4QY6
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![BU of 4qy6 by Molmil](/molmil-images/mine/4qy6) | Crystal structures of chimeric beta-lactamase cTEM-19m showing different conformations | 分子名称: | Beta-lactamase TEM, Beta-lactamase PSE-4, CHLORIDE ION, ... | 著者 | Park, J, Gobeil, S, Pelletier, J.N, Berghuis, A.M. | 登録日 | 2014-07-23 | 公開日 | 2015-08-12 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.15 Å) | 主引用文献 | Crystal structures of chimeric beta-lactamase cTEM-19m showing different conformations To be Published
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4R4R
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![BU of 4r4r by Molmil](/molmil-images/mine/4r4r) | Crystal structure of chimeric beta-lactamase cTEM-19m at 1.2 angstrom resolution | 分子名称: | Beta-lactamase TEM,Beta-lactamase PSE-4, CHLORIDE ION, MAGNESIUM ION | 著者 | Park, J, Gobeil, S, Pelletier, J.N, Berghuis, A.M. | 登録日 | 2014-08-19 | 公開日 | 2015-11-11 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | The Structural Dynamics of Engineered beta-Lactamases Vary Broadly on Three Timescales yet Sustain Native Function. Sci Rep, 9, 2019
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4RG4
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![BU of 4rg4 by Molmil](/molmil-images/mine/4rg4) | |
3SFM
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![BU of 3sfm by Molmil](/molmil-images/mine/3sfm) | |
3SG9
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![BU of 3sg9 by Molmil](/molmil-images/mine/3sg9) | |
4QXS
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![BU of 4qxs by Molmil](/molmil-images/mine/4qxs) | Crystal structure of human FPPS in complex with WC01088 | 分子名称: | (2-{2-[(2S)-3-methylbutan-2-yl]-5-phenyl-1H-indol-3-yl}ethane-1,1-diyl)bis(phosphonic acid), Farnesyl pyrophosphate synthase, GLYCEROL, ... | 著者 | Park, J, Zielinski, M, Weiling, C, Tsantrizos, Y.S, Berghuis, A.M. | 登録日 | 2014-07-21 | 公開日 | 2015-02-25 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Probing the molecular and structural elements of ligands binding to the active site versus an allosteric pocket of the human farnesyl pyrophosphate synthase. Bioorg.Med.Chem.Lett., 25, 2015
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4QY5
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![BU of 4qy5 by Molmil](/molmil-images/mine/4qy5) | Crystal structures of chimeric beta-lactamase cTEM-19m showing different conformations | 分子名称: | Beta-lactamase TEM,Beta-lactamase PSE-4, CHLORIDE ION, MAGNESIUM ION | 著者 | Park, J, Gobeil, S, Pelletier, J.N, Berghuis, A.M. | 登録日 | 2014-07-23 | 公開日 | 2015-08-12 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.501 Å) | 主引用文献 | Crystal structures of chimeric beta-lactamase cTEM-19m showing different conformations To be Published
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3UCL
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![BU of 3ucl by Molmil](/molmil-images/mine/3ucl) | |
1EBF
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![BU of 1ebf by Molmil](/molmil-images/mine/1ebf) | HOMOSERINE DEHYDROGENASE FROM S. CEREVISIAE COMPLEX WITH NAD+ | 分子名称: | HOMOSERINE DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, SODIUM ION | 著者 | DeLaBarre, B, Thompson, P.R, Wright, G.D, Berghuis, A.M. | 登録日 | 2000-01-24 | 公開日 | 2000-03-08 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Crystal structures of homoserine dehydrogenase suggest a novel catalytic mechanism for oxidoreductases. Nat.Struct.Biol., 7, 2000
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1EBU
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![BU of 1ebu by Molmil](/molmil-images/mine/1ebu) | HOMOSERINE DEHYDROGENASE COMPLEX WITH NAD ANALOGUE AND L-HOMOSERINE | 分子名称: | 3-AMINOMETHYL-PYRIDINIUM-ADENINE-DINUCLEOTIDE, HOMOSERINE DEHYDROGENASE, L-HOMOSERINE, ... | 著者 | DeLaBarre, B, Thompson, P.R, Wright, G.D, Berghuis, A.M. | 登録日 | 2000-01-24 | 公開日 | 2000-03-08 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Crystal structures of homoserine dehydrogenase suggest a novel catalytic mechanism for oxidoreductases. Nat.Struct.Biol., 7, 2000
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1GIL
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![BU of 1gil by Molmil](/molmil-images/mine/1gil) | |
1GFI
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![BU of 1gfi by Molmil](/molmil-images/mine/1gfi) | STRUCTURES OF ACTIVE CONFORMATIONS OF GI ALPHA 1 AND THE MECHANISM OF GTP HYDROLYSIS | 分子名称: | GUANINE NUCLEOTIDE-BINDING PROTEIN G, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Coleman, D.E, Berghuis, A.M, Sprang, S.R. | 登録日 | 1994-11-11 | 公開日 | 1995-03-31 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis. Science, 265, 1994
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5IQG
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![BU of 5iqg by Molmil](/molmil-images/mine/5iqg) | Aminoglycoside Phosphotransferase (2'')-Ia (CTD of AAC(6')-Ie/APH(2'')-Ia) in complex with GDP, Magnesium, and Gentamicin C1 | 分子名称: | Bifunctional AAC/APH, CHLORIDE ION, GUANOSINE-5'-DIPHOSPHATE, ... | 著者 | Caldwell, S.J, Berghuis, A.M. | 登録日 | 2016-03-10 | 公開日 | 2016-05-25 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Antibiotic Binding Drives Catalytic Activation of Aminoglycoside Kinase APH(2)-Ia. Structure, 24, 2016
