1BD3
 
 | | STRUCTURE OF THE APO URACIL PHOSPHORIBOSYLTRANSFERASE, 2 MUTANT C128V | | Descriptor: | PHOSPHATE ION, URACIL PHOSPHORIBOSYLTRANSFERASE | | Authors: | Schumacher, M.A, Carter, D, Scott, D, Roos, D, Ullman, B, Brennan, R.G. | | Deposit date: | 1998-05-12 | | Release date: | 1999-05-18 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.93 Å) | | Cite: | Crystal structures of Toxoplasma gondii uracil phosphoribosyltransferase reveal the atomic basis of pyrimidine discrimination and prodrug binding.
EMBO J., 17, 1998
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1BD4
 | | UPRT-URACIL COMPLEX | | Descriptor: | PHOSPHATE ION, URACIL, URACIL PHOSPHORIBOSYLTRANSFERASE | | Authors: | Schumacher, M.A, Carter, D, Scott, D, Roos, D, Ullman, B, Brennan, R.G. | | Deposit date: | 1998-05-12 | | Release date: | 1999-05-18 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Crystal structures of Toxoplasma gondii uracil phosphoribosyltransferase reveal the atomic basis of pyrimidine discrimination and prodrug binding.
EMBO J., 17, 1998
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6U9X
 | | Structure of T. brucei MERS1-RNA complex | | Descriptor: | Mitochondrial edited mRNA stability factor 1, RNA (5'-R(*GP*AP*GP*AP*GP*GP*GP*GP*GP*UP*U)-3') | | Authors: | Schumacher, M.A. | | Deposit date: | 2019-09-09 | | Release date: | 2019-11-06 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structures of MERS1, the 5' processing enzyme of mitochondrial mRNAs inTrypanosoma brucei.
Rna, 26, 2020
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6UMK
 | | Structure of E. coli FtsZ(L178E)-GDP complex | | Descriptor: | Cell division protein FtsZ, GUANOSINE-5'-DIPHOSPHATE | | Authors: | Schumacher, M.A. | | Deposit date: | 2019-10-09 | | Release date: | 2020-02-05 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (1.35 Å) | | Cite: | High-resolution crystal structures of Escherichia coli FtsZ bound to GDP and GTP.
Acta Crystallogr.,Sect.F, 76, 2020
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1HAC
 | | CROSSLINKED HAEMOGLOBIN | | Descriptor: | 2,6-DICARBOXYNAPHTHALENE, CARBON MONOXIDE, HEMOGLOBIN A, ... | | Authors: | Schumacher, M.A, Dixon, M.M, Kluger, R, Jones, R.T, Brennan, R.G. | | Deposit date: | 1996-03-13 | | Release date: | 1997-11-12 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Allosteric intermediates indicate R2 is the liganded hemoglobin end state.
Proc.Natl.Acad.Sci.USA, 94, 1997
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6UNX
 | | Structure of E. coli FtsZ(L178E)-GTP complex | | Descriptor: | Cell division protein FtsZ, GUANOSINE-5'-TRIPHOSPHATE | | Authors: | Schumacher, M.A. | | Deposit date: | 2019-10-13 | | Release date: | 2020-02-05 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | High-resolution crystal structures of Escherichia coli FtsZ bound to GDP and GTP.
Acta Crystallogr.,Sect.F, 76, 2020
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1PNR
 | | PURINE REPRESSOR-HYPOXANTHINE-PURF-OPERATOR COMPLEX | | Descriptor: | DNA (5'-D(*AP*AP*CP*GP*AP*AP*AP*AP*CP*GP*TP*TP*TP*TP*CP*GP*T )-3'), HYPOXANTHINE, PROTEIN (PURINE REPRESSOR) | | Authors: | Schumacher, M.A, Choi, K.Y, Zalkin, H, Brennan, R.G. | | Deposit date: | 1995-03-29 | | Release date: | 1995-11-20 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Crystal structure of LacI member, PurR, bound to DNA: minor groove binding by alpha helices.
Science, 266, 1994
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1DBQ
 | | DNA-BINDING REGULATORY PROTEIN | | Descriptor: | MAGNESIUM ION, PURINE REPRESSOR | | Authors: | Schumacher, M.A, Choi, K.Y, Lu, F, Zalkin, H, Brennan, R.G. | | Deposit date: | 1996-02-13 | | Release date: | 1996-12-07 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Mechanism of corepressor-mediated specific DNA binding by the purine repressor.
Cell(Cambridge,Mass.), 83, 1995
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3HZI
 | | Structure of mdt protein | | Descriptor: | 5'-D(*DAP*DCP*DTP*DAP*DTP*DCP*DCP*DCP*DCP*DTP*DTP*DAP*DAP*DGP*DGP*DGP*DGP*DAP*DTP*DAP*DG)-3', ADENOSINE-5'-TRIPHOSPHATE, HTH-type transcriptional regulator hipB, ... | | Authors: | Schumacher, M.A. | | Deposit date: | 2009-06-23 | | Release date: | 2009-07-28 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.98 Å) | | Cite: | Molecular mechanisms of HipA-mediated multidrug tolerance and its neutralization by HipB.
