6XXP
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8HRG
| Tail tube of DT57C bacteriophage in the full state | 分子名称: | Tail tube protein | 著者 | Ayala, R, Moiseenko, A.V, Chen, T.H, Kulikov, E.E, Golomidova, A.K, Orekhov, P.S, Street, M.A, Sokolova, O.S, Letarov, A.V, Wolf, M. | 登録日 | 2022-12-15 | 公開日 | 2023-12-13 | 最終更新日 | 2023-12-27 | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | 主引用文献 | Nearly complete structure of bacteriophage DT57C reveals architecture of head-to-tail interface and lateral tail fibers. Nat Commun, 14, 2023
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6VA4
| Solution Structure of the Tau pre-mRNA Exon 10 Splicing Regulatory Element Bound to MIP | 分子名称: | N-[3-(8-methoxy-4-oxo-4,5-dihydro-3H-pyrimido[5,4-b]indol-3-yl)propyl]-N-methylcyclohexanaminium, RNA (5'-R(*CP*AP*CP*AP*CP*GP*UP*CP*GP*G)-3'), RNA (5'-R(*CP*CP*GP*GP*CP*AP*GP*UP*GP*UP*G)-3') | 著者 | Chen, J.L, Fountain, M.A, Disney, M.D. | 登録日 | 2019-12-16 | 公開日 | 2020-05-20 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Design, Optimization, and Study of Small Molecules That Target Tau Pre-mRNA and Affect Splicing. J.Am.Chem.Soc., 142, 2020
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8HRE
| Straight fiber of DT57C bacteriophage in the full state | 分子名称: | Central straight fiber | 著者 | Ayala, R, Moiseenko, A.V, Chen, T.H, Kulikov, E.E, Golomidova, A.K, Orekhov, P.S, Street, M.A, Sokolova, O.S, Letarov, A.V, Wolf, M. | 登録日 | 2022-12-15 | 公開日 | 2023-12-13 | 最終更新日 | 2023-12-27 | 実験手法 | ELECTRON MICROSCOPY (5.5 Å) | 主引用文献 | Nearly complete structure of bacteriophage DT57C reveals architecture of head-to-tail interface and lateral tail fibers. Nat Commun, 14, 2023
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6XU2
| Human karyopherin RanBP5 (isoform-3) | 分子名称: | Antipain, Importin-5, NICKEL (II) ION | 著者 | Swale, C, McCarthy, A.A, Berger, I, Bieniossek, C, Delmas, B, Ruigrok, R.W.H, Crepin, T. | 登録日 | 2020-01-17 | 公開日 | 2020-04-22 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.834 Å) | 主引用文献 | X-ray Structure of the Human Karyopherin RanBP5, an Essential Factor for Influenza Polymerase Nuclear Trafficking. J.Mol.Biol., 432, 2020
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8HQK
| Capsid of DT57C bacteriophage in the empty state | 分子名称: | Major head protein | 著者 | Ayala, R, Moiseenko, A.V, Kulikov, E.E, Golomidova, A.K, Orekhov, P.S, Street, M.A, Sokolova, O.S, Letarov, A.V, Wolf, M. | 登録日 | 2022-12-13 | 公開日 | 2023-12-13 | 最終更新日 | 2023-12-27 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Nearly complete structure of bacteriophage DT57C reveals architecture of head-to-tail interface and lateral tail fibers. Nat Commun, 14, 2023
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5N1Z
| Crystal structure of the BCL6 BTB domain in complex with pyrazolo-pyrimidine macrocyclic ligand | 分子名称: | B-cell lymphoma 6 protein, CHLORIDE ION, pyrazolo-pyrimidine macrocycle | 著者 | Robb, G, Ferguson, A, Hargreaves, D. | 登録日 | 2017-02-06 | 公開日 | 2017-05-17 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.81 Å) | 主引用文献 | Discovery of Pyrazolo[1,5-a]pyrimidine B-Cell Lymphoma 6 (BCL6) Binders and Optimization to High Affinity Macrocyclic Inhibitors. J. Med. Chem., 60, 2017
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6PLE
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5N1X
