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3H7H
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BU of 3h7h by Molmil
Crystal structure of the human transcription elongation factor DSIF, hSpt4/hSpt5 (176-273)
Descriptor: BETA-MERCAPTOETHANOL, Transcription elongation factor SPT4, Transcription elongation factor SPT5, ...
Authors:Wenzel, S, Wohrl, B.M, Rosch, P, Martins, B.M.
Deposit date:2009-04-27
Release date:2009-12-08
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Crystal structure of the human transcription elongation factor DSIF hSpt4 subunit in complex with the hSpt5 dimerization interface
Biochem.J., 425, 2010
5ZM0
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BU of 5zm0 by Molmil
X-ray structure of animal-like Cryptochrome from Chlamydomonas reinhardtii
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, Cryptochrome photoreceptor, ...
Authors:Franz, S, Ignatz, E, Wenzel, S, Zielosko, H, Gusti Ngurah Putu, E.P, Maestre-Reyna, M, Tsai, M.-D, Yamamoto, J, Mittag, M, Essen, L.-O.
Deposit date:2018-03-31
Release date:2018-07-25
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structure of the bifunctional cryptochrome aCRY from Chlamydomonas reinhardtii
Nucleic Acids Res., 46, 2018
2JX2
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BU of 2jx2 by Molmil
Solution conformation of RNA-bound NELF-E RRM
Descriptor: Negative elongation factor E
Authors:Jampani, N, Schweimer, K, Wenzel, S, Woehrl, B.M, Roesch, P.
Deposit date:2007-11-02
Release date:2008-04-08
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:NELF-E RRM Undergoes Major Structural Changes in Flexible Protein Regions on Target RNA Binding
Biochemistry, 47, 2008
6FN3
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BU of 6fn3 by Molmil
X-ray structure of animal-like Cryptochrome from Chlamydomonas reinhardtii
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Cryptochrome photoreceptor, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Franz, S, Ignatz, E, Wenzel, S, Zielosko, H, Yamamoto, J, Mittag, M, Essen, L.-O.
Deposit date:2018-02-02
Release date:2018-08-01
Last modified:2018-09-19
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of the bifunctional cryptochrome aCRY from Chlamydomonas reinhardtii.
Nucleic Acids Res., 46, 2018
6FN0
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BU of 6fn0 by Molmil
The animal-like Cryptochrome from Chlamydomonas reinhardtii in complex with 6-4 DNA
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, Cryptochrome photoreceptor, ...
Authors:Franz, S, Ignatz, E, Wenzel, S, Zielosko, H, Yamamoto, J, Mittag, M, Essen, L.-O.
Deposit date:2018-02-02
Release date:2018-08-01
Last modified:2018-09-19
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structure of the bifunctional cryptochrome aCRY from Chlamydomonas reinhardtii.
Nucleic Acids Res., 46, 2018
6FN2
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BU of 6fn2 by Molmil
X-ray structure of animal-like Cryptochrome from Chlamydomonas reinhardtii
Descriptor: 8-HYDROXY-10-(D-RIBO-2,3,4,5-TETRAHYDROXYPENTYL)-5-DEAZAISOALLOXAZINE, CHLORIDE ION, Cryptochrome photoreceptor, ...
Authors:Franz, S, Ignatz, E, Wenzel, S, Zielosko, H, Yamamoto, J, Mittag, M, Essen, L.-O.
Deposit date:2018-02-02
Release date:2018-08-01
Last modified:2018-09-19
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of the bifunctional cryptochrome aCRY from Chlamydomonas reinhardtii.
Nucleic Acids Res., 46, 2018
6GQ3
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BU of 6gq3 by Molmil
Human asparagine synthetase (ASNS) in complex with 6-diazo-5-oxo-L-norleucine (DON) at 1.85 A resolution
Descriptor: 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 5-OXO-L-NORLEUCINE, ...
Authors:Zhu, W, Radadiya, A, Bisson, C, Jin, Y, Nordin, B.E, Imasaki, T, Wenzel, S, Sedelnikova, S.E, Berry, A.H, Nomanbhoy, T.K, Kozarich, J.W, Takagi, Y, Rice, D.W, Richards, N.G.J.
Deposit date:2018-06-07
Release date:2019-09-18
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:High-resolution crystal structure of human asparagine synthetase enables analysis of inhibitor binding and selectivity.
Commun Biol, 2, 2019
2BZ2
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BU of 2bz2 by Molmil
Solution structure of NELF E RRM
Descriptor: NEGATIVE ELONGATION FACTOR E
Authors:Schweimer, K, Rao, J.N, Neumann, L, Rosch, P, Wohrl, B.M.
Deposit date:2005-08-10
Release date:2006-08-16
Last modified:2018-02-28
Method:SOLUTION NMR
Cite:Structural studies on the RNA-recognition motif of NELF E, a cellular negative transcription elongation factor involved in the regulation of HIV transcription.
Biochem. J., 400, 2006
7ROZ
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BU of 7roz by Molmil
Structure of RNA-dependent RNA polymerase 2 (RDR2) from Arabidopsis thaliana
Descriptor: MAGNESIUM ION, RNA-dependent RNA polymerase 2
Authors:Fukudome, A, Pikaard, C.S, Takagi, Y.
Deposit date:2021-08-02
Release date:2021-12-08
Last modified:2022-06-22
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structure and RNA template requirements of Arabidopsis RNA-DEPENDENT RNA POLYMERASE 2.
