6RV2
Crystal structure of the human two pore domain potassium ion channel TASK-1 (K2P3.1) in a closed conformation
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Potassium channel subfamily K member 3 | polymer | 264 | 30117.0 | 4 | UniProt (O14649) Pfam (PF07885) | Homo sapiens (Human) | Acid-sensitive potassium channel protein TASK-1,TWIK-related acid-sensitive K(+) channel 1,Two pore potassium channel KT3.1,Two pore K(+) channel KT3.1 |
| 2 | E, F, G, L, Q... (A, C) | POTASSIUM ION | non-polymer | 39.1 | 8 | Chemie (K) PubChem (813) | |||
| 3 | H, I, M, N, U... (A, B, C, D) | CHOLESTEROL HEMISUCCINATE | non-polymer | 486.7 | 7 | Chemie (Y01) PubChem (16219150) PubChem (22210610) PubChem (65082) PubChem (45489984) PubChem (363416) PubChem (60078761) PubChem (500055) PubChem (73440805) PubChem (57163942) PubChem (89891013) PubChem (99567468) PubChem (124427194) PubChem (124897021) PubChem (124897020) PubChem (10005657) PubChem (130340716) PubChem (99567469) PubChem (11969853) PubChem (137392566) PubChem (137496323) PubChem (124301053) PubChem (124302591) PubChem (124303794) PubChem (124421343) PubChem (124427195) PubChem (13301926) PubChem (13301927) PubChem (124914595) PubChem (124914596) PubChem (155804219) PubChem (169132514) PubChem (131705526) PubChem (137332121) PubChem (137496357) PubChem (146157332) PubChem (154929912) PubChem (155199678) PubChem (156327905) PubChem (156426247) PubChem (156516588) PubChem (166979870) PubChem (167024614) PubChem (169132513) PubChem (170117245) PubChem (172400028) | |||
| 4 | J, O, V (A, B, C) | DECYL-BETA-D-MALTOPYRANOSIDE | non-polymer | 482.6 | 3 | Chemie (DMU) PubChem (24776995) PubChem (16396531) PubChem (45253991) PubChem (45254001) PubChem (24802064) PubChem (56845266) PubChem (58112552) PubChem (45253971) PubChem (59518661) PubChem (49866911) PubChem (70796430) PubChem (70839938) PubChem (71307274) PubChem (3637526) PubChem (5288091) PubChem (95370473) PubChem (98046563) PubChem (5288728) PubChem (101207920) PubChem (126735852) PubChem (95370474) PubChem (95370475) PubChem (95370476) PubChem (98046559) PubChem (98046561) PubChem (100941450) PubChem (100950626) PubChem (102219024) PubChem (118704896) PubChem (123134571) PubChem (124867949) PubChem (124867950) PubChem (124867951) PubChem (124867952) PubChem (126731012) PubChem (126731036) PubChem (126735974) PubChem (168490163) | |||
| 5 | K, P, W, Z (A, B, D) | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE | non-polymer | 790.1 | 4 | Chemie (PC1) PubChem (65146) PubChem (94190) PubChem (10417837) | |||
| 6 | AA, BA, CA, DA (A, B, C, D) | water | water | 18.0 | 31 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 259 (UniProt: O14649)
| PDB | External Database | Details |
|---|---|---|
| Asn 260 | - | expression tag |
| Leu 261 | - | expression tag |
| Tyr 262 | - | expression tag |
| Phe 263 | - | expression tag |
| Gln 264 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 120468.1 | |
| Non-Polymers* | Number of molecules | 22 |
| Total formula weight | 8328.1 | |
| All* | Total formula weight | 128796.2 |