Science, 323, 2009
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1ZX4
 | | Structure of ParB bound to DNA | | Descriptor: | CITRIC ACID, Plasmid Partition par B protein, parS-small DNA centromere site | | Authors: | Schumacher, M.A, Funnell, B.E. | | Deposit date: | 2005-06-06 | | Release date: | 2005-11-29 | | Last modified: | 2017-10-04 | | Method: | X-RAY DIFFRACTION (2.98 Å) | | Cite: | Structures of ParB bound to DNA reveal mechanism of partition complex formation.
Nature, 438, 2005
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4E03
 | | Structure of ParF-ADP form 2 | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Plasmid partitioning protein ParF | | Authors: | Schumacher, M.A, Ye, Q, Barge, M.R, Barilla, D, Hayes, F. | | Deposit date: | 2012-03-02 | | Release date: | 2012-06-13 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.45 Å) | | Cite: | Structural Mechanism of ATP-induced Polymerization of the Partition Factor ParF: IMPLICATIONS FOR DNA SEGREGATION.
J.Biol.Chem., 287, 2012
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4DZZ
 | | Structure of ParF-ADP, crystal form 1 | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Plasmid partitioning protein ParF | | Authors: | Schumacher, M.A, Ye, Q, Barge, M.R, Barilla, D, Hayes, F. | | Deposit date: | 2012-03-01 | | Release date: | 2012-06-13 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Structural Mechanism of ATP-induced Polymerization of the Partition Factor ParF: IMPLICATIONS FOR DNA SEGREGATION.
J.Biol.Chem., 287, 2012
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4E09
 | | Structure of ParF-AMPPCP, I422 form | | Descriptor: | PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, Plasmid partitioning protein ParF, SULFATE ION | | Authors: | Schumacher, M.A, Ye, Q, Barge, M.R, Barilla, D, Hayes, F. | | Deposit date: | 2012-03-02 | | Release date: | 2012-06-13 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.99 Å) | | Cite: | Structural Mechanism of ATP-induced Polymerization of the Partition Factor ParF: IMPLICATIONS FOR DNA SEGREGATION.
J.Biol.Chem., 287, 2012
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4E07
 | | ParF-AMPPCP-C2221 form | | Descriptor: | PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, Plasmid partitioning protein ParF | | Authors: | Schumacher, M.A, Ye, Q, Barge, M.R, Barilla, D, Hayes, F. | | Deposit date: | 2012-03-02 | | Release date: | 2012-06-13 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Structural Mechanism of ATP-induced Polymerization of the Partition Factor ParF: IMPLICATIONS FOR DNA SEGREGATION.
J.Biol.Chem., 287, 2012
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3MKZ
 | | Structure of SopB(155-272)-18mer complex, P21 form | | Descriptor: | CALCIUM ION, DNA (5'-D(*CP*TP*GP*GP*GP*AP*CP*CP*AP*TP*GP*GP*TP*CP*CP*CP*AP*G)-3'), Protein sopB | | Authors: | Schumacher, M.A. | | Deposit date: | 2010-04-15 | | Release date: | 2010-05-05 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.98 Å) | | Cite: | Insight into F plasmid DNA segregation revealed by structures of SopB and SopB-DNA complexes.
Nucleic Acids Res., 38, 2010
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3MKW
 | | Structure of sopB(155-272)-18mer complex, I23 form | | Descriptor: | DNA (5'-D(*CP*TP*GP*GP*GP*AP*CP*CP*AP*TP*GP*GP*TP*CP*CP*CP*AP*G)-3'), Protein sopB, SULFATE ION | | Authors: | Schumacher, M.A, Piro, K, Xu, W. | | Deposit date: | 2010-04-15 | | Release date: | 2010-05-05 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.99 Å) | | Cite: | Insight into F plasmid DNA segregation revealed by structures of SopB and SopB-DNA complexes.
Nucleic Acids Res., 38, 2010
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3MKY
 | | Structure of SopB(155-323)-18mer DNA complex, I23 form | | Descriptor: | DNA (5'-D(*CP*TP*GP*GP*GP*AP*CP*CP*AP*TP*GP*GP*TP*CP*CP*CP*AP*G)-3'), Protein sopB, SULFATE ION | | Authors: | Schumacher, M.A, Piro, K, Xu, W. | | Deposit date: | 2010-04-15 | | Release date: | 2010-05-05 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.86 Å) | | Cite: | Insight into F plasmid DNA segregation revealed by structures of SopB and SopB-DNA complexes.
