7Y7V
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![BU of 7y7v by Molmil](/molmil-images/mine/7y7v) | Cryo-EM structure of human apo GABA transporter GAT1 in an inward-open state | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Sodium- and chloride-dependent GABA transporter 1 | 著者 | Zhu, A, Huang, J, Kong, F, Tan, J, Lei, J, Yuan, Y, Yan, C. | 登録日 | 2022-06-22 | 公開日 | 2023-04-26 | 最終更新日 | 2023-08-16 | 実験手法 | ELECTRON MICROSCOPY (2.2 Å) | 主引用文献 | Molecular basis for substrate recognition and transport of human GABA transporter GAT1. Nat.Struct.Mol.Biol., 30, 2023
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7Y9O
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![BU of 7y9o by Molmil](/molmil-images/mine/7y9o) | Crystal structure of a CYP109B4 variant from Bacillus sonorensis | 分子名称: | CALCIUM ION, Cytochrome P450 monooxygenase YjiB, IMIDAZOLE, ... | 著者 | Shen, P.P, Huang, J.-W, Li, X, Liu, W.D, Chen, C.-C, Guo, R.-T. | 登録日 | 2022-06-25 | 公開日 | 2023-05-03 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.84 Å) | 主引用文献 | Rationally Controlling Selective Steroid Hydroxylation via Scaffold Sampling of a P450 Family Acs Catalysis, 13, 2023
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1C2A
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![BU of 1c2a by Molmil](/molmil-images/mine/1c2a) | CRYSTAL STRUCTURE OF BARLEY BBI | 分子名称: | BOWMAN-BIRK TRYPSIN INHIBITOR | 著者 | Song, H.K, Kim, Y.S, Yang, J.K, Moon, J, Lee, J.Y, Suh, S.W. | 登録日 | 1999-07-23 | 公開日 | 1999-12-29 | 最終更新日 | 2022-12-21 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Crystal structure of a 16 kDa double-headed Bowman-Birk trypsin inhibitor from barley seeds at 1.9 A resolution. J.Mol.Biol., 293, 1999
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5LU5
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![BU of 5lu5 by Molmil](/molmil-images/mine/5lu5) | A quantum half-site enzyme | 分子名称: | 7-O-phosphono-D-glycero-alpha-D-manno-heptopyranose, ACETATE ION, DI(HYDROXYETHYL)ETHER, ... | 著者 | Vivoli, M, Harmer, N.J, Pang, J. | 登録日 | 2016-09-08 | 公開日 | 2017-12-06 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | A half-site multimeric enzyme achieves its cooperativity without conformational changes. Sci Rep, 7, 2017
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7Y97
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![BU of 7y97 by Molmil](/molmil-images/mine/7y97) | Crystal structure of CYP109B4 from Bacillus Sonorensis | 分子名称: | Cytochrome P450 monooxygenase YjiB, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Shen, P.P, Huang, J.-W, Li, X, Liu, W.D, Chen, C.-C, Guo, R.-T. | 登録日 | 2022-06-24 | 公開日 | 2023-05-03 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.36 Å) | 主引用文献 | Rationally Controlling Selective Steroid Hydroxylation via Scaffold Sampling of a P450 Family Acs Catalysis, 13, 2023
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2OIE
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![BU of 2oie by Molmil](/molmil-images/mine/2oie) | Crystal structure of RS21-C6 core segment RSCUT | 分子名称: | RS21-C6, SULFATE ION | 著者 | Wu, B, Liu, Y, Zhao, Q, Liao, S, Zhang, J, Bartlam, M, Chen, W, Rao, Z. | 登録日 | 2007-01-10 | 公開日 | 2007-03-06 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Crystal Structure of RS21-C6, Involved in Nucleoside Triphosphate Pyrophosphohydrolysis J.Mol.Biol., 367, 2007
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4J9Z
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![BU of 4j9z by Molmil](/molmil-images/mine/4j9z) | Calcium-calmodulin complexed with the calmodulin binding domain from a small conductance potassium channel splice variant and NS309 | 分子名称: | (3E)-6,7-dichloro-3-(hydroxyimino)-1,3-dihydro-2H-indol-2-one, CALCIUM ION, Calmodulin, ... | 著者 | Zhang, M, Pascal, J.M, Zhang, J.-F. | 登録日 | 2013-02-17 | 公開日 | 2013-03-27 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.66 Å) | 主引用文献 | Unstructured to structured transition of an intrinsically disordered protein peptide in coupling Ca2+-sensing and SK channel activation. Proc.Natl.Acad.Sci.USA, 110, 2013
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5I0A
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![BU of 5i0a by Molmil](/molmil-images/mine/5i0a) | RecA mini intein in complex with cisplatin | 分子名称: | 3,3',3''-phosphanetriyltripropanoic acid, Cisplatin, Intein, ... | 著者 | Li, Z, Zhang, J, Li, H.M. | 登録日 | 2016-02-03 | 公開日 | 2016-09-21 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Structural insights into protein splicing inhibition by platinum therapeutics as potential anti-microbials To be published
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3UQH