| Crystal structure of the BCL6 BTB domain in complex with pyrazolo-pyrimidine ligand | 分子名称: | B-cell lymphoma 6 protein, ~{N}-ethyl-5-pyridin-3-yl-pyrazolo[1,5-a]pyrimidin-7-amine | 著者 | Robb, G, Ferguson, A, Hargreaves, D. | 登録日 | 2017-02-06 | 公開日 | 2017-05-17 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.72 Å) | 主引用文献 | Discovery of Pyrazolo[1,5-a]pyrimidine B-Cell Lymphoma 6 (BCL6) Binders and Optimization to High Affinity Macrocyclic Inhibitors. J. Med. Chem., 60, 2017
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5N3C
| cAMP-dependent Protein Kinase A from Cricetulus griseus in complex with fragment like molecule Thiophene-3-Carboximidamide | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, [azanyl(thiophen-3-yl)methylidene]azanium, cAMP dependent protein kinase inhibitor alpha-like protein, ... | 著者 | Siefker, C, Heine, A, Klebe, G. | 登録日 | 2017-02-08 | 公開日 | 2018-02-28 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.772 Å) | 主引用文献 | Fragment Binding to Kinase Hinge: If Charge Distribution and Local pK a Shifts Mislead Popular Bioisosterism Concepts. Angew.Chem.Int.Ed.Engl., 2020
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8HO3
| Capsid of DT57C bacteriophage in the full state | 分子名称: | Major head protein | 著者 | Ayala, R, Moiseenko, A.V, Chen, T.H, Kulikov, E.E, Golomidova, A.K, Orekhov, P.S, Street, M.A, Sokolova, O.S, Letarov, A.V, Wolf, M. | 登録日 | 2022-12-09 | 公開日 | 2023-12-13 | 最終更新日 | 2023-12-27 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Nearly complete structure of bacteriophage DT57C reveals architecture of head-to-tail interface and lateral tail fibers. Nat Commun, 14, 2023
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7TAB
| G-925 bound to the SMARCA4 (BRG1) Bromodomain | 分子名称: | 2-(6-amino-5-phenylpyridazin-3-yl)phenol, Isoform 4 of Transcription activator BRG1 | 著者 | Tang, Y, Poy, F, Taylor, A.M, Cochran, A.G, Bellon, S.F. | 登録日 | 2021-12-20 | 公開日 | 2022-08-17 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.16 Å) | 主引用文献 | GNE-064: A Potent, Selective, and Orally Bioavailable Chemical Probe for the Bromodomains of SMARCA2 and SMARCA4 and the Fifth Bromodomain of PBRM1. J.Med.Chem., 65, 2022
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8U4A
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8HQZ
| Baseplate of DT57C bacteriophage in the full state | 分子名称: | Baseplate hub protein, Distal tail protein, L-shaped tail fiber assembly, ... | 著者 | Ayala, R, Moiseenko, A.V, Chen, T.H, Kulikov, E.E, Golomidova, A.K, Orekhov, P.S, Street, M.A, Sokolova, O.S, Letarov, A.V, Wolf, M. | 登録日 | 2022-12-14 | 公開日 | 2023-12-13 | 最終更新日 | 2023-12-27 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Nearly complete structure of bacteriophage DT57C reveals architecture of head-to-tail interface and lateral tail fibers. Nat Commun, 14, 2023
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6MUX
| The structure of the Plasmodium falciparum 20S proteasome in complex with one PA28 activator | 分子名称: | 20S proteasome alpha-1 subunit, 20S proteasome alpha-2 subunit, 20S proteasome alpha-3 subunit, ... | 著者 | Metcalfe, R.D, Xie, S.C, Hanssen, E, Gillett, D.L, Leis, A.P, Tilley, L, Griffin, M.D.W. | 登録日 | 2018-10-23 | 公開日 | 2019-08-07 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | The structure of the PA28-20S proteasome complex from Plasmodium falciparum and implications for proteostasis. Nat Microbiol, 4, 2019
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8U4F
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5N86
