3HRF
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![BU of 3hrf by Molmil](/molmil-images/mine/3hrf) | Crystal structure of Human PDK1 kinase domain in complex with an allosteric activator bound to the PIF-pocket | Descriptor: | (2Z)-5-(4-chlorophenyl)-3-phenylpent-2-enoic acid, 3-phosphoinositide-dependent protein kinase 1, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | Authors: | Hindie, V, Alzari, P.M, Biondi, R.M. | Deposit date: | 2009-06-09 | Release date: | 2009-09-15 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structure and allosteric effects of low-molecular-weight activators on the protein kinase PDK1. Nat.Chem.Biol., 5, 2009
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8BVE
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![BU of 8bve by Molmil](/molmil-images/mine/8bve) | MoeA2 from Corynebacterium glutamicum | Descriptor: | CITRIC ACID, Molybdopterin molybdenumtransferase, SODIUM ION | Authors: | Martinez, M, Haouz, A, Wehenkel, A.M, Alzari, P.M. | Deposit date: | 2022-12-03 | Release date: | 2023-02-22 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (2.14 Å) | Cite: | Eukaryotic-like gephyrin and cognate membrane receptor coordinate corynebacterial cell division and polar elongation. Biorxiv, 2023
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3GIF
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![BU of 3gif by Molmil](/molmil-images/mine/3gif) | Crystal structure of DesKC_H188E in complex with ADP | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, Sensor histidine kinase desK | Authors: | Trajtenberg, F, Albanesi, D, Alzari, P.M, Buschiazzo, A, de Mendoza, D. | Deposit date: | 2009-03-05 | Release date: | 2009-09-15 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural plasticity and catalysis regulation of a thermosensor histidine kinase Proc.Natl.Acad.Sci.USA, 106, 2009
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1FAI
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![BU of 1fai by Molmil](/molmil-images/mine/1fai) | THREE-DIMENSIONAL STRUCTURE OF TWO CRYSTAL FORMS OF FAB R19.9, FROM A MONOCLONAL ANTI-ARSONATE ANTIBODY | Descriptor: | IGG2B-KAPPA R19.9 FAB (HEAVY CHAIN), IGG2B-KAPPA R19.9 FAB (LIGHT CHAIN) | Authors: | Lascombe, M.B, Alzari, P.M, Poljak, R.J, Nisonoff, A. | Deposit date: | 1992-05-27 | Release date: | 1992-10-15 | Last modified: | 2024-06-05 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Three-dimensional structure of two crystal forms of FabR19.9 from a monoclonal anti-arsonate antibody. Proc.Natl.Acad.Sci.USA, 89, 1992
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3HRC
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![BU of 3hrc by Molmil](/molmil-images/mine/3hrc) | |
1EW3
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![BU of 1ew3 by Molmil](/molmil-images/mine/1ew3) | CRYSTAL STRUCTURE OF THE MAJOR HORSE ALLERGEN EQU C 1 | Descriptor: | ALLERGEN EQU C 1 | Authors: | Lascombe, M.B, Gregoire, C, Poncet, P, Tavares, G.A, Rosinski-Chupin, I, Rabillon, J, Goubran-Botros, H, Mazie, J.C, David, B, Alzari, P.M. | Deposit date: | 2000-04-21 | Release date: | 2000-05-03 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal structure of the allergen Equ c 1. A dimeric lipocalin with restricted IgE-reactive epitopes. J.Biol.Chem., 275, 2000
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6SAT
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![BU of 6sat by Molmil](/molmil-images/mine/6sat) | |
6SCS
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![BU of 6scs by Molmil](/molmil-images/mine/6scs) | |
6I2Q
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![BU of 6i2q by Molmil](/molmil-images/mine/6i2q) | Crystal structure of the wild-type SucA domain of Mycobacterium smegmatis KGD (alpha-ketoglutarate decarboxylase), in complex with GarA | Descriptor: | CALCIUM ION, Glycogen accumulation regulator GarA, MAGNESIUM ION, ... | Authors: | Wagner, T, Bellinzoni, M, Alzari, P.M. | Deposit date: | 2018-11-01 | Release date: | 2019-05-22 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Structural insights into the functional versatility of an FHA domain protein in mycobacterial signaling. Sci.Signal., 12, 2019
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2V06
