6VA4
Solution Structure of the Tau pre-mRNA Exon 10 Splicing Regulatory Element Bound to MIP
Summary for 6VA4
Entry DOI | 10.2210/pdb6va4/pdb |
NMR Information | BMRB: 30700 |
Descriptor | RNA (5'-R(*CP*CP*GP*GP*CP*AP*GP*UP*GP*UP*G)-3'), RNA (5'-R(*CP*AP*CP*AP*CP*GP*UP*CP*GP*G)-3'), N-[3-(8-methoxy-4-oxo-4,5-dihydro-3H-pyrimido[5,4-b]indol-3-yl)propyl]-N-methylcyclohexanaminium (3 entities in total) |
Functional Keywords | adenine bulge, rna complex, a-form tau rna hairpin, rna, mip |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 7083.60 |
Authors | Chen, J.L.,Fountain, M.A.,Disney, M.D. (deposition date: 2019-12-16, release date: 2020-05-20, Last modification date: 2024-05-15) |
Primary citation | Chen, J.L.,Zhang, P.,Abe, M.,Aikawa, H.,Zhang, L.,Frank, A.J.,Zembryski, T.,Hubbs, C.,Park, H.,Withka, J.,Steppan, C.,Rogers, L.,Cabral, S.,Pettersson, M.,Wager, T.T.,Fountain, M.A.,Rumbaugh, G.,Childs-Disney, J.L.,Disney, M.D. Design, Optimization, and Study of Small Molecules That Target Tau Pre-mRNA and Affect Splicing. J.Am.Chem.Soc., 142:8706-8727, 2020 Cited by PubMed: 32364710DOI: 10.1021/jacs.0c00768 PDB entries with the same primary citation |
Experimental method | SOLUTION NMR |
Structure validation
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