8W7D
 
 | | Crystal structure of EcPPAT-FR901483 complex | | 分子名称: | Amidophosphoribosyltransferase, [(1S,3S,6S,7S,8R,9S)-6-[(4-methoxyphenyl)methyl]-3-(methylamino)-7-oxidanyl-5-azatricyclo[6.3.1.0^1,5]dodecan-9-yl] dihydrogen phosphate | | 著者 | Hara, K, Hashimoto, H, Nakahara, M, Sato, M, Watanabe, K. | | 登録日 | 2023-08-30 | | 公開日 | 2023-12-13 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.81 Å) | | 主引用文献 | Uncommon Arrangement of Self-resistance Allows Biosynthesis of de novo Purine Biosynthesis Inhibitor that Acts as an Immunosuppressor.
J.Am.Chem.Soc., 145, 2023
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6KWJ
 | | A Crystal Structure of OspA mutant | | 分子名称: | Outer surface protein A | | 著者 | Kiya, M, Makabe, K. | | 登録日 | 2019-09-07 | | 公開日 | 2020-09-09 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | | 主引用文献 | beta-Strand-mediated Domain-swapping in the Absence of Hydrophobic Core Repacking.
J.Mol.Biol., 436, 2024
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6KWV
 | | A Crystal Structure of OspA mutant | | 分子名称: | Outer surface protein A | | 著者 | Kiya, M, Makabe, K. | | 登録日 | 2019-09-08 | | 公開日 | 2020-09-09 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.37 Å) | | 主引用文献 | beta-Strand-mediated Domain-swapping in the Absence of Hydrophobic Core Repacking.
J.Mol.Biol., 436, 2024
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6LJY
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2EK9
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8Y2S
 | | P-hydroxybenzoate hydroxylase complexed with 4-hydroxy-3-methylbenzoic acid | | 分子名称: | 3-methyl-4-oxidanyl-benzoic acid, 4-hydroxybenzoate 3-monooxygenase, FLAVIN-ADENINE DINUCLEOTIDE | | 著者 | Hara, K, Hashimoto, H, Matsushita, T, Kishimoto, S, Watanabe, K. | | 登録日 | 2024-01-27 | | 公開日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Functional Enhancement of Flavin-Containing Monooxygenase through Machine Learning Methodology
Acs Catalysis, 14, 2024
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8YHR
 | | DHODH in complex with furocoumavirin | | 分子名称: | 4-methyl-8-[(S)-oxidanyl(phenyl)methyl]-9-phenyl-furo[2,3-h]chromen-2-one, ACETATE ION, Dihydroorotate dehydrogenase (quinone), ... | | 著者 | Hara, K, Okumura, H, Nakahara, M, Sato, M, Hashimoto, H, Osada, H, Watanabe, K. | | 登録日 | 2024-02-28 | | 公開日 | 2024-05-22 | | 最終更新日 | 2024-06-05 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Structural and Functional Analyses of Inhibition of Human Dihydroorotate Dehydrogenase by Antiviral Furocoumavirin.
Biochemistry, 63, 2024
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7F4B
 | | The crystal structure of the immature apo-enzyme of homoserine dehydrogenase from the hyperthermophilic archaeon Sulfurisphaera tokodaii. | | 分子名称: | MAGNESIUM ION, homoserine dehydrogenase | | 著者 | Kurihara, E, Kubota, T, Watanabe, K, Ogata, K, Kaneko, R, Oshima, T, Yoshimune, K, Goto, M. | | 登録日 | 2021-06-18 | | 公開日 | 2022-06-22 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | Conformational changes in the catalytic region are responsible for heat-induced activation of hyperthermophilic homoserine dehydrogenase.
Commun Biol, 5, 2022
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7F4C
 | | The crystal structure of the immature holo-enzyme of homoserine dehydrogenase complexed with NADP and 1,4-butandiol from the hyperthermophilic archaeon Sulfurisphaera tokodaii. | | 分子名称: | 1,4-BUTANEDIOL, Homoserine dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | 著者 | Ogata, K, Kaneko, R, Kubota, T, Watanabe, K, Kurihara, E, Oshima, T, Yoshimune, K, Goto, M. | | 登録日 | 2021-06-18 | | 公開日 | 2022-06-22 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Conformational changes in the catalytic region are responsible for heat-induced activation of hyperthermophilic homoserine dehydrogenase.
Commun Biol, 5, 2022
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7CP7
 | | Crystal structure of FqzB, native proteins | | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, IODIDE ION, MAK1-like monooxygenase | | 著者 | Hara, K, Hashimoto, H, Matsushita, T, Kishimoto, S, Watanabe, K. | | 登録日 | 2020-08-06 | | 公開日 | 2020-12-30 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structural and Functional Analyses of a Spiro-Carbon-Forming, Highly Promiscuous Epoxidase from Fungal Natural Product Biosynthesis.
Biochemistry, 59, 2020
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7CP6
 | | Crystal structure of FqzB | | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, IODIDE ION, MAK1-like monooxygenase, ... | | 著者 | Hara, K, Hashimoto, H, Matsushita, T, Kishimoto, S, Watanabe, K. | | 登録日 | 2020-08-06 | | 公開日 | 2020-12-30 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Structural and Functional Analyses of a Spiro-Carbon-Forming, Highly Promiscuous Epoxidase from Fungal Natural Product Biosynthesis.
