6UTG
 
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4B10
 | | Plasmodium vivax N-myristoyltransferase with a non-hydrolysable co- factor | | 分子名称: | 2-oxopentadecyl-CoA, CHLORIDE ION, DIMETHYL SULFOXIDE, ... | | 著者 | Yu, Z, Brannigan, J.A, Moss, D.K, Brzozowski, A.M, Wilkinson, A.J, Holder, A.A, Tate, E.W, Leatherbarrow, R.J. | | 登録日 | 2012-07-06 | | 公開日 | 2012-10-17 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.56 Å) | | 主引用文献 | Design and Synthesis of Inhibitors of Plasmodium Falciparum N-Myristoyltransferase, a Promising Target for Anti-Malarial Drug Discovery.
J.Med.Chem., 55, 2012
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4B13
 | | Plasmodium vivax N-myristoyltransferase with a bound benzofuran inhibitor (compound 25) | | 分子名称: | 2-oxopentadecyl-CoA, 4-{[2-(3-benzyl-1,2,4-oxadiazol-5-yl)-3-methyl-1-benzofuran-4-yl]oxy}piperidine, CHLORIDE ION, ... | | 著者 | Yu, Z, Brannigan, J.A, Moss, D.K, Brzozowski, A.M, Wilkinson, A.J, Holder, A.A, Tate, E.W, Leatherbarrow, R.J. | | 登録日 | 2012-07-06 | | 公開日 | 2012-10-17 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.58 Å) | | 主引用文献 | Design and Synthesis of Inhibitors of Plasmodium Falciparum N-Myristoyltransferase, a Promising Target for Antimalarial Drug Discovery.
J.Med.Chem., 55, 2012
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4B11
 | | Plasmodium vivax N-myristoyltransferase with a bound benzofuran inhibitor (compound 13) | | 分子名称: | 2-oxopentadecyl-CoA, 3-methyl-N-(naphthalen-1-ylmethyl)-4-piperidin-4-yloxy-1-benzofuran-2-carboxamide, CHLORIDE ION, ... | | 著者 | Yu, Z, Brannigan, J.A, Moss, D.K, Brzozowski, A.M, Wilkinson, A.J, Holder, A.A, Tate, E.W, Leatherbarrow, R.J. | | 登録日 | 2012-07-06 | | 公開日 | 2012-10-17 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.59 Å) | | 主引用文献 | Design and Synthesis of Inhibitors of Plasmodium Falciparum N-Myristoyltransferase, a Promising Target for Anti-Malarial Drug Discovery.
J.Med.Chem., 55, 2012
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4B12
 | | Plasmodium vivax N-myristoyltransferase with a bound benzofuran inhibitor (compound 23) | | 分子名称: | 1-[3-methyl-4-(piperidin-4-yloxy)-1-benzofuran-2-yl]-3-phenylpropan-1-one, 2-oxopentadecyl-CoA, CHLORIDE ION, ... | | 著者 | Yu, Z, Brannigan, J.A, Moss, D.K, Brzozowski, A.M, Wilkinson, A.J, Holder, A.A, Tate, E.W, Leatherbarrow, R.J. | | 登録日 | 2012-07-06 | | 公開日 | 2012-10-17 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | | 主引用文献 | Design and Synthesis of Inhibitors of Plasmodium Falciparum N-Myristoyltransferase, a Promising Target for Anti-Malarial Drug Discovery.
J.Med.Chem., 55, 2012
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4B14
 | | Plasmodium vivax N-myristoyltransferase with a bound benzofuran inhibitor (compound 26) | | 分子名称: | 2-oxopentadecyl-CoA, 3-methoxybenzyl 3-methyl-4-(piperidin-4-yloxy)-1-benzofuran-2-carboxylate, CHLORIDE ION, ... | | 著者 | Yu, Z, Brannigan, J.A, Moss, D.K, Brzozowski, A.M, Wilkinson, A.J, Holder, A.A, Tate, E.W, Leatherbarrow, R.J. | | 登録日 | 2012-07-06 | | 公開日 | 2012-10-17 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Design and Synthesis of Inhibitors of Plasmodium Falciparum N-Myristoyltransferase, a Promising Target for Anti-Malarial Drug Discovery.
