7P3C

EED in complex with compound 4

Summary for 7P3C

• Entry DOI: 10.2210/pdb7p3c/pdb
• Descriptor: Polycomb protein EED, N-(2,3-dihydro-1-benzofuran-4-ylmethyl)-8-(4-methylsulfonylphenyl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine, N-[5-[(5-fluoranyl-2,3-dihydro-1-benzofuran-4-yl)methylamino]-[1,2,4]triazolo[4,3-c]pyrimidin-8-yl]benzamide, ... (4 entities in total)
• Functional Keywords: methyl transferase eed prc2 epigenetic h3k27 wd40 inhibitor, protein binding
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 85424.26

Authors

Read, J.A. (deposition date: 2021-07-07, release date: 2021-12-08, Last modification date: 2024-01-31)

• Primary citation: Bagal, S.K.,Gregson, C.,O' Donovan, D.H.,Pike, K.G.,Bloecher, A.,Barton, P.,Borodovsky, A.,Code, E.,Fillery, S.M.,Hsu, J.H.,Kawatkar, S.P.,Li, C.,Longmire, D.,Nai, Y.,Nash, S.C.,Pike, A.,Robinson, J.,Read, J.A.,Rawlins, P.B.,Shen, M.,Tang, J.,Wang, P.,Woods, H.,Williamson, B.; Diverse, Potent, and Efficacious Inhibitors That Target the EED Subunit of the Polycomb Repressive Complex 2 Methyltransferase.; J.Med.Chem., 64:17146-17183, 2021; PubMed: 34807608; DOI: 10.1021/acs.jmedchem.1c01161

Experimental method

X-RAY DIFFRACTION (1.61 Å)