7AJA
 
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6VPB
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7AJW
 | | Structure of DYRK1A in complex with compound 46 | | 分子名称: | 4-[2-methyl-3-(2-phenoxyethyl)imidazo[4,5-b]pyridin-5-yl]pyridine-2,6-diamine, CHLORIDE ION, Dual specificity tyrosine-phosphorylation-regulated kinase 1A | | 著者 | Dokurno, P, Surgenor, A.E, Kotschy, A. | | 登録日 | 2020-09-29 | | 公開日 | 2021-05-26 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Structure-Guided Discovery of Potent and Selective DYRK1A Inhibitors.
J.Med.Chem., 64, 2021
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5K97
 | | Flap endonuclease 1 (FEN1) D233N with cleaved product fragment and Sm3+ | | 分子名称: | 1,2-ETHANEDIOL, DNA (5'-D(*AP*CP*CP*GP*TP*CP*C)-3'), DNA (5'-D(*AP*CP*TP*CP*TP*GP*CP*CP*TP*CP*AP*AP*GP*AP*CP*GP*GP*T)-3'), ... | | 著者 | Tsutakawa, S.E, Arvai, A.S, Tainer, J.A. | | 登録日 | 2016-05-31 | | 公開日 | 2017-06-28 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.102 Å) | | 主引用文献 | Phosphate steering by Flap Endonuclease 1 promotes 5'-flap specificity and incision to prevent genome instability.
Nat Commun, 8, 2017
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6VPQ
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4V7G
 | | Crystal Structure of Lumazine Synthase from Bacillus Anthracis | | 分子名称: | 6,7-dimethyl-8-ribityllumazine synthase, PHOSPHATE ION | | 著者 | Morgunova, E, Illarionov, B, Saller, S, Popov, A, Sambaiah, T, Bacher, A, Cushman, M, Fischer, M, Ladenstein, R. | | 登録日 | 2009-09-16 | | 公開日 | 2014-07-09 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | | 主引用文献 | Structural study and thermodynamic characterization of inhibitor binding to lumazine synthase from Bacillus anthracis.
Acta Crystallogr.,Sect.D, 66, 2010
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2VKO
 | | Structure of the soluble domain of the membrane protein TM1634 from Thermotoga maritima | | 分子名称: | HEXAETHYLENE GLYCOL, TETRAETHYLENE GLYCOL, TM1634 | | 著者 | McCleverty, C.J, Columbus, L, Kreusch, A, Lesley, S.A, Joint Center for Structural Genomics (JCSG) | | 登録日 | 2007-12-20 | | 公開日 | 2008-04-08 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | | 主引用文献 | Structure and Ligand Binding of the Soluble Domain of a Thermotoga Maritima Membrane Protein of Unknown Function Tm1634.
Protein Sci., 17, 2008
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4I4L
 | | Crystal Structure of Nucleotide-Bound W-W-W ClpX Hexamer | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ATP-dependent Clp protease ATP-binding subunit ClpX, SULFATE ION | | 著者 | Glynn, S.E, Nager, A.R, Stinson, B.S, Schmitz, K.R, Baker, T.A, Sauer, R.T. | | 登録日 | 2012-11-27 | | 公開日 | 2013-05-15 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (3.6981 Å) | | 主引用文献 | Nucleotide Binding and Conformational Switching in the Hexameric Ring of a AAA+ Machine.
Cell(Cambridge,Mass.), 153, 2013
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7AIQ
 | | Structure of Human Potassium Chloride Transporter KCC1 in NaCl (Subclass 1) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-TRIPHOSPHATE, Solute carrier family 12 member 4, ... | | 著者 | Ebenhoch, R, Chi, G, Man, H, Wang, D, McKinley, G, Mukhopadhyay, S.M.M, MacLean, E.M, Chalk, R, Moreau, C, Snee, M, Bohstedt, T, Singh, N.K, Abrusci, P, Liko, I, Tehan, B.G, Almeida, F.G, Arrowsmith, C.H, Tang, H, Robinson, C.V, Bountra, C, Edwards, A.M, Marsden, B.D, Burgess-Brown, N.A, Duerr, K.L, Structural Genomics Consortium (SGC) | | 登録日 | 2020-09-28 | | 公開日 | 2021-06-02 | | 最終更新日 | 2021-07-28 | | 実験手法 | ELECTRON MICROSCOPY (3.72 Å) | | 主引用文献 | Phospho-regulation, nucleotide binding and ion access control in potassium-chloride cotransporters.
