1BMK
| THE COMPLEX STRUCTURE OF THE MAP KINASE P38/SB218655 | 分子名称: | 4-(FLUOROPHENYL)-1-CYCLOPROPYLMETHYL-5-(2-AMINO-4-PYRIMIDINYL)IMIDAZOLE, PROTEIN (MAP KINASE P38) | 著者 | Wang, Z, Canagarajah, B, Boehm, J.C, Kassis, S, Cobb, M.H, Young, P.R, Abdel-Meguid, S, Adams, J.L, Goldsmith, E.J. | 登録日 | 1998-07-23 | 公開日 | 1999-07-23 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structural basis of inhibitor selectivity in MAP kinases. Structure, 6, 1998
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1BL6
| THE COMPLEX STRUCTURE OF THE MAP KINASE P38/SB216995 | 分子名称: | 4-(4-FLUOROPHENYL)-1-CYCLOROPROPYLMETHYL-5-(4-PYRIDYL)-IMIDAZOLE, PROTEIN (MAP KINASE P38) | 著者 | Wang, Z, Canagarajah, B.J, Boehm, J.C, Kassis, S, Cobb, M.H, Young, P.R, Abdel-Meguid, S, Adams, J.L, Goldsmith, E.J. | 登録日 | 1998-07-11 | 公開日 | 1999-07-26 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structural basis of inhibitor selectivity in MAP kinases. Structure, 6, 1998
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1BL7
| THE COMPLEX STRUCTURE OF THE MAP KINASE P38/SB220025 | 分子名称: | 4-(4-FLUOROPHENYL)-1-(4-PIPERIDINYL)-5-(2-AMINO-4-PYRIMIDINYL)-IMIDAZOLE, PROTEIN (MAP KINASE P38) | 著者 | Wang, Z, Canagarajah, B.J, Boehm, J.C, Kassis, S, Cobb, M.H, Young, P.R, Abdel-Meguid, S, Adams, J.L, Goldsmith, E.J. | 登録日 | 1998-07-23 | 公開日 | 1999-07-26 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structural basis of inhibitor selectivity in MAP kinases. Structure, 6, 1998
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1A9U
| THE COMPLEX STRUCTURE OF THE MAP KINASE P38/SB203580 | 分子名称: | 4-[5-(4-FLUORO-PHENYL)-2-(4-METHANESULFINYL-PHENYL)-3H-IMIDAZOL-4-YL]-PYRIDINE, MAP KINASE P38 | 著者 | Wang, Z, Canagarajah, B, Boehm, J.C, Kassis, S, Cobb, M.H, Young, P.R, Abdel-Meguid, S, Adams, J.L, Goldsmith, E.J. | 登録日 | 1998-04-10 | 公開日 | 1999-04-20 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structural basis of inhibitor selectivity in MAP kinases. Structure, 6, 1998
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4BZ1
| Structure of dengue virus EDIII in complex with Fab 3e31 | 分子名称: | CHLORIDE ION, ENVELOPE PROTEIN, FAB 3E31 HEAVY CHAIN, ... | 著者 | Li, J, Watterson, D, Chang, C.W, Li, X.Q, Ericsson, D.J, Qiu, L.W, Cai, J.P, Chen, J, Fry, S.R, Cooper, M.A, Che, X.Y, Young, P.R, Kobe, B. | 登録日 | 2013-07-23 | 公開日 | 2014-08-13 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Structure of Dengue Virus Ediii in Complex with Fab 3E31 To be Published
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4BZ2
| Structure of dengue virus EDIII in complex with Fab 2D73 | 分子名称: | CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ENVELOPE PROTEIN, ... | 著者 | Li, J, Watterson, D, Chang, C.W, Li, X.Q, Ericsson, D.J, Qiu, L.W, Cai, J.P, Chen, J, Fry, S.R, Cooper, M.A, Che, X.Y, Young, P.R, Kobe, B. | 登録日 | 2013-07-23 | 公開日 | 2014-08-13 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | 主引用文献 | Structure of Dengue Virus Ediii in Complex with Fab 2D73 To be Published
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3ERK
| THE COMPLEX STRUCTURE OF THE MAP KINASE ERK2/SB220025 | 分子名称: | 4-(4-FLUOROPHENYL)-1-(4-PIPERIDINYL)-5-(2-AMINO-4-PYRIMIDINYL)-IMIDAZOLE, EXTRACELLULAR REGULATED KINASE 2 | 著者 | Wang, Z, Canagarajah, B, Boehm, J.C, Cobb, M.H, Young, P.R, Abdel-Meguid, S, Adams, J.L, Goldsmith, E.J. | 登録日 | 1998-07-09 | 公開日 | 1999-07-22 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structural basis of inhibitor selectivity in MAP kinases. Structure, 6, 1998
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1HIB
| THE STRUCTURE OF AN INTERLEUKIN-1 BETA MUTANT WITH REDUCED BIOACTIVITY SHOWS MULTIPLE SUBTLE CHANGES IN CONFORMATION THAT AFFECT PROTEIN-PROTEIN RECOGNITION | 分子名称: | INTERLEUKIN-1 BETA | 著者 | Camacho, N.P, Smith, D.R, Goldman, A, Schneider, B, Green, D, Young, P.R, Berman, H.M. | 登録日 | 1993-03-29 | 公開日 | 1994-01-31 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structure of an interleukin-1 beta mutant with reduced bioactivity shows multiple subtle changes in conformation that affect protein-protein recognition. Biochemistry, 32, 1993