J.Med.Chem., 55, 2012
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4UFW
 | | Plasmodium vivax N-myristoyltransferase in complex with a pyridyl inhibitor (compound 22) | | 分子名称: | 2-oxopentadecyl-CoA, 4-chloranyl-N-[2-(3-methoxyphenyl)ethanimidoyl]-2-piperidin-4-yloxy-benzamide, CHLORIDE ION, ... | | 著者 | Yu, Z, Brannigan, J.A, Rangachari, K, Heal, W.P, Wilkinson, A.J, Holder, A.A, Tate, E.W, Leatherbarrow, R.J. | | 登録日 | 2015-03-19 | | 公開日 | 2016-02-03 | | 最終更新日 | 2016-04-20 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Discovery of Pyridyl-Based Inhibitors of Plasmodium Falciparum N-Myristoyltransferase
Medchemcomm, 6, 2015
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4UFX
 | | Plasmodium vivax N-myristoyltransferase in complex with a pyridyl inhibitor (compound 19) | | 分子名称: | 2-oxopentadecyl-CoA, CHLORIDE ION, DIMETHYL SULFOXIDE, ... | | 著者 | Yu, Z, Brannigan, J.A, Rangachari, K, Heal, W.P, Wilkinson, A.J, Holder, A.A, Tate, E.W, Leatherbarrow, R.J. | | 登録日 | 2015-03-19 | | 公開日 | 2016-02-03 | | 最終更新日 | 2016-04-20 | | 実験手法 | X-RAY DIFFRACTION (1.49 Å) | | 主引用文献 | Discovery of Pyridyl-Based Inhibitors of Plasmodium Falciparum N-Myristoyltransferase
Medchemcomm, 6, 2015
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4UFV
 | | Plasmodium vivax N-myristoyltransferase in complex with a pyridyl inhibitor (compound 18) | | 分子名称: | 2-oxopentadecyl-CoA, CHLORIDE ION, DIMETHYL SULFOXIDE, ... | | 著者 | Yu, Z, Brannigan, J.A, Rangachari, K, Heal, W.P, Wilkinson, A.J, Holder, A.A, Tate, E.W, Leatherbarrow, R.J. | | 登録日 | 2015-03-19 | | 公開日 | 2016-02-03 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Discovery of Pyridyl-Based Inhibitors of Plasmodium Falciparum N-Myristoyltransferase
Medchemcomm, 6, 2015
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2GKS
 | | Crystal Structure of the Bi-functional ATP Sulfurylase-APS Kinase from Aquifex aeolicus, a Chemolithotrophic Thermophile | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Bifunctional SAT/APS kinase | | 著者 | Yu, Z, MacRea, I.J, Lansdon, E.B, Segel, I.H, Fisher, A.J. | | 登録日 | 2006-04-03 | | 公開日 | 2007-03-06 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.31 Å) | | 主引用文献 | Crystal structure of the bifunctional ATP sulfurylase-APS kinase from the chemolithotrophic thermophile Aquifex aeolicus.
J.Mol.Biol., 365, 2007
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2OQ2
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8D51
 | | Parathyroid hormone 1 receptor extracellular domain complexed with a peptide ligand containing beta-3-homotryptophan | | 分子名称: | 1,2-ETHANEDIOL, PTHrP[1-36], Parathyroid hormone/parathyroid hormone-related peptide receptor, ... | | 著者 | Yu, Z, Kreitler, D.F, Gellman, S.H. | | 登録日 | 2022-06-03 | | 公開日 | 2023-06-14 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Harnessing Aromatic-Histidine Interactions through Synergistic Backbone Extension and Side Chain Modification.
Angew.Chem.Int.Ed.Engl., 62, 2023
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8D52
 | | Parathyroid hormone 1 receptor extracellular domain complexed with a peptide ligand containing (2-naphthyl)-beta-3-homoalanine | | 分子名称: | 1,2-ETHANEDIOL, PTHrP[1-36], Parathyroid hormone/parathyroid hormone-related peptide receptor, ... | | 著者 | Yu, Z, Kreitler, D.F, Gellman, S.H. | | 登録日 | 2022-06-03 | | 公開日 | 2023-06-14 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.02 Å) | | 主引用文献 | Harnessing Aromatic-Histidine Interactions through Synergistic Backbone Extension and Side Chain Modification.
