1M4G
| Aminoglycoside 2'-N-acetyltransferase from Mycobacterium tuberculosis-Complex with Coenzyme A and Ribostamycin | Descriptor: | 3'-PHOSPHATE-ADENOSINE-5'-DIPHOSPHATE, Aminoglycoside 2'-N-acetyltransferase, COENZYME A, ... | Authors: | Vetting, M.W, Hegde, S.S, Javid-Majd, F, Blanchard, J.S, Roderick, S.L. | Deposit date: | 2002-07-02 | Release date: | 2002-08-28 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Aminoglycoside 2'-N-acetyltransferase from Mycobacterium tuberculosis in complex with coenzyme A and aminoglycoside substrates. Nat.Struct.Biol., 9, 2002
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2TDT
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1BW9
| PHENYLALANINE DEHYDROGENASE STRUCTURE IN TERNARY COMPLEX WITH NAD+ AND PHENYLPYRUVATE | Descriptor: | 1,2-ETHANEDIOL, 3-PHENYLPYRUVIC ACID, ISOPROPYL ALCOHOL, ... | Authors: | Vanhooke, J.L, Thoden, J.B, Brunhuber, N.M.W, Blanchard, J.L, Holden, H.M. | Deposit date: | 1998-10-01 | Release date: | 1999-05-18 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Phenylalanine dehydrogenase from Rhodococcus sp. M4: high-resolution X-ray analyses of inhibitory ternary complexes reveal key features in the oxidative deamination mechanism. Biochemistry, 38, 1999
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3C8Z
| The 1.6 A Crystal Structure of MshC: The Rate Limiting Enzyme in the Mycothiol Biosynthetic Pathway | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 5'-O-(N-(L-CYSTEINYL)-SULFAMOYL)ADENOSINE, Cysteinyl-tRNA synthetase, ... | Authors: | Tremblay, L.W, Fan, F, Vetting, M.W, Blanchard, J.S. | Deposit date: | 2008-02-14 | Release date: | 2008-12-30 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | The 1.6 A crystal structure of Mycobacterium smegmatis MshC: the penultimate enzyme in the mycothiol biosynthetic pathway. Biochemistry, 47, 2008
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1M44
| Aminoglycoside 2'-N-acetyltransferase from Mycobacterium tuberculosis-APO Structure | Descriptor: | Aminoglycoside 2'-N-acetyltransferase, SULFATE ION | Authors: | Vetting, M.W, Hegde, S.S, Javid-Majd, F, Blanchard, J.S, Roderick, S.L. | Deposit date: | 2002-07-02 | Release date: | 2002-08-28 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Aminoglycoside 2'-N-acetyltransferase from Mycobacterium tuberculosis in complex with coenzyme A and aminoglycoside substrates. Nat.Struct.Biol., 9, 2002
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1M4D
| Aminoglycoside 2'-N-acetyltransferase from Mycobacterium tuberculosis-Complex with Coenzyme A and Tobramycin | Descriptor: | 3'-PHOSPHATE-ADENOSINE-5'-DIPHOSPHATE, Aminoglycoside 2'-N-acetyltransferase, COENZYME A, ... | Authors: | Vetting, M.W, Hegde, S.S, Javid-Majd, F, Blanchard, J.S, Roderick, S.L. | Deposit date: | 2002-07-02 | Release date: | 2002-08-28 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Aminoglycoside 2'-N-acetyltransferase from Mycobacterium tuberculosis in complex with coenzyme A and aminoglycoside substrates. Nat.Struct.Biol., 9, 2002
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1M4I
| Aminoglycoside 2'-N-acetyltransferase from Mycobacterium tuberculosis-Complex with Coenzyme A and Kanamycin A | Descriptor: | 3'-PHOSPHATE-ADENOSINE-5'-DIPHOSPHATE, Aminoglycoside 2'-N-acetyltransferase, COENZYME A, ... | Authors: | Vetting, M.W, Hegde, S.S, Javid-Majd, F, Blanchard, J.S, Roderick, S.L. | Deposit date: | 2002-07-02 | Release date: | 2002-08-28 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Aminoglycoside 2'-N-acetyltransferase from Mycobacterium tuberculosis in complex with coenzyme A and aminoglycoside substrates. Nat.Struct.Biol., 9, 2002