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![BU of 3uqh by Molmil](/molmil-images/mine/3uqh) | Crystal structure of aba receptor pyl10 (apo) | 分子名称: | Abscisic acid receptor PYL10, SULFATE ION | 著者 | Sun, D.M, Wang, H.P, Wu, M.H, Zang, J.Y, Tian, C.L. | 登録日 | 2011-11-20 | 公開日 | 2011-12-14 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Crystal Structure of Aba Receptor Pyl10 To be Published
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7Y98
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![BU of 7y98 by Molmil](/molmil-images/mine/7y98) | Crystal structure of CYP109B4 from Bacillus Sonorensis in complex with Testosterone | 分子名称: | Cytochrome P450 monooxygenase YjiB, PROTOPORPHYRIN IX CONTAINING FE, TESTOSTERONE | 著者 | Shen, P.P, Huang, J.-W, Li, X, Liu, W.D, Chen, C.-C, Guo, R.-T. | 登録日 | 2022-06-24 | 公開日 | 2023-05-03 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.27 Å) | 主引用文献 | Rationally Controlling Selective Steroid Hydroxylation via Scaffold Sampling of a P450 Family Acs Catalysis, 13, 2023
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3UWO
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![BU of 3uwo by Molmil](/molmil-images/mine/3uwo) | Structure Guided Development of Novel Thymidine Mimetics targeting Pseudomonas aeruginosa Thymidylate Kinase: from Hit to Lead Generation | 分子名称: | 3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamide, Thymidylate kinase | 著者 | Choi, J.Y, Plummer, M.S, Starr, J, Desbonnet, C.R, Soutter, H.H, Chang, J, Miller, J.R, Dillman, K, Miller, A.A, Roush, W.R. | 登録日 | 2011-12-02 | 公開日 | 2012-02-01 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structure guided development of novel thymidine mimetics targeting Pseudomonas aeruginosa thymidylate kinase: from hit to lead generation. J.Med.Chem., 55, 2012
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4J9Y
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![BU of 4j9y by Molmil](/molmil-images/mine/4j9y) | Calcium-calmodulin complexed with the calmodulin binding domain from a small conductance potassium channel splice variant | 分子名称: | CALCIUM ION, Calmodulin, GLYCEROL, ... | 著者 | Zhang, M, Pascal, J.M, Zhang, J.-F. | 登録日 | 2013-02-17 | 公開日 | 2013-03-27 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.51 Å) | 主引用文献 | Unstructured to structured transition of an intrinsically disordered protein peptide in coupling Ca2+-sensing and SK channel activation. Proc.Natl.Acad.Sci.USA, 110, 2013
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3ZD9
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![BU of 3zd9 by Molmil](/molmil-images/mine/3zd9) | Potassium bound structure of E. coli ExoIX in P21 | 分子名称: | POTASSIUM ION, PROTEIN XNI | 著者 | Anstey-Gilbert, C.S, Hemsworth, G.R, Flemming, C.S, Hodskinson, M.R.G, Zhang, J, Sedelnikova, S.E, Stillman, T.J, Sayers, J.R, Artymiuk, P.J. | 登録日 | 2012-11-26 | 公開日 | 2013-07-10 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | The Structure of E. Coli Exoix - Implications for DNA Binding and Catalysis in Flap Endonucleases Nucleic Acids Res., 41, 2013
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5ZM5
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![BU of 5zm5 by Molmil](/molmil-images/mine/5zm5) | Crystal structure of human ORP1-ORD in complex with cholesterol at 2.6 A resolution | 分子名称: | CHOLESTEROL, Oxysterol-binding protein-related protein 1 | 著者 | Dong, J, Wang, J, Wu, J.W. | 登録日 | 2018-04-01 | 公開日 | 2019-02-27 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Allosteric enhancement of ORP1-mediated cholesterol transport by PI(4,5)P2/PI(3,4)P2. Nat Commun, 10, 2019
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4JGY
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![BU of 4jgy by Molmil](/molmil-images/mine/4jgy) | Crystal structure of human coxsackievirus A16 uncoating intermediate (space group P4232) | 分子名称: | Polyprotein, capsid protein VP1, capsid protein VP2, ... | 著者 | Ren, J, Wang, X, Hu, Z, Gao, Q, Sun, Y, Li, X, Porta, C, Walter, T.S, Gilbert, R.J, Zhao, Y, Axford, D, Williams, M, Mcauley, K, Rowlands, D.J, Yin, W, Wang, J, Stuart, D.I, Rao, Z, Fry, E.E. | 登録日 | 2013-03-04 | 公開日 | 2013-06-05 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Picornavirus uncoating intermediate captured in atomic detail. Nat Commun, 4, 2013
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5EFI
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![BU of 5efi by Molmil](/molmil-images/mine/5efi) | Crystal structure of mouse CD1d in complex with the p99p lipopeptide | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Antigen-presenting glycoprotein CD1d1, ... | 著者 | Girardi, E, Wang, J, Zajonc, D.M. | 登録日 | 2015-10-23 | 公開日 | 2016-03-30 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structure of an alpha-Helical Peptide and Lipopeptide Bound to the Nonclassical Major Histocompatibility Complex (MHC) Class I Molecule CD1d. J.Biol.Chem., 291, 2016