Proc.Natl.Acad.Sci.USA, 118, 2021
7RQS
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BU of 7rqs by Molmil
Arabidopsis RNA-dependent RNA polymerase 2
Descriptor: MAGNESIUM ION, RNA-dependent RNA polymerase 2
Authors:Fukudome, A, Pikaard, C.S, Takagi, Y.
Deposit date:2021-08-07
Release date:2021-12-08
Last modified:2022-06-22
Method:ELECTRON MICROSCOPY (3.57 Å)
Cite:Structure and RNA template requirements of Arabidopsis RNA-DEPENDENT RNA POLYMERASE 2.
Proc.Natl.Acad.Sci.USA, 118, 2021
5NCH
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BU of 5nch by Molmil
GriE apo form
Descriptor: Leucine hydroxylase
Authors:Lukat, P, Blankenfeldt, W, Mueller, R.
Deposit date:2017-03-05
Release date:2017-10-04
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.819 Å)
Cite:Biosynthesis of methyl-proline containing griselimycins, natural products with anti-tuberculosis activity.
Chem Sci, 8, 2017
5NCI
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BU of 5nci by Molmil
GriE in complex with cobalt, alpha-ketoglutarate and l-leucine
Descriptor: 2-OXOGLUTARIC ACID, COBALT (II) ION, LEUCINE, ...
Authors:Lukat, P, Blankenfeldt, W, Mueller, R.
Deposit date:2017-03-05
Release date:2017-10-04
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.755 Å)
Cite:Biosynthesis of methyl-proline containing griselimycins, natural products with anti-tuberculosis activity.
Chem Sci, 8, 2017
5NCJ
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BU of 5ncj by Molmil
GriE in complex with manganese, succinate and (2S,4R)-5-hydroxyleucine
Descriptor: (2S,4R)-5-hydroxyleucine, Leucine hydroxylase, MANGANESE (II) ION, ...
Authors:Lukat, P, Blankenfeldt, W, Mueller, R.
Deposit date:2017-03-05
Release date:2017-10-04
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.529 Å)
Cite:Biosynthesis of methyl-proline containing griselimycins, natural products with anti-tuberculosis activity.
Chem Sci, 8, 2017
6DY7
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BU of 6dy7 by Molmil
WDR5 in complex with a WIN site inhibitor
Descriptor: DIMETHYL SULFOXIDE, N-[3-(2,4-dichlorophenoxy)propyl]-1H-imidazol-2-amine, SULFATE ION, ...
Authors:Phan, J, Wang, F, Fesik, S.W.
Deposit date:2018-07-01
Release date:2019-03-13
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity.
Cell Rep, 26, 2019
6E1Y
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BU of 6e1y by Molmil
Discovery of Potent 2-Aryl-6,7-Dihydro-5HPyrrolo[ 1,2-a]imidazoles as WDR5 WIN-site Inhibitors Using Fragment-Based Methods and Structure-Based Design
Descriptor: N-[(1S)-1-(3-chlorophenyl)ethyl]-3-{[(4,5-dihydro-1H-imidazol-2-yl)amino]methyl}benzamide, WD repeat-containing protein 5
Authors:Phan, J, Fesik, S.W.
Deposit date:2018-07-10
Release date:2019-03-13
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.219 Å)
Cite:Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity.
Cell Rep, 26, 2019
6DYA
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BU of 6dya by Molmil
WDR5 in complex with a WIN site inhibitor
Descriptor: DIMETHYL SULFOXIDE, N-[(3,5-dichlorophenyl)methyl]-3-[(1H-imidazol-1-yl)methyl]benzamide, SULFATE ION, ...
Authors:Phan, J, Wang, F, Fesik, S.W.
Deposit date:2018-07-01
Release date:2019-03-13
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.56 Å)
Cite:Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity.
Cell Rep, 26, 2019
6E1Z
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BU of 6e1z by Molmil
Displacement of WDR5 from chromatin by a pharmacological WIN site inhibitor with picomolar affinity
Descriptor: 5-[(1H-imidazol-1-yl)methyl]furan-2-carboxylic acid, WD repeat-containing protein 5
Authors:Phan, J, Fesik, S.W.
Deposit date:2018-07-10
Release date:2019-03-13
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity.
Cell Rep, 26, 2019
6E23
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BU of 6e23 by Molmil
Displacement of WDR5 from chromatin by a pharmacological WIN site inhibitor with picomolar affinity
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, N-[(3,4-dichlorophenyl)methyl]-3-(6-fluoro-2-methylpyridin-3-yl)-5-{[(2E)-2-imino-3-methyl-2,3-dihydro-1H-imidazol-1-yl]methyl}benzamide, WD repeat-containing protein 5
Authors:Phan, J, Fesik, S.W.
Deposit date:2018-07-10
Release date:2019-03-13
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity.
Cell Rep, 26, 2019
6E22
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BU of 6e22 by Molmil
Displacement of WDR5 from chromatin by a pharmacological WIN site inhibitor with picomolar affinity
Descriptor: 3-{[(4,5-dihydro-1H-imidazol-2-yl)amino]methyl}-N-[(3,5-dimethoxyphenyl)methyl]-4-fluorobenzamide, SULFATE ION, WD repeat-containing protein 5
Authors:Phan, J, Fesik, S.W.
Deposit date:2018-07-10
Release date:2019-03-13
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity.
Cell Rep, 26, 2019

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