2G1D
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![BU of 2g1d by Molmil](/molmil-images/mine/2g1d) | Solution Structure of Ribosomal Protein S24E from Thermoplasma acidophilum | Descriptor: | 30S ribosomal protein S24e | Authors: | Jeon, B.-Y, Hong, E.-M, Jung, J.-W, Yee, A, Arrowsmith, C.H, Lee, W. | Deposit date: | 2006-02-14 | Release date: | 2007-02-14 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Solution structure of TA1092, a ribosomal protein S24e from Thermoplasma acidophilum Proteins, 64, 2006
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3JPX
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![BU of 3jpx by Molmil](/molmil-images/mine/3jpx) | EED: A Novel Histone Trimethyllysine Binder Within The EED-EZH2 Polycomb Complex | Descriptor: | HISTONE PEPTIDE, Polycomb protein EED | Authors: | Xu, C, Bian, C.B, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Min, J, Structural Genomics Consortium (SGC) | Deposit date: | 2009-09-04 | Release date: | 2009-10-20 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Binding of different histone marks differentially regulates the activity and specificity of polycomb repressive complex 2 (PRC2). Proc.Natl.Acad.Sci.USA, 107, 2010
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3JUS
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![BU of 3jus by Molmil](/molmil-images/mine/3jus) | Crystal structure of human lanosterol 14alpha-demethylase (CYP51) in complex with econazole | Descriptor: | 1-[(2R)-2-[(4-chlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole, 1-[(2S)-2-[(4-CHLOROBENZYL)OXY]-2-(2,4-DICHLOROPHENYL)ETHYL]-1H-IMIDAZOLE, Cycloheptakis-(1-4)-(alpha-D-glucopyranose), ... | Authors: | Strushkevich, N, MacKenzie, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Usanov, S.A, Park, H, Structural Genomics Consortium (SGC) | Deposit date: | 2009-09-15 | Release date: | 2010-03-02 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structural basis of human CYP51 inhibition by antifungal azoles. J. Mol. Biol., 397, 2010
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3JZG
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![BU of 3jzg by Molmil](/molmil-images/mine/3jzg) | Structure of EED in complex with H3K27me3 | Descriptor: | HISTONE PEPTIDE, Polycomb protein EED | Authors: | Xu, C, Bian, C.B, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Min, J, Structural Genomics Consortium (SGC) | Deposit date: | 2009-09-23 | Release date: | 2009-12-15 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Binding of different histone marks differentially regulates the activity and specificity of polycomb repressive complex 2 (PRC2). Proc.Natl.Acad.Sci.USA, 107, 2010
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2JUF
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![BU of 2juf by Molmil](/molmil-images/mine/2juf) | NMR solution structure of PARC CPH Domain. NESG Target HR3443B/SGC-Toronto | Descriptor: | p53-associated parkin-like cytoplasmic protein | Authors: | Kaustov, L, Liao, J.C.C, Lemak, S, Duan, S, Muhandiram, R, Karra, M, Srisailam, S.H, Sundstrom, M, Weigelt, J, Edwards, A.M, Dhe-Paganon, S, Arrowsmith, C.H, Structural Genomics Consortium (SGC), Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2007-08-23 | Release date: | 2007-10-16 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | NMR Solution Structure of PARC CPH Domain. To be Published
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2JRJ
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![BU of 2jrj by Molmil](/molmil-images/mine/2jrj) | Solution structure of the human Pirh2 RING-H2 domain. Northeast Structural Genomics Consortium Target HT2B | Descriptor: | Ring finger and CHY zinc finger domain containing protein 1, ZINC ION | Authors: | Sheng, Y, Lemak, A, Laister, R.C, Wu, B, Arrowsmith, C.H, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2007-06-27 | Release date: | 2007-07-10 | Last modified: | 2023-12-20 | Method: | SOLUTION NMR | Cite: | Molecular basis of Pirh2-mediated p53 ubiquitylation. Nat.Struct.Mol.Biol., 15, 2008
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2JYA