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6K99
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![BU of 6k99 by Molmil](/molmil-images/mine/6k99) | Structure of ASC CARD filament | 分子名称: | Apoptosis-associated speck-like protein containing a CARD | 著者 | Gong, Q, Xu, C, Zhang, J, Boo, Z.Z, Wu, B. | 登録日 | 2019-06-14 | 公開日 | 2020-09-16 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | Structural basis for distinct inflammasome complex assembly by human NLRP1 and CARD8. Nat Commun, 12, 2021
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5ZM8
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![BU of 5zm8 by Molmil](/molmil-images/mine/5zm8) | Crystal structure of ORP2-ORD in complex with PI(4,5)P2 | 分子名称: | Oxysterol-binding protein-related protein 2, [(2~{S})-1-octadecanoyloxy-3-[oxidanyl-[(1~{R},2~{R},3~{S},4~{S},5~{S},6~{S})-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propan-2-yl] icosa-5,8,11,14-tetraenoate | 著者 | Wang, H, Dong, J.Q, Wang, J, Wu, J.W. | 登録日 | 2018-04-01 | 公開日 | 2019-01-02 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | ORP2 Delivers Cholesterol to the Plasma Membrane in Exchange for Phosphatidylinositol 4, 5-Bisphosphate (PI(4,5)P2). Mol. Cell, 73, 2019
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8HZR
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![BU of 8hzr by Molmil](/molmil-images/mine/8hzr) | Crystal structure of SARS-Cov-2 main protease S46F mutant in complex with PF07321332 | 分子名称: | (1R,2S,5S)-N-{(1E,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide, 3C-like proteinase nsp5 | 著者 | Zeng, X.Y, Zhang, J, Li, J. | 登録日 | 2023-01-09 | 公開日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.92 Å) | 主引用文献 | Crystal structure of SARS-Cov-2 main protease
S46F mutant in complex with PF07321332 To Be Published
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4PZE
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![BU of 4pze by Molmil](/molmil-images/mine/4pze) | |
3UXM
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![BU of 3uxm by Molmil](/molmil-images/mine/3uxm) | Structure Guided Development of Novel Thymidine Mimetics targeting Pseudomonas aeruginosa Thymidylate Kinase: from Hit to Lead Generation | 分子名称: | 5'-deoxy-5'-fluorothymidine, MAGNESIUM ION, Thymidylate kinase | 著者 | Choi, J.Y, Plummer, M.S, Starr, J, Desbonnet, C.R, Soutter, H.H, Chang, J, Miller, J.R, Dillman, K, Miller, A.A, Roush, W.R. | 登録日 | 2011-12-05 | 公開日 | 2012-02-01 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Structure guided development of novel thymidine mimetics targeting Pseudomonas aeruginosa thymidylate kinase: from hit to lead generation. J.Med.Chem., 55, 2012
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3HAG
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![BU of 3hag by Molmil](/molmil-images/mine/3hag) | Crystal structure of the Hepatitis E Virus-like Particle | 分子名称: | Capsid protein | 著者 | Guu, T.S.Y, Liu, Z, Ye, Q, Mata, D.A, Li, K, Yin, C, Zhang, J, Tao, Y.J. | 登録日 | 2009-05-01 | 公開日 | 2009-09-01 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | 主引用文献 | Structure of the hepatitis E virus-like particle suggests mechanisms for virus assembly and receptor binding. Proc.Natl.Acad.Sci.USA, 106, 2009
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2OQF
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![BU of 2oqf by Molmil](/molmil-images/mine/2oqf) | Structure of a synthetic, non-natural analogue of RNase A: [N71K(Ade), D83A]RNase A | 分子名称: | Ribonuclease pancreatic | 著者 | Boerema, D.J, Tereshko, V.A, Zhang, J.L, He, C, Kent, S.B.H. | 登録日 | 2007-01-31 | 公開日 | 2008-02-12 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Design, Synthesis, and Characterization of Non-natural RNase A Analogues with Enhanced Second-step Catalytic Activity To be Published
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7ENY
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![BU of 7eny by Molmil](/molmil-images/mine/7eny) | Crystal structure of hydroxysteroid dehydrogenase from Escherichia coli | 分子名称: | 7alpha-hydroxysteroid dehydrogenase | 著者 | Kim, K.-H, Lee, C.W, Pardhe, D.P, Hwang, J, Do, H, Lee, Y.M, Lee, J.H, Oh, T.-J. | 登録日 | 2021-04-21 | 公開日 | 2021-07-14 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.703 Å) | 主引用文献 | Crystal structure of an apo 7 alpha-hydroxysteroid dehydrogenase reveals key structural changes induced by substrate and co-factor binding. J.Steroid Biochem.Mol.Biol., 212, 2021
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6UP3
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![BU of 6up3 by Molmil](/molmil-images/mine/6up3) | |