7DVK
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![BU of 7dvk by Molmil](/molmil-images/mine/7dvk) | PyrI4 in complex with intermolecular Diels-Alder product | Descriptor: | GLYCEROL, Spiro-conjugate synthase, methyl 4-[[(1S,6S)-6-(dimethylcarbamoyl)cyclohex-2-en-1-yl]carbamoyloxymethyl]benzoate | Authors: | Kashyap, R, Addlagatta, A. | Deposit date: | 2021-01-13 | Release date: | 2021-08-18 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Exo-selective intermolecular Diels-Alder reaction by PyrI4 and AbnU on non-natural substrates. Commun Chem, 2021
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7DVI
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6K26
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![BU of 6k26 by Molmil](/molmil-images/mine/6k26) | Crystal structure of Vibrio cholerae methionine aminopeptidase | Descriptor: | Methionine aminopeptidase, SODIUM ION | Authors: | Pillalamarri, V, Addlagatta, A. | Deposit date: | 2019-05-13 | Release date: | 2020-05-20 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Methionine aminopeptidases with short sequence inserts within the catalytic domain are differentially inhibited: Structural and biochemical studies of three proteins from Vibrio spp. Eur.J.Med.Chem., 209, 2020
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6KSG
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![BU of 6ksg by Molmil](/molmil-images/mine/6ksg) | Vibrio cholerae Methionine Aminopeptidase in holo form | Descriptor: | GLYCEROL, Methionine aminopeptidase, NICKEL (II) ION, ... | Authors: | Pillalamarri, V, Addlagatta, A. | Deposit date: | 2019-08-23 | Release date: | 2020-08-26 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Methionine aminopeptidases with short sequence inserts within the catalytic domain are differentially inhibited: Structural and biochemical studies of three proteins from Vibrio spp. Eur.J.Med.Chem., 209, 2020
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6LH7
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![BU of 6lh7 by Molmil](/molmil-images/mine/6lh7) | |
6LZB
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![BU of 6lzb by Molmil](/molmil-images/mine/6lzb) | crystal structure of Human Methionine aminopeptidase (HsMetAP1b) in complex with AN-P2-5H-06 | Descriptor: | 1-[(3-methoxyphenyl)methyl]-~{N}-oxidanyl-pyrrolo[2,3-b]pyridine-5-carboxamide, COBALT (II) ION, GLYCEROL, ... | Authors: | sandeep, C.B, Addlagatta, A. | Deposit date: | 2020-02-18 | Release date: | 2021-02-24 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.29 Å) | Cite: | Selective inhibition of Helicobacter pylori methionine aminopeptidase by azaindole hydroxamic acid derivatives: Design, synthesis, in vitro biochemical and structural studies. Bioorg.Chem., 115, 2021
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6LZC
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![BU of 6lzc by Molmil](/molmil-images/mine/6lzc) | crystal structure of Human Methionine aminopeptidase (HsMetAP1b) in complex with KV-P2-4H-05 | Descriptor: | COBALT (II) ION, GLYCEROL, MAGNESIUM ION, ... | Authors: | Sandeep, C.B, Addlagatta, A. | Deposit date: | 2020-02-18 | Release date: | 2021-02-24 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.35 Å) | Cite: | Selective inhibition of Helicobacter pylori methionine aminopeptidase by azaindole hydroxamic acid derivatives: Design, synthesis, in vitro biochemical and structural studies. Bioorg.Chem., 115, 2021
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4Q4I
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![BU of 4q4i by Molmil](/molmil-images/mine/4q4i) | Crystal structure of E.coli aminopeptidase N in complex with amastatin | Descriptor: | Amastatin, Aminopeptidase N, GLYCEROL, ... | Authors: | Reddi, R, Ganji, R.J, Addlagatta, A. | Deposit date: | 2014-04-14 | Release date: | 2015-04-15 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.31 Å) | Cite: | Structural basis for the inhibition of M1 family aminopeptidases by the natural product actinonin: Crystal structure in complex with E. coli aminopeptidase N. Protein Sci., 24, 2015
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4OOK
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![BU of 4ook by Molmil](/molmil-images/mine/4ook) | Third Metal bound M.tuberculosis methionine aminopeptidase | Descriptor: | COBALT (II) ION, Methionine aminopeptidase 2, SODIUM ION | Authors: | Reddi, R, Addlagatta, A. | Deposit date: | 2014-02-03 | Release date: | 2015-02-04 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Selective targeting of the conserved active site cysteine of Mycobacterium tuberculosis methionine aminopeptidase with electrophilic reagents Febs J., 281, 2014
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4Q4E
