8DMM
 
 | | Structure of the vanadate-trapped MsbA bound to KDL | | 分子名称: | (2~{R},4~{R},5~{R},6~{R})-6-[(1~{R})-1,2-bis(oxidanyl)ethyl]-2-[(2~{R},4~{R},5~{R},6~{R})-6-[(1~{R})-1,2-bis(oxidanyl)ethyl]-2-carboxy-2-[[(2~{R},3~{S},4~{R},5~{R},6~{R})-5-[[(3~{R})-3-dodecanoyloxytetradecanoyl]amino]-6-[[(2~{R},3~{S},4~{R},5~{R},6~{R})-3-oxidanyl-5-[[(3~{R})-3-oxidanyltetradecanoyl]amino]-4-[(3~{R})-3-oxidanyltetradecanoyl]oxy-6-phosphonooxy-oxan-2-yl]methoxy]-3-phosphonooxy-4-[(3~{R})-3-tetradecanoyloxytetradecanoyl]oxy-oxan-2-yl]methoxy]-5-oxidanyl-oxan-4-yl]oxy-4,5-bis(oxidanyl)oxane-2-carboxylic acid, ADP ORTHOVANADATE, ATP-binding transport protein MsbA | | 著者 | Liu, C, Lyu, J, Laganowsky, A.D, Zhao, M. | | 登録日 | 2022-07-08 | | 公開日 | 2022-12-14 | | 最終更新日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (3.47 Å) | | 主引用文献 | Structural basis for lipid and copper regulation of the ABC transporter MsbA.
Nat Commun, 13, 2022
|
|
8TRD
 | |
7OZ2
 | | Crystal structure of HIV-1 reverse transcriptase with a double stranded DNA showing a transient P-pocket | | 分子名称: | CADMIUM ION, DNA (28-MER), DNA (5'-D(*AP*CP*AP*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*GP*CP*GP*CP*CP*G)-3'), ... | | 著者 | Martinez, S.E, Singh, A.K, Das, K. | | 登録日 | 2021-06-25 | | 公開日 | 2021-12-08 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | | 主引用文献 | Sliding of HIV-1 reverse transcriptase over DNA creates a transient P pocket - targeting P-pocket by fragment screening.
Nat Commun, 12, 2021
|
|
8EA3
 | | V-K CAST Transpososome from Scytonema hofmanni, major configuration | | 分子名称: | 30S ribosomal protein S15, ADENOSINE-5'-TRIPHOSPHATE, Cas12k, ... | | 著者 | Rizo, A.N, Park, J.-U, Tsai, A.W, Kellogg, E.H. | | 登録日 | 2022-08-27 | | 公開日 | 2022-11-30 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Structures of the holo CRISPR RNA-guided transposon integration complex.
Nature, 613, 2023
|
|
7OZW
 | |
9BIY
 | |
7P3C
 | | EED in complex with compound 4 | | 分子名称: | N-(2,3-dihydro-1-benzofuran-4-ylmethyl)-8-(4-methylsulfonylphenyl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine, N-[5-[(5-fluoranyl-2,3-dihydro-1-benzofuran-4-yl)methylamino]-[1,2,4]triazolo[4,3-c]pyrimidin-8-yl]benzamide, Polycomb protein EED | | 著者 | Read, J.A. | | 登録日 | 2021-07-07 | | 公開日 | 2021-12-08 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.61 Å) | | 主引用文献 | Diverse, Potent, and Efficacious Inhibitors That Target the EED Subunit of the Polycomb Repressive Complex 2 Methyltransferase.
J.Med.Chem., 64, 2021
|
|
8WKX
 | | Cryo-EM structure of DSR2 | | 分子名称: | SIR2-like domain-containing protein | | 著者 | Gao, A, Huang, J, Zhu, K. | | 登録日 | 2023-09-28 | | 公開日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (4.15 Å) | | 主引用文献 | Molecular basis of bacterial DSR2 anti-phage defense and viral immune evasion.