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![BU of 2v06 by Molmil](/molmil-images/mine/2v06) | Crystal structure of the PPM Ser-Thr phosphatase MsPP from Mycobacterium smegmatis at pH 5.5 | Descriptor: | CHLORIDE ION, MAGNESIUM ION, SER-THR PHOSPHATASE MSPP | Authors: | Wehenkel, A, Bellinzoni, M, Schaeffer, F, Villarino, A, Alzari, P.M. | Deposit date: | 2007-05-08 | Release date: | 2007-10-16 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.05 Å) | Cite: | Structural and Binding Studies of the Three-Metal Center in Two Mycobacterial Ppm Ser/Thr Protein Phosphatases. J.Mol.Biol., 374, 2007
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2UYQ
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![BU of 2uyq by Molmil](/molmil-images/mine/2uyq) | Crystal structure of ML2640c from Mycobacterium leprae in complex with S-adenosylmethionine | Descriptor: | HYPOTHETICAL PROTEIN ML2640, S-ADENOSYLMETHIONINE | Authors: | Grana, M, Buschiazzo, A, Wehenkel, A, Haouz, A, Miras, I, Shepard, W, Alzari, P.M. | Deposit date: | 2007-04-11 | Release date: | 2007-08-07 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | The Crystal Structure of M. Leprae Ml2640C Defines a Large Family of Putative S-Adenosylmethionine- Dependent Methyltransferases in Mycobacteria. Protein Sci., 16, 2007
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2UYO
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![BU of 2uyo by Molmil](/molmil-images/mine/2uyo) | Crystal structure of ML2640c from Mycobacterium leprae in an hexagonal crystal form | Descriptor: | HYPOTHETICAL PROTEIN ML2640 | Authors: | Grana, M, Buschiazzo, A, Wehenkel, A, Haouz, A, Miras, I, Shepard, W, Alzari, P.M. | Deposit date: | 2007-04-11 | Release date: | 2007-08-07 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | The Crystal Structure of M. Leprae Ml2640C Defines a Large Family of Putative S-Adenosylmethionine- Dependent Methyltransferases in Mycobacteria. Protein Sci., 16, 2007
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4PMO
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![BU of 4pmo by Molmil](/molmil-images/mine/4pmo) | Crystal structure of the Mycobacterium tuberculosis Tat-secreted protein Rv2525c, monoclinic crystal form I | Descriptor: | FORMIC ACID, GLYCEROL, SODIUM ION, ... | Authors: | Bellinzoni, M, Haouz, A, Shepard, W, Alzari, P.M. | Deposit date: | 2014-05-22 | Release date: | 2014-10-08 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.33 Å) | Cite: | Structural studies suggest a peptidoglycan hydrolase function for the Mycobacterium tuberculosis Tat-secreted protein Rv2525c. J.Struct.Biol., 188, 2014
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5LFK
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![BU of 5lfk by Molmil](/molmil-images/mine/5lfk) | Crystal structure of CpxAHDC (hemiphosphorylated form) | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, SULFATE ION, ... | Authors: | Mechaly, A.E, Alzari, P.M. | Deposit date: | 2016-07-01 | Release date: | 2017-06-07 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.094 Å) | Cite: | Structural Coupling between Autokinase and Phosphotransferase Reactions in a Bacterial Histidine Kinase. Structure, 25, 2017
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1CEN
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1CEO
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3GIE
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![BU of 3gie by Molmil](/molmil-images/mine/3gie) | Crystal structure of DesKC_H188E in complex with AMP-PCP | Descriptor: | MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, Sensor histidine kinase desK | Authors: | Trajtenberg, F, Albanesi, D, Alzari, P.M, Buschiazzo, A, de Mendoza, D. | Deposit date: | 2009-03-05 | Release date: | 2009-09-15 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Structural plasticity and catalysis regulation of a thermosensor histidine kinase Proc.Natl.Acad.Sci.USA, 106, 2009
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5M07
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![BU of 5m07 by Molmil](/molmil-images/mine/5m07) | Crystal structure of Mycobacterium tuberculosis PknI kinase domain, C20A mutant | Descriptor: | SODIUM ION, Serine/threonine-protein kinase PknI | Authors: | Lisa, M.N, Wagner, T, Alexandre, M, Barilone, N, Raynal, B, Alzari, P.M, Bellinzoni, M. | Deposit date: | 2016-10-03 | Release date: | 2017-01-11 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | The crystal structure of PknI from Mycobacterium tuberculosis shows an inactive, pseudokinase-like conformation. FEBS J., 284, 2017
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5M08
