3RM0
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![BU of 3rm0 by Molmil](/molmil-images/mine/3rm0) | Human Thrombin in complex with MI354 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Hirudin variant-2, ... | 著者 | Biela, A, Heine, A, Klebe, G. | 登録日 | 2011-04-20 | 公開日 | 2012-04-25 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (1.34 Å) | 主引用文献 | Ligand binding stepwise disrupts water network in thrombin: enthalpic and entropic changes reveal classical hydrophobic effect J.Med.Chem., 55, 2012
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3RLY
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![BU of 3rly by Molmil](/molmil-images/mine/3rly) | Human Thrombin in complex with MI329 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Hirudin variant-2, ... | 著者 | Biela, A, Heine, A, Klebe, G. | 登録日 | 2011-04-20 | 公開日 | 2012-04-25 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (1.51 Å) | 主引用文献 | Ligand binding stepwise disrupts water network in thrombin: enthalpic and entropic changes reveal classical hydrophobic effect J.Med.Chem., 55, 2012
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3RMN
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![BU of 3rmn by Molmil](/molmil-images/mine/3rmn) | Human Thrombin in complex with MI341 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Hirudin variant-2, ... | 著者 | Biela, A, Heine, A, Klebe, G. | 登録日 | 2011-04-21 | 公開日 | 2012-04-25 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | 主引用文献 | Ligand binding stepwise disrupts water network in thrombin: enthalpic and entropic changes reveal classical hydrophobic effect J.Med.Chem., 55, 2012
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3U9A
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![BU of 3u9a by Molmil](/molmil-images/mine/3u9a) | Human Thrombin In Complex With MI330 | 分子名称: | (2S)-N-[[2-(aminomethyl)-5-chloranyl-phenyl]methyl]-1-[(2S)-2-[(3-chloranyl-4-methoxy-phenyl)sulfonylamino]-4-[(4-cyanophenyl)methylamino]-4-oxidanylidene-butanoyl]pyrrolidine-2-carboxamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ... | 著者 | Biela, A, Heine, A, Klebe, G. | 登録日 | 2011-10-18 | 公開日 | 2012-10-24 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (1.58 Å) | 主引用文献 | Thrombin Inhibition To be Published
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3T5F
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![BU of 3t5f by Molmil](/molmil-images/mine/3t5f) | Human Thrombin In Complex With MI340 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Hirudin variant-2, ... | 著者 | Biela, A, Heine, A, Klebe, G. | 登録日 | 2011-07-27 | 公開日 | 2012-08-01 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | Ligand binding stepwise disrupts water network in thrombin: enthalpic and entropic changes reveal classical hydrophobic effect J.Med.Chem., 55, 2012
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3UWJ
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![BU of 3uwj by Molmil](/molmil-images/mine/3uwj) | Human Thrombin In Complex With MI353 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Hirudin variant-2, N-(benzylsulfonyl)-D-leucyl-N-(4-carbamimidoylbenzyl)-L-prolinamide, ... | 著者 | Biela, A, Heine, A, Klebe, G. | 登録日 | 2011-12-02 | 公開日 | 2012-12-12 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Ligand binding stepwise disrupts water network in thrombin: enthalpic and entropic changes reveal classical hydrophobic effect J.Med.Chem., 55, 2012
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3U98
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![BU of 3u98 by Molmil](/molmil-images/mine/3u98) | Human Thrombin In Complex With MI001 | 分子名称: | (2S)-1-[(2R)-2-(benzylsulfonylamino)-5-guanidino-pentanoyl]-N-[(4-carbamimidoylphenyl)methyl]pyrrolidine-2-carboxamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, Hirudin variant-2, ... | 著者 | Biela, A, Heine, A, Klebe, G. | 登録日 | 2011-10-18 | 公開日 | 2012-10-24 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | Thrombin Inhibition To be Published