Biochemistry, 59, 2020
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5FHI
 | | Crystallographic structure of PsoE without Co | | 分子名称: | GLUTATHIONE, Glutathione S-transferase, putative | | 著者 | Hara, K, Hashimoto, H, Yamamoto, T, Tsunematsu, Y, Watanabe, K. | | 登録日 | 2015-12-22 | | 公開日 | 2016-04-20 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.41 Å) | | 主引用文献 | Oxidative trans to cis Isomerization of Olefins in Polyketide Biosynthesis.
Angew. Chem. Int. Ed. Engl., 55, 2016
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5YGY
 | | Crystal Structure of BACE1 in complex with (S)-N-(3-(2-amino-6-(fluoromethyl)-4 -methyl-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-5-cyanopicolinamide | | 分子名称: | Beta-secretase 1, GLYCEROL, IODIDE ION, ... | | 著者 | Fuchino, K, Mitsuoka, Y, Masui, M, Kurose, N, Yoshida, S, Komano, K, Yamamoto, T, Ogawa, M, Unemura, C, Hosono, M, Ito, H, Sakaguchi, G, Ando, S, Ohnishi, S, Kido, Y, Fukushima, T, Miyajima, H, Hiroyama, S, Koyabu, K, Dhuyvetter, D, Borghys, H, Gijsen, H, Yamano, Y, Iso, Y, Kusakabe, K. | | 登録日 | 2017-09-27 | | 公開日 | 2018-05-23 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Rational Design of Novel 1,3-Oxazine Based beta-Secretase (BACE1) Inhibitors: Incorporation of a Double Bond To Reduce P-gp Efflux Leading to Robust A beta Reduction in the Brain
J. Med. Chem., 61, 2018
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5YGX
 | | Structure of BACE1 in complex with N-(3-((4R,5R,6S)-2-amino-6-(1,1-difluoroethyl)-5-fluoro-4-methyl-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-5-(fluoromethoxy)pyrazine-2-carboxamide | | 分子名称: | Beta-secretase 1, DIMETHYL SULFOXIDE, GLYCEROL, ... | | 著者 | Nakahara, K, Fuchino, K, Komano, K, Asada, N, Tadano, G, Hasegawa, T, Yamamoto, T, Sako, Y, Ogawa, M, Unemura, C, Hosono, M, Sakaguchi, G, Ando, S, Ohnishi, S, Kido, Y, Fukushima, T, Dhuyvetter, D, Borghys, H, Gijsen, H, Yamano, Y, Iso, Y, Kusakabe, K. | | 登録日 | 2017-09-27 | | 公開日 | 2018-08-08 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Discovery of Potent and Centrally Active 6-Substituted 5-Fluoro-1,3-dihydro-oxazine beta-Secretase (BACE1) Inhibitors via Active Conformation Stabilization
J. Med. Chem., 61, 2018
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7BR0
 | | Crystal structure of AclR, a thioredoxin oxidoreductase fold protein carrying the CXXH catalytic motif | | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, Pyr_redox_2 domain-containing protein | | 著者 | Hara, K, Hashimoto, H, Maeda, N, Watanabe, K, Hertweck, C, Tsunematsu, Y. | | 登録日 | 2020-03-26 | | 公開日 | 2020-12-23 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.003 Å) | | 主引用文献 | Specialized Flavoprotein Promotes Sulfur Migration and Spiroaminal Formation in Aspirochlorine Biosynthesis.
J.Am.Chem.Soc., 143, 2021
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4DCQ
 | | Crystal Structure of the Fab Fragment of 3B5H10, an Antibody-Specific for Extended Polyglutamine Repeats (orthorhombic form) | | 分子名称: | 1,2-ETHANEDIOL, 3B5H10 FAB Heavy Chain, 3B5H10 FAB Light Chain | | 著者 | Peters-Libeu, C.A, Tran, T, Finkbeiner, S, Weisgraber, K. | | 登録日 | 2012-01-18 | | 公開日 | 2012-02-22 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | | 主引用文献 | Disease-associated polyglutamine stretches in monomeric huntingtin adopt a compact structure.
J.Mol.Biol., 421, 2012
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1IZC
 | | Crystal Structure Analysis of Macrophomate synthase | | 分子名称: | MAGNESIUM ION, PYRUVIC ACID, macrophomate synthase intermolecular Diels-Alderase | | 著者 | Ose, T, Watanabe, K, Mie, T, Honma, M, Watanabe, H, Yao, M, Oikawa, H, Tanaka, I. | | 登録日 | 2002-10-01 | | 公開日 | 2003-04-01 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Insight into a natural Diels-Alder reaction from the structure of macrophomate synthase.
