7VBC
 
 | | Back track state of human RNA Polymerase I Elongation Complex | | Descriptor: | DNA (5'-D(*GP*TP*AP*CP*TP*GP*TP*CP*CP*TP*CP*TP*GP*G)-3'), DNA (5'-D(P*AP*GP*GP*AP*CP*AP*GP*CP*GP*TP*GP*TP*CP*AP*GP*CP*AP*AP*TP*A)-3'), DNA-directed RNA polymerase I subunit RPA1, ... | | Authors: | Zhao, D, Liu, W, Chen, K, Yang, H, Xu, Y. | | Deposit date: | 2021-08-31 | | Release date: | 2022-02-16 | | Method: | ELECTRON MICROSCOPY (3.01 Å) | | Cite: | Structure of the human RNA polymerase I elongation complex.
Cell Discov, 7, 2021
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7VBB
 | | Structure of the post state human RNA Polymerase I Elongation Complex | | Descriptor: | DNA (25-MER), DNA (5'-D(*CP*TP*GP*TP*CP*CP*TP*CP*TP*GP*GP*CP*GP*A)-3'), DNA-directed RNA polymerase I subunit RPA1, ... | | Authors: | Zhao, D, Liu, W, Chen, K, Yang, H, Xu, Y. | | Deposit date: | 2021-08-31 | | Release date: | 2022-03-02 | | Method: | ELECTRON MICROSCOPY (2.81 Å) | | Cite: | Structure of the human RNA polymerase I elongation complex.
Cell Discov, 7, 2021
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7W33
 | | The crystal structure of human CtsL in complex with 14a | | Descriptor: | N-[(2S)-3-(4-fluorophenyl)-1-oxidanylidene-1-[[(2R,3S)-3-oxidanyl-4-oxidanylidene-1-[(3S)-2-oxidanylidenepiperidin-3-yl]-4-[(phenylmethyl)amino]butan-2-yl]amino]propan-2-yl]-1-benzofuran-2-carboxamide, Procathepsin L | | Authors: | Zhao, Y, Shao, M, Zhao, J, Yang, H, Rao, Z. | | Deposit date: | 2021-11-25 | | Release date: | 2023-05-31 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.39 Å) | | Cite: | The crystal structure of human CtsL in complex with 14a
To Be Published
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7W34
 | | The crystal structure of human CtsL in complex with 14b | | Descriptor: | N-[(2S)-3-cyclohexyl-1-oxidanylidene-1-[[(2S,3S)-3-oxidanyl-4-oxidanylidene-1-[(3S)-2-oxidanylidenepiperidin-3-yl]-4-[(phenylmethyl)amino]butan-2-yl]amino]propan-2-yl]-1-benzofuran-2-carboxamide, Procathepsin L | | Authors: | Zhao, Y, Shao, M, Zhao, J, Yang, H, Rao, Z. | | Deposit date: | 2021-11-25 | | Release date: | 2023-05-31 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.89 Å) | | Cite: | The crystal structure of human CtsL in complex with 14a
To Be Published
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7W7O
 | | The crystal structure of human Calpain-1 protease core in complex with 14a | | Descriptor: | CALCIUM ION, Calpain-1 catalytic subunit, HYDROSULFURIC ACID, ... | | Authors: | Zhao, Y, Zhao, J, Shao, M, Yang, H, Rao, Z. | | Deposit date: | 2021-12-06 | | Release date: | 2023-06-07 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.59 Å) | | Cite: | The crystal structure of human Calpain-1 protease core in complex with 14a
To Be Published
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7X79
 | | The crystal structure of human Calpain-1 protease core in complex with 14b | | Descriptor: | CALCIUM ION, Calpain-1 catalytic subunit, HYDROSULFURIC ACID, ... | | Authors: | Zhao, Y, Zhao, J, Shao, M, Yang, H, Rao, Z. | | Deposit date: | 2022-03-09 | | Release date: | 2023-06-14 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | The crystal structure of human Calpain-1 protease core in complex with 14a
To Be Published
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1IYJ
 | | STRUCTURE OF A BRCA2-DSS1 COMPLEX | | Descriptor: | Deleted in split hand/split foot protein 1, breast cancer susceptibility | | Authors: | Pavletich, N.P, Jeffrey, P.D, Yang, H.J. | | Deposit date: | 2002-08-28 | | Release date: | 2002-10-02 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (3.4 Å) | | Cite: | BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA structure.
Science, 297, 2002
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4YKN
 | | Pi3K alpha lipid kinase with Active Site Inhibitor | | Descriptor: | 3-(6-methoxypyridin-3-yl)-5-[({4-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfamoyl]phenyl}amino)methyl]benzoic acid, Phosphatidylinositol 3-kinase regulatory subunit alpha,Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform fusion protein | | Authors: | Elkins, P.A. | | Deposit date: | 2015-03-04 | | Release date: | 2015-06-17 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Discovery of a Potent Class of PI3K alpha Inhibitors with Unique Binding Mode via Encoded Library Technology (ELT).