Embo J., 40, 2021
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3WCQ
 | | Crystal structure analysis of Cyanidioschyzon melorae ferredoxin D58N mutant | | 分子名称: | FE2/S2 (INORGANIC) CLUSTER, Ferredoxin | | 著者 | Ueno, Y, Matsumoto, T, Yamano, A, Imai, T, Morimoto, Y. | | 登録日 | 2013-05-31 | | 公開日 | 2013-08-07 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (0.97 Å) | | 主引用文献 | Increasing the electron-transfer ability of Cyanidioschyzon merolae ferredoxin by a one-point mutation - A high resolution and Fe-SAD phasing crystal structure analysis of the Asp58Asn mutant
Biochem.Biophys.Res.Commun., 436, 2013
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7ZH7
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6VV1
 | | Crystal structure of Eis from Mycobacterium tuberculosis in complex with inhibitor SGT384 | | 分子名称: | 2-[(4-amino-6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-2-yl)sulfanyl]-N-[2-(piperidin-1-yl)ethyl]acetamide, DI(HYDROXYETHYL)ETHER, DIMETHYL SULFOXIDE, ... | | 著者 | Punetha, A, Hou, C, Ngo, H.X, Garneau-Tsodikova, S, Tsodikov, O.V. | | 登録日 | 2020-02-16 | | 公開日 | 2020-06-03 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | | 主引用文献 | Structure-Guided Optimization of Inhibitors of Acetyltransferase Eis fromMycobacterium tuberculosis.
Acs Chem.Biol., 15, 2020
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4W4T
 | | The crystal structure of the terminal R domain from the myxalamid PKS-NRPS biosynthetic pathway | | 分子名称: | ACETATE ION, MxaA | | 著者 | Tsai, S.C, Keasling, J.D, Luo, R, Barajas, J.F, Phelan, R.M, Schaub, A.J, Kliewer, J. | | 登録日 | 2014-08-15 | | 公開日 | 2015-08-12 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.845 Å) | | 主引用文献 | Comprehensive Structural and Biochemical Analysis of the Terminal Myxalamid Reductase Domain for the Engineered Production of Primary Alcohols.
Chem.Biol., 22, 2015
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1SSV
 | | Compensating bends in a 16 base-pair DNA oligomer containing a T3A3 segment | | 分子名称: | 5'-D(*CP*GP*AP*GP*GP*TP*TP*TP*AP*AP*AP*CP*CP*TP*CP*G)-3' | | 著者 | McAteer, K, Aceves-Gaona, A, Michalczyk, R, Buchko, G.W, Isern, N.G, Silks, L.A, Miller, J.H, Kennedy, M.A. | | 登録日 | 2004-03-24 | | 公開日 | 2004-12-07 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Compensating bends in a 16-base-pair DNA oligomer containing a T(3)A(3) segment: A NMR study of global DNA curvature
Biopolymers, 75, 2004
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5DG9
 | | CRYSTAL STRUCTURE OF HUMAN DNA POLYMERASE ETA INSERTING dGMPNPP ACROSS A DNA TEMPLATE CONTAINING 1,N6-ETHENODEOXYADENOSINE LESION | | 分子名称: | 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]guanosine, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), DNA (5'-D(*CP*AP*TP*(EDA)P*AP*TP*GP*AP*CP*GP*CP*T)-3'), ... | | 著者 | Patra, A, Egli, M. | | 登録日 | 2015-08-27 | | 公開日 | 2016-06-08 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | Structural and Kinetic Analysis of Miscoding Opposite the DNA Adduct 1,N6-Ethenodeoxyadenosine by Human Translesion DNA Polymerase eta.
J.Biol.Chem., 291, 2016
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4ICM
 | | Crystal structure of 5-carboxyvanillate decarboxylase LigW from Sphingomonas paucimobilis | | 分子名称: | 5-carboxyvanillate decarboxylase, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | | 著者 | Fedorov, A.A, Fedorov, E.V, Vladimirova, A, Raushel, F.M, Almo, S.C. | | 登録日 | 2012-12-10 | | 公開日 | 2013-12-11 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.825 Å) | | 主引用文献 | Crystal structure of 5-carboxyvanillate decarboxylase LigW from Sphingomonas paucimobilis
To be Published
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6VWW
 | | Crystal Structure of NSP15 Endoribonuclease from SARS CoV-2. | | 分子名称: | ACETIC ACID, CHLORIDE ION, GLYCEROL, ... | | 著者 | Kim, Y, Jedrzejczak, R, Maltseva, N, Endres, M, Godzik, A, Michalska, K, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | | 登録日 | 2020-02-20 | | 公開日 | 2020-03-04 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Crystal structure of Nsp15 endoribonuclease NendoU from SARS-CoV-2.
