7JIS

HUMAN PI3KDELTA IN COMPLEX WITH COMPOUND 2F

Summary for 7JIS

• Entry DOI: 10.2210/pdb7jis/pdb
• Descriptor: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform, Phosphatidylinositol 3-kinase regulatory subunit alpha, (3S)-3-benzyl-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3-methyl-1,3-dihydro-2H-indol-2-one, ... (4 entities in total)
• Functional Keywords: pi3kdelta kinase, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 137955.73

Authors

Lesburg, C.A.,Augustin, M. (deposition date: 2020-07-23, release date: 2020-12-30, Last modification date: 2024-04-03)

• Primary citation: Methot, J.L.,Achab, A.,Christopher, M.,Zhou, H.,McGowan, M.A.,Trotter, B.W.,Fradera, X.,Lesburg, C.A.,Goldenblatt, P.,Hill, A.,Chen, D.,Otte, K.M.,Augustin, M.,Shah, S.,Katz, J.D.; Optimization of Versatile Oxindoles as Selective PI3K delta Inhibitors.; Acs Med.Chem.Lett., 11:2461-2469, 2020; PubMed: 33335668; DOI: 10.1021/acsmedchemlett.0c00441

Experimental method

X-RAY DIFFRACTION (2.42 Å)