6RV2

Crystal structure of the human two pore domain potassium ion channel TASK-1 (K2P3.1) in a closed conformation

Summary for 6RV2

Entry DOI	10.2210/pdb6rv2/pdb
Descriptor	Potassium channel subfamily K member 3, POTASSIUM ION, CHOLESTEROL HEMISUCCINATE, ... (6 entities in total)
Functional Keywords	membrane protein, potassium channel, structural genomics, structural genomics consortium, sgc
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	128796.19
Authors	Rodstrom, K.E.J.,Pike, A.C.W.,Zhang, W.,Quigley, A.,Speedman, D.,Mukhopadhyay, S.M.M.,Shrestha, L.,Chalk, R.,Venkaya, S.,Bushell, S.R.,Tessitore, A.,Burgess-Brown, N.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Carpenter, E.P.,Structural Genomics Consortium (SGC) (deposition date: 2019-05-30, release date: 2019-08-07, Last modification date: 2024-01-24)
Primary citation	Rodstrom, K.E.J.,Kiper, A.K.,Zhang, W.,Rinne, S.,Pike, A.C.W.,Goldstein, M.,Conrad, L.J.,Delbeck, M.,Hahn, M.G.,Meier, H.,Platzk, M.,Quigley, A.,Speedman, D.,Shrestha, L.,Mukhopadhyay, S.M.M.,Burgess-Brown, N.A.,Tucker, S.J.,Muller, T.,Decher, N.,Carpenter, E.P. A lower X-gate in TASK channels traps inhibitors within the vestibule. Nature, 582:443-447, 2020 Cited by PubMed: 32499642 DOI: 10.1038/s41586-020-2250-8 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3 Å)

Structure validation