Nat Commun, 15, 2024
|
|
6OC0
 | | Crystal structure of human DHODH with OSU-03012 | | 分子名称: | Dihydroorotate dehydrogenase (quinone), mitochondrial, FLAVIN MONONUCLEOTIDE, ... | | 著者 | Durst, M.A, Lavie, A. | | 登録日 | 2019-03-21 | | 公開日 | 2019-11-13 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | Metabolic Modifier Screen Reveals Secondary Targets of Protein Kinase Inhibitors within Nucleotide Metabolism.
Cell Chem Biol, 27, 2020
|
|
8WKS
 | |
7P3G
 | | EED in complex with compound 4 | | 分子名称: | N-(2,3-dihydro-1-benzofuran-4-ylmethyl)-8-(4-methylsulfonylphenyl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine, N5-[(5-fluoranyl-2,3-dihydro-1-benzofuran-4-yl)methyl]-N8-methyl-N8-(1-methylpyrazol-3-yl)-[1,2,4]triazolo[4,3-c]pyrimidine-5,8-diamine, Polycomb protein EED | | 著者 | Read, J.A. | | 登録日 | 2021-07-07 | | 公開日 | 2021-12-08 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.39 Å) | | 主引用文献 | Diverse, Potent, and Efficacious Inhibitors That Target the EED Subunit of the Polycomb Repressive Complex 2 Methyltransferase.
J.Med.Chem., 64, 2021
|
|
7MK1
 | | Structure of a protein-modified aptamer complex | | 分子名称: | Antiviral innate immune response receptor RIG-I, DNA (41-MER), MAGNESIUM ION, ... | | 著者 | Ren, X, Pyle, A.M. | | 登録日 | 2021-04-21 | | 公開日 | 2021-11-03 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Evolving A RIG-I Antagonist: A Modified DNA Aptamer Mimics Viral RNA.
J.Mol.Biol., 433, 2021
|
|
7P8R
 | |
6OHH
 | | Structure of EF1p2_mFAP2b bound to DFHBI | | 分子名称: | (5Z)-5-(3,5-difluoro-4-hydroxybenzylidene)-2,3-dimethyl-3,5-dihydro-4H-imidazol-4-one, CALCIUM ION, EF1p2_mFAP2b | | 著者 | Doyle, L.A, Stoddard, B.L. | | 登録日 | 2019-04-05 | | 公開日 | 2020-04-08 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Incorporation of sensing modalities into de novo designed fluorescence-activating proteins
Nat Commun, 12, 2021
|
|
6M7K
 | | Structure of mouse RECON (AKR1C13) in complex with cyclic AMP-AMP-GMP (cAAG) | | 分子名称: | 1,2-ETHANEDIOL, Aldo-keto reductase family 1 member C13, cyclic AMP-AMP-GMP | | 著者 | Eaglesham, J.B, Whiteley, A.T, de Oliveira Mann, C.C, Morehouse, B.R, Nieminen, E.A, King, D.S, Lee, A.S.Y, Mekalanos, J.J, Kranzusch, P.J. | | 登録日 | 2018-08-20 | | 公開日 | 2019-02-20 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | | 主引用文献 | Bacterial cGAS-like enzymes synthesize diverse nucleotide signals.
Nature, 567, 2019
|
|
7P3B
 | | Human RNA ligase RTCB in complex with GMP and Co(II) | | 分子名称: | ACETATE ION, COBALT (II) ION, FORMIC ACID, ... | | 著者 | Kroupova, A, Ackle, F, Jinek, M. | | 登録日 | 2021-07-07 | | 公開日 | 2021-12-22 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Molecular architecture of the human tRNA ligase complex.
