6LZC

crystal structure of Human Methionine aminopeptidase (HsMetAP1b) in complex with KV-P2-4H-05

Summary for 6LZC

• Entry DOI: 10.2210/pdb6lzc/pdb
• Descriptor: Methionine aminopeptidase 1, COBALT (II) ION, ~{N}-oxidanyl-1-(phenylmethyl)pyrrolo[2,3-b]pyridine-4-carboxamide, ... (7 entities in total)
• Functional Keywords: methionine aminopeptidase, hydrolase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 37644.65

Authors

Sandeep, C.B.,Addlagatta, A. (deposition date: 2020-02-18, release date: 2021-02-24, Last modification date: 2023-11-29)

• Primary citation: Bala, S.,Yellamanda, K.V.,Kadari, A.,Ravinuthala, V.S.U.,Kattula, B.,Singh, O.V.,Gundla, R.,Addlagatta, A.; Selective inhibition of Helicobacter pylori methionine aminopeptidase by azaindole hydroxamic acid derivatives: Design, synthesis, in vitro biochemical and structural studies.; Bioorg.Chem., 115:105185-105185, 2021; PubMed: 34329997; DOI: 10.1016/j.bioorg.2021.105185

Experimental method

X-RAY DIFFRACTION (1.35 Å)