Nucleic Acids Res., 38, 2010
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3OQN
 | | Structure of ccpa-hpr-ser46-p-gntr-down cre | | Descriptor: | 5'-D(*AP*TP*GP*GP*TP*AP*CP*CP*GP*CP*TP*TP*TP*CP*AP*A)-3', 5'-D(*TP*TP*GP*AP*AP*AP*GP*CP*GP*GP*TP*AP*CP*CP*AP*T)-3', Catabolite control protein A, ... | | Authors: | Schumacher, M.A, Sprehe, M, Bartholomae, M, Hillen, W, Brennan, R.G. | | Deposit date: | 2010-09-03 | | Release date: | 2010-12-08 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (3.3 Å) | | Cite: | Structures of carbon catabolite protein A-(HPr-Ser46-P) bound to diverse catabolite response element sites reveal the basis for high-affinity binding to degenerate DNA operators.
Nucleic Acids Res., 39, 2011
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3OQO
 | | Ccpa-hpr-ser46p-syn cre | | Descriptor: | 5'-D(*CP*TP*GP*AP*AP*AP*GP*CP*GP*CP*TP*AP*AP*CP*AP*G)-3', 5'-D(*CP*TP*GP*TP*TP*AP*GP*CP*GP*CP*TP*TP*TP*CP*AP*G)-3', Catabolite control protein A, ... | | Authors: | schumacher, M.A, Sprehe, M, Bartholomae, M, Hillen, W, Brennan, R.G. | | Deposit date: | 2010-09-03 | | Release date: | 2011-10-26 | | Last modified: | 2014-04-09 | | Method: | X-RAY DIFFRACTION (2.97 Å) | | Cite: | Structures of carbon catabolite protein A-(HPr-Ser46-P) bound to diverse catabolite response element sites reveal the basis for high-affinity binding to degenerate DNA operators.
Nucleic Acids Res., 39, 2011
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3DNU
 | | structure of MDT protein | | Descriptor: | CHLORIDE ION, PHOSPHATE ION, Protein hipA | | Authors: | schumacher, M.A. | | Deposit date: | 2008-07-02 | | Release date: | 2009-01-27 | | Last modified: | 2021-10-20 | | Method: | X-RAY DIFFRACTION (1.54 Å) | | Cite: | Molecular mechanisms of HipA-mediated multidrug tolerance and its neutralization by HipB.
Science, 323, 2009
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3DNT
 | | structures of MDT proteins | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Protein hipA, ... | | Authors: | Schumacher, M.A. | | Deposit date: | 2008-07-02 | | Release date: | 2009-01-27 | | Last modified: | 2021-10-20 | | Method: | X-RAY DIFFRACTION (1.66 Å) | | Cite: | Molecular mechanisms of HipA-mediated multidrug tolerance and its neutralization by HipB.
Science, 323, 2009
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3DNV
 | | MDT Protein | | Descriptor: | DNA (5'-D(*DAP*DCP*DTP*DAP*DTP*DCP*DCP*DCP*DCP*DTP*DTP*DAP*DAP*DGP*DGP*DGP*DGP*DAP*DTP*DAP*DG)-3'), HTH-type transcriptional regulator hipB, Protein hipA, ... | | Authors: | schumacher, M.A. | | Deposit date: | 2008-07-02 | | Release date: | 2009-01-27 | | Last modified: | 2023-04-05 | | Method: | X-RAY DIFFRACTION (2.68 Å) | | Cite: | Molecular mechanisms of HipA-mediated multidrug tolerance and its neutralization by HipB.
Science, 323, 2009
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3FBR
 | | structure of HipA-amppnp-peptide | | Descriptor: | PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, Serine/threonine-protein kinase toxin HipA, peptide of EF-Tu | | Authors: | Schumacher, M.A. | | Deposit date: | 2008-11-19 | | Release date: | 2009-02-10 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (3.5 Å) | | Cite: | Molecular mechanisms of HipA-mediated multidrug tolerance and its neutralization by HipB.
Science, 323, 2009
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4R4E
 | | Structure of GlnR-DNA complex | | Descriptor: | 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, DNA (5'-D(*AP*TP*TP*CP*TP*GP*AP*CP*A)-3'), DNA (5'-D(*TP*GP*TP*CP*AP*GP*TP*A)-3'), ... | | Authors: | Schumacher, M.A. | | Deposit date: | 2014-08-19 | | Release date: | 2015-03-04 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.57 Å) | | Cite: | Structures of regulatory machinery reveal novel molecular mechanisms controlling B. subtilis nitrogen homeostasis.
Genes Dev., 29, 2015
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4R22
 | | TnrA-DNA complex | | Descriptor: | DNA (5'-D(*CP*GP*TP*GP*TP*AP*AP*GP*GP*AP*AP*TP*TP*CP*TP*GP*AP*CP*AP*CP*G)-3'), HTH-type transcriptional regulator TnrA | | Authors: | Schumacher, M.A. | | Deposit date: | 2014-08-08 | | Release date: | 2015-03-04 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structures of regulatory machinery reveal novel molecular mechanisms controlling B. subtilis nitrogen homeostasis.
Genes Dev., 29, 2015
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