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5IO5
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![BU of 5io5 by Molmil](/molmil-images/mine/5io5) | |
6RVV
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![BU of 6rvv by Molmil](/molmil-images/mine/6rvv) | Structure of left-handed protein cage consisting of 24 eleven-membered ring proteins held together by gold (I) bridges. | 分子名称: | GOLD ION, Transcription attenuation protein MtrB | 著者 | Malay, A.D, Miyazaki, N, Biela, A.P, Iwasaki, K, Heddle, J.G. | 登録日 | 2019-06-03 | 公開日 | 2019-06-12 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | An ultra-stable gold-coordinated protein cage displaying reversible assembly. Nature, 569, 2019
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6RVW
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![BU of 6rvw by Molmil](/molmil-images/mine/6rvw) | Structure of right-handed protein cage consisting of 24 eleven-membered ring proteins held together by gold (I) bridges. | 分子名称: | GOLD ION, Transcription attenuation protein MtrB | 著者 | Malay, A.D, Miyazaki, N, Biela, A.P, Iwasaki, K, Heddle, J.G. | 登録日 | 2019-06-03 | 公開日 | 2019-06-12 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | An ultra-stable gold-coordinated protein cage displaying reversible assembly. Nature, 569, 2019
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5IO6
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![BU of 5io6 by Molmil](/molmil-images/mine/5io6) | |
5IO7
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![BU of 5io7 by Molmil](/molmil-images/mine/5io7) | |
6TXJ
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![BU of 6txj by Molmil](/molmil-images/mine/6txj) | Crystal structure of thermotoga maritima A42V E65D Ferritin | 分子名称: | EICOSANE, FE (III) ION, Ferritin, ... | 著者 | Wilk, P, Grudnik, P, Kumar, M, Heddle, J, Chakraborti, S, Biela, A.P. | 登録日 | 2020-01-14 | 公開日 | 2021-07-28 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.17 Å) | 主引用文献 | A single residue can modulate nanocage assembly in salt dependent ferritin. Nanoscale, 13, 2021
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3FLF
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![BU of 3flf by Molmil](/molmil-images/mine/3flf) | Thermolysin inhibition | 分子名称: | CALCIUM ION, GLYCEROL, N-[(S)-({[(benzyloxy)carbonyl]amino}methyl)(hydroxy)phosphoryl]-L-valyl-L-leucine, ... | 著者 | Englert, L, Biela, A, Heine, A, Klebe, G. | 登録日 | 2008-12-18 | 公開日 | 2010-01-12 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.97 Å) | 主引用文献 | Displacement of disordered water molecules from hydrophobic pocket creates enthalpic signature: binding of phosphonamidate to the S1'-pocket of thermolysin. Biochim.Biophys.Acta, 1800, 2010
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3FV4
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![BU of 3fv4 by Molmil](/molmil-images/mine/3fv4) | Thermolysin inhibition | 分子名称: | CALCIUM ION, DIMETHYL SULFOXIDE, GLYCEROL, ... | 著者 | Englert, L, Biela, A, Heine, A, Klebe, G. | 登録日 | 2009-01-15 | 公開日 | 2010-02-09 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.56 Å) | 主引用文献 | Displacement of disordered water molecules from hydrophobic pocket creates enthalpic signature: binding of phosphonamidate to the S1'-pocket of thermolysin. Biochim.Biophys.Acta, 1800, 2010
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3FVP
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![BU of 3fvp by Molmil](/molmil-images/mine/3fvp) | Thermolysin inhibition | 分子名称: | CALCIUM ION, DIMETHYL SULFOXIDE, GLYCEROL, ... | 著者 | Englert, L, Biela, A, Heine, A, Klebe, G. | 登録日 | 2009-01-16 | 公開日 | 2010-02-09 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.41 Å) | 主引用文献 | Thermolysin inhibition To be Published
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8A0E