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![BU of 2jya by Molmil](/molmil-images/mine/2jya) | NMR solution structure of protein ATU1810 from Agrobacterium tumefaciens. Northeast Structural Genomics Consortium target AtR23, Ontario Centre for Structural Proteomics Target ATC1776 | Descriptor: | Uncharacterized protein Atu1810 | Authors: | Lemak, A, Yee, A, Gutmanas, A, Fares, C, Karra, M, Semesi, A, Arrowsmith, C.H, Northeast Structural Genomics Consortium (NESG), Ontario Centre for Structural Proteomics (OCSP) | Deposit date: | 2007-12-07 | Release date: | 2007-12-25 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Solution structure of protein ATU1810 form Agrobacterium tumefaciens. To be Published
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2JXX
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![BU of 2jxx by Molmil](/molmil-images/mine/2jxx) | NMR solution structure of Ubiquitin-like domain of NFATC2IP. Northeast Structural Genomics Consortium target HR5627 | Descriptor: | NFATC2-interacting protein | Authors: | Doherty, R.S, Dhe-Paganon, S, Fares, C, Lemak, A, Butler, C, Srisailam, S, Karra, M, Yee, A, Edwards, A.M, Weigelt, J, Arrowsmith, C.H, Northeast Structural Genomics Consortium (NESG), Structural Genomics Consortium (SGC) | Deposit date: | 2007-11-30 | Release date: | 2007-12-11 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Solution structure of Ubiquitin-like domain of NFATC2IP. TO BE PUBLISHED
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3JUV
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![BU of 3juv by Molmil](/molmil-images/mine/3juv) | Crystal structure of human lanosterol 14alpha-demethylase (CYP51) | Descriptor: | Cycloheptakis-(1-4)-(alpha-D-glucopyranose), Lanosterol 14-alpha demethylase, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Strushkevich, N, MacKenzie, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Usanov, S.A, Park, H, Structural Genomics Consortium (SGC) | Deposit date: | 2009-09-15 | Release date: | 2010-03-02 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (3.12 Å) | Cite: | Structural basis of human CYP51 inhibition by antifungal azoles. J. Mol. Biol., 397, 2010
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3I2B
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![BU of 3i2b by Molmil](/molmil-images/mine/3i2b) | The crystal structure of human 6 Pyruvoyl Tetrahydrobiopterin Synthase | Descriptor: | 1,2-ETHANEDIOL, 6-pyruvoyl tetrahydrobiopterin synthase, DI(HYDROXYETHYL)ETHER, ... | Authors: | Ugochukwu, E, Cocking, R, Pilka, E, Yue, W.W, Bray, J.E, Chaikuad, A, Krojer, T, Muniz, J, von Delft, F, Bountra, C, Arrowsmith, C.H, Weigelt, J, Edwards, A, Oppermann, U, Structural Genomics Consortium (SGC) | Deposit date: | 2009-06-29 | Release date: | 2009-07-28 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | The crystal structure of human 6 Pyruvoyl Tetrahydrobiopterin Synthase To be Published
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3JYU
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![BU of 3jyu by Molmil](/molmil-images/mine/3jyu) | Crystal structure of the N-terminal domains of the ubiquitin specific peptidase 4 (USP4) | Descriptor: | 3-PYRIDINIUM-1-YLPROPANE-1-SULFONATE, Ubiquitin carboxyl-terminal hydrolase | Authors: | Bacik, J.P, Avvakumov, G, Walker, J.R, Xue, S, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC) | Deposit date: | 2009-09-22 | Release date: | 2009-10-20 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.37 Å) | Cite: | Crystal structure of the N-terminal domains of the ubiquitin specific peptidase 4 (USP4) To be Published
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3K1Z
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![BU of 3k1z by Molmil](/molmil-images/mine/3k1z) | Crystal Structure of Human Haloacid Dehalogenase-like Hydrolase Domain containing 3 (HDHD3) | Descriptor: | 1,2-ETHANEDIOL, GLYCEROL, Haloacid dehalogenase-like hydrolase domain-containing protein 3 | Authors: | Ugochukwu, E, Guo, K, Yue, W.W, Pilka, E, Picaud, S, Muniz, J, Pike, A.C.W, Krojer, T, Gomes, M, von Delft, F, Bountra, C, Arrowsmith, C.H, Weigelt, J, Edwards, A, Kavanagh, K, Oppermann, U, Structural Genomics Consortium (SGC) | Deposit date: | 2009-09-29 | Release date: | 2009-11-03 | Last modified: | 2017-11-01 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Crystal Structure of Human Haloacid Dehalogenase-like Hydrolase Domain containing 3 (HDHD3) To be Published
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3K2O
