5I0Y
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5IF1
| Crystal structure apo CDK2/cyclin A | 分子名称: | Cyclin-A2, Cyclin-dependent kinase 2 | 著者 | Ayaz, P, Andres, D, Kwiatkowski, D.A, Kolbe, C, Lienau, P, Siemeister, G, Luecking, U, Stegmann, C.M. | 登録日 | 2016-02-25 | 公開日 | 2016-04-27 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.61 Å) | 主引用文献 | Conformational Adaption May Explain the Slow Dissociation Kinetics of Roniciclib (BAY 1000394), a Type I CDK Inhibitor with Kinetic Selectivity for CDK2 and CDK9. Acs Chem.Biol., 11, 2016
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3PD1
| Caspase-3 K242A | 分子名称: | Caspase-3, Inhibitor Ac-DEVD-CMK | 著者 | Walters, J, Swartz, P, Mattos, C, Clark, A.C. | 登録日 | 2010-10-22 | 公開日 | 2011-02-23 | 最終更新日 | 2013-02-27 | 実験手法 | X-RAY DIFFRACTION (1.62 Å) | 主引用文献 | Thermodynamic, enzymatic and structural effects of removing a salt bridge at the base of loop 4 in (pro)caspase-3. Arch.Biochem.Biophys., 508, 2011
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6T04
| Crystal structure of YTHDC1 with fragment 17 (DHU_DC1_042) | 分子名称: | 2-phenyl-4,5-dihydro-1~{H}-imidazole, SULFATE ION, YTH domain-containing protein 1 | 著者 | Bedi, R.K, Huang, D, Sledz, P, Caflisch, A. | 登録日 | 2019-10-02 | 公開日 | 2020-03-04 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Selectively Disrupting m6A-Dependent Protein-RNA Interactions with Fragments. Acs Chem.Biol., 15, 2020
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8D3O
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8D3I
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7AUD
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5AJV
| Human PFKFB3 in complex with an indole inhibitor 1 | 分子名称: | (2S)-2-amino-N-[4-[(2-amino-3-cyano-1H-indol-5-yl)oxy]phenyl]-3-hydroxy-propanamide, 2,6-di-O-phosphono-beta-D-fructofuranose, HUMAN PFKFB3, ... | 著者 | Boyd, S, Brookfield, J.L, Critchlow, S.E, Cumming, I.A, Curtis, N.J, Debreczeni, J.E, Degorce, S.L, Donald, C, Evans, N.J, Groombridge, S, Hopcroft, P, Jones, N.P, Kettle, J.G, Lamont, S, Lewis, H.J, MacFaull, P, McLoughlin, S.B, Rigoreau, L.J.M, Smith, J.M, St-Gallay, S, Stock, J.K, Wheatley, E.R, Winter, J, Wingfield, J. | 登録日 | 2015-02-27 | 公開日 | 2015-04-22 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (3.01 Å) | 主引用文献 | Structure-Based Design of Potent and Selective Inhibitors of the Metabolic Kinase Pfkfb3. J.Med.Chem., 58, 2015
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6SSM
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6T12
| Crystal structure of YTHDC1 with fragment 30 (DHU_DC1_220) | 分子名称: | SULFATE ION, YTHDC1, ~{N},2,3-trimethyl-1~{H}-indole-5-carboxamide | 著者 | Bedi, R.K, Huang, D, Sledz, P, Caflisch, A. | 登録日 | 2019-10-03 | 公開日 | 2020-03-04 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.46 Å) | 主引用文献 | Selectively Disrupting m6A-Dependent Protein-RNA Interactions with Fragments. Acs Chem.Biol., 15, 2020
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8D3N
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5A16
| Crystal structure of Fab4201 raised against Human Erythrocyte Anion Exchanger 1 | 分子名称: | FAB4201 HEAVY CHAIN | 著者 | Arakawa, T, Kobayashi-Yugiri, T, Alguel, Y, Weyand, S, Iwanari, H, Hatae, H, Iwata, M, Abe, Y, Hino, T, Ikeda-Suno, C, Kuma, H, Kang, D, Murata, T, Hamakubo, T, Cameron, A, Kobayashi, T, Hamasaki, N, Iwata, S. | 登録日 | 2015-04-28 | 公開日 | 2015-06-10 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Crystal Structure of the Anion Exchanger Domain of Human Erythrocyte Band 3 Science, 350, 2015
