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7AJW

Structure of DYRK1A in complex with compound 46

Summary for 7AJW
Entry DOI10.2210/pdb7ajw/pdb
Related7aj2 7aj4 7aj5 7aj7 7aj8 7aja 7ajm 7ajs 7ajv
DescriptorDual specificity tyrosine-phosphorylation-regulated kinase 1A, 4-[2-methyl-3-(2-phenoxyethyl)imidazo[4,5-b]pyridin-5-yl]pyridine-2,6-diamine, CHLORIDE ION, ... (4 entities in total)
Functional Keywordsserine/threonine-protein kinase, phosphoprotein, kinase selectivity, transferase, sbdd, small molecule inhibitor
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total formula weight42078.45
Authors
Dokurno, P.,Surgenor, A.E.,Kotschy, A. (deposition date: 2020-09-29, release date: 2021-05-26, Last modification date: 2024-01-31)
Primary citationWeber, C.,Sipos, M.,Paczal, A.,Balint, B.,Kun, V.,Foloppe, N.,Dokurno, P.,Massey, A.J.,Walmsley, D.L.,Hubbard, R.E.,Murray, J.,Benwell, K.,Edmonds, T.,Demarles, D.,Bruno, A.,Burbridge, M.,Cruzalegui, F.,Kotschy, A.
Structure-Guided Discovery of Potent and Selective DYRK1A Inhibitors.
J.Med.Chem., 64:6745-6764, 2021
Cited by
PubMed: 33975430
DOI: 10.1021/acs.jmedchem.1c00023
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.8 Å)
Structure validation

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