7LMY
 
 | | Cryo-EM structure of human p97 in complex with NMS-873 in the presence of ATP, Npl4/Ufd1, and Ub6 | | 分子名称: | 3-[3-cyclopentylsulfanyl-5-[[3-methyl-4-(4-methylsulfonylphenyl)phenoxy]methyl]-1,2,4-triazol-4-yl]pyridine, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | | 著者 | Pan, M, Yu, Y, Liu, L, Zhao, M. | | 登録日 | 2021-02-06 | | 公開日 | 2021-09-15 | | 実験手法 | ELECTRON MICROSCOPY (2.4 Å) | | 主引用文献 | Mechanistic insight into substrate processing and allosteric inhibition of human p97.
Nat.Struct.Mol.Biol., 28, 2021
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7LN5
 | | Cryo-EM structure of human p97 in complex with Npl4/Ufd1 and polyubiquitinated Ub-Eos (CHAPSO, Class 1, Close State) | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | | 著者 | Pan, M, Yu, Y, Liu, L, Zhao, M. | | 登録日 | 2021-02-06 | | 公開日 | 2021-09-15 | | 実験手法 | ELECTRON MICROSCOPY (3.09 Å) | | 主引用文献 | Mechanistic insight into substrate processing and allosteric inhibition of human p97.
Nat.Struct.Mol.Biol., 28, 2021
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7LN3
 | | Cryo-EM structure of human p97 in complex with Npl4/Ufd1 and polyubiquitinated Ub-Eos (FOM, Class 2) | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | | 著者 | Pan, M, Yu, Y, Liu, L, Zhao, M. | | 登録日 | 2021-02-06 | | 公開日 | 2021-09-15 | | 実験手法 | ELECTRON MICROSCOPY (3.45 Å) | | 主引用文献 | Mechanistic insight into substrate processing and allosteric inhibition of human p97.
Nat.Struct.Mol.Biol., 28, 2021
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7LN0
 | | Cryo-EM structure of human p97 in complex with Npl4/Ufd1 and Ub6 (Class 2) | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Hexa-ubiquitin, ... | | 著者 | Pan, M, Yu, Y, Liu, L, Zhao, M. | | 登録日 | 2021-02-06 | | 公開日 | 2021-09-15 | | 実験手法 | ELECTRON MICROSCOPY (2.98 Å) | | 主引用文献 | Mechanistic insight into substrate processing and allosteric inhibition of human p97.
Nat.Struct.Mol.Biol., 28, 2021
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7LN1
 | | Cryo-EM structure of human p97 in complex with Npl4/Ufd1 and Ub6 (Class 3) | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Hexa-ubiquitin, ... | | 著者 | Pan, M, Yu, Y, Liu, L, Zhao, M. | | 登録日 | 2021-02-06 | | 公開日 | 2021-09-15 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Mechanistic insight into substrate processing and allosteric inhibition of human p97.
Nat.Struct.Mol.Biol., 28, 2021
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7LN2
 | | Cryo-EM structure of human p97 in complex with Npl4/Ufd1 and polyubiquitinated Ub-Eos (FOM, Class 1) | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | | 著者 | Pan, M, Yu, Y, Liu, L, Zhao, M. | | 登録日 | 2021-02-06 | | 公開日 | 2021-09-15 | | 実験手法 | ELECTRON MICROSCOPY (3.63 Å) | | 主引用文献 | Mechanistic insight into substrate processing and allosteric inhibition of human p97.
Nat.Struct.Mol.Biol., 28, 2021
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7LMZ
 | | Cryo-EM structure of human p97 in complex with Npl4/Ufd1 and Ub6 (Class 1) | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Hexa-ubiquitin, ... | | 著者 | Pan, M, Yu, Y, Liu, L, Zhao, M. | | 登録日 | 2021-02-06 | | 公開日 | 2021-09-15 | | 実験手法 | ELECTRON MICROSCOPY (3.06 Å) | | 主引用文献 | Mechanistic insight into substrate processing and allosteric inhibition of human p97.
Nat.Struct.Mol.Biol., 28, 2021
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7LN6
 | | Cryo-EM structure of human p97 in complex with Npl4/Ufd1 and polyubiquitinated Ub-Eos (CHAPSO, Class 2, Open State) | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | | 著者 | Pan, M, Yu, Y, Liu, L, Zhao, M. | | 登録日 | 2021-02-06 | | 公開日 | 2021-09-15 | | 実験手法 | ELECTRON MICROSCOPY (3.58 Å) | | 主引用文献 | Mechanistic insight into substrate processing and allosteric inhibition of human p97.