Acs Med.Chem.Lett., 6, 2015
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5WBL
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5WBK
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5WBI
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6P3X
 | | Crystal Structure of Full Length APOBEC3G E/Q (pH 7.0) | | Descriptor: | Apolipoprotein B mRNA editing enzyme, catalytic peptide-like 3G, ZINC ION | | Authors: | Yang, H.J, Li, S.X, Chen, X.S. | | Deposit date: | 2019-05-25 | | Release date: | 2020-02-12 | | Last modified: | 2023-07-26 | | Method: | X-RAY DIFFRACTION (2.402 Å) | | Cite: | Understanding the structural basis of HIV-1 restriction by the full length double-domain APOBEC3G.
Nat Commun, 11, 2020
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6P3Z
 | | Crystal Structure of Full Length APOBEC3G E/Q (pH 5.2) | | Descriptor: | Apolipoprotein B mRNA editing enzyme, catalytic peptide-like 3G, ZINC ION | | Authors: | Yang, H.J, Li, S.X, Chen, X.S. | | Deposit date: | 2019-05-25 | | Release date: | 2020-02-12 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2.844 Å) | | Cite: | Understanding the structural basis of HIV-1 restriction by the full length double-domain APOBEC3G.
Nat Commun, 11, 2020
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6P3Y
 | | Crystal Structure of Full Length APOBEC3G E/Q (pH 7.4) | | Descriptor: | Apolipoprotein B mRNA editing enzyme, catalytic peptide-like 3G, ZINC ION | | Authors: | Yang, H.J, Li, S.X, Chen, X.S. | | Deposit date: | 2019-05-25 | | Release date: | 2020-02-12 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2.57 Å) | | Cite: | Understanding the structural basis of HIV-1 restriction by the full length double-domain APOBEC3G.
Nat Commun, 11, 2020
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6P40
 | | Crystal Structure of Full Length APOBEC3G FKL | | Descriptor: | Apolipoprotein B mRNA editing enzyme, catalytic peptide-like 3G, ZINC ION | | Authors: | Yang, H.J, Li, S.X, Chen, X.S. | | Deposit date: | 2019-05-25 | | Release date: | 2020-02-12 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2.452 Å) | | Cite: | Understanding the structural basis of HIV-1 restriction by the full length double-domain APOBEC3G.
Nat Commun, 11, 2020
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8EDJ
 | | Crystal structure of rA3G-ssRNA-GA | | Descriptor: | DNA dC->dU-editing enzyme APOBEC-3G, RNA (5'-R(P*UP*GP*AP*UP*UP*U)-3'), SULFATE ION, ... | | Authors: | Pacheco, J, Yang, H.J, Li, S.-X, Chen, X.S. | | Deposit date: | 2022-09-04 | | Release date: | 2023-01-11 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (1.83 Å) | | Cite: | Structural basis of sequence-specific RNA recognition by the antiviral factor APOBEC3G.
Nat Commun, 13, 2022
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3MF5
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4JSN
 | | structure of mTORdeltaN-mLST8 complex | | Descriptor: | Serine/threonine-protein kinase mTOR, Target of rapamycin complex subunit LST8 | | Authors: | Pavletich, N.P. | | Deposit date: | 2013-03-22 | | Release date: | 2013-05-08 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | mTOR kinase structure, mechanism and regulation.
Nature, 497, 2013
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8DZ8
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5WBJ
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7JY9
 | | Structure of a 9 base pair RecA-D loop complex | | Descriptor: | DNA (27-MER), DNA (42-MER), MAGNESIUM ION, ... | | Authors: | Pavletich, N.P. | | Deposit date: | 2020-08-29 | | Release date: | 2020-11-04 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | Mechanism of strand exchange from RecA-DNA synaptic and D-loop structures.
Nature, 586, 2020
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7JY6
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7JY8
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7JY7
 | | Structure of a 12 base pair RecA-D loop complex | | Descriptor: | DNA (27-MER), DNA (48-MER), MAGNESIUM ION, ... | | Authors: | Pavletich, N.P. | | Deposit date: | 2020-08-29 | | Release date: | 2020-11-04 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Mechanism of strand exchange from RecA-DNA synaptic and D-loop structures.
Nature, 586, 2020
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4UV7
 | | The complex structure of extracellular domain of EGFR and GC1118A | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, EPIDERMAL GROWTH FACTOR RECEPTOR, ... | | Authors: | Yoo, J.H, Cho, H.S. | | Deposit date: | 2014-08-05 | | Release date: | 2015-10-14 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Gc1118, an Anti-Egfr Antibody with a Distinct Binding Epitope and Superior Inhibitory Activity Against High-Affinity Egfr Ligands.
Mol.Cancer Ther., 15, 2016
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