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![BU of 5m08 by Molmil](/molmil-images/mine/5m08) | Crystal structure of Mycobacterium tuberculosis PknI kinase domain, C20A_R136A double mutant | Descriptor: | Serine/threonine-protein kinase PknI | Authors: | Lisa, M.N, Wagner, T, Alexandre, M, Barilone, N, Raynal, B, Alzari, P.M, Bellinzoni, M. | Deposit date: | 2016-10-03 | Release date: | 2017-01-11 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (3.03 Å) | Cite: | The crystal structure of PknI from Mycobacterium tuberculosis shows an inactive, pseudokinase-like conformation. FEBS J., 284, 2017
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5M09
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![BU of 5m09 by Molmil](/molmil-images/mine/5m09) | Crystal structure of Mycobacterium tuberculosis PknI kinase domain, C20A_R136N double mutant | Descriptor: | SODIUM ION, Serine/threonine-protein kinase PknI | Authors: | Lisa, M.N, Wagner, T, Alexandre, M, Barilone, N, Raynal, B, Alzari, P.M, Bellinzoni, M. | Deposit date: | 2016-10-03 | Release date: | 2017-01-11 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.98 Å) | Cite: | The crystal structure of PknI from Mycobacterium tuberculosis shows an inactive, pseudokinase-like conformation. FEBS J., 284, 2017
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4PMQ
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![BU of 4pmq by Molmil](/molmil-images/mine/4pmq) | Crystal structure of the Mycobacterium tuberculosis Tat-secreted protein Rv2525c in complex with L-tartrate (orthorhombic crystal form) | Descriptor: | GLYCEROL, L(+)-TARTARIC ACID, Tat-secreted protein Rv2525c | Authors: | Bellinzoni, M, Haouz, A, Shepard, W, Alzari, P.M. | Deposit date: | 2014-05-22 | Release date: | 2014-10-08 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.61 Å) | Cite: | Structural studies suggest a peptidoglycan hydrolase function for the Mycobacterium tuberculosis Tat-secreted protein Rv2525c. J.Struct.Biol., 188, 2014
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5LVL
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![BU of 5lvl by Molmil](/molmil-images/mine/5lvl) | Human PDK1 Kinase Domain in Complex with Compound PS653 Bound to the ATP-Binding Site | Descriptor: | 2,6-DIHYDROANTHRA/1,9-CD/PYRAZOL-6-ONE, 3-phosphoinositide-dependent protein kinase 1, DIMETHYL SULFOXIDE, ... | Authors: | Schulze, J.O, Saladino, G, Busschots, K, Neimanis, S, Suess, E, Odadzic, D, Zeuzem, S, Hindie, V, Herbrand, A.K, Lisa, M.N, Alzari, P.M, Gervasio, F.L, Biondi, R.M. | Deposit date: | 2016-09-14 | Release date: | 2016-10-19 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Bidirectional Allosteric Communication between the ATP-Binding Site and the Regulatory PIF Pocket in PDK1 Protein Kinase. Cell Chem Biol, 23, 2016
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5LVO
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![BU of 5lvo by Molmil](/molmil-images/mine/5lvo) | Human PDK1 Kinase Domain in Complex with Allosteric Compound PSE10 Bound to the PIF-Pocket | Descriptor: | 2-oxidanylidenepropyl ~{N}-(2-chloranyl-6-fluoranyl-phenyl)carbonyl-~{N}'-(4-chlorophenyl)carbamimidothioate, 3-phosphoinositide-dependent protein kinase 1, ADENOSINE-5'-TRIPHOSPHATE, ... | Authors: | Schulze, J.O, Saladino, G, Busschots, K, Neimanis, S, Suess, E, Odadzic, D, Zeuzem, S, Hindie, V, Herbrand, A.K, Lisa, M.N, Alzari, P.M, Gervasio, F.L, Biondi, R.M. | Deposit date: | 2016-09-14 | Release date: | 2016-10-19 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.09 Å) | Cite: | Bidirectional Allosteric Communication between the ATP-Binding Site and the Regulatory PIF Pocket in PDK1 Protein Kinase. Cell Chem Biol, 23, 2016
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6SCP
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![BU of 6scp by Molmil](/molmil-images/mine/6scp) | |
2AH2
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![BU of 2ah2 by Molmil](/molmil-images/mine/2ah2) | Trypanosoma cruzi trans-sialidase in complex with 2,3-difluorosialic acid (covalent intermediate) | Descriptor: | 5-acetamido-3,5-dideoxy-3-fluoro-D-erythro-alpha-L-manno-non-2-ulopyranosonic acid, CHLORIDE ION, GLYCEROL, ... | Authors: | Amaya, M.F, Watts, A.G, Damager, I, Wehenkel, A, Nguyen, T, Buschiazzo, A, Paris, G, Frasch, A.C, Withers, S.G, Alzari, P.M. | Deposit date: | 2005-07-27 | Release date: | 2005-08-23 | Last modified: | 2021-10-20 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structural Insights into the Catalytic Mechanism of Trypanosoma cruzi trans-Sialidase Structure, 12, 2004
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