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3E90

West Nile vi rus NS2B-NS3protease in complexed with inhibitor Naph-KKR-H

Functional Information from GO Data
ChainGOidnamespacecontents
A0004252molecular_functionserine-type endopeptidase activity
A0044423cellular_componentvirion component
B0003723molecular_functionRNA binding
B0003724molecular_functionRNA helicase activity
B0005524molecular_functionATP binding
C0004252molecular_functionserine-type endopeptidase activity
C0044423cellular_componentvirion component
D0003723molecular_functionRNA binding
D0003724molecular_functionRNA helicase activity
D0005524molecular_functionATP binding
Functional Information from PDB Data
site_idAC1
Number of Residues27
DetailsBINDING SITE FOR RESIDUE NKK B 195
ChainResidue
AGLY83
BPHE130
BTHR132
BGLY133
BTHR134
BSER135
BGLY151
BASN152
BGLY153
BTYR161
BHOH214
AASN84
BHOH231
BHOH240
BHOH273
BHOH275
DTRP89
DASN90
DGLN92
DGLU122
APHE85
AGLN86
AASP90
AHOH120
BHIS51
BASP75
BASP129

site_idAC2
Number of Residues25
DetailsBINDING SITE FOR RESIDUE NKK D 195
ChainResidue
AVAL77
AARG78
AGLN86
ALEU87
AMET88
AGLY94
AHOH104
AHOH111
CGLY83
CASN84
CPHE85
CGLN86
DHIS51
DASP75
DASP129
DPHE130
DTHR132
DSER135
DGLY151
DASN152
DGLY153
DTYR161
DHOH228
DHOH237
DHOH243

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsACT_SITE: Charge relay system; for serine protease NS3 activity => ECO:0000255|PROSITE-ProRule:PRU00860
ChainResidueDetails
BHIS51
BASP75
BSER135
DHIS51
DASP75
DSER135

227344

PDB entries from 2024-11-13

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