5M08

Crystal structure of Mycobacterium tuberculosis PknI kinase domain, C20A_R136A double mutant

Summary for 5M08

• Entry DOI: 10.2210/pdb5m08/pdb
• Descriptor: Serine/threonine-protein kinase PknI (2 entities in total)
• Functional Keywords: tuberculosis, kinase, signalling, signaling protein
• Biological source: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
• Cellular location: Cytoplasm : P9WI69
• Total number of polymer chains: 2
• Total formula weight: 59104.59

Authors

Lisa, M.N.,Wagner, T.,Alexandre, M.,Barilone, N.,Raynal, B.,Alzari, P.M.,Bellinzoni, M. (deposition date: 2016-10-03, release date: 2017-01-11, Last modification date: 2024-01-17)

• Primary citation: Lisa, M.N.,Wagner, T.,Alexandre, M.,Barilone, N.,Raynal, B.,Alzari, P.M.,Bellinzoni, M.; The crystal structure of PknI from Mycobacterium tuberculosis shows an inactive, pseudokinase-like conformation.; FEBS J., 284:602-614, 2017; PubMed: 28054744; DOI: 10.1111/febs.14003

Experimental method

X-RAY DIFFRACTION (3.03 Å)