8IL3
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![BU of 8il3 by Molmil](/molmil-images/mine/8il3) | Cryo-EM structure of CD38 in complex with FTL004 | Descriptor: | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1, Heavy chain, Light chain | Authors: | Yang, J, Wang, Y, Zhang, G. | Deposit date: | 2023-03-01 | Release date: | 2023-03-29 | Method: | ELECTRON MICROSCOPY (3.86 Å) | Cite: | FTL004, an anti-CD38 mAb with negligible RBC binding and enhanced pro-apoptotic activity, is a novel candidate for treatments of multiple myeloma and non-Hodgkin lymphoma. J Hematol Oncol, 15, 2022
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6TJY
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![BU of 6tjy by Molmil](/molmil-images/mine/6tjy) | Crystal structure of haemagglutinin from (A/seal/Germany/1/2014) seal H10N7 influenza virus | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | Authors: | Zhang, J, Xiong, X, Purkiss, A, Walker, P, Gamblin, S, Skehel, J.J. | Deposit date: | 2019-11-27 | Release date: | 2020-10-21 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.82 Å) | Cite: | Hemagglutinin Traits Determine Transmission of Avian A/H10N7 Influenza Virus between Mammals. Cell Host Microbe, 28, 2020
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4V43
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6TJW
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![BU of 6tjw by Molmil](/molmil-images/mine/6tjw) | Crystal structure of the haemagglutinin mutant (Gln226Leu, Del228) from an H10N7 seal influenza virus isolated in Germany | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Zhang, J, Xiong, X, Purkiss, A, Walker, P, Gamblin, S, Skehel, J.J. | Deposit date: | 2019-11-27 | Release date: | 2020-10-21 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.31 Å) | Cite: | Hemagglutinin Traits Determine Transmission of Avian A/H10N7 Influenza Virus between Mammals. Cell Host Microbe, 28, 2020
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8XAI
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![BU of 8xai by Molmil](/molmil-images/mine/8xai) | |
8HUW
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![BU of 8huw by Molmil](/molmil-images/mine/8huw) | Crystal structure of SARS-Cov-2 main protease K90R mutant in complex with S217622 | Descriptor: | 3C-like proteinase nsp5, 6-[(6-chloranyl-2-methyl-indazol-5-yl)amino]-3-[(1-methyl-1,2,4-triazol-3-yl)methyl]-1-[[2,4,5-tris(fluoranyl)phenyl]methyl]-1,3,5-triazine-2,4-dione | Authors: | Wang, J, Zhang, J, Li, J. | Deposit date: | 2022-12-24 | Release date: | 2023-06-21 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Structural basis for the inhibition of coronaviral main proteases by ensitrelvir. Structure, 31, 2023
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7T02
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![BU of 7t02 by Molmil](/molmil-images/mine/7t02) | |
7SXO
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![BU of 7sxo by Molmil](/molmil-images/mine/7sxo) | Yeast Lon (PIM1) with endogenous substrate | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Lon protease homolog, ... | Authors: | Yang, J, Song, A.S, Wiseman, R.L, Lander, G.C. | Deposit date: | 2021-11-24 | Release date: | 2022-01-12 | Last modified: | 2022-07-27 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Cryo-EM structure of hexameric yeast Lon protease (PIM1) highlights the importance of conserved structural elements. J.Biol.Chem., 298, 2022
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4LR3
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![BU of 4lr3 by Molmil](/molmil-images/mine/4lr3) | Crystal structure of E. coli YfbU at 2.5 A resolution | Descriptor: | MAGNESIUM ION, PHOSPHATE ION, protein YfbU | Authors: | Wang, J, Wing, R.A. | Deposit date: | 2013-07-19 | Release date: | 2014-04-30 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Diamonds in the rough: a strong case for the inclusion of weak-intensity X-ray diffraction data. Acta Crystallogr.,Sect.D, 70, 2014
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6NTF
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![BU of 6ntf by Molmil](/molmil-images/mine/6ntf) | Crystal structure of a computationally optimized H5 influenza hemagglutinin | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, DI(HYDROXYETHYL)ETHER, ... | Authors: | Huang, J, Bar-Peled, Y, Mousa, J.J. | Deposit date: | 2019-01-29 | Release date: | 2019-09-18 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural and antigenic characterization of a computationally-optimized H5 hemagglutinin influenza vaccine. Vaccine, 37, 2019
