6W25
 
 | | Crystal structure of the Melanocortin-4 Receptor (MC4R) in complex with SHU9119 | | 分子名称: | CALCIUM ION, Melanocortin receptor 4,GlgA glycogen synthase,Melanocortin receptor 4, OLEIC ACID, ... | | 著者 | Yu, J, Gimenez, L.E, Hernandez, C.C, Wu, Y, Wein, A.H, Han, G.W, McClary, K, Mittal, S.R, Burdsall, K, Stauch, B, Wu, L, Stevens, S.N, Peisley, A, Williams, S.Y, Chen, V, Millhauser, G.L, Zhao, S, Cone, R.D, Stevens, R.C. | | 登録日 | 2020-03-04 | | 公開日 | 2020-04-29 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | | 主引用文献 | Determination of the melanocortin-4 receptor structure identifies Ca2+as a cofactor for ligand binding.
Science, 368, 2020
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1FI9
 | | SOLUTION STRUCTURE OF THE IMIDAZOLE COMPLEX OF CYTOCHROME C | | 分子名称: | CYTOCHROME C, HEME C, IMIDAZOLE | | 著者 | Banci, L, Bertini, I, Liu, G, Lu, J, Reddig, T, Tang, W, Wu, Y, Zhu, D. | | 登録日 | 2000-08-03 | | 公開日 | 2000-08-23 | | 最終更新日 | 2022-02-23 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Effects of extrinsic imidazole ligation on the molecular and electronic structure of cytochrome c
J.Biol.Inorg.Chem., 6, 2001
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8SSX
 | | Crystal structure of Bacillus anthracis dihydrofolate reductase at 1.65-A resolution | | 分子名称: | 1,2-ETHANEDIOL, Dihydrofolate reductase, SULFATE ION | | 著者 | Shaw, G.X, Li, Y, Wu, Y, Yan, H, Ji, X. | | 登録日 | 2023-05-09 | | 公開日 | 2023-05-17 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | Crystal structure of Bacillus anthracis dihydrofolate reductase at 1.65-A resolution
To be published
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1CS7
 | | SYNTHETIC DNA HAIRPIN WITH STILBENEDIETHER LINKER | | 分子名称: | 5'-D(GP*(BRU)P*TP*TP*TP*GP*(S02)*CP*AP*AP*AP*AP*C)-3', STRONTIUM ION | | 著者 | Lewis, F.D, Liu, X, Wu, Y, Miller, S.E, Wasielewski, M.R, Letsinger, R.L, Sanishvili, R, Joachimiak, A, Tereshko, V, Egli, M. | | 登録日 | 1999-08-17 | | 公開日 | 2001-10-19 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Structure and Photoinduced Electron Transfer in Exceptionally Stable Synthetic DNA Hairpins with Stilbenediether Linkers
J.Am.Chem.Soc., 121, 1999
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6IEC
 | | Structure of RVFV Gn and human monoclonal antibody R17 | | 分子名称: | NSmGnGc, R17 H chain, R17 L chain | | 著者 | Wang, Q.H, Wu, Y, Gao, F, Qi, J.X, Gao, G.F. | | 登録日 | 2018-09-13 | | 公開日 | 2019-04-10 | | 最終更新日 | 2019-07-10 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Neutralization mechanism of human monoclonal antibodies against Rift Valley fever virus.
Nat Microbiol, 4, 2019
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6IEA
 | | Structure of RVFV Gn and human monoclonal antibody R13 | | 分子名称: | DI(HYDROXYETHYL)ETHER, GLYCEROL, NSmGnGc, ... | | 著者 | Wang, Q.H, Wu, Y, Gao, F, Qi, J.X, Gao, G.F. | | 登録日 | 2018-09-13 | | 公開日 | 2019-04-10 | | 最終更新日 | 2019-07-10 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Neutralization mechanism of human monoclonal antibodies against Rift Valley fever virus.
Nat Microbiol, 4, 2019
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6IEK
 | | Structure of RVFV Gn and human monoclonal antibody R12 | | 分子名称: | Heavy chain of Fab R12, Light chain of Fab R12, NSmGnGc | | 著者 | Wang, Q.H, Wu, Y, Gao, F, Qi, J.X, Gao, G.F. | | 登録日 | 2018-09-14 | | 公開日 | 2019-04-10 | | 最終更新日 | 2019-07-10 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Neutralization mechanism of human monoclonal antibodies against Rift Valley fever virus.
Nat Microbiol, 4, 2019
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6IEB
 | | Structure of RVFV Gn and human monoclonal antibody R15 | | 分子名称: | NSmGnGc, R15 H chain, R15 L chain | | 著者 | Wang, Q.H, Wu, Y, Gao, F, Qi, J.X, Gao, G.F. | | 登録日 | 2018-09-13 | | 公開日 | 2019-04-10 | | 最終更新日 | 2019-07-10 | | 実験手法 | X-RAY DIFFRACTION (2.409 Å) | | 主引用文献 | Neutralization mechanism of human monoclonal antibodies against Rift Valley fever virus.
