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7JIS
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HUMAN PI3KDELTA IN COMPLEX WITH COMPOUND 2F
分子名称: (3S)-3-benzyl-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3-methyl-1,3-dihydro-2H-indol-2-one, Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
著者Lesburg, C.A, Augustin, M.
登録日2020-07-23
公開日2020-12-30
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.42 Å)
主引用文献Optimization of Versatile Oxindoles as Selective PI3K delta Inhibitors.
Acs Med.Chem.Lett., 11, 2020
7JIU
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HUMAN PI3KDELTA IN COMPLEX WITH COMPOUND 2F
分子名称: (3S)-3-benzyl-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3-methyl-1,3-dihydro-2H-indol-2-one, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
著者Lesburg, C.A, Augustin, M.
登録日2020-07-23
公開日2021-06-30
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.12 Å)
主引用文献Optimization of Versatile Oxindoles as Selective PI3K delta Inhibitors.
Acs Med.Chem.Lett., 11, 2020
7XTQ
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Cryo-EM structure of the R399-bound GPBAR-Gs complex
分子名称: G-protein coupled bile acid receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Ma, L, Yang, F, Wu, X, Mao, C, Sun, J, Yu, X, Zhang, Y, Zhang, P.
登録日2022-05-17
公開日2022-07-06
最終更新日2022-08-03
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Structural basis and molecular mechanism of biased GPBAR signaling in regulating NSCLC cell growth via YAP activity.
Proc.Natl.Acad.Sci.USA, 119, 2022
7X26
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S41 neutralizing antibody Fab(MERS-CoV)
分子名称: Spike glycoprotein, antibody S41 heavy chain, antibody S41 light chain
著者Zeng, J.W, Zhang, S.Y, Wang, X.W.
登録日2022-02-25
公開日2022-11-09
最終更新日2022-11-23
実験手法ELECTRON MICROSCOPY (3.685 Å)
主引用文献Cryoelectron microscopy structures of a human neutralizing antibody bound to MERS-CoV spike glycoprotein.
Front Microbiol, 13, 2022
7YFT
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BU of 7yft by Molmil
Crystal structure of the P450 BM3 heme domain mutant F87A/T268V/A82C/L181M in complex with N-imidazolyl-pentanoyl-L-phenylalanine, indane and hydroxylamine
分子名称: (2~{S})-2-(5-imidazol-1-ylpentanoylamino)-3-phenyl-propanoic acid, 2,3-dihydro-1H-indene, Bifunctional cytochrome P450/NADPH--P450 reductase, ...
著者Dong, S, Chen, J, Jiang, Y, Cong, Z, Feng, Y.
登録日2022-07-09
公開日2023-05-24
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Regiodivergent and Enantioselective Hydroxylation of C-H bonds by Synergistic Use of Protein Engineering and Exogenous Dual-Functional Small Molecules.
Angew.Chem.Int.Ed.Engl., 62, 2023
7YDE
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Crystal structure of the P450 BM3 heme domain mutant F87T/T268V/I263V in complex with N-imidazolyl-hexanoyl-L-phenylalanine and hydroxylamine
分子名称: (2S)-2-(6-imidazol-1-ylhexanoylamino)-3-phenyl-propanoic acid, Bifunctional cytochrome P450/NADPH--P450 reductase, HYDROXYAMINE, ...
著者Dong, S, Chen, J, Jiang, Y, Cong, Z, Feng, Y.
登録日2022-07-04
公開日2023-05-24
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.789 Å)
主引用文献Regiodivergent and Enantioselective Hydroxylation of C-H bonds by Synergistic Use of Protein Engineering and Exogenous Dual-Functional Small Molecules.
Angew.Chem.Int.Ed.Engl., 62, 2023
7YJF
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Crystal structure of the P450 BM3 heme domain mutant F87A/T268P/V78I in complex with N-imidazolyl-pentanoyl-L-phenylalanine and hydroxylamine
分子名称: (2~{S})-2-(5-imidazol-1-ylpentanoylamino)-3-phenyl-propanoic acid, HYDROXYAMINE, P450 BM3 heme domain mutant F87A/T268P/V78I, ...
著者Dong, S, Chen, J, Jiang, Y, Cong, Z, Feng, Y.
登録日2022-07-20
公開日2023-05-24
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.515 Å)
主引用文献Regiodivergent and Enantioselective Hydroxylation of C-H bonds by Synergistic Use of Protein Engineering and Exogenous Dual-Functional Small Molecules.
Angew.Chem.Int.Ed.Engl., 62, 2023
7YJE
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BU of 7yje by Molmil
Crystal structure of the P450 BM3 heme domain mutant F87G/T268V/A184V/A328V in complex with N-imidazolyl-hexanoyl-L-phenylalanine and acetate ion
分子名称: (2S)-2-(6-imidazol-1-ylhexanoylamino)-3-phenyl-propanoic acid, ACETATE ION, Bifunctional cytochrome P450/NADPH--P450 reductase, ...