Angew.Chem.Int.Ed.Engl., 62, 2023
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8H1C
 | | Cryo-EM structure of Oryza sativa plastid glycyl-tRNA synthetase in complex with two tRNAs (one in tRNA binding state and the other in tRNA locked state) | | 分子名称: | Glycine--tRNA ligase, tRNA(gly) (74-MER) | | 著者 | Yu, Z, Wu, Z, Li, Y, Lu, G, Lin, J. | | 登録日 | 2022-10-02 | | 公開日 | 2023-04-26 | | 最終更新日 | 2023-05-24 | | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | | 主引用文献 | Structural basis of a two-step tRNA recognition mechanism for plastid glycyl-tRNA synthetase.
Nucleic Acids Res., 51, 2023
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4OWP
 | | Crystal structure of rpn11 in a heterodimer complex with rpn8, representing the active portion of the proteasome lid. | | 分子名称: | 26S proteasome regulatory subunit RPN11, 26S proteasome regulatory subunit RPN8, ZINC ION | | 著者 | Yu, Z, Mansour, W, Nakasone, M.A, Glickman, M.H, Dvir, H. | | 登録日 | 2014-02-03 | | 公開日 | 2015-08-05 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | | 主引用文献 | Crystal structure of rpn11 in a heterodimer complex with rpn8, representing the active portion of the proteasome lid.In preparation.
To Be Published
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7TZO
 | | The apo structure of human mTORC2 complex | | 分子名称: | Rapamycin-insensitive companion of mTOR, Serine/threonine-protein kinase mTOR, Target of rapamycin complex 2 subunit MAPKAP1, ... | | 著者 | Yu, Z, Chen, J, Pearce, D. | | 登録日 | 2022-02-16 | | 公開日 | 2023-01-11 | | 実験手法 | ELECTRON MICROSCOPY (3.28 Å) | | 主引用文献 | Interactions between mTORC2 core subunits Rictor and mSin1 dictate selective and context-dependent phosphorylation of substrate kinases SGK1 and Akt.
J.Biol.Chem., 298, 2022
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8HQL
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7XK1
 | | Cryo-EM structure of Oryza sativa plastid glycyl-tRNA synthetase in complex with two tRNAs (both in tRNA binding states) | | 分子名称: | Glycine--tRNA ligase, tRNA(gly) | | 著者 | Yu, Z, Wu, Z, Li, Y, Lu, G, Lin, J. | | 登録日 | 2022-04-19 | | 公開日 | 2023-05-03 | | 最終更新日 | 2023-05-24 | | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | | 主引用文献 | Structural basis of a two-step tRNA recognition mechanism for plastid glycyl-tRNA synthetase.
Nucleic Acids Res., 51, 2023
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7XK0
 | | Cryo-EM strucrture of Oryza sativa plastid glycyl-tRNA synthetase in complex with tRNA (tRNA locked state) | | 分子名称: | Glycine--tRNA ligase, tRNA(gly) | | 著者 | Yu, Z, Wu, Z, Li, Y, Lu, G, Lin, J. | | 登録日 | 2022-04-19 | | 公開日 | 2023-05-03 | | 最終更新日 | 2023-05-24 | | 実験手法 | ELECTRON MICROSCOPY (3.59 Å) | | 主引用文献 | Structural basis of a two-step tRNA recognition mechanism for plastid glycyl-tRNA synthetase.
Nucleic Acids Res., 51, 2023
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7XJZ
 | | Cryo-EM strucrture of Oryza sativa plastid glycyl-tRNA synthetase in complex with tRNA (tRNA binding state) | | 分子名称: | Glycine--tRNA ligase, tRNA(gly) | | 著者 | Yu, Z, Wu, Z, Li, Y, Lu, G, Lin, J. | | 登録日 | 2022-04-19 | | 公開日 | 2023-05-03 | | 最終更新日 | 2023-05-24 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Structural basis of a two-step tRNA recognition mechanism for plastid glycyl-tRNA synthetase.
Nucleic Acids Res., 51, 2023
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7XJY
 | | Cryo-EM structure of Oryza sativa plastid glycyl-tRNA synthetase (apo form) | | 分子名称: | Glycine--tRNA ligase | | 著者 | Yu, Z, Wu, Z, Li, Y, Lu, G, Lin, J. | | 登録日 | 2022-04-19 | | 公開日 | 2023-05-03 | | 最終更新日 | 2023-05-24 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Structural basis of a two-step tRNA recognition mechanism for plastid glycyl-tRNA synthetase.
Nucleic Acids Res., 51, 2023
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6UTF
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6UTH
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6UTJ
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6UTI
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