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![BU of 3k2o by Molmil](/molmil-images/mine/3k2o) | Structure of an oxygenase | Descriptor: | ACETATE ION, Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6, CHLORIDE ION, ... | Authors: | Krojer, T, McDonough, M.A, Clifton, I.J, Mantri, M, Ng, S.S, Pike, A.C.W, Butler, D.S, Webby, C.J, Kochan, G, Bhatia, C, Bray, J.E, Chaikuad, A, Gileadi, O, von Delft, F, Weigelt, J, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Schofield, C.J, Kavanagh, K.L, Oppermann, U, Structural Genomics Consortium (SGC) | Deposit date: | 2009-09-30 | Release date: | 2009-11-03 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Crystal Structure of the 2-Oxoglutarate- and Fe(II)-Dependent Lysyl Hydroxylase JMJD6. J.Mol.Biol., 401, 2010
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3K35
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![BU of 3k35 by Molmil](/molmil-images/mine/3k35) | Crystal Structure of Human SIRT6 | Descriptor: | ADENOSINE-5-DIPHOSPHORIBOSE, NAD-dependent deacetylase sirtuin-6, SULFATE ION, ... | Authors: | Pan, P.W, Dong, A, Qiu, W, Loppnau, P, Wang, J, Ravichandran, M, Bochkarev, A, Bountra, C, Weigelt, J, Arrowsmith, C.H, Min, J, Edwards, A.M, Structural Genomics Consortium (SGC) | Deposit date: | 2009-10-01 | Release date: | 2009-12-08 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure and biochemical functions of SIRT6. J.Biol.Chem., 286, 2011
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2JV8
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![BU of 2jv8 by Molmil](/molmil-images/mine/2jv8) | Solution structure of protein NE1242 from Nitrosomonas europaea. Northeast Structural Genomics Consortium Target NeT4 | Descriptor: | Uncharacterized protein NE1242 | Authors: | Wu, Y, Yee, A, Zeri, A.C, Guido, V, Sukumaran, D, Arrowsmith, C.H, Szyperski, T, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2007-09-12 | Release date: | 2007-12-25 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Solution NMR structure of protein NE1242 from Nitrosomonas europaea. To be Published
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2JYN
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![BU of 2jyn by Molmil](/molmil-images/mine/2jyn) | A novel solution NMR structure of protein yst0336 from Saccharomyces cerevisiae. Northeast Structural Genomics Consortium target YT51/Ontario Centre for Structural Proteomics target yst0336 | Descriptor: | UPF0368 protein YPL225W | Authors: | Wu, B, Yee, A, Fares, C, Lemak, A, Gutmanas, A, Semest, A, Arrowsmith, C.H, Northeast Structural Genomics Consortium (NESG), Ontario Centre for Structural Proteomics (OCSP) | Deposit date: | 2007-12-14 | Release date: | 2007-12-25 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | A novel solution NMR structure of protein yst0336 from Saccharomyces cerevisiae. To be Published
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2JZ6
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![BU of 2jz6 by Molmil](/molmil-images/mine/2jz6) | Solution structure of 50S ribosomal protein L28 from Thermotoga maritima. Northeast Structural Genomics Consortium target VR97 | Descriptor: | 50S ribosomal protein L28 | Authors: | Wu, Y, Singarapu, K.K, Guido, V, Yee, A, Sukumaran, D, Arrowsmith, C.H, Szyperski, T, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2007-12-28 | Release date: | 2008-01-29 | Last modified: | 2024-05-08 | Method: | SOLUTION NMR | Cite: | Solution structure of 50S ribosomal protein L28 from Thermotoga maritima. Northeast Structural Genomics Consortium target VR97. To be Published
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3HMI
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![BU of 3hmi by Molmil](/molmil-images/mine/3hmi) | The crystal structure of human ABL2 in complex with 5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE | Descriptor: | 5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE, Tyrosine-protein kinase ABL2 | Authors: | Ugochukwu, E, Salah, E, Barr, A, Mahajan, P, Shrestha, B, Savitsky, P, Chaikuad, A, Allerston, C, von Delft, F, Bountra, C, Arrowsmith, C.H, Weigelt, J, Edwards, A, Knapp, S, Structural Genomics Consortium (SGC) | Deposit date: | 2009-05-29 | Release date: | 2009-07-07 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | The crystal structure of human ABL2 in complex with 5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE To be Published
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3K26