Elife, 10, 2021
|
|
6M9C
 | | PSEUDOMONAS SERINE-CARBOXYL PROTEINASE (SEDOLISIN) COMPLEXED WITH THE INHIBITOR Pseudotyrostatin | | 分子名称: | ACETIC ACID, CALCIUM ION, Pseudotyrostatin, ... | | 著者 | Wlodawer, A, Li, M, Gustchina, A, Dauter, Z, Uchida, K, Oyama, H, Goldfarb, N.E, Dunn, B.M, Oda, K. | | 登録日 | 2018-08-23 | | 公開日 | 2018-10-24 | | 最終更新日 | 2024-07-10 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Inhibitor complexes of the Pseudomonas serine-carboxyl proteinase
Biochemistry, 40, 2001
|
|
9BIZ
 | |
8WO0
 | | CryoEM structure of ZIKV rsNS1 filament | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Non-structural protein 1 | | 著者 | Chew, B.L.A, Luo, D. | | 登録日 | 2023-10-06 | | 公開日 | 2024-05-08 | | 実験手法 | ELECTRON MICROSCOPY (8 Å) | | 主引用文献 | Structural basis of Zika virus NS1 multimerization and human antibody recognition
Npj Viruses, 2, 2024
|
|
8WKT
 | | Cryo-EM structure of DSR2-DSAD1 complex | | 分子名称: | SIR2-like domain-containing protein, SPbeta prophage-derived uncharacterized protein YotI | | 著者 | Gao, A, Huang, J, Zhu, K. | | 登録日 | 2023-09-28 | | 公開日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (3.86 Å) | | 主引用文献 | Molecular basis of bacterial DSR2 anti-phage defense and viral immune evasion.
Nat Commun, 15, 2024
|
|
8UX5
 | |
6OJ1
 | | Crystal Structure of Aspergillus fumigatus Ega3 | | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Bamford, N.C, Subramanian, A.S, Millan, C, Uson, I, Howell, P.L. | | 登録日 | 2019-04-10 | | 公開日 | 2019-08-14 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | | 主引用文献 | Ega3 from the fungal pathogenAspergillus fumigatusis an endo-alpha-1,4-galactosaminidase that disrupts microbial biofilms.
J.Biol.Chem., 294, 2019
|
|
8DO5
 | | Crystal structure of NahE in complex with intermediate (R)-4-hydroxy-4-(2-hydroxyphenyl)-2-iminobutanoate | | 分子名称: | (4R)-4-hydroxy-4-(2-hydroxyphenyl)butanoic acid, DIMETHYL SULFOXIDE, Trans-ohydrobenzylidenepyruvate hydratase aldolase | | 著者 | LeVieux, J.A, Hardtke, H.A, Zhang, Y.J. | | 登録日 | 2022-07-12 | | 公開日 | 2022-12-28 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | A mutagenic analysis of NahE, a hydratase-aldolase in the naphthalene degradative pathway.
Arch.Biochem.Biophys., 733, 2023
|
|
7A5Z
 | | Structure of VIM-2 metallo-beta-lactamase with hydrolysed Faropenem imine product | | 分子名称: | (5~{Z})-2-[1,3-bis(oxidanyl)-1-oxidanylidene-butan-2-yl]-5-(4-oxidanylbutylidene)-2~{H}-1,3-thiazole-4-carboxylic acid, Beta-lactamase VIM-2, CHLORIDE ION, ... | | 著者 | Lucic, A, Schofield, C.J. | | 登録日 | 2020-08-24 | | 公開日 | 2021-02-24 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.29 Å) | | 主引用文献 | Faropenem reacts with serine and metallo-beta-lactamases to give multiple products.
Eur.J.Med.Chem., 215, 2021
|
|
7M95
 | | Bovine sigma-2 receptor bound to Z1241145220 | | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 3-[1-(3-phenylpropyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine, CHOLESTEROL, ... | | 著者 | Alon, A, Kruse, A.C. | | 登録日 | 2021-03-30 | | 公開日 | 2021-12-15 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.41 Å) | | 主引用文献 | Structures of the sigma 2 receptor enable docking for bioactive ligand discovery.
Nature, 600, 2021
|
|
