3DWM
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![BU of 3dwm by Molmil](/molmil-images/mine/3dwm) | Crystal structure of Mycobacterium tuberculosis CysO, an antigen | Descriptor: | 9.5 kDa culture filtrate antigen cfp10A | Authors: | Jurgenson, C.T, Burns, K.E, Begley, T.P, Ealick, S.E. | Deposit date: | 2008-07-22 | Release date: | 2008-09-23 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.69 Å) | Cite: | Crystal structure of a sulfur carrier protein complex found in the cysteine biosynthetic pathway of Mycobacterium tuberculosis. Biochemistry, 47, 2008
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3EPN
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![BU of 3epn by Molmil](/molmil-images/mine/3epn) | Crystal structure of Caulobacter crescentus ThiC complexed with imidazole ribonucleotide | Descriptor: | 1-(5-O-phosphono-beta-D-ribofuranosyl)-1H-imidazole, Thiamine biosynthesis protein thiC | Authors: | Li, S, Chatterjee, A, Zhang, Y, Grove, T.L, Lee, M, Krebs, C, Booker, S.J, Begley, T.P, Ealick, S.E. | Deposit date: | 2008-09-29 | Release date: | 2008-10-28 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.11 Å) | Cite: | Reconstitution of ThiC in thiamine pyrimidine biosynthesis expands the radical SAM superfamily Nat.Chem.Biol., 4, 2008
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3DWI
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![BU of 3dwi by Molmil](/molmil-images/mine/3dwi) | Crystal structure of Mycobacterium tuberculosis CysM, the cysteine synthase B | Descriptor: | Cysteine synthase B, PYRIDOXAL-5'-PHOSPHATE, SULFATE ION | Authors: | Jurgenson, C.T, Burns, K.E, Begley, T.P, Ealick, S.E. | Deposit date: | 2008-07-22 | Release date: | 2008-09-23 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.81 Å) | Cite: | Crystal structure of a sulfur carrier protein complex found in the cysteine biosynthetic pathway of Mycobacterium tuberculosis. Biochemistry, 47, 2008
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3EPO
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![BU of 3epo by Molmil](/molmil-images/mine/3epo) | Crystal structure of Caulobacter crescentus ThiC complexed with HMP-P | Descriptor: | (4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL DIHYDROGEN PHOSPHATE, Thiamine biosynthesis protein thiC | Authors: | Li, S, Chatterjee, A, Zhang, Y, Grove, T.L, Lee, M, Krebs, C, Booker, S.J, Begley, T.P, Ealick, S.E. | Deposit date: | 2008-09-29 | Release date: | 2008-10-28 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Reconstitution of ThiC in thiamine pyrimidine biosynthesis expands the radical SAM superfamily Nat.Chem.Biol., 4, 2008
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3NL6
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![BU of 3nl6 by Molmil](/molmil-images/mine/3nl6) | The Crystal Structure of Candida glabrata THI6, a Bifunctional Enzyme involved in Thiamin Biosyhthesis of Eukaryotes | Descriptor: | MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, THIAMIN PHOSPHATE, ... | Authors: | Paul, D, Chatterjee, A, Begley, T.P, Ealick, S.E. | Deposit date: | 2010-06-21 | Release date: | 2010-11-10 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.612 Å) | Cite: | Domain Organization in Candida glabrata THI6, a Bifunctional Enzyme Required for Thiamin Biosynthesis in Eukaryotes . Biochemistry, 49, 2010
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3O16
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![BU of 3o16 by Molmil](/molmil-images/mine/3o16) | Crystal Structure of Bacillus subtilis Thiamin Phosphate Synthase K159A | Descriptor: | Thiamine-phosphate pyrophosphorylase | Authors: | McCulloch, K.M, Hanes, J.W, Abdelwahed, S, Mahanta, N, Hazra, A, Ishida, K, Begley, T.P, Ealick, S.E. | Deposit date: | 2010-07-20 | Release date: | 2011-07-27 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal Structure and Kinetic Characterization of Bacillus subtilis Thiamin
Phosphate Synthase with a Carboxylated Thiazole Phosphate to be published
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3O63
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![BU of 3o63 by Molmil](/molmil-images/mine/3o63) | Crystal Structure of Thiamin Phosphate Synthase from Mycobacterium tuberculosis | Descriptor: | PHOSPHATE ION, Probable thiamine-phosphate pyrophosphorylase | Authors: | McCulloch, K.M, Ramamoorthy, D, Ishida, K, Guida, W.C, Begley, T.P, Ealick, S.E. | Deposit date: | 2010-07-28 | Release date: | 2011-07-27 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Crystal Structure and Identification of Potential Inhibitor Compounds for Mycobacterium tuberculosis Thiamin Phosphate Synthase to be published