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5U3F
| Structure of Mycobacterium tuberculosis IlvE, a branched-chain amino acid transaminase, in complex with D-cycloserine derivative | Descriptor: | (5-hydroxy-6-methyl-4-{[(3-oxo-2,3-dihydro-1,2-oxazol-4-yl)amino]methyl}pyridin-3-yl)methyl dihydrogen phosphate, Branched-chain-amino-acid aminotransferase | Authors: | Favrot, L, Amorim Franco, T.M, Blanchard, J.S. | Deposit date: | 2016-12-02 | Release date: | 2017-03-22 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.695 Å) | Cite: | Mechanism-Based Inhibition of the Mycobacterium tuberculosis Branched-Chain Aminotransferase by d- and l-Cycloserine. ACS Chem. Biol., 12, 2017
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1DIH
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1G2O
| CRYSTAL STRUCTURE OF PURINE NUCLEOSIDE PHOSPHORYLASE FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH A TRANSITION-STATE INHIBITOR | Descriptor: | 1,4-DIDEOXY-4-AZA-1-(S)-(9-DEAZAHYPOXANTHIN-9-YL)-D-RIBITOL, PHOSPHATE ION, PURINE NUCLEOSIDE PHOSPHORYLASE | Authors: | Shi, W, Basso, L.A, Tyler, P.C, Furneaux, R.H, Blanchard, J.S, Almo, S.C, Schramm, V.L. | Deposit date: | 2000-10-20 | Release date: | 2001-08-01 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Structures of purine nucleoside phosphorylase from Mycobacterium tuberculosis in complexes with immucillin-H and its pieces. Biochemistry, 40, 2001
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1TDT
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1I80
| CRYSTAL STRUCTURE OF M. TUBERCULOSIS PNP IN COMPLEX WITH IMINORIBITOL, 9-DEAZAHYPOXANTHINE AND PHOSPHATE ION | Descriptor: | 9-DEAZAHYPOXANTHINE, IMINORIBITOL, PHOSPHATE ION, ... | Authors: | Shi, W, Basso, L.A, Tyler, P.C, Furneaux, R.H, Blanchard, J.S, Almo, S.C, Schramm, V.L. | Deposit date: | 2001-03-12 | Release date: | 2001-08-01 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structures of purine nucleoside phosphorylase from Mycobacterium tuberculosis in complexes with immucillin-H and its pieces. Biochemistry, 40, 2001
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2JEV
| Crystal structure of human spermine,spermidine acetyltransferase in complex with a bisubstrate analog (N1-acetylspermine-S-CoA). | Descriptor: | (3R)-27-AMINO-3-HYDROXY-2,2-DIMETHYL-4,8,14-TRIOXO-12-THIA-5,9,15,19,24-PENTAAZAHEPTACOS-1-YL [(2S,3R,4S,5S)-5-(6-AMINO-9H-PURIN-9-YL)-4-HYDROXY-3-(PHOSPHONOOXY)TETRAHYDROFURAN-2-YL]METHYL DIHYDROGEN DIPHOSPHATE, DIAMINE ACETYLTRANSFERASE 1 | Authors: | Hegde, S.S, Chandler, J, Vetting, M.W, Yu, M, Blanchard, J.S. | Deposit date: | 2007-01-23 | Release date: | 2007-06-05 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Mechanistic and Structural Analysis of Human Spermidine/Spermine N(1)-Acetyltransferase. Biochemistry, 46, 2007
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3DWZ
| Meropenem Covalent Adduct with TB Beta-lactamase | Descriptor: | (2S,3R,4S)-4-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-2-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-3-methyl-3,4-dihydro-2H-pyrrole-5-carboxylic acid, Beta-lactamase, PHOSPHATE ION | Authors: | Tremblay, L.W, Hugonnet, J.E, Blanchard, J.S. | Deposit date: | 2008-07-23 | Release date: | 2009-03-10 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Meropenem-clavulanate is effective against extensively drug-resistant Mycobacterium tuberculosis Science, 323, 2009