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![BU of 4q4e by Molmil](/molmil-images/mine/4q4e) | Crystal structure of E.coli aminopeptidase N in complex with actinonin | Descriptor: | ACTINONIN, Aminopeptidase N, GLYCEROL, ... | Authors: | Reddi, R, Ganji, R.J, Addlagatta, A. | Deposit date: | 2014-04-14 | Release date: | 2015-04-15 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural basis for the inhibition of M1 family aminopeptidases by the natural product actinonin: Crystal structure in complex with E. coli aminopeptidase N. Protein Sci., 24, 2015
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3ROR
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![BU of 3ror by Molmil](/molmil-images/mine/3ror) | |
6M00
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![BU of 6m00 by Molmil](/molmil-images/mine/6m00) | |
4U6W
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![BU of 4u6w by Molmil](/molmil-images/mine/4u6w) | |
4U71
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![BU of 4u71 by Molmil](/molmil-images/mine/4u71) | |
4U75
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![BU of 4u75 by Molmil](/molmil-images/mine/4u75) | HsMetAP (F309M) in complex with Methionine | Descriptor: | COBALT (II) ION, GLYCEROL, METHIONINE, ... | Authors: | Arya, T, Addlagatta, A. | Deposit date: | 2014-07-30 | Release date: | 2015-03-25 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.94 Å) | Cite: | Identification of the Molecular Basis of Inhibitor Selectivity between the Human and Streptococcal Type I Methionine Aminopeptidases J.Med.Chem., 58, 2015
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4U6E
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![BU of 4u6e by Molmil](/molmil-images/mine/4u6e) | HsMetAP in complex with (amino(phenyl)methyl)phosphonic acid | Descriptor: | COBALT (II) ION, Methionine aminopeptidase 1, [(R)-amino(phenyl)methyl]phosphonic acid | Authors: | Arya, T, Addlagatta, A. | Deposit date: | 2014-07-28 | Release date: | 2015-03-25 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Identification of the Molecular Basis of Inhibitor Selectivity between the Human and Streptococcal Type I Methionine Aminopeptidases J.Med.Chem., 58, 2015
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4U6Z
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![BU of 4u6z by Molmil](/molmil-images/mine/4u6z) | |
4U1B
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![BU of 4u1b by Molmil](/molmil-images/mine/4u1b) | HsMetAP in complex with (1-amino-2-propylpentyl)phosphonic acid | Descriptor: | COBALT (II) ION, GLYCEROL, Methionine aminopeptidase 1, ... | Authors: | Arya, T, Addlagatta, A. | Deposit date: | 2014-07-15 | Release date: | 2015-03-25 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | Identification of the Molecular Basis of Inhibitor Selectivity between the Human and Streptococcal Type I Methionine Aminopeptidases J.Med.Chem., 58, 2015
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4U6J
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![BU of 4u6j by Molmil](/molmil-images/mine/4u6j) | HsMetAP in complex with methionine | Descriptor: | COBALT (II) ION, GLYCEROL, METHIONINE, ... | Authors: | Arya, T, Addlagatta, A. | Deposit date: | 2014-07-29 | Release date: | 2015-03-25 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.56 Å) | Cite: | Identification of the Molecular Basis of Inhibitor Selectivity between the Human and Streptococcal Type I Methionine Aminopeptidases J.Med.Chem., 58, 2015
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4U6C
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![BU of 4u6c by Molmil](/molmil-images/mine/4u6c) | |
4U69
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![BU of 4u69 by Molmil](/molmil-images/mine/4u69) | HsMetAP complex with (1-amino-2-methylpentyl)phosphonic acid | Descriptor: | COBALT (II) ION, Methionine aminopeptidase 1, POTASSIUM ION, ... | Authors: | Arya, T, Addlagatta, A. | Deposit date: | 2014-07-28 | Release date: | 2015-03-25 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Identification of the Molecular Basis of Inhibitor Selectivity between the Human and Streptococcal Type I Methionine Aminopeptidases J.Med.Chem., 58, 2015
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4U70
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![BU of 4u70 by Molmil](/molmil-images/mine/4u70) | |
4U76
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![BU of 4u76 by Molmil](/molmil-images/mine/4u76) | HsMetAP (F309M) holo form | Descriptor: | COBALT (II) ION, GLYCEROL, Methionine aminopeptidase 1, ... | Authors: | Arya, T, Addlagatta, A. | Deposit date: | 2014-07-30 | Release date: | 2015-03-25 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.87 Å) | Cite: | Identification of the Molecular Basis of Inhibitor Selectivity between the Human and Streptococcal Type I Methionine Aminopeptidases J.Med.Chem., 58, 2015
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4U73
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5ZI7
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![BU of 5zi7 by Molmil](/molmil-images/mine/5zi7) | |