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3NL2
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![BU of 3nl2 by Molmil](/molmil-images/mine/3nl2) | The Crystal Structure of Candida glabrata THI6, a Bifunctional Enzyme involved in Thiamin Biosyhthesis of Eukaryotes | Descriptor: | Thiamine biosynthetic bifunctional enzyme | Authors: | Paul, D, Chatterjee, A, Begley, T.P, Ealick, S.E. | Deposit date: | 2010-06-21 | Release date: | 2010-11-10 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (3.08 Å) | Cite: | Domain Organization in Candida glabrata THI6, a Bifunctional Enzyme Required for Thiamin Biosynthesis in Eukaryotes . Biochemistry, 49, 2010
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3NM3
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![BU of 3nm3 by Molmil](/molmil-images/mine/3nm3) | The Crystal Structure of Candida glabrata THI6, a Bifunctional Enzyme involved in Thiamin Biosyhthesis of Eukaryotes | Descriptor: | MAGNESIUM ION, PYROPHOSPHATE 2-, THIAMIN PHOSPHATE, ... | Authors: | Paul, D, Chatterjee, A, Begley, T.P, Ealick, S.E. | Deposit date: | 2010-06-21 | Release date: | 2010-11-10 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (3.102 Å) | Cite: | Domain Organization in Candida glabrata THI6, a Bifunctional Enzyme Required for Thiamin Biosynthesis in Eukaryotes . Biochemistry, 49, 2010
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3NM1
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![BU of 3nm1 by Molmil](/molmil-images/mine/3nm1) | The Crystal Structure of Candida glabrata THI6, a Bifunctional Enzyme involved in Thiamin Biosyhthesis of Eukaryotes | Descriptor: | 2-TRIFLUOROMETHYL-5-METHYLENE-5H-PYRIMIDIN-4-YLIDENEAMINE, 4-methyl-5-[2-(phosphonooxy)ethyl]-1,3-thiazole-2-carboxylic acid, MAGNESIUM ION, ... | Authors: | Paul, D, Chatterjee, A, Begley, T.P, Ealick, S.E. | Deposit date: | 2010-06-21 | Release date: | 2010-11-10 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (3.211 Å) | Cite: | Domain Organization in Candida glabrata THI6, a Bifunctional Enzyme Required for Thiamin Biosynthesis in Eukaryotes . Biochemistry, 49, 2010
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3NL5
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![BU of 3nl5 by Molmil](/molmil-images/mine/3nl5) | The Crystal Structure of Candida glabrata THI6, a Bifunctional Enzyme involved in Thiamin Biosyhthesis of Eukaryotes | Descriptor: | 2-(4-METHYL-THIAZOL-5-YL)-ETHANOL, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... | Authors: | Paul, D, Chatterjee, A, Begley, T.P, Ealick, S.E. | Deposit date: | 2010-06-21 | Release date: | 2010-11-10 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Domain Organization in Candida glabrata THI6, a Bifunctional Enzyme Required for Thiamin Biosynthesis in Eukaryotes . Biochemistry, 49, 2010
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3NL3
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![BU of 3nl3 by Molmil](/molmil-images/mine/3nl3) | The Crystal Structure of Candida glabrata THI6, a Bifunctional Enzyme involved in Thiamin Biosyhthesis of Eukaryotes | Descriptor: | MAGNESIUM ION, THIAMIN PHOSPHATE, Thiamine biosynthetic bifunctional enzyme | Authors: | Paul, D, Chatterjee, A, Begley, T.P, Ealick, S.E. | Deposit date: | 2010-06-21 | Release date: | 2010-11-10 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (3.007 Å) | Cite: | Domain Organization in Candida glabrata THI6, a Bifunctional Enzyme Required for Thiamin Biosynthesis in Eukaryotes . Biochemistry, 49, 2010
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3O15
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![BU of 3o15 by Molmil](/molmil-images/mine/3o15) | Crystal Structure of Bacillus subtilis Thiamin Phosphate Synthase Complexed with a Carboxylated Thiazole Phosphate | Descriptor: | 2-TRIFLUOROMETHYL-5-METHYLENE-5H-PYRIMIDIN-4-YLIDENEAMINE, 4-methyl-5-[2-(phosphonooxy)ethyl]-1,3-thiazole-2-carboxylic acid, PYROPHOSPHATE 2-, ... | Authors: | McCulloch, K.M, Hanes, J.W, Abdelwahed, S, Mahanta, N, Hazra, A, Ishida, K, Begley, T.P, Ealick, S.E. | Deposit date: | 2010-07-20 | Release date: | 2011-07-27 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Crystal Structure and Kinetic Characterization of Bacillus subtilis
Thiamin Phosphate Synthase with a Carboxylated Thiazole Phosphate to be published
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3THI
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![BU of 3thi by Molmil](/molmil-images/mine/3thi) | |
3PKX
