2W1Z
 
 | | ROP2 from Toxoplasma gondii: A virulence factor with a protein- kinase fold and no enzymatic activity. | | 分子名称: | ROP2, SULFATE ION | | 著者 | Labesse, G, Gelin, M, Bessin, Y, Lebrun, M, Arold, S.T, Dubremetz, J.-F. | | 登録日 | 2008-10-21 | | 公開日 | 2008-12-09 | | 最終更新日 | 2011-09-21 | | 実験手法 | X-RAY DIFFRACTION (1.97 Å) | | 主引用文献 | Rop2 from Toxoplasma Gondii: A Virulence Factor with a Protein-Kinase Fold and No Enzymatic Activity.
Structure, 17, 2009
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2I2A
 | | Crystal structure of LmNADK1 from Listeria monocytogenes | | 分子名称: | GLYCEROL, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Probable inorganic polyphosphate/ATP-NAD kinase 1 | | 著者 | Labesse, G. | | 登録日 | 2006-08-16 | | 公開日 | 2007-08-07 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | NAD kinases use substrate-assisted catalysis for specific recognition of NAD.
J.Biol.Chem., 282, 2007
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6GJV
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7BIX
 | | Crystal structure of UMPK from M. tuberculosis in complex with UDP and UTP (C2 form) | | 分子名称: | URIDINE 5'-TRIPHOSPHATE, URIDINE-5'-DIPHOSPHATE, Uridylate kinase | | 著者 | Labesse, G, Walter, P, Haouz, A, Mechaly, A.E, Munier-Lehmann, H. | | 登録日 | 2021-01-13 | | 公開日 | 2022-03-02 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (3.12 Å) | | 主引用文献 | Structural basis for the allosteric inhibition of UMP kinase from Gram-positive bacteria, a promising antibacterial target.
Febs J., 289, 2022
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6GK9
 | | Inhibited structure of IMPDH from Pseudomonas aeruginosa | | 分子名称: | (5~{S})-7-azanyl-5-(4-chlorophenyl)-2,4-bis(oxidanylidene)-1,5-dihydropyrano[2,3-d]pyrimidine-6-carbonitrile, Inosine-5'-monophosphate dehydrogenase, SULFATE ION | | 著者 | Labesse, G, Alexandre, T, Haouz, A, Munier-Lehmann, H. | | 登録日 | 2018-05-18 | | 公開日 | 2019-02-27 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.54 Å) | | 主引用文献 | First-in-class allosteric inhibitors of bacterial IMPDHs.
Eur J Med Chem, 167, 2019
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7QBJ
 | | bacterial IMPDH chimera | | 分子名称: | Inosine-5'-monophosphate dehydrogenase | | 著者 | Labesse, G, Gelin, M, Munier-Lehmann, H, Gedeon, A, Haouz, A. | | 登録日 | 2021-11-19 | | 公開日 | 2023-05-31 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.27 Å) | | 主引用文献 | Insight into the role of the Bateman domain at the molecular and physiological levels through engineered IMP dehydrogenases.
Protein Sci., 32, 2023
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7QDX
 | | bacterial IMPDH chimera | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Inosine-5'-monophosphate dehydrogenase, MAGNESIUM ION | | 著者 | Labesse, G, Gelin, M, Munier-Lehmann, H, Gedeon, A, Haouz, A. | | 登録日 | 2021-11-30 | | 公開日 | 2023-06-14 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Insight into the role of the Bateman domain at the molecular and physiological levels through engineered IMP dehydrogenases.
Protein Sci., 32, 2023
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7QEM
 | | bacterial IMPDH chimera | | 分子名称: | INOSINIC ACID, Inosine-5'-monophosphate dehydrogenase | | 著者 | Labesse, G, Gelin, M, Gedeon, A, Haouz, A, Munier-Lehmann, H. | | 登録日 | 2021-12-03 | | 公開日 | 2023-06-14 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (3.09 Å) | | 主引用文献 | Insight into the role of the Bateman domain at the molecular and physiological levels through engineered IMP dehydrogenases.