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7ENU
| Crystal structure of iron-saturated C-terminal half of lactoferrin produced proteolytically using pepsin at 2.32A resolution | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CARBONATE ION, FE (III) ION, ... | 著者 | Singh, J, Maurya, A, Viswanathan, V, Singh, P.K, Sharma, P, Sharma, S, Singh, T.P. | 登録日 | 2021-04-19 | 公開日 | 2021-05-19 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.322 Å) | 主引用文献 | Crystal structure of iron-saturated C-terminal half of lactoferrin produced proteolytically using pepsin at 2.32A resolution To Be Published
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3C8H
| Crystal structure of the enterobactin esterase FES from Shigella flexneri in the presence of 2,3-Di-hydroxy-N-benzoyl-serine | 分子名称: | Enterochelin esterase | 著者 | Kim, Y, Maltseva, N, Abergel, R, Holzle, D, Raymond, K, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | 登録日 | 2008-02-12 | 公開日 | 2008-02-26 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.48 Å) | 主引用文献 | Siderophore Mediated Iron Acquisition: Structure and Specificity of Enterobactin Esterase from Shigella flexneri. To be Published
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8CR2
| Homo sapiens Get1/Get2 heterotetramer (a3' deletion variant) in complex with a Get3 dimer | 分子名称: | ATPase ASNA1, Guided entry of tail-anchored proteins factor CAMLG,Guided entry of tail-anchored proteins factor 1, ZINC ION | 著者 | McDowell, M.A, Heimes, M, Wild, K, Sinning, I. | 登録日 | 2023-03-07 | 公開日 | 2023-11-29 | 最終更新日 | 2024-10-09 | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | 主引用文献 | The GET insertase exhibits conformational plasticity and induces membrane thinning. Nat Commun, 14, 2023
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8B30
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7RXV
| Human Methionine Adenosyltransferase 2A bound to Methylthioadenosine, Malonate (MLA) and MgF3 | 分子名称: | 5'-DEOXY-5'-METHYLTHIOADENOSINE, ALANINE, GLYCEROL, ... | 著者 | Fedorov, E, Niland, C.N, Schramm, V.L, Ghosh, A. | 登録日 | 2021-08-23 | 公開日 | 2021-11-03 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.07 Å) | 主引用文献 | Mechanism of Triphosphate Hydrolysis by Human MAT2A at 1.07 angstrom Resolution. J.Am.Chem.Soc., 143, 2021
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7YH6
| Structure of SARS-CoV-2 spike RBD in complex with neutralizing antibody NIV-8 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, NIV-8 Fab heavy chain, NIV-8 Fab light chain, ... | 著者 | Moriyama, S, Anraku, Y, Muranishi, S, Adachi, Y, Kuroda, D, Higuchi, Y, Kotaki, R, Tonouchi, K, Yumoto, K, Suzuki, T, Kita, S, Someya, T, Fukuhara, H, Kuroda, Y, Yamamoto, T, Onodera, T, Fukushi, S, Maeda, K, Nakamura-Uchiyama, F, Hashiguchi, T, Hoshino, A, Maenaka, K, Takahashi, Y. | 登録日 | 2022-07-12 | 公開日 | 2023-07-19 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Structural delineation and computational design of SARS-CoV-2-neutralizing antibodies against Omicron subvariants. Nat Commun, 14, 2023
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4DC6
