6RUP
| Human mitochondrial single-stranded DNA binding protein, SSBP1, at 2.1 A resolution - elucidated sequence | Descriptor: | MAGNESIUM ION, SER-SER-SER-SER, Single-stranded DNA-binding protein, ... | Authors: | Tarres-Sole, A, Chakraborty, A, Spelbrink, H.N, Delettre, C, Sola, M. | Deposit date: | 2019-05-28 | Release date: | 2019-10-09 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Dominant mutations in mtDNA maintenance gene SSBP1 cause optic atrophy and foveopathy. J.Clin.Invest., 130, 2020
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3L8L
| Gramicidin D complex with sodium iodide | Descriptor: | GRAMICIDIN D, IODIDE ION, METHANOL, ... | Authors: | Olczak, A, Glowka, M.L, Szczesio, M, Bojarska, J, Wawrzak, Z, Duax, W.L. | Deposit date: | 2009-12-31 | Release date: | 2010-07-28 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.25 Å) | Cite: | The first crystal structure of a gramicidin complex with sodium: high-resolution study of a nonstoichiometric gramicidin D-NaI complex. Acta Crystallogr.,Sect.D, 66, 2010
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8ANU
| Crystal structure of protein phi3T-93 | Descriptor: | NICKEL (II) ION, YopN. Phi3T_93 | Authors: | Zamora-Caballero, S, Marina, A. | Deposit date: | 2022-08-05 | Release date: | 2023-10-25 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.310147 Å) | Cite: | Antagonistic interactions between phage and host factors control arbitrium lysis-lysogeny decision. Nat Microbiol, 9, 2024
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8AFW
| Tube assembly of Atg18-WT | Descriptor: | Autophagy-related protein 18 | Authors: | Mann, D, Fromm, S, Martinez-Sanchez, A, Gopaldass, N, Mayer, A, Sachse, C. | Deposit date: | 2022-07-18 | Release date: | 2023-11-01 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Atg18 oligomer organization in assembled tubes and on lipid membrane scaffolds. Nat Commun, 14, 2023
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6RV2
| Crystal structure of the human two pore domain potassium ion channel TASK-1 (K2P3.1) in a closed conformation | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CHOLESTEROL HEMISUCCINATE, DECYL-BETA-D-MALTOPYRANOSIDE, ... | Authors: | Rodstrom, K.E.J, Pike, A.C.W, Zhang, W, Quigley, A, Speedman, D, Mukhopadhyay, S.M.M, Shrestha, L, Chalk, R, Venkaya, S, Bushell, S.R, Tessitore, A, Burgess-Brown, N, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Carpenter, E.P, Structural Genomics Consortium (SGC) | Deposit date: | 2019-05-30 | Release date: | 2019-08-07 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | A lower X-gate in TASK channels traps inhibitors within the vestibule. Nature, 582, 2020
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8UPH
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5MUK
| Glycoside Hydrolase BT3686 | Descriptor: | Neuraminidase | Authors: | Munoz-Munoz, J, Cartmell, A, Terrapon, N, Henrissat, B, Gilbert, H.J. | Deposit date: | 2017-01-13 | Release date: | 2017-04-26 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.49 Å) | Cite: | Unusual active site location and catalytic apparatus in a glycoside hydrolase family. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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8UQK
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8G8X
| X-ray co-crystal structure of compound 27 in with complex JAK2 | Descriptor: | 3-cyclopropyl-1-{5-methyl-2-[(3-methyl-1,2-thiazol-5-yl)amino]pyrimidin-4-yl}azetidin-3-ol, Tyrosine-protein kinase JAK2 | Authors: | Miller, S.T, Ellis, D.A. | Deposit date: | 2023-02-20 | Release date: | 2023-06-21 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.97 Å) | Cite: | Eyes on Topical Ocular Disposition: The Considered Design of a Lead Janus Kinase (JAK) Inhibitor That Utilizes a Unique Azetidin-3-Amino Bridging Scaffold to Attenuate Off-Target Kinase Activity, While Driving Potency and Aqueous Solubility. J.Med.Chem., 66, 2023
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5M87
| Crystal structure of Eremococcus coleocola manganese transporter | Descriptor: | DECYL-BETA-D-MALTOPYRANOSIDE, Divalent metal cation transporter MntH | Authors: | Manatschal, C, Ehrnstorfer, I.A, Arnold, F.M, Laederach, J, Dutzler, R. | Deposit date: | 2016-10-28 | Release date: | 2017-01-11 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Structural and mechanistic basis of proton-coupled metal ion transport in the SLC11/NRAMP family. Nat Commun, 8, 2017
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6PDT
| cryoEM structure of yeast glucokinase filament | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Glucokinase-1, MAGNESIUM ION, ... | Authors: | Lynch, E.M, Dosey, A.M, Farrell, D.P, Stoddard, P.R, Kollman, J.M. | Deposit date: | 2019-06-19 | Release date: | 2020-03-11 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Polymerization in the actin ATPase clan regulates hexokinase activity in yeast. Science, 367, 2020
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8AZ5