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2XT4
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2XT2
| Structure of the pentapeptide repeat protein AlbG, a resistance factor for the topoisomerase poison albicidin. | Descriptor: | MCBG-LIKE PROTEIN, SULFATE ION | Authors: | Vetting, M.W, Hegde, S.S, Blanchard, J.S. | Deposit date: | 2010-10-05 | Release date: | 2010-10-13 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.999 Å) | Cite: | Pentapeptide-Repeat Proteins that Act as Topoisomerase Poison Resistance Factors Have a Common Dimer Interface. Acta Crystallogr.,Sect.F, 67, 2011
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1XDI
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1S7N
| Ribosomal L7/L12 alpha-N-protein acetyltransferase in complex with Coenzyme A (CoA free sulfhydryl) | Descriptor: | COENZYME A, acetyl transferase | Authors: | Vetting, M.W, de Carvalho, L.P, Roderick, S.L, Blanchard, J.S. | Deposit date: | 2004-01-29 | Release date: | 2005-03-15 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | A novel dimeric structure of the RimL Nalpha-acetyltransferase from Salmonella typhimurium. J.Biol.Chem., 280, 2005
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2C27
| The Structure of Mycothiol Synthase in Complex with des- AcetylMycothiol and CoenzymeA. | Descriptor: | (1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside, ACETYL COENZYME *A, COENZYME A, ... | Authors: | Vetting, M.W, Yu, M, Rendle, P.M, Blanchard, J.S. | Deposit date: | 2005-09-26 | Release date: | 2005-12-01 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | The Substrate-Induced Conformational Change of Mycobacterium Tuberculosis Mycothiol Synthase. J.Biol.Chem., 281, 2006
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2PR2
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1S7F
| RimL- Ribosomal L7/L12 alpha-N-protein acetyltransferase crystal form I (apo) | Descriptor: | CHLORIDE ION, MALONIC ACID, acetyl transferase | Authors: | Vetting, M.W, de Carvalho, L.P, Roderick, S.L, Blanchard, J.S. | Deposit date: | 2004-01-29 | Release date: | 2005-03-15 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | A novel dimeric structure of the RimL Nalpha-acetyltransferase from Salmonella typhimurium. J.Biol.Chem., 280, 2005
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1S7L
| RimL- Ribosomal L7/L12 alpha-N-protein acetyltransferase in complex with Coenzyme A (CoA-Cys134 Disulfide) | Descriptor: | COENZYME A, SULFATE ION, acetyl transferase | Authors: | Vetting, M.W, de Carvalho, L.P, Roderick, S.L, Blanchard, J.S. | Deposit date: | 2004-01-29 | Release date: | 2005-03-15 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | A novel dimeric structure of the RimL Nalpha-acetyltransferase from Salmonella typhimurium. J.Biol.Chem., 280, 2005
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1S7K
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2VZY
| Crystal structure of Rv0802c from Mycobacterium tuberculosis in an unliganded form. | Descriptor: | 2-ETHOXYETHANOL, ACETATE ION, CITRATE ANION, ... | Authors: | Vetting, M.W, Errey, J.C, Blanchard, J.S. | Deposit date: | 2008-08-07 | Release date: | 2009-04-07 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Rv0802C from Mycobacterium Tuberculosis: The First Structure of a Succinyltransferase with the Gnat Fold. Acta Crystallogr.,Sect.F, 64, 2008
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2VZZ
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