著者Dong, S, Chen, J, Jiang, Y, Cong, Z, Feng, Y.
登録日2022-07-20
公開日2023-05-24
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Regiodivergent and Enantioselective Hydroxylation of C-H bonds by Synergistic Use of Protein Engineering and Exogenous Dual-Functional Small Molecules.
Angew.Chem.Int.Ed.Engl., 62, 2023
7YDA
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BU of 7yda by Molmil
Crystal structure of the P450 BM3 heme domain mutant F87V/T268V/A184V in complex with N-imidazolyl-pentanoyl-L-phenylalanine and hydroxylamine
分子名称: (2~{S})-2-(5-imidazol-1-ylpentanoylamino)-3-phenyl-propanoic acid, Bifunctional cytochrome P450/NADPH--P450 reductase, HYDROXYAMINE, ...
著者Dong, S, Chen, J, Jiang, Y, Cong, Z, Feng, Y.
登録日2022-07-04
公開日2023-05-24
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.557 Å)
主引用文献Regiodivergent and Enantioselective Hydroxylation of C-H bonds by Synergistic Use of Protein Engineering and Exogenous Dual-Functional Small Molecules.
Angew.Chem.Int.Ed.Engl., 62, 2023
7YDD
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Crystal structure of the P450 BM3 heme domain mutant F87A/T268P/V78I in complex with N-imidazolyl-pentanoyl-L-phenylalanine,propylbenzene and hydroxylamine
分子名称: (2~{S})-2-(5-imidazol-1-ylpentanoylamino)-3-phenyl-propanoic acid, HYDROXYAMINE, P450 BM3 heme domain mutant F87A/T268P/V78I, ...
著者Dong, S, Chen, J, Jiang, Y, Cong, Z, Feng, Y.
登録日2022-07-04
公開日2023-05-24
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.663 Å)
主引用文献Regiodivergent and Enantioselective Hydroxylation of C-H bonds by Synergistic Use of Protein Engineering and Exogenous Dual-Functional Small Molecules.
Angew.Chem.Int.Ed.Engl., 62, 2023
7YJG
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BU of 7yjg by Molmil
Crystal structure of the P450 BM3 heme domain mutant F87A/T268V/A82C/L181M in complex with N-imidazolyl-pentanoyl-L-phenylalanine and hydroxylamine
分子名称: (2~{S})-2-(5-imidazol-1-ylpentanoylamino)-3-phenyl-propanoic acid, Bifunctional cytochrome P450/NADPH--P450 reductase, HYDROXYAMINE, ...
著者Dong, S, Chen, J, Jiang, Y, Cong, Z, Feng, Y.
登録日2022-07-20
公開日2023-05-24
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.684 Å)
主引用文献Regiodivergent and Enantioselective Hydroxylation of C-H bonds by Synergistic Use of Protein Engineering and Exogenous Dual-Functional Small Molecules.
Angew.Chem.Int.Ed.Engl., 62, 2023
7YDC
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BU of 7ydc by Molmil
Crystal structure of the P450 BM3 heme domain mutant F87L/T268V/V78C in complex with N-imidazolyl-pentanoyl-L-phenylalanine and hydroxylamine
分子名称: (2~{S})-2-(5-imidazol-1-ylpentanoylamino)-3-phenyl-propanoic acid, Bifunctional cytochrome P450/NADPH--P450 reductase, HYDROXYAMINE, ...
著者Dong, S, Chen, J, Jiang, Y, Cong, Z, Feng, Y.
登録日2022-07-04
公開日2023-05-24
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.609 Å)
主引用文献Regiodivergent and Enantioselective Hydroxylation of C-H bonds by Synergistic Use of Protein Engineering and Exogenous Dual-Functional Small Molecules.
Angew.Chem.Int.Ed.Engl., 62, 2023
7YDB
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Crystal structure of the P450 BM3 heme domain mutant F87V/T268I in complex with N-imidazolyl-pentanoyl-L-phenylalanine,ethylbenzene and hydroxylamine
分子名称: (2~{S})-2-(5-imidazol-1-ylpentanoylamino)-3-phenyl-propanoic acid, Bifunctional cytochrome P450/NADPH--P450 reductase, HYDROXYAMINE, ...
著者Dong, S, Chen, J, Jiang, Y, Cong, Z, Feng, Y.
登録日2022-07-04
公開日2023-05-24
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.472 Å)
主引用文献Regiodivergent and Enantioselective Hydroxylation of C-H bonds by Synergistic Use of Protein Engineering and Exogenous Dual-Functional Small Molecules.