| Crystal structure of FAS1 domain of hyaluronic acid receptor stabilin-2 | 分子名称: | Stabilin-2 | 著者 | Twarda-Clapa, A, Labuzek, B, Grudnik, P, Dubin, G, Holak, T.A. | 登録日 | 2017-02-23 | 公開日 | 2018-06-27 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.484 Å) | 主引用文献 | Crystal structure of the FAS1 domain of the hyaluronic acid receptor stabilin-2. Acta Crystallogr D Struct Biol, 74, 2018
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6PNQ
| Crystal structure of the SS2A splice insert-containing neurexin-1 LNS2 domain in complex with neurexophilin-1 | 分子名称: | Neurexin-1, Neurexophilin-1 | 著者 | Wilson, S.C, White, K.I, Zhou, Q, Brunger, A.T. | 登録日 | 2019-07-02 | 公開日 | 2019-10-09 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.947 Å) | 主引用文献 | Structures of neurexophilin-neurexin complexes reveal a regulatory mechanism of alternative splicing. Embo J., 38, 2019
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5N5Q
| Human TTR altered conformation from soaking in iron chloride. | 分子名称: | ACETATE ION, FE (III) ION, Transthyretin, ... | 著者 | Ciccone, L, Savko, M, Shepard, W, Stura, E.A. | 登録日 | 2017-02-14 | 公開日 | 2018-03-07 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.53 Å) | 主引用文献 | Copper mediated amyloid-beta binding to Transthyretin. Sci Rep, 8, 2018
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7ST3
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6VGN
| ClpP1P2 complex from M. tuberculosis bound to ADEP | 分子名称: | ATP-dependent Clp protease proteolytic subunit, ATP-dependent Clp protease proteolytic subunit 1, R0M-WFP-ALO-PRO-YCP-ALA-MP8 | 著者 | Ripstein, Z.A, Vahidi, S, Rubinstein, J.L, Kay, L.E. | 登録日 | 2020-01-08 | 公開日 | 2020-03-18 | 最終更新日 | 2020-04-01 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | An allosteric switch regulatesMycobacterium tuberculosisClpP1P2 protease function as established by cryo-EM and methyl-TROSY NMR. Proc.Natl.Acad.Sci.USA, 117, 2020
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8HQO
| Neck of DT57C bacteriophage in the full state | 分子名称: | Head completion protein, Portal protein, Tail terminator protein, ... | 著者 | Ayala, R, Moiseenko, A.V, Chen, T.H, Kulikov, E.E, Golomidova, A.K, Orekhov, P.S, Street, M.A, Sokolova, O.S, Letarov, A.V, Wolf, M. | 登録日 | 2022-12-13 | 公開日 | 2023-12-13 | 最終更新日 | 2023-12-27 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Nearly complete structure of bacteriophage DT57C reveals architecture of head-to-tail interface and lateral tail fibers. Nat Commun, 14, 2023
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7STG
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6X91
| Crystal structure of MBP-fused human APOBEC1 | 分子名称: | CACODYLATE ION, Maltodextrin-binding protein, C->U-editing enzyme APOBEC-1 chimera, ... | 著者 | Wolfe, A.D, Li, S.-X, Chen, X.S. | 登録日 | 2020-06-02 | 公開日 | 2020-12-09 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (3.51 Å) | 主引用文献 | The structure of APOBEC1 and insights into its RNA and DNA substrate selectivity. NAR Cancer, 2, 2020
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7TD9
| G-059 bound to the SMARCA4 (BRG1) Bromodomain | 分子名称: | 4-phenyl-5H-pyridazino[4,3-b]indol-3-amine, Isoform 4 of Transcription activator BRG1 | 著者 | Tang, Y, Poy, F, Taylor, A.M, Cochran, A.G, Bellon, S.F. | 登録日 | 2021-12-30 | 公開日 | 2022-08-17 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.61 Å) | 主引用文献 | GNE-064: A Potent, Selective, and Orally Bioavailable Chemical Probe for the Bromodomains of SMARCA2 and SMARCA4 and the Fifth Bromodomain of PBRM1. J.Med.Chem., 65, 2022
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