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8I4Z
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![BU of 8i4z by Molmil](/molmil-images/mine/8i4z) | CalA3 with hydrolysis product | Descriptor: | 11-oxidanylidene-11-(1~{H}-pyrrol-2-yl)undecanoic acid, Beta-ketoacyl-acyl-carrier-protein synthase I | Authors: | Wang, J, Wang, Z. | Deposit date: | 2023-01-21 | Release date: | 2023-02-22 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (3.97 Å) | Cite: | C-N bond formation by a polyketide synthase. Nat Commun, 14, 2023
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8I4Y
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![BU of 8i4y by Molmil](/molmil-images/mine/8i4y) | CalA3 complex structure with amidation product | Descriptor: | 11-oxidanylidene-11-(1~{H}-pyrrol-2-yl)undecanoic acid, 3-HYDROXYANTHRANILIC ACID, Beta-ketoacyl-acyl-carrier-protein synthase I | Authors: | Wang, J, Wang, Z. | Deposit date: | 2023-01-21 | Release date: | 2023-02-22 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (3.84 Å) | Cite: | C-N bond formation by a polyketide synthase. Nat Commun, 14, 2023
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8HW4
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![BU of 8hw4 by Molmil](/molmil-images/mine/8hw4) | Cryo-EM structure of dehydroepiandrosterone sulfate-bound human ABC transporter ABCC3 in nanodiscs | Descriptor: | 17-oxoandrost-5-en-3beta-yl hydrogen sulfate, ATP-binding cassette sub-family C member 3 | Authors: | Wang, J, Wang, F.F, Chen, Y.X, Zhou, C.Z. | Deposit date: | 2022-12-28 | Release date: | 2023-06-07 | Last modified: | 2023-10-11 | Method: | ELECTRON MICROSCOPY (3.52 Å) | Cite: | Placing steroid hormones within the human ABCC3 transporter reveals a compatible amphiphilic substrate-binding pocket. Embo J., 42, 2023
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8HVH
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![BU of 8hvh by Molmil](/molmil-images/mine/8hvh) | Cryo-EM structure of ABC transporter ABCC3 | Descriptor: | ATP-binding cassette sub-family C member 3 | Authors: | Wang, J, Wang, F.F, Chen, Y.X, Zhou, C.Z. | Deposit date: | 2022-12-26 | Release date: | 2023-06-07 | Last modified: | 2023-10-11 | Method: | ELECTRON MICROSCOPY (3.07 Å) | Cite: | Placing steroid hormones within the human ABCC3 transporter reveals a compatible amphiphilic substrate-binding pocket. Embo J., 42, 2023
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8HW2
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![BU of 8hw2 by Molmil](/molmil-images/mine/8hw2) | Cryo-EM structure of beta-estradiol 17-(beta-D-glucuronide)-bound human ABC transporter ABCC3 in nanodiscs | Descriptor: | ATP-binding cassette sub-family C member 3, Estradiol-17beta-glucuronide | Authors: | Wang, J, Wang, F.F, Chen, Y.X, Zhou, C.Z. | Deposit date: | 2022-12-28 | Release date: | 2023-06-07 | Last modified: | 2023-10-11 | Method: | ELECTRON MICROSCOPY (3.65 Å) | Cite: | Placing steroid hormones within the human ABCC3 transporter reveals a compatible amphiphilic substrate-binding pocket. Embo J., 42, 2023
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8HXS
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![BU of 8hxs by Molmil](/molmil-images/mine/8hxs) | Small_spotted catshark CD8alpha | Descriptor: | T-cell surface glycoprotein CD8 alpha chain | Authors: | Wang, J, Zou, J. | Deposit date: | 2023-01-05 | Release date: | 2023-02-22 | Last modified: | 2024-04-17 | Method: | X-RAY DIFFRACTION (1.35 Å) | Cite: | The first crystal structure of CD8 alpha alpha from a cartilaginous fish. Front Immunol, 14, 2023
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6CX9
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![BU of 6cx9 by Molmil](/molmil-images/mine/6cx9) | Structure of alpha-GSA[16,6P] bound by CD1d and in complex with the Va14Vb8.2 TCR | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Antigen-presenting glycoprotein CD1d1, ... | Authors: | Wang, J, Zajonc, D. | Deposit date: | 2018-04-02 | Release date: | 2019-04-10 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.36 Å) | Cite: | A molecular switch in mouse CD1d modulates natural killer T cell activation by alpha-galactosylsphingamides. J.Biol.Chem., 294, 2019
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1K6Y