Angew.Chem.Int.Ed.Engl., 62, 2023
7YJH
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BU of 7yjh by Molmil
Crystal structure of the P450 BM3 heme domain mutant F87V/T268I in complex with N-imidazolyl-pentanoyl-L-phenylalanine and hydroxylamine
分子名称: (2~{S})-2-(5-imidazol-1-ylpentanoylamino)-3-phenyl-propanoic acid, Bifunctional cytochrome P450/NADPH--P450 reductase, HYDROXYAMINE, ...
著者Dong, S, Chen, J, Jiang, Y, Cong, Z, Feng, Y.
登録日2022-07-20
公開日2023-05-24
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.792 Å)
主引用文献Regiodivergent and Enantioselective Hydroxylation of C-H bonds by Synergistic Use of Protein Engineering and Exogenous Dual-Functional Small Molecules.
Angew.Chem.Int.Ed.Engl., 62, 2023
7YD9
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BU of 7yd9 by Molmil
Crystal structure of the P450 BM3 heme domain mutant F87G/T268V/A184V/A328V in complex with N-imidazolyl-hexanoyl-L-phenylalanine,methylbenzene and hydroxylamine
分子名称: (2S)-2-(6-imidazol-1-ylhexanoylamino)-3-phenyl-propanoic acid, Bifunctional cytochrome P450/NADPH--P450 reductase, HYDROXYAMINE, ...
著者Dong, S, Chen, J, Jiang, Y, Cong, Z, Feng, Y.
登録日2022-07-04
公開日2023-05-24
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.748 Å)
主引用文献Regiodivergent and Enantioselective Hydroxylation of C-H bonds by Synergistic Use of Protein Engineering and Exogenous Dual-Functional Small Molecules.
Angew.Chem.Int.Ed.Engl., 62, 2023
7YIL
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The structure of GINS from Methanocaldococcus jannaschii
分子名称: GINS
著者Wang, W.W, Liu, X.P.
登録日2022-07-16
公開日2023-07-19
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.17 Å)
主引用文献The structure of GINS from Methanocaldococcus jannaschii
To Be Published
7YIK
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The structure of archaeal nuclease RecJ2 from Methanocaldococcus jannaschii
分子名称: nuclease RecJ2
著者Wang, W.W, Liu, X.P.
登録日2022-07-16
公開日2023-07-19
実験手法X-RAY DIFFRACTION (2.191 Å)
主引用文献The structure of archaeal nuclease RecJ2 from Methanocaldococcus jannaschii
To Be Published
7YKV
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The structure of archaeal nuclease RecJ2 from Methanocaldococcus jannaschii
分子名称: 1,2-ETHANEDIOL, GLYCEROL, [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)furan-3-yl] [5-(6-aminopurin-9-yl)-3-oxidanyl-furan-2-yl]methyl hydrogen phosphate, ...
著者Wang, W.W, Liu, X.P.
登録日2022-07-24
公開日2023-07-26
実験手法X-RAY DIFFRACTION (2.04 Å)
主引用文献The structure of archaeal nuclease RecJ2 from Methanocaldococcus jannaschii
To Be Published
7YOS
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Recj2 and Mn complex from Methanocaldococcus jannaschii
分子名称: MANGANESE (II) ION, nuclease RecJ2
著者Wang, W.W, Liu, X.P.
登録日2022-08-02
公開日2023-08-02
実験手法X-RAY DIFFRACTION (2.17 Å)
主引用文献The structure of nuclease RecJ2 from Methanocaldococcus jannaschii
To Be Published
7YOQ
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Recj2 and CMP complex from Methanocaldococcus jannaschii
分子名称: [5-(4-azanyl-2-oxidanylidene-pyrimidin-1-yl)-3,4-bis(oxidanyl)furan-2-yl]methyl dihydrogen phosphate, nuclease RecJ2
著者Wang, W.W, Liu, X.P.
登録日2022-08-02
公開日2023-08-02
実験手法X-RAY DIFFRACTION (2.265 Å)
主引用文献The structure of nuclease RecJ2 from Methanocaldococcus jannaschii
To Be Published
7YOR
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Recj2 and dCMP complex from Methanocaldococcus jannaschii
分子名称: 1,2-ETHANEDIOL, [5-(4-azanyl-2-oxidanylidene-pyrimidin-1-yl)-3-oxidanyl-furan-2-yl]methyl dihydrogen phosphate, archaeal nuclease RecJ2
著者Wang, W.W, Liu, X.P.
登録日2022-08-02
公開日2023-08-02
実験手法X-RAY DIFFRACTION (2.53 Å)
主引用文献The structure of nuclease RecJ2 from Methanocaldococcus jannaschii
To Be Published
7X27
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MERS-CoV spike complex
分子名称: Spike glycoprotein
著者Zeng, J.W, Zhang, S.Y, Wang, X.W.
登録日2022-02-25
公開日2023-03-22
実験手法ELECTRON MICROSCOPY (2.49 Å)
主引用文献cryo-EM structures of a human neutralizing antibody bound to MERS-CoV spike glycoprotein
To Be Published

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件を2024-05-15に公開中

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