Protein Sci., 32, 2023
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7R4K
 | | Crystal structure of human mitochondrial NAD kinase | | 分子名称: | MAGNESIUM ION, NAD kinase 2, mitochondrial, ... | | 著者 | Labesse, G, Mary, C, Gelin, M, Lionne, C. | | 登録日 | 2022-02-08 | | 公開日 | 2022-07-06 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (3.33 Å) | | 主引用文献 | Crystal structure of human NADK2 reveals a dimeric organization and active site occlusion by lysine acetylation.
Mol.Cell, 82, 2022
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7R4J
 | | Crystal structure of human mitochondrial NAD kinase | | 分子名称: | CALCIUM ION, NAD kinase 2, mitochondrial | | 著者 | Labesse, G, Mary, C, Gelin, M, Lionne, C. | | 登録日 | 2022-02-08 | | 公開日 | 2022-07-06 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | | 主引用文献 | Crystal structure of human NADK2 reveals a dimeric organization and active site occlusion by lysine acetylation.
Mol.Cell, 82, 2022
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7R4M
 | | Crystal structure of mitochondrial NAD kinase | | 分子名称: | CALCIUM ION, NAD kinase 2, mitochondrial, ... | | 著者 | Labesse, G, Mary, C, Gelin, M, Lionne, C. | | 登録日 | 2022-02-08 | | 公開日 | 2022-07-06 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (2.29 Å) | | 主引用文献 | Crystal structure of human NADK2 reveals a dimeric organization and active site occlusion by lysine acetylation.
Mol.Cell, 82, 2022
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7R4L
 | | Crystal structure of human mitochondrial NAD kinase | | 分子名称: | FE (III) ION, NAD kinase 2, mitochondrial, ... | | 著者 | Labesse, G, Mary, C, Gelin, M, Lionne, C. | | 登録日 | 2022-02-08 | | 公開日 | 2022-07-06 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Crystal structure of human NADK2 reveals a dimeric organization and active site occlusion by lysine acetylation.
Mol.Cell, 82, 2022
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4DQW
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5AHM
 | | IMP-bound form of the DeltaCBS mutant of IMPDH from Pseudomonas aeruginosa | | 分子名称: | INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE, INOSINIC ACID, PHOSPHATE ION | | 著者 | Labesse, G, Alexandre, T, Gelin, M, Haouz, A, Munier-Lehmann, H. | | 登録日 | 2015-02-06 | | 公開日 | 2015-07-15 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.74 Å) | | 主引用文献 | Crystallographic Studies of Two Variants of Pseudomonas Aeruginosa Impdh with Impaired Allosteric Regulation
Acta Crystallogr.,Sect.D, 71, 2015
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3NWY
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4FYI
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4FYH
 | | Crystal structure of rcl with phospho-triciribine | | 分子名称: | 5-methyl-1-(5-O-phosphono-beta-D-ribofuranosyl)-1,5-dihydro-1,4,5,6,8-pentaazaacenaphthylen-3-amine, Deoxyribonucleoside 5'-monophosphate N-glycosidase, SULFATE ION | | 著者 | Labesse, G, Padilla, A, Kaminski, P.A. | | 登録日 | 2012-07-04 | | 公開日 | 2013-01-02 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.44 Å) | | 主引用文献 | Structure of the oncoprotein Rcl bound to three nucleotide analogues.
Acta Crystallogr.,Sect.D, 69, 2013
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4FYK
 | | Crystal structure of rcl with 5'-phiosphorothioate-adenosine | | 分子名称: | ADENOSINE -5'-THIO-MONOPHOSPHATE, Deoxyribonucleoside 5'-monophosphate N-glycosidase, SULFATE ION | | 著者 | Labesse, G, Padilla, A, Kaminski, P.A. | | 登録日 | 2012-07-04 | | 公開日 | 2013-01-02 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | | 主引用文献 | Structure of the oncoprotein Rcl bound to three nucleotide analogues.