Nat.Struct.Mol.Biol., 28, 2021
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7MEX
 | | Structure of yeast Ubr1 in complex with Ubc2 and N-degron | | 分子名称: | E3 ubiquitin-protein ligase UBR1, N-degron, Ubiquitin, ... | | 著者 | Pan, M, Zheng, Q, Wang, T, Liang, L, Yu, Y, Liu, L, Zhao, M. | | 登録日 | 2021-04-08 | | 公開日 | 2021-11-24 | | 最終更新日 | 2021-12-22 | | 実験手法 | ELECTRON MICROSCOPY (3.35 Å) | | 主引用文献 | Structural insights into Ubr1-mediated N-degron polyubiquitination.
Nature, 600, 2021
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7MEY
 | | Structure of yeast Ubr1 in complex with Ubc2 and monoubiquitinated N-degron | | 分子名称: | 2-(ethylamino)ethane-1-thiol, E3 ubiquitin-protein ligase UBR1, Monoubiquitinated N-degron, ... | | 著者 | Pan, M, Zheng, Q, Wang, T, Liang, L, Yu, Y, Liu, L, Zhao, M. | | 登録日 | 2021-04-08 | | 公開日 | 2021-11-24 | | 最終更新日 | 2021-12-22 | | 実験手法 | ELECTRON MICROSCOPY (3.67 Å) | | 主引用文献 | Structural insights into Ubr1-mediated N-degron polyubiquitination.
Nature, 600, 2021
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4WVR
 | | Crystal structure of Dscam1 Ig7 domain, isoform 5 | | 分子名称: | Down syndrome cell adhesion molecule, isoform AK | | 著者 | Chen, Q, Yu, Y, Li, S, Cheng, L. | | 登録日 | 2014-11-07 | | 公開日 | 2015-11-18 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.948 Å) | | 主引用文献 | Structural basis of Dscam1 homodimerization: Insights into context constraint for protein recognition
Sci Adv, 2, 2016
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4X83
 | | Crystal structure of Dscam1 isoform 7.44, N-terminal four Ig domains | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ... | | 著者 | Chen, Q, Yu, Y, Li, S.A, Cheng, L. | | 登録日 | 2014-12-10 | | 公開日 | 2015-12-16 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.902 Å) | | 主引用文献 | Structural basis of Dscam1 homodimerization: Insights into context constraint for protein recognition
Sci Adv, 2, 2016
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4X9B
 | | Crystal structure of Dscam1 isoform 4.44, N-terminal four Ig domains | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Down syndrome cell adhesion molecule, isoform 4.44, ... | | 著者 | Chen, Q, Yu, Y, Li, S.A, Cheng, L. | | 登録日 | 2014-12-11 | | 公開日 | 2015-12-16 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Structural basis of Dscam1 homodimerization: Insights into context constraint for protein recognition
Sci Adv, 2, 2016
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4X9F
 | | Crystal structure of Dscam1 isoform 6.9, N-terminal four Ig domains | | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Down Syndrome Cell Adhesion Molecule isoform 6.9, GLYCEROL, ... | | 著者 | Chen, Q, Yu, Y, Li, S.A, Cheng, L. | | 登録日 | 2014-12-11 | | 公開日 | 2015-12-16 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | | 主引用文献 | Structural basis of Dscam1 homodimerization: Insights into context constraint for protein recognition
Sci Adv, 2, 2016
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4X5L
 | | Crystal structure of Dscam1 Ig7 domain, isoform 9 | | 分子名称: | Down syndrome cell adhesion molecule, isoform AM, SODIUM ION | | 著者 | Chen, Q, Yu, Y, Li, S.A, Cheng, L. | | 登録日 | 2014-12-05 | | 公開日 | 2015-12-09 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.374 Å) | | 主引用文献 | Structural basis of Dscam1 homodimerization: Insights into context constraint for protein recognition
Sci Adv, 2, 2016
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4XHQ
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4XB7
 | | Crystal structure of Dscam1 isoform 4.4, N-terminal four Ig domains | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Down syndrome cell adhesion molecule, isoform 4.4, ... | | 著者 | Chen, Q, Yu, Y, Li, S.A, Cheng, L. | | 登録日 | 2014-12-16 | | 公開日 | 2015-12-16 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (4.004 Å) | | 主引用文献 | Structural basis of Dscam1 homodimerization: Insights into context constraint for protein recognition
Sci Adv, 2, 2016
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4X9G