Nature, 422, 2003
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1LZD
 | | DISSECTION OF PROTEIN-CARBOHYDRATE INTERACTIONS IN MUTANT HEN EGG-WHITE LYSOZYME COMPLEXES AND THEIR HYDROLYTIC ACTIVITY | | 分子名称: | HEN EGG WHITE LYSOZYME | | 著者 | Maenaka, K, Matsushima, M, Song, H, Watanabe, K, Kumagai, I. | | 登録日 | 1995-02-10 | | 公開日 | 1995-05-08 | | 最終更新日 | 2017-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Dissection of protein-carbohydrate interactions in mutant hen egg-white lysozyme complexes and their hydrolytic activity.
J.Mol.Biol., 247, 1995
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1LZB
 | | DISSECTION OF PROTEIN-CARBOHYDRATE INTERACTIONS IN MUTANT HEN EGG-WHITE LYSOZYME COMPLEXES AND THEIR HYDROLYTIC ACTIVITY | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, HEN EGG WHITE LYSOZYME | | 著者 | Maenaka, K, Matsushima, M, Song, H, Watanabe, K, Kumagai, I. | | 登録日 | 1995-02-10 | | 公開日 | 1995-05-08 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Dissection of protein-carbohydrate interactions in mutant hen egg-white lysozyme complexes and their hydrolytic activity.
J.Mol.Biol., 247, 1995
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5F8B
 | | Crystallographic Structure of PsoE with Co | | 分子名称: | (5~{S},8~{S},9~{R})-2-[(~{E})-hex-1-enyl]-8-methoxy-3-methyl-9-oxidanyl-8-(phenylcarbonyl)-1-oxa-7-azaspiro[4.4]non-2-ene-4,6-dione, COBALT (II) ION, GLUTATHIONE, ... | | 著者 | Hara, K, Hashimoto, H, Yamamoto, T, Tsunematsu, Y, Watanabe, K. | | 登録日 | 2015-12-09 | | 公開日 | 2016-04-20 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.54 Å) | | 主引用文献 | Oxidative trans to cis Isomerization of Olefins in Polyketide Biosynthesis.
Angew. Chem. Int. Ed. Engl., 55, 2016
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1LZA
 | | DISSECTION OF PROTEIN-CARBOHYDRATE INTERACTIONS IN MUTANT HEN EGG-WHITE LYSOZYME COMPLEXES AND THEIR HYDROLYTIC ACTIVITY | | 分子名称: | HEN EGG WHITE LYSOZYME | | 著者 | Maenaka, K, Matsushima, M, Song, H, Watanabe, K, Kumagai, I. | | 登録日 | 1995-02-10 | | 公開日 | 1995-05-08 | | 最終更新日 | 2017-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Dissection of protein-carbohydrate interactions in mutant hen egg-white lysozyme complexes and their hydrolytic activity.
J.Mol.Biol., 247, 1995
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4TKC
 | | Japanese Marasmius oreades lectin complexed with mannose | | 分子名称: | GLYCEROL, Mannose recognizing lectin, alpha-D-mannopyranose, ... | | 著者 | Noma, Y, Shimokawa, M, Maeganeku, C, Motoshima, H, Watanabe, K, Minami, Y, Yagi, F. | | 登録日 | 2014-05-26 | | 公開日 | 2015-06-03 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (1.29 Å) | | 主引用文献 | Structure of Japanese Marasmius oreades lectin complexed with mannose.
To Be Published
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1LZG
 | | DISSECTION OF PROTEIN-CARBOHYDRATE INTERACTIONS IN MUTANT HEN EGG-WHITE LYSOZYME COMPLEXES AND THEIR HYDROLYTIC ACTIVITY | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, HEN EGG WHITE LYSOZYME | | 著者 | Maenaka, K, Matsushima, M, Song, H, Watanabe, K, Kumagai, I. | | 登録日 | 1995-02-10 | | 公開日 | 1995-05-08 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Dissection of protein-carbohydrate interactions in mutant hen egg-white lysozyme complexes and their hydrolytic activity.
J.Mol.Biol., 247, 1995
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1LZE
 | | DISSECTION OF PROTEIN-CARBOHYDRATE INTERACTIONS IN MUTANT HEN EGG-WHITE LYSOZYME COMPLEXES AND THEIR HYDROLYTIC ACTIVITY | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, HEN EGG WHITE LYSOZYME | | 著者 | Maenaka, K, Matsushima, M, Song, H, Watanabe, K, Kumagai, I. | | 登録日 | 1995-02-10 | | 公開日 | 1995-05-08 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Dissection of protein-carbohydrate interactions in mutant hen egg-white lysozyme complexes and their hydrolytic activity.
J.Mol.Biol., 247, 1995
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1LZC
 | | DISSECTION OF PROTEIN-CARBOHYDRATE INTERACTIONS IN MUTANT HEN EGG-WHITE LYSOZYME COMPLEXES AND THEIR HYDROLYTIC ACTIVITY | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, HEN EGG WHITE LYSOZYME | | 著者 | Maenaka, K, Matsushima, M, Song, H, Watanabe, K, Kumagai, I. | | 登録日 | 1995-02-10 | | 公開日 | 1995-05-08 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Dissection of protein-carbohydrate interactions in mutant hen egg-white lysozyme complexes and their hydrolytic activity.
J.Mol.Biol., 247, 1995
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