Nat Microbiol, 4, 2019
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2F1I
 | | Recombinase in Complex with AMP-PNP | | 分子名称: | DNA repair and recombination protein radA, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | | 著者 | Qian, X, He, Y, Wu, Y, Luo, Y. | | 登録日 | 2005-11-14 | | 公開日 | 2006-05-30 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Asp302 determines potassium dependence of a RadA recombinase from Methanococcus voltae.
J.Mol.Biol., 360, 2006
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2F1H
 | | RECOMBINASE IN COMPLEX WITH AMP-PNP and Potassium | | 分子名称: | DNA repair and recombination protein radA, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | | 著者 | Qian, X, He, Y, Wu, Y, Luo, Y. | | 登録日 | 2005-11-14 | | 公開日 | 2006-05-30 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Asp302 determines potassium dependence of a RadA recombinase from Methanococcus voltae.
J.Mol.Biol., 360, 2006
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2F1J
 | | Recombinase in Complex with ADP | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, DNA repair and recombination protein radA, MAGNESIUM ION | | 著者 | Qian, X, He, Y, Wu, Y, Luo, Y. | | 登録日 | 2005-11-14 | | 公開日 | 2006-05-30 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Asp302 determines potassium dependence of a RadA recombinase from Methanococcus voltae.
J.Mol.Biol., 360, 2006
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1TMM
 | | Crystal structure of ternary complex of E.coli HPPK(W89A) with MGAMPCPP and 6-Hydroxymethylpterin | | 分子名称: | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, 6-HYDROXYMETHYLPTERIN, ACETATE ION, ... | | 著者 | Blaszczyk, J, Li, Y, Wu, Y, Shi, G, Ji, X, Yan, H. | | 登録日 | 2004-06-10 | | 公開日 | 2005-06-21 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | | 主引用文献 | Is the Critical Role of Loop 3 of Escherichia coli 6-Hydroxymethyl-7,8-dihydropterin Pyrophosphokinase in Catalysis Due to Loop-3 Residues Arginine-84 and Tryptophan-89? Site-Directed Mutagenesis, Biochemical, and Crystallographic Studies.
Biochemistry, 44, 2005
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4H53
 | | Influenza N2-Tyr406Asp neuraminidase in complex with beta-Neu5Ac | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | 著者 | Vavricka, C.J, Liu, Y, Kiyota, H, Sriwilaijaroen, N, Qi, J, Tanaka, K, Wu, Y, Li, Q, Li, Y, Yan, J, Suzuki, Y, Gao, G.F. | | 登録日 | 2012-09-18 | | 公開日 | 2013-02-20 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Influenza neuraminidase operates via a nucleophilic mechanism and can be targeted by covalent inhibitors
Nat Commun, 4, 2013
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4H52
 | | Wild-type influenza N2 neuraminidase covalent complex with 3-fluoro-Neu5Ac | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-acetamido-3,5-dideoxy-3-fluoro-D-erythro-alpha-L-manno-non-2-ulopyranosonic acid, CALCIUM ION, ... | | 著者 | Vavricka, C.J, Liu, Y, Kiyota, H, Sriwilaijaroen, N, Qi, J, Tanaka, K, Wu, Y, Li, Q, Li, Y, Yan, J, Suzuki, Y, Gao, G.F. | | 登録日 | 2012-09-18 | | 公開日 | 2013-02-20 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.803 Å) | | 主引用文献 | Influenza neuraminidase operates via a nucleophilic mechanism and can be targeted by covalent inhibitors
Nat Commun, 4, 2013
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6XQI
 | | Structure of HIV-1 Vpr in complex with the human nucleotide excision repair protein hHR23A | | 分子名称: | ASN-PRO-LEU-GLU-PHE-LEU, Protein Vpr, UV excision repair protein RAD23 homolog A, ... | | 著者 | Calero, G.C, Wu, Y, Weiss, S.C. | | 登録日 | 2020-07-09 | | 公開日 | 2021-08-11 | | 最終更新日 | 2021-12-08 | | 実験手法 | X-RAY DIFFRACTION (2.34 Å) | | 主引用文献 | Structure of HIV-1 Vpr in complex with the human nucleotide excision repair protein hHR23A.
Nat Commun, 12, 2021
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6XQJ
 | | Structure of HIV-1 Vpr in complex with the human nucleotide excision repair protein hHR23A | | 分子名称: | Protein Vpr,UV excision repair protein RAD23 homolog A, ZINC ION | | 著者 | Byeon, I.-J.L, Calero, G, Wu, Y, Byeon, C.H, Gronenborn, A.M. | | 登録日 | 2020-07-09 | | 公開日 | 2021-11-17 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structure of HIV-1 Vpr in complex with the human nucleotide excision repair protein hHR23A.