 | | Crystal structure of Dscam1 isoform 6.44, N-terminal four Ig domains | | 分子名称: | Down Syndrome Cell Adhesion Molecule isoform 6.44, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | | 著者 | Chen, Q, Yu, Y, Li, S.A, Cheng, L. | | 登録日 | 2014-12-11 | | 公開日 | 2015-12-16 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (3.403 Å) | | 主引用文献 | Structural basis of Dscam1 homodimerization: Insights into context constraint for protein recognition
Sci Adv, 2, 2016
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4X9I
 | | Crystal structure of Dscam1 isoform 9.44, N-terminal four Ig domains | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Down Syndrome Cell Adhesion Molecule, isoform 9.44, ... | | 著者 | Chen, Q, Yu, Y, Li, S.A, cheng, L. | | 登録日 | 2014-12-11 | | 公開日 | 2015-12-16 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.904 Å) | | 主引用文献 | Structural basis of Dscam1 homodimerization: Insights into context constraint for protein recognition
Sci Adv, 2, 2016
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4XB8
 | | Crystal structure of Dscam1 isoform 9.44, N-terminal four Ig domains (with zinc) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Down Syndrome Cell Adhesion Molecule, ... | | 著者 | Chen, Q, Yu, Y, Li, S.A, cheng, L. | | 登録日 | 2014-12-16 | | 公開日 | 2015-12-16 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (3.202 Å) | | 主引用文献 | Structural basis of Dscam1 homodimerization: Insights into context constraint for protein recognition
Sci Adv, 2, 2016
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5BOA
 | | Crystal Structure of the Meningitis Pathogen Streptococcus suis adhesion Fhb bound to the disaccharide receptor Gb2 | | 分子名称: | Translation initiation factor 2 (IF-2 GTPase), alpha-D-galactopyranose-(1-4)-beta-D-galactopyranose | | 著者 | Zhang, C, Yu, Y, Yang, M, Jiang, Y. | | 登録日 | 2015-05-27 | | 公開日 | 2016-05-04 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.708 Å) | | 主引用文献 | Structural basis of the interaction between the meningitis pathogen Streptococcus suis adhesin Fhb and its human receptor.
Febs Lett., 590, 2016
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7CDA
 | | Crystal structure of T2R-TTL-PAC complex | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, GLYCEROL, ... | | 著者 | Chen, L.J, Chen, Q, Yu, Y, Yang, J.H. | | 登録日 | 2020-06-19 | | 公開日 | 2021-06-23 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.659 Å) | | 主引用文献 | Small Molecules Promote Selective Denaturation and Degradation of Tubulin Heterodimers through a Low-Barrier Hydrogen Bond.
J.Med.Chem., 65, 2022
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7CEK
 | | Crystal structure of T2R-TTL-BML-284 complex | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, CHLORIDE ION, ... | | 著者 | Chen, L.J, Chen, Q, Yu, Y, Yang, J.H. | | 登録日 | 2020-06-23 | | 公開日 | 2021-06-23 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.696 Å) | | 主引用文献 | Small Molecules Promote Selective Denaturation and Degradation of Tubulin Heterodimers through a Low-Barrier Hydrogen Bond.
J.Med.Chem., 65, 2022
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7CE6
 | | Crystal structure of T2R-TTL-Compound9 complex | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, GLYCEROL, ... | | 著者 | Chen, L.J, Chen, Q, Yu, Y, Yang, J.H. | | 登録日 | 2020-06-22 | | 公開日 | 2021-06-30 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.695 Å) | | 主引用文献 | Small Molecules Promote Selective Denaturation and Degradation of Tubulin Heterodimers through a Low-Barrier Hydrogen Bond.
J.Med.Chem., 65, 2022
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7CLD
 | | Crystal structure of T2R-TTL-Cevipabulin complex | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 6-[2,6-bis(fluoranyl)-4-[3-(methylamino)propoxy]phenyl]-5-chloranyl-N-[(2S)-1,1,1-tris(fluoranyl)propan-2-yl]-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine, CALCIUM ION, ... | | 著者 | Chen, L.J, Chen, Q, Yu, Y, Yang, J.H. | | 登録日 | 2020-07-20 | | 公開日 | 2021-07-07 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.611 Å) | | 主引用文献 | Cevipabulin-tubulin complex reveals a novel agent binding site on alpha-tubulin with tubulin degradation effect.
Sci Adv, 7, 2021
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