Acta Crystallogr.,Sect.D, 69, 2013
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5AHN
 | | IMP-bound form of the D199N mutant of IMPDH from Pseudomonas aeruginosa | | 分子名称: | INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE, INOSINIC ACID, MAGNESIUM ION | | 著者 | Labesse, G, Alexandre, T, Gelin, M, Haouz, A, Munier-Lehmann, H. | | 登録日 | 2015-02-06 | | 公開日 | 2015-07-15 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.652 Å) | | 主引用文献 | Crystallographic Studies of Two Variants of Pseudomonas Aeruginosa Impdh with Impaired Allosteric Regulation
Acta Crystallogr.,Sect.D, 71, 2015
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5AHL
 | | Apo-form of the DeltaCBS mutant of IMPDH from Pseudomonas aeruginosa | | 分子名称: | INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE, SODIUM ION | | 著者 | Labesse, G, Alexandre, T, Gelin, M, Haouz, A, Munier-Lehmann, H. | | 登録日 | 2015-02-06 | | 公開日 | 2015-07-15 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.951 Å) | | 主引用文献 | Crystallographic Studies of Two Variants of Pseudomonas Aeruginosa Impdh with Impaired Allosteric Regulation
Acta Crystallogr.,Sect.D, 71, 2015
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5TKM
 | | Crystal structure of human APOBEC3B N-terminal Domain | | 分子名称: | DNA dC->dU-editing enzyme APOBEC-3B, ZINC ION | | 著者 | Xiao, X, Yang, H, Arutiunian, V, Besse, G, Morimoto, C, Zirkle, B, Chen, X.S. | | 登録日 | 2016-10-07 | | 公開日 | 2017-06-14 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structural determinants of APOBEC3B non-catalytic domain for molecular assembly and catalytic regulation.
Nucleic Acids Res., 45, 2017
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2I1W
 | | Crystal structure of NAD kinase 1 from Listeria monocytogenes | | 分子名称: | IODIDE ION, Probable inorganic polyphosphate/ATP-NAD kinase 1 | | 著者 | Poncet-Montange, G, Assairi, L, Arold, S, Pochet, S, Labesse, G. | | 登録日 | 2006-08-15 | | 公開日 | 2007-08-07 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.34 Å) | | 主引用文献 | NAD kinases use substrate-assisted catalysis for specific recognition of NAD.
J.Biol.Chem., 282, 2007
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5DHT
 | | Crystal structure of NAD kinase 1 from Listeria monocytogenes in complex with a novel inhibitor | | 分子名称: | 5'-azido-8-[(2-{[2-(3-bromophenyl)ethyl]amino}-2-oxoethyl)sulfanyl]-5'-deoxyadenosine, CITRIC ACID, GLYCEROL, ... | | 著者 | Gelin, M, Paoletti, J, Assairi, L, Huteau, V, Pochet, S, Labesse, G. | | 登録日 | 2015-08-31 | | 公開日 | 2016-09-14 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.59 Å) | | 主引用文献 | 8-Thioalkyl-adenosine derivatives inhibit Listeria monocytogenes NAD kinase through a novel binding mode.
Eur.J.Med.Chem., 124, 2016
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5DHS
 | | Crystal structure of NAD kinase 1 from Listeria monocytogenes in complex with a novel inhibitor | | 分子名称: | 5'-azido-5'-deoxy-8-[(2-{[2-(3-ethynylphenyl)ethyl]amino}-2-oxoethyl)sulfanyl]adenosine, CITRIC ACID, GLYCEROL, ... | | 著者 | Gelin, M, Paoletti, J, Assairi, L, Huteau, V, Pochet, S, Labesse, G. | | 登録日 | 2015-08-31 | | 公開日 | 2016-09-14 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.62 Å) | | 主引用文献 | 8-Thioalkyl-adenosine derivatives inhibit Listeria monocytogenes NAD kinase through a novel binding mode.
Eur.J.Med.Chem., 124, 2016
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2I2D
 | | Crystal structure of LmNADK1 | | 分子名称: | BIS{[(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL} DIHYDROGEN DIPHOSPHATE, CITRIC ACID, Probable inorganic polyphosphate/ATP-NAD kinase 1 | | 著者 | Poncet-Montange, G, Labesse, G. | | 登録日 | 2006-08-16 | | 公開日 | 2007-08-07 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.22 Å) | | 主引用文献 | NAD kinases use substrate-assisted catalysis for specific recognition of NAD.
J.Biol.Chem., 282, 2007
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