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5IQE
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![BU of 5iqe by Molmil](/molmil-images/mine/5iqe) | Aminoglycoside Phosphotransferase (2'')-Ia (CTD of AAC(6')-Ie/APH(2'')-Ia) in complex with GMPPNP, Magnesium, and Neomycin B | 分子名称: | Bifunctional AAC/APH, GLYCEROL, MAGNESIUM ION, ... | 著者 | Caldwell, S.J, Berghuis, A.M. | 登録日 | 2016-03-10 | 公開日 | 2016-05-25 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Antibiotic Binding Drives Catalytic Activation of Aminoglycoside Kinase APH(2)-Ia. Structure, 24, 2016
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5IQC
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![BU of 5iqc by Molmil](/molmil-images/mine/5iqc) | Aminoglycoside Phosphotransferase (2'')-Ia (CTD of AAC(6')-Ie/APH(2'')-Ia) in complex with GMPPNP, Magnesium, and Gentamicin C1 | 分子名称: | Bifunctional AAC/APH, CHLORIDE ION, GLYCEROL, ... | 著者 | Caldwell, S.J, Berghuis, A.M. | 登録日 | 2016-03-10 | 公開日 | 2016-05-25 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Antibiotic Binding Drives Catalytic Activation of Aminoglycoside Kinase APH(2)-Ia. Structure, 24, 2016
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5IQA
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5IQI
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5IQD
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![BU of 5iqd by Molmil](/molmil-images/mine/5iqd) | Aminoglycoside Phosphotransferase (2'')-Ia (CTD of AAC(6')-Ie/APH(2'')-Ia) in complex with GMPPNP, Magnesium, and Ribostamycin | 分子名称: | Bifunctional AAC/APH, CHLORIDE ION, MAGNESIUM ION, ... | 著者 | Caldwell, S.J, Berghuis, A.M. | 登録日 | 2016-03-10 | 公開日 | 2016-05-25 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Antibiotic Binding Drives Catalytic Activation of Aminoglycoside Kinase APH(2)-Ia. Structure, 24, 2016
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5IQH
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5IQF
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5IQB
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![BU of 5iqb by Molmil](/molmil-images/mine/5iqb) | Aminoglycoside Phosphotransferase (2'')-Ia (CTD of AAC(6')-Ie/APH(2'')-Ia) in complex with GMPPNP, Magnesium, and Kanamycin A | 分子名称: | Bifunctional AAC/APH, CHLORIDE ION, KANAMYCIN A, ... | 著者 | Caldwell, S.J, Berghuis, A.M. | 登録日 | 2016-03-10 | 公開日 | 2016-05-25 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Antibiotic Binding Drives Catalytic Activation of Aminoglycoside Kinase APH(2)-Ia. Structure, 24, 2016
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5JA0
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![BU of 5ja0 by Molmil](/molmil-images/mine/5ja0) | Crystal structure of human FPPS with allosterically bound FPP | 分子名称: | FARNESYL DIPHOSPHATE, Farnesyl pyrophosphate synthase, PHOSPHATE ION | 著者 | Park, J, Zielinski, M, Tsantrizos, Y.S, Berghuis, A.M. | 登録日 | 2016-04-11 | 公開日 | 2017-01-25 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Human farnesyl pyrophosphate synthase is allosterically inhibited by its own product. Nat Commun, 8, 2017
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5JV0
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![BU of 5jv0 by Molmil](/molmil-images/mine/5jv0) | Crystal structure of human FPPS in complex with an allosteric inhibitor CL-08-038 | 分子名称: | Farnesyl pyrophosphate synthase, SULFATE ION, [(1R)-2-(3-fluorophenyl)-1-{[6-(4-methylphenyl)thieno[2,3-d]pyrimidin-4-yl]amino}ethyl]phosphonic acid | 著者 | Park, J, Leung, C.Y, Tsantrizos, Y.S, Berghuis, A.M. | 登録日 | 2016-05-10 | 公開日 | 2017-03-15 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Pharmacophore Mapping of Thienopyrimidine-Based Monophosphonate (ThP-MP) Inhibitors of the Human Farnesyl Pyrophosphate Synthase. J. Med. Chem., 60, 2017
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5JV1
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![BU of 5jv1 by Molmil](/molmil-images/mine/5jv1) | Crystal structure of human FPPS in complex with an allosteric inhibitor CL-08-066 | 分子名称: | Farnesyl pyrophosphate synthase, SULFATE ION, [(1R)-1-{[6-(3-chloro-4-methylphenyl)thieno[2,3-d]pyrimidin-4-yl]amino}-2-(3-fluorophenyl)ethyl]phosphonic acid | 著者 | Park, J, Leung, C.Y, Tsantrizos, Y.S, Berghuis, A.M. | 登録日 | 2016-05-10 | 公開日 | 2017-03-15 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Pharmacophore Mapping of Thienopyrimidine-Based Monophosphonate (ThP-MP) Inhibitors of the Human Farnesyl Pyrophosphate Synthase. J. Med. Chem., 60, 2017
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1D9U
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![BU of 1d9u by Molmil](/molmil-images/mine/1d9u) | BACTERIOPHAGE LAMBDA LYSOZYME COMPLEXED WITH A CHITOHEXASACHARIDE | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BACTERIOPHAGE LAMBDA LYSOZYME, ... | 著者 | Leung, A.K.W, Duewel, H.S, Honek, J.F, Berghuis, A.M. | 登録日 | 1999-10-30 | 公開日 | 2001-05-23 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Crystal structure of the lytic transglycosylase from bacteriophage lambda in complex with hexa-N-acetylchitohexaose. Biochemistry, 40, 2001
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