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4ERK
| THE COMPLEX STRUCTURE OF THE MAP KINASE ERK2/OLOMOUCINE | 分子名称: | EXTRACELLULAR REGULATED KINASE 2, OLOMOUCINE, SULFATE ION | 著者 | Wang, Z, Canagarajah, B, Boehm, J.C, Cobb, M.H, Young, P.R, Abdel-Meguid, S, Adams, J.L, Goldsmith, E.J. | 登録日 | 1998-07-09 | 公開日 | 1999-07-22 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structural basis of inhibitor selectivity in MAP kinases. Structure, 6, 1998
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7BSD
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7BSC
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6CZV
| BRD4(BD1) complexed with 2759 | 分子名称: | 1,2-ETHANEDIOL, 1-benzyl-5-(3,5-dimethyl-1,2-oxazol-4-yl)pyridin-2(1H)-one, Bromodomain-containing protein 4 | 著者 | Lakshminarasimhan, D, White, A, Suto, R.K. | 登録日 | 2018-04-09 | 公開日 | 2018-09-26 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.88 Å) | 主引用文献 | Design and Characterization of Novel Covalent Bromodomain and Extra-Terminal Domain (BET) Inhibitors Targeting a Methionine. J. Med. Chem., 61, 2018
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6CZU
| BRD4(BD1) complexed with 3219 | 分子名称: | 1,2-ETHANEDIOL, 5-(3,5-dimethyl-1,2-oxazol-4-yl)-1-({4-[(1R)-1-hydroxyethyl]phenyl}methyl)pyridin-2(1H)-one, Bromodomain-containing protein 4, ... | 著者 | Lakshminarasimhan, D, White, A, Suto, R.K. | 登録日 | 2018-04-09 | 公開日 | 2018-09-26 | 最終更新日 | 2018-10-10 | 実験手法 | X-RAY DIFFRACTION (1.47 Å) | 主引用文献 | Design and Characterization of Novel Covalent Bromodomain and Extra-Terminal Domain (BET) Inhibitors Targeting a Methionine. J. Med. Chem., 61, 2018
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3E90
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4YH3
| Crystal structure of human BRD4(1) in complex with 4-[(2E)-3-(4-methoxyphenyl)-2-phenylprop-2-enoyl]-3,4-dihydroquinoxalin-2(1H)-one (compound 19a) | 分子名称: | 4-[(2E)-3-(4-methoxyphenyl)-2-phenylprop-2-enoyl]-3,4-dihydroquinoxalin-2(1H)-one, Bromodomain-containing protein 4 | 著者 | White, A, Lakshminarasimhan, D, Suto, R.K. | 登録日 | 2015-02-26 | 公開日 | 2016-01-13 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Discovery of a new chemical series of BRD4(1) inhibitors using protein-ligand docking and structure-guided design. Bioorg.Med.Chem.Lett., 25, 2015
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4YH4
| Crystal structure of human BRD4(1) in complex with 4-[(5-phenylpyridin-3-yl)carbonyl]-3,4-dihydroquinoxalin-2(1H)-one (compound 19d) | 分子名称: | 4-[(5-phenylpyridin-3-yl)carbonyl]-3,4-dihydroquinoxalin-2(1H)-one, Bromodomain-containing protein 4, GLYCEROL, ... | 著者 | Lakshminarasimhan, D, White, A, Suto, R.K. | 登録日 | 2015-02-26 | 公開日 | 2016-01-13 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.33 Å) | 主引用文献 | Discovery of a new chemical series of BRD4(1) inhibitors using protein-ligand docking and structure-guided design. Bioorg.Med.Chem.Lett., 25, 2015
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5DW1
| X-ray crystal structure of human BRD2(BD2) in complex with RVX297 to 1.55 A resolution | 分子名称: | 2-{3,5-dimethyl-4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}-5,7-dimethoxyquinazolin-4(3H)-one, Bromodomain-containing protein 2, SODIUM ION | 著者 | White, A, Fontano, E, Suto, R.K. | 登録日 | 2015-09-22 | 公開日 | 2016-06-22 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | RVX-297- a novel BD2 selective inhibitor of BET bromodomains. Biochem.Biophys.Res.Commun., 477, 2016
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5DW2
| X-ray crystal structure of human BRD4(BD1) in complex with RVX297 to 1.12 A resolution | 分子名称: | 1,2-ETHANEDIOL, 2-{3,5-dimethyl-4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}-5,7-dimethoxyquinazolin-4(3H)-one, Bromodomain-containing protein 4 | 著者 | White, A, Fontano, E, Suto, R.K. | 登録日 | 2015-09-22 | 公開日 | 2016-06-22 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.12 Å) | 主引用文献 | RVX-297- a novel BD2 selective inhibitor of BET bromodomains. Biochem.Biophys.Res.Commun., 477, 2016