Nat Commun, 12, 2021
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6IQT
 | | Crystal Structure of CagV, a VirB8 homolog of T4SS from Helicobacter pylori Strain 26695 | | 分子名称: | Cag pathogenicity island protein (Cag10) | | 著者 | Wu, X, Zhao, Y, Sun, L, Jiang, M, Wang, Q, Wang, Q, Yang, W, Wu, Y. | | 登録日 | 2018-11-08 | | 公開日 | 2019-11-13 | | 最終更新日 | 2020-04-29 | | 実験手法 | X-RAY DIFFRACTION (1.922 Å) | | 主引用文献 | Crystal structure of CagV, the Helicobacter pylori homologue of the T4SS protein VirB8.
Febs J., 286, 2019
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6JHO
 | | The complex crystal structure of Cagbeta with CagZ revealed a novel regulatory mechanism for T4SS coupling ATPase in Helicobacter pylori | | 分子名称: | Cag pathogenicity island protein (Cag5), Cag pathogenicity island protein (Cag6) | | 著者 | Wu, X, Zhao, Y, Sun, L, Ye, X, Jiang, M, Wang, Q, Wang, Q, Wu, Y. | | 登録日 | 2019-02-18 | | 公開日 | 2020-02-19 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | The complex crystal structure of Cagbeta with CagZ revealed a novel regulatory mechanism in VirD4 coupling ATPase
To Be Published
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6IJI
 | | Crystal structure of PDE10 in complex with inhibitor 2b | | 分子名称: | 2-{2-[5-methyl-1-(pyridin-4-yl)-1H-benzimidazol-2-yl]ethyl}-1H-benzo[de]isoquinoline-1,3(2H)-dione, MAGNESIUM ION, ZINC ION, ... | | 著者 | Huang, Y.Y, Yu, Y.F, Zhang, C, Wu, D, Wu, Y, Luo, H.B. | | 登録日 | 2018-10-10 | | 公開日 | 2019-04-10 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Validation of Phosphodiesterase-10 as a Novel Target for Pulmonary Arterial Hypertension via Highly Selective and Subnanomolar Inhibitors.
J. Med. Chem., 62, 2019
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6IJH
 | | Crystal structure of PDE10 in complex with inhibitor AF-399/14387019 | | 分子名称: | 2-[2-(4-phenyl-5-sulfanylidene-4,5-dihydro-1H-1,2,4-triazol-3-yl)ethyl]-1H-benzo[de]isoquinoline-1,3(2H)-dione, MAGNESIUM ION, ZINC ION, ... | | 著者 | Huang, Y.Y, Yu, Y.F, Zhang, C, Wu, D, Wu, Y, Luo, H.B. | | 登録日 | 2018-10-10 | | 公開日 | 2019-04-10 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Validation of Phosphodiesterase-10 as a Novel Target for Pulmonary Arterial Hypertension via Highly Selective and Subnanomolar Inhibitors.
J. Med. Chem., 62, 2019
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2B21
 | | RADA Recombinase in complex with AMPPNP at pH 6.0 | | 分子名称: | DNA repair and recombination protein radA, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | | 著者 | Qian, X, He, Y, Wu, Y, Luo, Y. | | 登録日 | 2005-09-16 | | 公開日 | 2006-08-29 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Crystal Structure of Methanococcus Voltae Rada at an Acidic pH
To be Published
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3N2N
 | | The Crystal Structure of Tumor Endothelial Marker 8 (TEM8) extracellular domain | | 分子名称: | ACETATE ION, Anthrax toxin receptor 1, MAGNESIUM ION | | 著者 | Fu, S, Tong, X.H, Wu, Y, Li, Y.Y, Rao, Z.H. | | 登録日 | 2010-05-18 | | 公開日 | 2011-01-05 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | The structure of tumor endothelial marker 8 (TEM8) extracellular domain and implications for its receptor function for recognizing anthrax toxin.
Plos One, 5, 2010
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6CLU
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6CLV
 | | Staphylococcus aureus Dihydropteroate Synthase (saDHPS) F17L E208K double mutant structure | | 分子名称: | 4-{[(2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}-N-(3,4-dimethyl-1,2-oxazol-5-yl)benzene-1-sulfonamide, Dihydropteroate synthase | | 著者 | Gajewski, S, Griffith, E.C, Wu, Y, White, S.W. | | 登録日 | 2018-03-02 | | 公開日 | 2018-08-22 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | The Structural and Functional Basis for Recurring Sulfa Drug Resistance Mutations inStaphylococcus aureusDihydropteroate Synthase.
Front Microbiol, 9, 2018
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3SOB
 | | The structure of the first YWTD beta propeller domain of LRP6 in complex with a FAB | | 分子名称: | CALCIUM ION, Low-density lipoprotein receptor-related protein 6, antibody heavy chain, ... | | 著者 | Wang, W, Bourhis, E, Tam, C, Zhang, Y, Rouge, L, Wu, Y, Franke, Y, Cochran, A.G. | | 登録日 | 2011-06-30 | | 公開日 | 2011-09-21 | | 最終更新日 | 2014-05-14 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Wnt antagonists bind through a short peptide to the first beta-propeller domain of LRP5/6.
Structure, 19, 2011
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