6WHO
 
 | | Histone deacetylases complex with peptide macrocycles | | 分子名称: | 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, Histone deacetylase 2, SODIUM ION, ... | | 著者 | Bera, A.K, Hosseinzadeh, P, Watson, P, Baker, D. | | 登録日 | 2020-04-08 | | 公開日 | 2021-04-21 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Anchor extension: a structure-guided approach to design cyclic peptides targeting enzyme active sites.
Nat Commun, 12, 2021
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6WHN
 | | Histone deacetylases complex with peptide macrocycles | | 分子名称: | 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, DI(HYDROXYETHYL)ETHER, Histone deacetylase 2, ... | | 著者 | Bera, A.K, Hosseinzadeh, P, Watson, P, Baker, D. | | 登録日 | 2020-04-08 | | 公開日 | 2021-04-21 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.54 Å) | | 主引用文献 | Anchor extension: a structure-guided approach to design cyclic peptides targeting enzyme active sites.
Nat Commun, 12, 2021
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6WHQ
 | | Histone deacetylases complex with peptide macrocycles | | 分子名称: | 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, Histone deacetylase 2, SODIUM ION, ... | | 著者 | Bera, A.K, Hosseinzadeh, P, Watson, P, Baker, D. | | 登録日 | 2020-04-08 | | 公開日 | 2021-04-21 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | | 主引用文献 | Anchor extension: a structure-guided approach to design cyclic peptides targeting enzyme active sites.
Nat Commun, 12, 2021
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6WI3
 | | Histone deacetylases complex with peptide macrocycles | | 分子名称: | (SHA)W(DTH)DN(DSN)(DME)(DAS)K peptide macrocycle, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, Histone deacetylase 2, ... | | 著者 | Bera, A.K, Hosseinzadeh, P, Watson, P, Baker, D. | | 登録日 | 2020-04-08 | | 公開日 | 2021-04-21 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | | 主引用文献 | Anchor extension: a structure-guided approach to design cyclic peptides targeting enzyme active sites.
Nat Commun, 12, 2021
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6WMK
 | | Crystal structure of beta sheet heterodimer LHD29 | | 分子名称: | Beta sheet heterodimer LHD29 - Chain A, Beta sheet heterodimer LHD29 - Chain B | | 著者 | Bera, A.K, Sahtoe, D.D, Kang, A, Sankaran, B, Baker, D. | | 登録日 | 2020-04-21 | | 公開日 | 2021-11-10 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Reconfigurable asymmetric protein assemblies through implicit negative design.
Science, 375, 2022
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1MHX
 | | Crystal Structures of the redesigned protein G variant NuG1 | | 分子名称: | immunoglobulin-binding protein G | | 著者 | Nauli, S, Kuhlman, B, Le Trong, I, Stenkamp, R.E, Teller, D.C, Baker, D. | | 登録日 | 2002-08-21 | | 公開日 | 2002-09-18 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Crystal structures and increased stabilization of the protein G variants with switched folding pathways NuG1 and NuG2
Protein Sci., 11, 2002
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2LPB
 | | Structure of the complex of the central activation domain of Gcn4 bound to the mediator co-activator domain 1 of Gal11/med15 | | 分子名称: | General control protein GCN4, Mediator of RNA polymerase II transcription subunit 15 | | 著者 | Brzovic, P.S, Heikaus, C.C, Kisselev, L, Vernon, R, Herbig, E, Pacheco, D, Warfield, L, Littlefield, P, Baker, D, Klevit, R.E, Hahn, S. | | 登録日 | 2012-02-07 | | 公開日 | 2012-02-22 | | 最終更新日 | 2024-05-01 | | 実験手法 | SOLUTION NMR | | 主引用文献 | The acidic transcription activator Gcn4 binds the mediator subunit Gal11/Med15 using a simple protein interface forming a fuzzy complex.
Mol.Cell, 44, 2011
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6WI5
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6WXO
 | | De novo TIM barrel-ferredoxin fold fusion homodimer with 2-histidine 2-glutamate centre TFD-HE | | 分子名称: | GLYCEROL, SULFATE ION, TFD-HE | | 著者 | Caldwell, S.J, Zeymer, C, Haydon, I.C, Huang, P, Hilvert, D, Baker, D. | | 登録日 | 2020-05-11 | | 公開日 | 2020-11-25 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.41 Å) | | 主引用文献 | Tight and specific lanthanide binding in a de novo TIM barrel with a large internal cavity designed by symmetric domain fusion.
Proc.Natl.Acad.Sci.USA, 117, 2020
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7CBC
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6X1K
 | | Solution NMR structure of de novo designed TMB2.3 | | 分子名称: | De novo designed transmembrane beta-barrel TMB2.3 | | 著者 | Liang, B, Vorobieva, A.A, Chow, C.M, Baker, D, Tamm, L.K. | | 登録日 | 2020-05-19 | | 公開日 | 2021-02-17 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | De novo design of transmembrane beta barrels.
Science, 371, 2021
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2LCB
 | | Solution Structure of a Minor and Transiently Formed State of a T4 Lysozyme Mutant | | 分子名称: | Lysozyme | | 著者 | Bouvignies, G, Vallurupalli, P, Hansen, D, Correia, B, Lange, O, Bah, A, Vernon, R.M, Dahlquist, F.W, Baker, D, Kay, L.E. | | 登録日 | 2011-04-26 | | 公開日 | 2011-08-17 | | 最終更新日 | 2024-05-01 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure of a minor and transiently formed state of a T4 lysozyme mutant.
