6OUB
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4ZTE
| Crystal structure of human E-Cadherin (residues 3-213) in complex with a peptidomimetic inhibitor | Descriptor: | CALCIUM ION, Cadherin-1, N-{[(2S,5S)-1-benzyl-5-(2-{[(2S,3S)-1-(tert-butylamino)-3-methyl-1-oxopentan-2-yl]amino}-2-oxoethyl)-3,6-dioxopiperazin-2-yl]methyl}-L-alpha-asparagine | Authors: | Nardone, V, Lucarelli, A.P, Dalle Vedove, A, Parisini, E. | Deposit date: | 2015-05-14 | Release date: | 2016-06-01 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.13 Å) | Cite: | Crystal Structure of Human E-Cadherin-EC1EC2 in Complex with a Peptidomimetic Competitive Inhibitor of Cadherin Homophilic Interaction. J.Med.Chem., 59, 2016
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6BKO
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5NIO
| EthR complex | Descriptor: | HTH-type transcriptional regulator EthR, SULFATE ION, ~{N}-butyl-4-methyl-piperidine-1-carboxamide | Authors: | Pohl, E, Tatum, N.J, Cole, J.C, Baulard, A.R. | Deposit date: | 2017-03-24 | Release date: | 2017-11-15 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | New active leads for tuberculosis booster drugs by structure-based drug discovery. Org. Biomol. Chem., 15, 2017
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6Y43
| Fibrinogen-like globe domain of human ANGPTL6 | Descriptor: | 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Angiopoietin-related protein 6, ... | Authors: | Coker, J.A, Krojer, T, Mutisya, J.M, Arrowsmith, C.H, Bountra, C, Midwood, K.S, Yue, W.W, Marsden, B.D, Structural Genomics Consortium (SGC) | Deposit date: | 2020-02-19 | Release date: | 2020-03-04 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Fibrinogen-like globe domain of human ANGPTL6 To Be Published
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4UCM
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1AMY
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6BKS
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6RH2
| Revisiting pH-gated conformational switch. Complex HK853-RR468 D53A pH 5.3 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Response regulator, SULFATE ION, ... | Authors: | Mideros-Mora, C, Casino, P, Marina, A. | Deposit date: | 2019-04-18 | Release date: | 2020-02-19 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Revisiting the pH-gated conformational switch on the activities of HisKA-family histidine kinases. Nat Commun, 11, 2020
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6NAX
| Olfactomedin domain of mouse myocilin | Descriptor: | CALCIUM ION, GLYCEROL, Myocilin, ... | Authors: | Patterson-Orazem, A.C, Hill, S.E, Lieberman, R.L. | Deposit date: | 2018-12-06 | Release date: | 2019-03-13 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.551 Å) | Cite: | Differential Misfolding Properties of Glaucoma-Associated Olfactomedin Domains from Humans and Mice. Biochemistry, 58, 2019
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6NB9
| Amyloid-Beta (20-34) with L-isoaspartate 23 | Descriptor: | Amyloid-beta A4 protein | Authors: | Sawaya, M.R, Warmack, R.A, Boyer, D.R, Zee, C.T, Richards, L.S, Cascio, D, Gonen, T, Clarke, S.G, Eisenberg, D.S. | Deposit date: | 2018-12-06 | Release date: | 2019-08-07 | Last modified: | 2022-09-07 | Method: | ELECTRON CRYSTALLOGRAPHY (1.05 Å) | Cite: | Structure of amyloid-beta (20-34) with Alzheimer's-associated isomerization at Asp23 reveals a distinct protofilament interface. Nat Commun, 10, 2019
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6RHQ
| Crystal Structure of Two-Domain Laccase mutant I170A from Streptomyces griseoflavus | Descriptor: | COPPER (II) ION, GLYCEROL, SULFATE ION, ... | Authors: | Gabdulkhakov, A.G, Tishchenko, T.V, Kolyadenko, I.A. | Deposit date: | 2019-04-22 | Release date: | 2019-07-17 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.98 Å) | Cite: | Investigations of Accessibility of T2/T3 Copper Center of Two-Domain Laccase fromStreptomyces griseoflavusAc-993. Int J Mol Sci, 20, 2019
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7ZTR
| Crystal structure of the carotenoid-binding protein domain from silkworm Bombyx mori (BmCBP) in the apoform, W232F mutant | Descriptor: | Carotenoid-binding protein | Authors: | Sluchanko, N.N, Boyko, K.M, Varfolomeeva, L.A, Slonimskiy, Y.B, Egorkin, N.A, Maksimov, E.G, Popov, V.O. | Deposit date: | 2022-05-11 | Release date: | 2022-10-26 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Silkworm carotenoprotein as an efficient carotenoid extractor, solubilizer and transporter. Int.J.Biol.Macromol., 223, 2022
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7JQ7
| The Phi-28 gp11 DNA packaging Motor | Descriptor: | Encapsidation protein, IODIDE ION, SULFATE ION | Authors: | Morais, M.C, White, M.A, Dill, E. | Deposit date: | 2020-08-10 | Release date: | 2021-06-16 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.895 Å) | Cite: | Atomistic basis of force generation, translocation, and coordination in a viral genome packaging motor. Nucleic Acids Res., 49, 2021