Protein Sci., 29, 2020
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2V51
 | | Structure of MAL-RPEL1 complexed to actin | | 分子名称: | ACTIN, ALPHA SKELETAL MUSCLE, ADENOSINE-5'-TRIPHOSPHATE, ... | | 著者 | Mouilleron, S, Guettler, S, Langer, C.A, Treisman, R, McDonald, N.Q. | | 登録日 | 2008-10-01 | | 公開日 | 2008-11-25 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | | 主引用文献 | Molecular basis for G-actin binding to RPEL motifs from the serum response factor coactivator MAL.
EMBO J., 27, 2008
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5VA6
 | | CRYSTAL STRUCTURE OF ATXR5 IN COMPLEX WITH HISTONE H3.1 MONO-METHYLATED ON R26 | | 分子名称: | Histone H3.1, Probable Histone-lysine N-methyltransferase ATXR5, S-ADENOSYL-L-HOMOCYSTEINE | | 著者 | Bergamin, E, Sarvan, S, Malette, J, Eram, M, Yeung, S, Mongeon, V, Joshi, M, Brunzelle, J.S, Michaels, S.D, Blais, A, Vedadi, M, Couture, J.-F. | | 登録日 | 2017-03-24 | | 公開日 | 2017-04-19 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Molecular basis for the methylation specificity of ATXR5 for histone H3.
Nucleic Acids Res., 45, 2017
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4IES
 | | Cys-persulfenate bound Cysteine Dioxygenase at pH 6.2 in the presence of Cys | | 分子名称: | Cysteine dioxygenase type 1, FE (III) ION, S-HYDROPEROXYCYSTEINE | | 著者 | Driggers, C.M, Cooley, R.B, Sankaran, B, Karplus, P.A. | | 登録日 | 2012-12-13 | | 公開日 | 2013-06-26 | | 最終更新日 | 2013-09-11 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | Cysteine Dioxygenase Structures from pH4 to 9: Consistent Cys-Persulfenate Formation at Intermediate pH and a Cys-Bound Enzyme at Higher pH.
J.Mol.Biol., 425, 2013
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1JVL
 | | Azurin dimer, covalently crosslinked through bis-maleimidomethylether | | 分子名称: | 1-[PYRROL-1-YL-2,5-DIONE-METHOXYMETHYL]-PYRROLE-2,5-DIONE, Azurin, COPPER (II) ION, ... | | 著者 | van Amsterdam, I.M.C, Ubbink, M, Einsle, O, Messerschmidt, A, Merli, A, Cavazzini, D, Rossi, G.L, Canters, G.W. | | 登録日 | 2001-08-30 | | 公開日 | 2002-01-04 | | 最終更新日 | 2021-10-27 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Dramatic modulation of electron transfer in protein complexes by crosslinking
Nat.Struct.Biol., 9, 2002
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3WLO
 | | Crystal Structure Analysis of Plant Exohydrolase | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-D-glucan exohydrolase isoenzyme ExoI, SULFATE ION, ... | | 著者 | Streltsov, V.A, Luang, S, Hrmova, M. | | 登録日 | 2013-11-12 | | 公開日 | 2015-03-25 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | | 主引用文献 | Discovery of processive catalysis by an exo-hydrolase with a pocket-shaped active site.
Nat Commun, 10, 2019
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4IF6
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2VKJ
 | | Structure of the soluble domain of the membrane protein TM1634 from Thermotoga maritima | | 分子名称: | SULFATE ION, TM1634 | | 著者 | McCleverty, C.J, Columbus, L, Kreusch, A, Lesley, S.A, Joint Center for Structural Genomics (JCSG) | | 登録日 | 2007-12-19 | | 公開日 | 2008-04-08 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | Structure and Ligand Binding of the Soluble Domain of a Thermotoga Maritima Membrane Protein of Unknown Function Tm1634.
Protein Sci., 17, 2008
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6PMP
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