6LZC
crystal structure of Human Methionine aminopeptidase (HsMetAP1b) in complex with KV-P2-4H-05
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | binding site for residue CO A 401 |
| Chain | Residue |
| A | ASP240 |
| A | HIS303 |
| A | GLU336 |
| A | GLU367 |
| A | CO402 |
| A | EYL403 |
| A | HOH505 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue CO A 402 |
| Chain | Residue |
| A | GLU367 |
| A | CO401 |
| A | EYL403 |
| A | HOH501 |
| A | ASP229 |
| A | ASP240 |
| site_id | AC3 |
| Number of Residues | 17 |
| Details | binding site for residue EYL A 403 |
| Chain | Residue |
| A | TYR195 |
| A | HIS212 |
| A | ASP229 |
| A | THR231 |
| A | ASP240 |
| A | PHE309 |
| A | HIS310 |
| A | GLU336 |
| A | TRP353 |
| A | GLU367 |
| A | CO401 |
| A | CO402 |
| A | GOL407 |
| A | HOH501 |
| A | HOH505 |
| A | HOH534 |
| A | HOH617 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue NA A 404 |
| Chain | Residue |
| A | ASN207 |
| A | VAL209 |
| A | SER363 |
| A | HOH596 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 405 |
| Chain | Residue |
| A | ARG106 |
| A | PRO107 |
| A | HIS177 |
| A | HIS180 |
| A | LEU181 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | binding site for residue GOL A 406 |
| Chain | Residue |
| A | ALA163 |
| A | GLY164 |
| A | HIS390 |
| A | SER393 |
| A | HOH509 |
| A | HOH520 |
| A | HOH532 |
| A | HOH541 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue GOL A 407 |
| Chain | Residue |
| A | HIS212 |
| A | TYR300 |
| A | HIS310 |
| A | EYL403 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | binding site for residue MG A 408 |
| Chain | Residue |
| A | HIS99 |
| A | HOH530 |
| A | HOH619 |
| A | HOH657 |
| A | HOH661 |
| A | HOH676 |
| A | HOH677 |
Functional Information from PROSITE/UniProt
| site_id | PS00680 |
| Number of Residues | 19 |
| Details | MAP_1 Methionine aminopeptidase subfamily 1 signature. YcGHGIHklfHtapnVp.HY |
| Chain | Residue | Details |
| A | TYR300-TYR318 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_03174","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"16724298","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16823043","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17114291","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 5 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_03174","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"16274222","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16724298","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16823043","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17114291","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
