3E90

West Nile vi rus NS2B-NS3protease in complexed with inhibitor Naph-KKR-H

Summary for 3E90

Entry DOI	10.2210/pdb3e90/pdb
Descriptor	NS2B cofactor, NS3 protease, N~2~-(naphthalen-2-ylcarbonyl)-L-lysyl-N-[(1S)-4-carbamimidamido-1-formylbutyl]-L-lysinamide, ... (4 entities in total)
Functional Keywords	west nile virus, ns3 protease, trypsin-like serine protease, protease inhibitor, catalytic histidine, induced fit, atp-binding, capsid protein, helicase, hydrolase, nucleotide-binding, rna replication, transmembrane, virion
Biological source	West Nile virus (WNV) More
Total number of polymer chains	4
Total formula weight	54633.15
Authors	Martin, J.L.,Robin, G. (deposition date: 2008-08-21, release date: 2009-01-20, Last modification date: 2023-11-01)
Primary citation	Robin, G.,Chappell, K.,Stoermer, M.J.,Hu, S.-H.,Young, P.R.,Fairlie, D.P.,Martin, J.L. Structure of West Nile virus NS3 protease: ligand stabilization of the catalytic conformation J.Mol.Biol., 385:1568-1577, 2009 Cited by PubMed: 19059417 DOI: 10.1016/j.jmb.2008.11.026 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.45 Å)

Structure validation