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![BU of 1k6y by Molmil](/molmil-images/mine/1k6y) | Crystal Structure of a Two-Domain Fragment of HIV-1 Integrase | Descriptor: | Integrase, PHOSPHATE ION, POTASSIUM ION, ... | Authors: | Wang, J, Ling, H, Yang, W, Craigie, R. | Deposit date: | 2001-10-17 | Release date: | 2001-12-21 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structure of a two-domain fragment of HIV-1 integrase: implications for domain organization in the intact protein. EMBO J., 20, 2001
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8HTX
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![BU of 8htx by Molmil](/molmil-images/mine/8htx) | Crystal structure of BANP in complex with methylated DNA | Descriptor: | DNA (5'-D(*CP*TP*CP*TP*(5CM)P*GP*CP*GP*AP*GP*AP*G)-3'), Protein BANP | Authors: | Zhang, J, Min, J, Liu, K. | Deposit date: | 2022-12-21 | Release date: | 2023-05-24 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural insights into DNA recognition by the BEN domain of the transcription factor BANP. J.Biol.Chem., 299, 2023
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5LP6
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![BU of 5lp6 by Molmil](/molmil-images/mine/5lp6) | Crystal structure of Tubulin-Stathmin-TTL-Thiocolchicine Complex | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, CHLORIDE ION, ... | Authors: | Marangon, J, Christodoulou, M, Casagrande, F, Tiana, G, Dalla Via, L, Aliverti, A, Passarella, D, Cappelletti, G, Ricagno, S. | Deposit date: | 2016-08-11 | Release date: | 2016-09-21 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Tools for the rational design of bivalent microtubule-targeting drugs. Biochem. Biophys. Res. Commun., 479, 2016
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6NXF
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![BU of 6nxf by Molmil](/molmil-images/mine/6nxf) | |
6CWB
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![BU of 6cwb by Molmil](/molmil-images/mine/6cwb) | Structure of alpha-GSA[8,4P] bound by CD1d and in complex with the Va14Vb8.2 TCR | Descriptor: | (5R,6S,7S)-5,6-dihydroxy-7-(octanoylamino)-N-[(1E)-4-phenylbutylidene]-8-{[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}octanamide (non-preferred name), 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Wang, J, Zajonc, D. | Deposit date: | 2018-03-30 | Release date: | 2019-04-03 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | A molecular switch in mouse CD1d modulates natural killer T cell activation by alpha-galactosylsphingamides. J.Biol.Chem., 294, 2019
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6CX5
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![BU of 6cx5 by Molmil](/molmil-images/mine/6cx5) | Structure of alpha-GSA[8,8P] bound by CD1d and in complex with the Va14Vb8.2 TCR | Descriptor: | (5R,6S,7S)-5,6-dihydroxy-7-(octanoylamino)-N-(8-phenyloctyl)-8-{[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}octanamide (non-preferred name), 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Wang, J, Zajonc, D. | Deposit date: | 2018-04-02 | Release date: | 2019-04-10 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | A molecular switch in mouse CD1d modulates natural killer T cell activation by alpha-galactosylsphingamides. J.Biol.Chem., 294, 2019
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6CW9
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![BU of 6cw9 by Molmil](/molmil-images/mine/6cw9) | Structure of alpha-GC[8,16P] bound by CD1d and in complex with the Va14Vb8.2 TCR | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Wang, J, Zajonc, D. | Deposit date: | 2018-03-30 | Release date: | 2019-04-03 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | A molecular switch in mouse CD1d modulates natural killer T cell activation by alpha-galactosylsphingamides. J.Biol.Chem., 294, 2019
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6CX7
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![BU of 6cx7 by Molmil](/molmil-images/mine/6cx7) | Structure of alpha-GSA[12,6P] bound by CD1d and in complex with the Va14Vb8.2 TCR | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Antigen-presenting glycoprotein CD1d1, ... | Authors: | Wang, J, Zajonc, D. | Deposit date: | 2018-04-02 | Release date: | 2019-04-10 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | A molecular switch in mouse CD1d modulates natural killer T cell activation by alpha-galactosylsphingamides. J.Biol.Chem., 294, 2019
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