| Crystal Structure of Thaumatin Exposed to Excessive SONICC Imaging Laser Dose. | 分子名称: | GLYCEROL, L(+)-TARTARIC ACID, Thaumatin I | 著者 | Mulichak, A.M, Becker, M, Kissick, D.J, Keefe, L.J, Fischetti, R.F, Simpson, G.J. | 登録日 | 2012-01-17 | 公開日 | 2013-01-23 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.48 Å) | 主引用文献 | Towards protein-crystal centering using second-harmonic generation (SHG) microscopy. Acta Crystallogr.,Sect.D, 69, 2013
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7AGI
| The structure of Artemis variant H35D | 分子名称: | 1,2-ETHANEDIOL, Protein artemis, ZINC ION | 著者 | Yosaatmadja, Y, Goubin, S, Newman, J.A, Mukhopadhyay, S.M.M, Dannerfjord, A.A, Burgess-Brown, N.A, von Delft, F, Arrowsmith, C.H, Bountra, C, Gileadi, O. | 登録日 | 2020-09-22 | 公開日 | 2020-10-28 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structural and mechanistic insights into the Artemis endonuclease and strategies for its inhibition. Nucleic Acids Res., 49, 2021
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5LLP
| Crystal structure of human carbonic anhydrase isozyme XII with 3-[(1S)-1,2,3,4-Tetrahydronapthalen-1-ylamino)-2,5,6-trifluoro-4-[(2-hydroxyethyl)sulfonyl]benzenesulfonamide | 分子名称: | 3-[(1S)-1,2,3,4-Tetrahydronapthalen-1-ylamino)-2,5,6-trifluoro-4-[(2-hydroxyethyl)sulfonyl]benzenesulfonamide, Carbonic anhydrase 12, ZINC ION | 著者 | Smirnov, A, Manakova, E, Grazulis, S. | 登録日 | 2016-07-28 | 公開日 | 2017-08-16 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.48 Å) | 主引用文献 | Crystal structure correlations with the intrinsic thermodynamics of human carbonic anhydrase inhibitor binding. PeerJ, 6, 2018
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5LUN
| Ethylene Forming Enzyme from Pseudomonas syringae pv. phaseolicola - P1 ultra-high resolution crystal form in complex with iron, N-oxalylglycine and arginine | 分子名称: | 2-oxoglutarate-dependent ethylene/succinate-forming enzyme, ARGININE, FE (III) ION, ... | 著者 | McDonough, M.A, Zhang, Z, Schofield, C.J. | 登録日 | 2016-09-09 | 公開日 | 2017-04-19 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.08 Å) | 主引用文献 | Structural and stereoelectronic insights into oxygenase-catalyzed formation of ethylene from 2-oxoglutarate. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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8CR1
| Homo sapiens Get1/Get2 heterotetramer in complex with a Get3 dimer | 分子名称: | ATPase ASNA1, Guided entry of tail-anchored proteins factor CAMLG,Guided entry of tail-anchored proteins factor 1,GET2-GET1, ZINC ION | 著者 | McDowell, M.A, Heimes, M, Wild, K, Sinning, I. | 登録日 | 2023-03-07 | 公開日 | 2023-11-29 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | The GET insertase exhibits conformational plasticity and induces membrane thinning. Nat Commun, 14, 2023
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6PQG
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2Y1H
| Crystal structure of the human TatD-domain protein 3 (TATDN3) | 分子名称: | 1,2-ETHANEDIOL, NICKEL (II) ION, PHOSPHATE ION, ... | 著者 | Muniz, J.R.C, Puranik, S, Krojer, T, Yue, W.W, Ugochukwu, E, Filippakopoulos, P, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Bountra, C, Kavanagh, K.L, Oppermann, U. | 登録日 | 2010-12-08 | 公開日 | 2010-12-29 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Crystal Structure of the Human Tatd-Domain Protein 3 (Tatdn3) To be Published
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