Last modified: | 2019-10-23 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Crystal Structure of Rimi from Salmonella Typhimurium Lt2, the Gnat Responsible for N{Alpha}- Acetylation of Ribosomal Protein S18. Protein Sci., 17, 2008
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2CNT
| RimI - Ribosomal S18 N-alpha-protein acetyltransferase in complex with CoenzymeA. | Descriptor: | COENZYME A, GLYCEROL, MODIFICATION OF 30S RIBOSOMAL SUBUNIT PROTEIN S18, ... | Authors: | Vetting, M.W, Bareich, D.C, Yu, M, Blanchard, J.S. | Deposit date: | 2006-05-23 | Release date: | 2007-06-19 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystal Structure of Rimi from Salmonella Typhimurium Lt2, the Gnat Responsible for N{Alpha}- Acetylation of Ribosomal Protein S18. Protein Sci., 17, 2008
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2CNS
| RimI - Ribosomal S18 N-alpha-protein acetyltransferase in complex with acetylCoA. | Descriptor: | ACETYL COENZYME *A, MODIFICATION OF 30S RIBOSOMAL SUBUNIT PROTEIN S18, PHOSPHATE ION | Authors: | Vetting, M.W, Bareich, D.C, Yu, M, Blanchard, J.S. | Deposit date: | 2006-05-23 | Release date: | 2007-06-19 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal Structure of Rimi from Salmonella Typhimurium Lt2, the Gnat Responsible for N{Alpha}- Acetylation of Ribosomal Protein S18. Protein Sci., 17, 2008
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2VQY
| Structure of AAC(6')-Ib in complex with Parmomycin and AcetylCoA. | Descriptor: | AAC(6')-IB, ACETYL COENZYME *A, CALCIUM ION, ... | Authors: | Vetting, M.W, Park, C.H, Hedge, S.S, Hooper, D.C, Blanchard, J.S. | Deposit date: | 2008-03-20 | Release date: | 2008-09-02 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Mechanistic and Structural Analysis of Aminoglycoside N-Acetyltransferase Aac(6')-Ib and its Bifunctional, Fluoroquinolone-Active Aac(6')-Ib-Cr Variant. Biochemistry, 47, 2008
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2VBQ
| Structure of AAC(6')-Iy in complex with bisubstrate analog CoA-S- monomethyl-acetylneamine. | Descriptor: | (3R,9Z)-17-[(2R,3S,4R,5R,6R)-5-amino-6-{[(1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl]oxy}-3,4-dihydroxytetrahydro-2H-pyran-2-yl]-3-hydroxy-2,2-dimethyl-4,8,15-trioxo-12-thia-5,9,16-triazaheptadec-9-en-1-yl [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]methyl dihydrogen diphosphate, AMINOGLYCOSIDE 6'-N-ACETYLTRANSFERASE, GLYCEROL, ... | Authors: | Vetting, M.W, Magalhaes, M.L, Freiburger, L, Gao, F, Auclair, K, Blanchard, J.S. | Deposit date: | 2007-09-14 | Release date: | 2008-01-08 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Kinetic and Structural Analysis of Bisubstrate Inhibition of the Salmonella Enterica Aminoglycoside 6'-N-Acetyltransferase. Biochemistry, 47, 2008
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2W7Z
| Structure of the pentapeptide repeat protein EfsQnr, a DNA gyrase inhibitor. Free amines modified by cyclic pentylation with glutaraldehyde. | Descriptor: | CHLORIDE ION, PENTAPEPTIDE REPEAT FAMILY PROTEIN | Authors: | Vetting, M.W, Hegde, S.S, Blanchard, J.S. | Deposit date: | 2009-01-06 | Release date: | 2009-05-05 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Crystallization of a Pentapeptide-Repeat Protein by Reductive Cyclic Pentylation of Free Amines with Glutaraldehyde. Acta Crystallogr.,Sect.D, 65, 2009
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2X9Q
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1F06
| THREE DIMENSIONAL STRUCTURE OF THE TERNARY COMPLEX OF CORYNEBACTERIUM GLUTAMICUM DIAMINOPIMELATE DEHYDROGENASE NADPH-L-2-AMINO-6-METHYLENE-PIMELATE | Descriptor: | L-2-AMINO-6-METHYLENE-PIMELIC ACID, MESO-DIAMINOPIMELATE D-DEHYDROGENASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Cirilli, M, Scapin, G, Sutherland, A, Caplan, J.F, Vederas, J.C, Blanchard, J.S. | Deposit date: | 2000-05-14 | Release date: | 2001-05-14 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | The three-dimensional structure of the ternary complex of Corynebacterium glutamicum diaminopimelate dehydrogenase-NADPH-L-2-amino-6-methylene-pimelate. Protein Sci., 9, 2000
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2BM5
| The Structure of MfpA (Rv3361c, P21 Crystal form). The Pentapeptide Repeat Protein from Mycobacterium tuberculosis Folds as A Right- handed Quadrilateral Beta-helix. | Descriptor: | PENTAPEPTIDE REPEAT FAMILY PROTEIN, SULFATE ION | Authors: | Hegde, S.S, Vetting, M.W, Roderick, S.L, Mitchenall, L.A, Maxwell, A, Takiff, H.E, Blanchard, J.S. | Deposit date: | 2005-03-09 | Release date: | 2005-06-07 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | A Fluroquinolone Resistance Protein from Mycobacterium Tuberculosis that Mimics DNA Science, 308, 2005
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2BM6
| The Structure of MfpA (Rv3361c, C2221 Crystal form). The Pentapeptide Repeat Protein from Mycobacterium tuberculosis Folds as A Right- handed Quadrilateral Beta-helix. | Descriptor: | CESIUM ION, PENTAPEPTIDE REPEAT FAMILY PROTEIN | Authors: | Hegde, S.S, Vetting, M.W, Roderick, S.L, Mitchenall, L.A, Maxwell, A, Takiff, H.E, Blanchard, J.S. | Deposit date: | 2005-03-09 | Release date: | 2005-06-07 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | A Fluroquinolone Resistance Protein from Mycobacterium Tuberculosis that Mimics DNA Science, 308, 2005
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2BUE
| Structure of AAC(6')-Ib in complex with Ribostamycin and Coenzyme A. | Descriptor: | AAC(6')-IB, CALCIUM ION, COENZYME A, ... | Authors: | Vetting, M.W, Park, C.H, Hedge, S.S, Hooper, D.C, Blanchard, J.S. | Deposit date: | 2008-03-20 | Release date: | 2008-09-02 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Mechanistic and Structural Analysis of Aminoglycoside N-Acetyltransferase Aac(6')-Ib and its Bifunctional, Fluoroquinolone-Active Aac(6')-Ib-Cr Variant. Biochemistry, 47, 2008
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