| IAPP S20G plateau-phase fibril polymorph 4PF-CU | Descriptor: | Islet amyloid polypeptide | Authors: | Wilkinson, M, Xu, Y, Gallardo, R, Radford, S.E, Ranson, N.A. | Deposit date: | 2022-09-05 | Release date: | 2024-01-10 | Method: | ELECTRON MICROSCOPY (2.3 Å) | Cite: | Structural evolution of fibril polymorphs during amyloid assembly. Cell, 186, 2023
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8UPM
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8UPK
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8AZ4
| IAPP S20G plateau-phase fibril polymorph 2PF-L | Descriptor: | Islet amyloid polypeptide | Authors: | Wilkinson, M, Xu, Y, Gallardo, R, Radford, S.E, Ranson, N.A. | Deposit date: | 2022-09-05 | Release date: | 2024-01-10 | Method: | ELECTRON MICROSCOPY (2.2 Å) | Cite: | Structural evolution of fibril polymorphs during amyloid assembly. Cell, 186, 2023
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8UQI
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8OFN
| Structure of the yellow fever virus (Asibi strain) dimeric envelope protein | Descriptor: | Envelope glycoprotein, SULFATE ION | Authors: | Covernton, E, Vaney, M.C, Barba-Spaeth, G, Rey, F.A. | Deposit date: | 2023-03-16 | Release date: | 2023-08-09 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.48 Å) | Cite: | New insight into flavivirus maturation from structure/function studies of the yellow fever virus envelope protein complex. Mbio, 14, 2023
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8AZ1
| IAPP S20G growth-phase fibril polymorph 2PF-C | Descriptor: | Islet amyloid polypeptide | Authors: | Wilkinson, M, Xu, Y, Gallardo, R, Radford, S.E, Ranson, N.A. | Deposit date: | 2022-09-05 | Release date: | 2024-01-10 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural evolution of fibril polymorphs during amyloid assembly. Cell, 186, 2023
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5MBW
| CRYSTAL STRUCTURE OF BACE-1 IN COMPLEX WITH Pep#3 | Descriptor: | BACE1 INHIBITOR PEPTIDE Pep#3, Beta-secretase 1, CHLORIDE ION | Authors: | Kuglstatter, A, Stihle, M, Benz, J. | Deposit date: | 2016-11-09 | Release date: | 2017-09-27 | Last modified: | 2017-11-01 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | Potent and Selective BACE-1 Peptide Inhibitors Lower Brain A beta Levels Mediated by Brain Shuttle Transport. EBioMedicine, 24, 2017
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8AZ2
| IAPP S20G growth-phase fibril polymorph 3PF-CU | Descriptor: | Islet amyloid polypeptide | Authors: | Wilkinson, M, Xu, Y, Gallardo, R, Radford, S.E, Ranson, N.A. | Deposit date: | 2022-09-05 | Release date: | 2024-01-10 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structural evolution of fibril polymorphs during amyloid assembly. Cell, 186, 2023
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7MIG
| Human CTPS1 bound to inhibitor T35 | Descriptor: | 2-{2-[(cyclopropanesulfonyl)amino]-1,3-thiazol-4-yl}-2-methyl-N-{5-[6-(trifluoromethyl)pyrazin-2-yl]pyridin-2-yl}propanamide, CTP synthase 1, GLUTAMINE, ... | Authors: | Lynch, E.M, Dimattia, M.A, Kollman, J.M. | Deposit date: | 2021-04-16 | Release date: | 2021-10-13 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structural basis for isoform-specific inhibition of human CTPS1. Proc.Natl.Acad.Sci.USA, 118, 2021
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6PAZ
| OXIDIZED MUTANT P80I PSEUDOAZURIN FROM A. FAECALIS | Descriptor: | COPPER (II) ION, PSEUDOAZURIN | Authors: | Adman, E.T, Libeu, C.A.P. | Deposit date: | 1997-02-21 | Release date: | 1997-08-20 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (1.91 Å) | Cite: | Site-directed mutants of pseudoazurin: explanation of increased redox potentials from X-ray structures and from calculation of redox potential differences. Biochemistry, 36, 1997
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5MCO
| CRYSTAL STRUCTURE OF BACE-1 IN COMPLEX WITH ACTIVE SITE INHIBITOR GRL-8234 AND EXOSITE PEPTIDE | Descriptor: | BACE-1 EXOSITE PEPTIDE, Beta-secretase 1, N-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-5-[methyl(methylsulfonyl)amino]-N'-[(1R)-1-phenylethyl]benzene-1,3-dicarboxamide | Authors: | Kuglstatter, A, Stihle, M, Benz, J. | Deposit date: | 2016-11-10 | Release date: | 2017-09-27 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.49 Å) | Cite: | Potent and Selective BACE-1 Peptide Inhibitors Lower Brain A beta Levels Mediated by Brain Shuttle Transport. EBioMedicine, 24, 2017
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5M6D
| Streptococcus pneumoniae Glyceraldehyde-3-Phosphate Dehydrogenase (SpGAPDH) crystal structure | Descriptor: | ACETIC ACID, CALCIUM ION, CHLORIDE ION, ... | Authors: | Gaboriaud, C, Moreau, C.P, Di Guilmi, A.M. | Deposit date: | 2016-10-25 | Release date: | 2017-01-11 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Deciphering Key Residues Involved in the Virulence-promoting Interactions between Streptococcus pneumoniae and Human Plasminogen. J. Biol. Chem., 292, 2017
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8AP5
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