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8PP0
| Crystal structure of Retinoic Acid Receptor alpha (RXRA) in complexed with JP147 | Descriptor: | 3-[4-[2,3-dihydro-1H-inden-4-yl(methyl)amino]-6-(trifluoromethyl)pyrimidin-2-yl]oxypropanoic acid, Nuclear receptor coactivator 2, Retinoic acid receptor RXR-alpha | Authors: | Chaikuad, A, Pollinger, J, Merk, D, Knapp, S, Structural Genomics Consortium (SGC) | Deposit date: | 2023-07-05 | Release date: | 2024-02-07 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structure-Guided Design of a Highly Potent Partial RXR Agonist with Superior Physicochemical Properties. J.Med.Chem., 67, 2024
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5KW2
| The extra-helical binding site of GPR40 and the structural basis for allosteric agonism and incretin stimulation | Descriptor: | (3~{S})-3-cyclopropyl-3-[2-[1-[2-[2,2-dimethylpropyl-(6-methylpyridin-2-yl)carbamoyl]-5-methoxy-phenyl]piperidin-4-yl]-1-benzofuran-6-yl]propanoic acid, Free fatty acid receptor 1,Lysozyme,Free fatty acid receptor 1 | Authors: | Ho, J.D, Chau, B, Rodgers, L, Lu, F, Wilbur, K.L, Otto, K.A, Chen, Y, Song, M, Riley, J.P, Yang, H.-C, Reynolds, N.A, Kahl, S.D, Lewis, A.P, Groshong, C, Madsen, R.E, Conners, K, Linswala, J.P, Gheyi, T, Saflor, M.D, Lee, M.R, Benach, J, Baker, K.A, Montrose-Rafizadeh, C, Genin, M.J, Miller, A.R, Hamdouchi, C. | Deposit date: | 2016-07-15 | Release date: | 2018-05-02 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.76 Å) | Cite: | Structural basis for GPR40 allosteric agonism and incretin stimulation. Nat Commun, 9, 2018
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7JPJ
| Crystal Structure of the essential dimeric LYSA from Phaeodactylum tricornutum | Descriptor: | D-LYSINE, Diaminopimelate decarboxylase, SULFATE ION | Authors: | Fedorov, E, Belinski, V.A, Brunson, J.K, Almo, S.C, Dupont, C.L, Ghosh, A. | Deposit date: | 2020-08-08 | Release date: | 2021-06-16 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.78 Å) | Cite: | The Phaeodactylum tricornutum diaminopimelate decarboxylase was acquired via horizontal gene transfer from bacteria and displays substrate promiscuity Biorxiv, 2020
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6GH4
| HLA-E*01:03 in complex with the Mtb44 peptide variant: Mtb44*P2-Gln. | Descriptor: | ARG-GLN-PRO-ALA-LYS-ALA-PRO-LEU-LEU, Beta-2-microglobulin, MHC class I antigen, ... | Authors: | Walters, L.C, Gillespie, G.M, McMichael, A.J, Rozbesky, D, Jones, E.Y, Harlos, K. | Deposit date: | 2018-05-04 | Release date: | 2018-08-08 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.16 Å) | Cite: | Pathogen-derived HLA-E bound epitopes reveal broad primary anchor pocket tolerability and conformationally malleable peptide binding. Nat Commun, 9, 2018
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5KOV
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7T89
| Light harvesting complex Phycocyanin PC577 from the cryptophyte Hemiselmis pacifica CCMP 706 | Descriptor: | DiCys-(15,16)-Dihydrobiliverdin, PHYCOCYANOBILIN, Phycoerythrin alpha subunit 1, ... | Authors: | Michie, K.A, Curmi, P.C, Harrop, S, Rathbone, H.W. | Deposit date: | 2021-12-16 | Release date: | 2023-02-15 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1 Å) | Cite: | Molecular structures reveal the origin of spectral variation in cryptophyte light harvesting antenna proteins. Protein Sci., 32, 2023
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7T8S
| Light Harvesting complex phycoerythrin PE 566, from the cryptophyte Cryptomonas pyrenoidifera | Descriptor: | Bilin 584 (doubly linked), Bilin 584 (single linked), Bilin 618 (single linked), ... | Authors: | Michie, K.A, Harrop, S.J, Rathbone, H.W, Wilk, K.E, Curmi, P.M.G. | Deposit date: | 2021-12-17 | Release date: | 2023-02-15 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Molecular structures reveal the origin of spectral variation in cryptophyte light harvesting antenna proteins. Protein Sci., 32, 2023
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7JQ6
| The Phi-28 gp11 DNA packaging Motor | Descriptor: | Encapsidation protein, SULFATE ION | Authors: | Morais, M.C, White, M.A, Dill, E. | Deposit date: | 2020-08-10 | Release date: | 2021-06-16 | Last modified: | 2021-07-14 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Atomistic basis of force generation, translocation, and coordination in a viral genome packaging motor. Nucleic Acids Res., 49, 2021
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6RJD
| Cryo-EM structure of St1Cas9-sgRNA-tDNA59-ntPAM complex. | Descriptor: | Streptococcus Thermophilus 1 Cas9, ntPAM, sgRNA (78-MER), ... | Authors: | Goulet, A, Chaves-Sanjuan, A, Cambillau, C. | Deposit date: | 2019-04-26 | Release date: | 2019-10-02 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Cas9 Allosteric Inhibition by the Anti-CRISPR Protein AcrIIA6. Mol.Cell, 76, 2019
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6NJ1
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7K75
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