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![BU of 3k26 by Molmil](/molmil-images/mine/3k26) | Complex structure of EED and trimethylated H3K4 | Descriptor: | HISTONE PEPTIDE, Polycomb protein EED | Authors: | Bian, C.B, Xu, C, Qiu, W, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Min, J, Structural Genomics Consortium (SGC) | Deposit date: | 2009-09-29 | Release date: | 2009-12-15 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.58 Å) | Cite: | Binding of different histone marks differentially regulates the activity and specificity of polycomb repressive complex 2 (PRC2). Proc.Natl.Acad.Sci.USA, 107, 2010
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2H9N
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![BU of 2h9n by Molmil](/molmil-images/mine/2h9n) | WDR5 in complex with monomethylated H3K4 peptide | Descriptor: | H3 histone, WD-repeat protein 5 | Authors: | Min, J.R, Schuetz, A, Allali-Hassani, A, Martin, F, Loppnau, P, Vedadi, M, Weigelt, J, Sundstrom, M, Edwards, A.M, Arrowsmith, C.H, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC) | Deposit date: | 2006-06-10 | Release date: | 2006-08-01 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural basis for molecular recognition and presentation of histone H3 By WDR5. Embo J., 25, 2006
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3HZT
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![BU of 3hzt by Molmil](/molmil-images/mine/3hzt) | Crystal structure of Toxoplasma gondii CDPK3, TGME49_105860 | Descriptor: | 5-[(E)-(5-CHLORO-2-OXO-1,2-DIHYDRO-3H-INDOL-3-YLIDENE)METHYL]-N-[2-(DIETHYLAMINO)ETHYL]-2,4-DIMETHYL-1H-PYRROLE-3-CARBOXAMIDE, Calcium-dependent protein kinase 3, GLYCEROL, ... | Authors: | Wernimont, A.K, Artz, J.D, Finnerty, P, Wasney, G, Allali-Hassani, A, Vedadi, M, Bochkarev, A, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Hui, R, Amani, M, Structural Genomics Consortium (SGC) | Deposit date: | 2009-06-24 | Release date: | 2009-07-21 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structures of apicomplexan calcium-dependent protein kinases reveal mechanism of activation by calcium. Nat.Struct.Mol.Biol., 17, 2010
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3I3T
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![BU of 3i3t by Molmil](/molmil-images/mine/3i3t) | Crystal structure of covalent ubiquitin-USP21 complex | Descriptor: | ETHANAMINE, Ubiquitin, Ubiquitin carboxyl-terminal hydrolase 21, ... | Authors: | Neculai, D, Avvakumov, G.V, Walker, J.R, Xue, S, Butler-Cole, C, Weigelt, J, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC) | Deposit date: | 2009-06-30 | Release date: | 2009-07-21 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.59 Å) | Cite: | A strategy for modulation of enzymes in the ubiquitin system. Science, 339, 2013
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2H9P
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![BU of 2h9p by Molmil](/molmil-images/mine/2h9p) | WDR5 in complex with trimethylated H3K4 peptide | Descriptor: | H3 histone, WD-repeat protein 5 | Authors: | Min, J.R, Schuetz, A, Allali-Hassani, A, Martin, F, Loppnau, P, Vedadi, M, Weigelt, J, Sundstrom, M, Edwards, A.M, Arrowsmith, C.H, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC) | Deposit date: | 2006-06-10 | Release date: | 2006-08-01 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.91 Å) | Cite: | Structural basis for molecular recognition and presentation of histone H3 By WDR5. Embo J., 25, 2006
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3I2N
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![BU of 3i2n by Molmil](/molmil-images/mine/3i2n) | Crystal Structure of WD40 repeats protein WDR92 | Descriptor: | WD repeat-containing protein 92 | Authors: | Amaya, M.F, Li, Z, He, H, Seitova, A, Ni, S, Edwards, A.M, Arrowsmith, C.H, Weigelt, J, Bountra, C, Bochkarev, A, Min, J, Ouyang, H, Structural Genomics Consortium (SGC) | Deposit date: | 2009-06-29 | Release date: | 2009-08-18 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Structure and function of WD40 domain proteins. Protein Cell, 2, 2011
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2HEH
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![BU of 2heh by Molmil](/molmil-images/mine/2heh) | Crystal Structure of the KIF2C motor domain | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, KIF2C protein, MAGNESIUM ION, ... | Authors: | Wang, J, Shen, Y, Tempel, W, Landry, R, Arrowsmith, C.H, Edwards, A.M, Sundstrom, M, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC) | Deposit date: | 2006-06-21 | Release date: | 2006-07-18 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Crystal structure of the kif2c motor domain to be published
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