5IQI

Aminoglycoside Phosphotransferase (2'')-Ia (CTD of AAC(6')-Ie/APH(2'')-Ia) Y237F mutant in complex with GMPPNP and Magnesium

Summary for 5IQI

Entry DOI	10.2210/pdb5iqi/pdb
Related	5BYL 5IQA 5IQB 5IQC 5IQD 5IQE 5IQF 5IQG 5IQH
Descriptor	Bifunctional AAC/APH, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, MAGNESIUM ION, ... (5 entities in total)
Functional Keywords	kinase, antibiotic, aminoglycoside, resistance, transferase
Biological source	Staphylococcus aureus
Cellular location	Cytoplasm: P0A0C1
Total number of polymer chains	4
Total formula weight	146118.38
Authors	Caldwell, S.J.,Berghuis, A.M. (deposition date: 2016-03-10, release date: 2016-05-25, Last modification date: 2023-09-27)
Primary citation	Caldwell, S.J.,Huang, Y.,Berghuis, A.M. Antibiotic Binding Drives Catalytic Activation of Aminoglycoside Kinase APH(2)-Ia. Structure, 24:935-945, 2016 Cited by PubMed: 27161980 DOI: 10.1016/j.str.2016.04.002 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.15 Å)

Structure validation