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![BU of 3pkx by Molmil](/molmil-images/mine/3pkx) | Crystal Structure of Toxoflavin Lyase (TflA) bound to Mn(II) and Toxoflavin | Descriptor: | 1,6-dimethylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione, MANGANESE (II) ION, Toxoflavin lyase (TflA) | Authors: | Fenwick, M.K, Philmus, B, Begley, T.P, Ealick, S.E. | Deposit date: | 2010-11-12 | Release date: | 2011-01-12 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Toxoflavin lyase requires a novel 1-his-2-carboxylate facial triad . Biochemistry, 50, 2011
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3RM5
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![BU of 3rm5 by Molmil](/molmil-images/mine/3rm5) | |
3RP7
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![BU of 3rp7 by Molmil](/molmil-images/mine/3rp7) | Crystal Structure of Klebsiella pneumoniae HpxO complexed with FAD and uric acid | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, URIC ACID, flavoprotein monooxygenase | Authors: | Hicks, K.A, O'Leary, S.E, Begley, T.P, Ealick, S.E. | Deposit date: | 2011-04-26 | Release date: | 2012-05-16 | Last modified: | 2013-02-06 | Method: | X-RAY DIFFRACTION (2.042 Å) | Cite: | Structural and Mechanistic Studies of HpxO, a Novel Flavin Adenine Dinucleotide-Dependent Urate Oxidase from Klebsiella pneumoniae. Biochemistry, 52, 2013
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3RP8
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![BU of 3rp8 by Molmil](/molmil-images/mine/3rp8) | Crystal Structure of Klebsiella pneumoniae R204Q HpxO complexed with FAD | Descriptor: | CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, flavoprotein monooxygenase | Authors: | Hicks, K.A, O'Leary, S.E, Begley, T.P, Ealick, S.E. | Deposit date: | 2011-04-26 | Release date: | 2012-05-16 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.968 Å) | Cite: | Structural and Mechanistic Studies of HpxO, a Novel Flavin Adenine Dinucleotide-Dependent Urate Oxidase from Klebsiella pneumoniae. Biochemistry, 52, 2013
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3PKV
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![BU of 3pkv by Molmil](/molmil-images/mine/3pkv) | |
3RP6
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![BU of 3rp6 by Molmil](/molmil-images/mine/3rp6) | Crystal Structure of Klebsiella pneumoniae HpxO complexed with FAD | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, flavoprotein monooxygenase | Authors: | Hicks, K.A, O'Leary, S.E, Begley, T.P, Ealick, S.E. | Deposit date: | 2011-04-26 | Release date: | 2012-05-16 | Last modified: | 2013-02-06 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural and Mechanistic Studies of HpxO, a Novel Flavin Adenine Dinucleotide-Dependent Urate Oxidase from Klebsiella pneumoniae. Biochemistry, 52, 2013
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3PKW
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![BU of 3pkw by Molmil](/molmil-images/mine/3pkw) | Crystal Structure of Toxoflavin Lyase (TflA) bound to Mn(II) | Descriptor: | MANGANESE (II) ION, Toxoflavin lyase (TflA) | Authors: | Fenwick, M.K, Philmus, B, Begley, T.P, Ealick, S.E. | Deposit date: | 2010-11-12 | Release date: | 2011-01-12 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Toxoflavin lyase requires a novel 1-his-2-carboxylate facial triad . Biochemistry, 50, 2011
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3RI6
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![BU of 3ri6 by Molmil](/molmil-images/mine/3ri6) | A Novel Mechanism of Sulfur Transfer Catalyzed by O-Acetylhomoserine Sulfhydrylase in Methionine Biosynthetic Pathway of Wolinella succinogenes | Descriptor: | O-ACETYLHOMOSERINE SULFHYDRYLASE | Authors: | Tran, T.H, Krishnamoorthy, K, Begley, T.P, Ealick, S.E. | Deposit date: | 2011-04-13 | Release date: | 2011-08-17 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | A novel mechanism of sulfur transfer catalyzed by O-acetylhomoserine sulfhydrylase in the methionine-biosynthetic pathway of Wolinella succinogenes. Acta Crystallogr.,Sect.D, 67, 2011
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3QH2
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![BU of 3qh2 by Molmil](/molmil-images/mine/3qh2) | Crystal structure of TenI from Bacillus subtilis complexed with product cThz-P | Descriptor: | 4-methyl-5-[2-(phosphonooxy)ethyl]-1,3-thiazole-2-carboxylic acid, Regulatory protein tenI, SULFATE ION | Authors: | Han, Y, Zhang, Y, Hazra, A, Chatterjee, A, Lai, R, Begley, T.P, Ealick, S.E. | Deposit date: | 2011-01-25 | Release date: | 2011-05-25 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.231 Å) | Cite: | A Missing Enzyme in Thiamin Thiazole Biosynthesis: Identification of TenI as a Thiazole Tautomerase. J.Am.Chem.Soc., 133, 2011
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