Nature, 477, 2011
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2LC9
 | | Solution Structure of a Minor and Transiently Formed State of a T4 Lysozyme Mutant | | 分子名称: | Lysozyme | | 著者 | Bouvignies, G, Vallurupalli, P, Hansen, D, Correia, B, Lange, O, Bah, A, Vernon, R.M, Dahlquist, F.W, Baker, D, Kay, L.E. | | 登録日 | 2011-04-26 | | 公開日 | 2011-08-17 | | 最終更新日 | 2024-05-01 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure of a minor and transiently formed state of a T4 lysozyme mutant.
Nature, 477, 2011
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2L9V
 | | NMR structure of the FF domain L24A mutant's folding transition state | | 分子名称: | Pre-mRNA-processing factor 40 homolog A | | 著者 | Korzhnev, D.M, Vernon, R.M, Religa, T.L, Hansen, A, Baker, D, Fersht, A.R, Kay, L.E. | | 登録日 | 2011-02-24 | | 公開日 | 2011-09-28 | | 最終更新日 | 2024-05-01 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Nonnative interactions in the FF domain folding pathway from an atomic resolution structure of a sparsely populated intermediate: an NMR relaxation dispersion study.
J.Am.Chem.Soc., 133, 2011
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4UOT
 | | Thermodynamic hyperstability in parametrically designed helical bundles | | 分子名称: | DESIGNED HELICAL BUNDLE 5H2L | | 著者 | Oberdorfer, G, Huang, P, Pei, X.Y, Xu, C, Gonen, T, Nannenga, B, DiMaio, D, Rogers, J, Luisi, B.F, Baker, D. | | 登録日 | 2014-06-09 | | 公開日 | 2014-11-05 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (1.69 Å) | | 主引用文献 | High Thermodynamic Stability of Parametrically Designed Helical Bundles
Science, 346, 2014
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8VEI
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8VEJ
 | | De novo designed cholic acid binder: CHD_buttress | | 分子名称: | CHD_buttress, CHOLIC ACID | | 著者 | Bera, A.K, Tran, L, Kang, A, Baker, D. | | 登録日 | 2023-12-19 | | 公開日 | 2024-07-17 | | 最終更新日 | 2024-07-31 | | 実験手法 | X-RAY DIFFRACTION (3.59 Å) | | 主引用文献 | Binding and sensing diverse small molecules using shape-complementary pseudocycles.
Science, 385, 2024
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2LPZ
 | | Atomic model of the Type-III Secretion System Needle | | 分子名称: | Protein prgI | | 著者 | Loquet, A, Sgourakis, N.G, Gupta, R, Giller, K, Riedel, D, Goosmann, C, Griesinger, C, Kolbe, M.G, Baker, D, Becker, S, Lange, A. | | 登録日 | 2012-02-21 | | 公開日 | 2012-05-16 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLID-STATE NMR | | 主引用文献 | Atomic model of the type III secretion system needle.
Nature, 486, 2012
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4UOS
 | | Thermodynamic hyperstability in parametrically designed helical bundles | | 分子名称: | DESIGNED HELICAL BUNDLE | | 著者 | Oberdorfer, G, Huang, P, Pei, X.Y, Xu, C, Gonen, T, Nannenga, B, DiMaio, D, Rogers, J, Luisi, B.F, Baker, D. | | 登録日 | 2014-06-09 | | 公開日 | 2014-11-05 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.63 Å) | | 主引用文献 | High Thermodynamic Stability of Parametrically Designed Helical Bundles
Science, 346, 2014
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8VC8
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2L69
 | | Solution NMR Structure of de novo designed protein, P-loop NTPase fold, Northeast Structural Genomics Consortium Target OR28 | | 分子名称: | Rossmann 2x3 fold protein | | 著者 | Liu, G, Koga, N, Koga, R, Xiao, R, Mao, A, Mao, B, Patel, D, Ciccosanti, C, Hamilton, K, Acton, T.B, Baker, D, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) | | 登録日 | 2010-11-17 | | 公開日 | 2011-01-12 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution NMR structure of de novo designed rossmann 2x3 fold protein, Northeast Structural Genomics Consortium Target OR28
To be Published
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2KS6
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5KCI
 | | Crystal Structure of HTC1 | | 分子名称: | GLYCEROL, SULFATE ION, Uncharacterized protein YPL067C, ... | | 著者 | Martin, R.M, Horowitz, S, Koepnick, B, Cooper, S, Flatten, J, Rogawski, D.S, Koropatkin, N.M, Beinlich, F.R.M, Players, F, Students, U.M, Popovic, Z, Baker, D, Khatib, F, Bardwell, J.C.A. | | 登録日 | 2016-06-06 | | 公開日 | 2016-09-21 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (1.833 Å) | | 主引用文献 | Determining crystal structures through crowdsourcing and coursework.
Nat Commun, 7, 2016
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6O0I
 | | NMR ensemble of computationally designed protein XAA | | 分子名称: | Design construct XAA | | 著者 | Wei, K.Y, Moschidi, D, Nerli, S, Sgourakis, N, Baker, D. | | 登録日 | 2019-02-16 | | 公開日 | 2020-04-22 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Computational design of closely related proteins that adopt two well-defined but structurally divergent folds.
Proc.Natl.Acad.Sci.USA, 117, 2020
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6Q38
 | | The Crystal structure of CK2a bound to P1-C4 | | 分子名称: | 3,5-bis(1-methyl-1,2,3-triazol-4-yl)benzoic acid, BENZOIC ACID, Casein kinase II subunit alpha, ... | | 著者 | Brear, P, Iegre, J, Baker, D, Tan, Y, Sore, H, Donovan, D, Spring, D, Chandra, V, Hyvonen, M. | | 登録日 | 2018-12-03 | | 公開日 | 2019-04-24 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (1.74 Å) | | 主引用文献 | Efficient development of stable and highly functionalised peptides targeting the CK2 alpha /CK2 beta protein-protein interaction.
Chem Sci, 10, 2019
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