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![BU of 8a0e by Molmil](/molmil-images/mine/8a0e) | CryoEM structure of DHS-eIF5A1 complex | 分子名称: | Deoxyhypusine synthase, Eukaryotic translation initiation factor 5A, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... | 著者 | Wator, E, Wilk, P, Biela, A.P, Rawski, M, Grudnik, P. | 登録日 | 2022-05-27 | 公開日 | 2023-04-05 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Cryo-EM structure of human eIF5A-DHS complex reveals the molecular basis of hypusination-associated neurodegenerative disorders. Nat Commun, 14, 2023
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8ASW
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![BU of 8asw by Molmil](/molmil-images/mine/8asw) | Cryo-EM structure of yeast Elp123 in complex with alanine tRNA | 分子名称: | 5'-DEOXYADENOSINE, Alanine tRNA, Elongator complex protein 1, ... | 著者 | Jaciuk, M, Scherf, D, Kaszuba, K, Gaik, M, Koscielniak, A, Krutyholowa, R, Rawski, M, Indyka, P, Biela, A, Dobosz, D, Lin, T.-Y, Abbassi, N, Hammermeister, A, Chramiec-Glabik, A, Kosinski, J, Schaffrath, R, Glatt, S. | 登録日 | 2022-08-21 | 公開日 | 2022-12-07 | 最終更新日 | 2024-07-24 | 実験手法 | ELECTRON MICROSCOPY (3.96 Å) | 主引用文献 | Cryo-EM structure of the fully assembled Elongator complex. Nucleic Acids Res., 51, 2023
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8AT6
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![BU of 8at6 by Molmil](/molmil-images/mine/8at6) | Cryo-EM structure of yeast Elp456 subcomplex | 分子名称: | Elongator complex protein 4, Elongator complex protein 5, Elongator complex protein 6 | 著者 | Jaciuk, M, Scherf, D, Kaszuba, K, Gaik, M, Koscielniak, A, Krutyholowa, R, Rawski, M, Indyka, P, Biela, A, Dobosz, D, Lin, T.-Y, Abbassi, N, Hammermeister, A, Chramiec-Glabik, A, Kosinski, J, Schaffrath, R, Glatt, S. | 登録日 | 2022-08-22 | 公開日 | 2022-12-07 | 最終更新日 | 2024-07-24 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Cryo-EM structure of the fully assembled Elongator complex. Nucleic Acids Res., 51, 2023
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8AVG
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![BU of 8avg by Molmil](/molmil-images/mine/8avg) | Cryo-EM structure of mouse Elp123 with bound SAM | 分子名称: | Elongator complex protein 1, Elongator complex protein 2, Elongator complex protein 3, ... | 著者 | Jaciuk, M, Scherf, D, Kaszuba, K, Gaik, M, Koscielniak, A, Krutyholowa, R, Rawski, M, Indyka, P, Biela, A, Dobosz, D, Lin, T.-Y, Abbassi, N, Hammermeister, A, Chramiec-Glabik, A, Kosinski, J, Schaffrath, R, Glatt, S. | 登録日 | 2022-08-26 | 公開日 | 2022-12-07 | 最終更新日 | 2024-07-24 | 実験手法 | ELECTRON MICROSCOPY (4.01 Å) | 主引用文献 | Cryo-EM structure of the fully assembled Elongator complex. Nucleic Acids Res., 51, 2023
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8ASV
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![BU of 8asv by Molmil](/molmil-images/mine/8asv) | Cryo-EM structure of yeast Elongator complex | 分子名称: | Elongator complex protein 1, Elongator complex protein 2, Elongator complex protein 3, ... | 著者 | Jaciuk, M, Scherf, D, Kaszuba, K, Gaik, M, Koscielniak, A, Krutyholowa, R, Rawski, M, Indyka, P, Biela, A, Dobosz, D, Lin, T.-Y, Abbassi, N, Hammermeister, A, Chramiec-Glabik, A, Kosinski, J, Schaffrath, R, Glatt, S. | 登録日 | 2022-08-21 | 公開日 | 2022-12-07 | 最終更新日 | 2024-07-24 | 実験手法 | ELECTRON MICROSCOPY (4.35 Å) | 主引用文献 | Cryo-EM structure of the fully assembled Elongator complex. Nucleic Acids Res., 51, 2023
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4H57
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![BU of 4h57 by Molmil](/molmil-images/mine/4h57) | Thermolysin inhibition | 分子名称: | CALCIUM ION, DIMETHYL SULFOXIDE, GLYCEROL, ... | 著者 | Englert, L, Biela, A, Heine, A, Klebe, G. | 登録日 | 2012-09-18 | 公開日 | 2012-10-03 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.56 Å) | 主引用文献 | Dissecting the hydrophobic effect on the molecular level: the role of water, enthalpy, and entropy in ligand binding to thermolysin. Angew.Chem.Int.Ed.Engl., 52, 2013
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