7JIU
HUMAN PI3KDELTA IN COMPLEX WITH COMPOUND 2F
Summary for 7JIU
Entry DOI | 10.2210/pdb7jiu/pdb |
Descriptor | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, (3S)-3-benzyl-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3-methyl-1,3-dihydro-2H-indol-2-one (3 entities in total) |
Functional Keywords | pi3kalpha kinase, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 110559.74 |
Authors | Lesburg, C.A.,Augustin, M. (deposition date: 2020-07-23, release date: 2021-06-30, Last modification date: 2024-04-03) |
Primary citation | Methot, J.L.,Achab, A.,Christopher, M.,Zhou, H.,McGowan, M.A.,Trotter, B.W.,Fradera, X.,Lesburg, C.A.,Goldenblatt, P.,Hill, A.,Chen, D.,Otte, K.M.,Augustin, M.,Shah, S.,Katz, J.D. Optimization of Versatile Oxindoles as Selective PI3K delta Inhibitors. Acs Med.Chem.Lett., 11:2461-2469, 2020 Cited by PubMed: 33335668DOI: 10.1021/acsmedchemlett.0c00441 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.12 Å) |
Structure validation
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