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7KVB
| Chimeric flavivirus between Binjari virus and Murray Valley encephalitis virus | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope protein E, Matrix protein M | 著者 | Hardy, J.M, Venugopal, H.V, Newton, N.D, Watterson, D, Coulibaly, F.J. | 登録日 | 2020-11-27 | 公開日 | 2020-12-23 | 最終更新日 | 2021-07-14 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | A unified route for flavivirus structures uncovers essential pocket factors conserved across pathogenic viruses. Nat Commun, 12, 2021
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7KV9
| Chimeric flavivirus between Binjari virus and West Nile (Kunjin) virus | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Matrix protein M, envelope protein E | 著者 | Hardy, J.M, Venugopal, H.V, Newton, N.D, Watterson, D, Coulibaly, F.J. | 登録日 | 2020-11-27 | 公開日 | 2020-12-23 | 最終更新日 | 2021-07-14 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | A unified route for flavivirus structures uncovers essential pocket factors conserved across pathogenic viruses. Nat Commun, 12, 2021
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7KV8
| Chimeric flavivirus between Binjari virus and Dengue virus serotype-2 | 分子名称: | (2S,3R,4Z)-3-hydroxy-2-[(9E)-octadec-9-enoylamino]octadec-4-en-1-yl dihydrogen phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope protein E, ... | 著者 | Hardy, J.M, Venugopal, H.V, Newton, N.D, Watterson, D, Coulibaly, F.J. | 登録日 | 2020-11-27 | 公開日 | 2020-12-23 | 最終更新日 | 2021-11-24 | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | 主引用文献 | A unified route for flavivirus structures uncovers essential pocket factors conserved across pathogenic viruses. Nat Commun, 12, 2021
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7KVA
| Structure of West Nile virus (Kunjin) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope protein E, Matrix protein M | 著者 | Hardy, J.M, Venugopal, H.V, Newton, N.D, Watterson, D, Coulibaly, F.J. | 登録日 | 2020-11-27 | 公開日 | 2020-12-23 | 最終更新日 | 2021-07-14 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | A unified route for flavivirus structures uncovers essential pocket factors conserved across pathogenic viruses. Nat Commun, 12, 2021
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4J3I
| X-ray crystal structure of bromodomain complex to 1.24 A resolution | 分子名称: | 1,2-ETHANEDIOL, 2-[4-(2-hydroxyethoxy)-3,5-dimethylphenyl]-5,7-dimethoxyquinazolin-4(3H)-one, Bromodomain-containing protein 4, ... | 著者 | Stein, A.J, White, A, Suto, R.K. | 登録日 | 2013-02-05 | 公開日 | 2014-01-15 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.24 Å) | 主引用文献 | RVX-208, an Inducer of ApoA-I in Humans, Is a BET Bromodomain Antagonist. Plos One, 8, 2013
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4J1P
| X-ray crystal structure of bromodomain 2 of human brd2 in complex with rvx208 to 1.08 A resolution | 分子名称: | 1,2-ETHANEDIOL, 2-[4-(2-hydroxyethoxy)-3,5-dimethylphenyl]-5,7-dimethoxyquinazolin-4(3H)-one, Bromodomain containing 2, ... | 著者 | Stein, A.J, White, A, Suto, R.K. | 登録日 | 2013-02-01 | 公開日 | 2014-01-15 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.08 Å) | 主引用文献 | RVX-208, an Inducer of ApoA-I in Humans, Is a BET Bromodomain Antagonist. Plos One, 8, 2013
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1IAN
| HUMAN P38 MAP KINASE INHIBITOR COMPLEX | 分子名称: | 4-[5-(3-IODO-PHENYL)-2-(4-METHANESULFINYL-PHENYL)-1H-IMIDAZOL-4-YL]-PYRIDINE, P38 MAP KINASE | 著者 | Tong, L. | 登録日 | 1997-03-07 | 公開日 | 1998-05-06 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | A highly specific inhibitor of human p38 MAP kinase binds in the ATP pocket. Nat.Struct.Biol., 4, 1997
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