1Y08
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![BU of 1y08 by Molmil](/molmil-images/mine/1y08) | Structure of the Streptococcal Endopeptidase IdeS, a Novel Cysteine Proteinase with Strict Specificity for IgG | Descriptor: | SULFATE ION, hypothetical protein SPy0861 | Authors: | Wenig, K, Chatwell, L, von Pawel-Rammingen, U, Bjoerck, L, Huber, R, Sondermann, P. | Deposit date: | 2004-11-15 | Release date: | 2004-12-21 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (1.93 Å) | Cite: | Structure of the streptococcal endopeptidase IdeS, a cysteine proteinase with strict specificity for IgG Proc.Natl.Acad.Sci.Usa, 101, 2004
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6OLA
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![BU of 6ola by Molmil](/molmil-images/mine/6ola) | Structure of the PCV2d virus-like particle | Descriptor: | Capsid protein, DNA (5'-D(P*CP*CP*GP*G)-3') | Authors: | Khayat, R, Wen, K, Alimova, A, Galarza, J, Gottlieb, P. | Deposit date: | 2019-04-16 | Release date: | 2019-09-25 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structural characterization of the PCV2d virus-like particle at 3.3 angstrom resolution reveals differences to PCV2a and PCV2b capsids, a tetranucleotide, and an N-terminus near the icosahedral 3-fold axes. Virology, 537, 2019
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5CP3
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![BU of 5cp3 by Molmil](/molmil-images/mine/5cp3) | Crystal Structure of an Antigen-Binding Fragment of Monoclonal Antibody against Sulfonamides in Complex with Sulfathiazole | Descriptor: | 4-amino-N-(1,3-thiazol-2-yl)benzenesulfonamide, CALCIUM ION, GLYCEROL, ... | Authors: | Wang, Z, Shen, J, Li, C, Li, Y, Wen, K, Yu, X, Zhang, X. | Deposit date: | 2015-07-21 | Release date: | 2015-08-05 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.99 Å) | Cite: | Class-specific Monoclonal Antibodies and Dihydropteroate Synthase in Bioassays used for the Detection of Sulfonamides: Structural Insights into Recognition Diversity. Anal. Chem., 91, 2019
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5CP7
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![BU of 5cp7 by Molmil](/molmil-images/mine/5cp7) | Crystal Structure of an Antigen-Binding Fragment of Monoclonal Antibody against Sulfonamides | Descriptor: | Heavy Chain of Antigen-Binding Fragment of Monoclonal Antibody of 4C7, Light Chain of Antigen-Binding Fragment of Monoclonal Antibody of 4C7 | Authors: | Wang, Z, Shen, J, Li, C, Li, Y, Wen, K, Yu, X, Zhang, X. | Deposit date: | 2015-07-21 | Release date: | 2015-08-05 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (3.01 Å) | Cite: | Class-specific Monoclonal Antibodies and Dihydropteroate Synthase in Bioassays used for the Detection of Sulfonamides: Structural Insights into Recognition Diversity. Anal. Chem., 91, 2019
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1XMK
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![BU of 1xmk by Molmil](/molmil-images/mine/1xmk) | The Crystal structure of the Zb domain from the RNA editing enzyme ADAR1 | Descriptor: | CADMIUM ION, CHLORIDE ION, Double-stranded RNA-specific adenosine deaminase, ... | Authors: | Athanasiadis, A, Placido, D, Maas, S, Brown II, B.A, Lowenhaupt, K, Rich, A. | Deposit date: | 2004-10-03 | Release date: | 2005-08-02 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (0.97 Å) | Cite: | The Crystal Structure of the Z[beta] Domain of the RNA-editing Enzyme ADAR1 Reveals Distinct Conserved Surfaces Among Z-domains. J.Mol.Biol., 351, 2005
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8SWK
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![BU of 8swk by Molmil](/molmil-images/mine/8swk) | Cryo-EM structure of NLRP3 closed hexamer | Descriptor: | 1-[4-(2-oxidanylpropan-2-yl)furan-2-yl]sulfonyl-3-(1,2,3,5-tetrahydro-s-indacen-4-yl)urea, ADENOSINE-5'-TRIPHOSPHATE, NACHT, ... | Authors: | Yu, X, Matico, R.E, Miller, R, Schoubroeck, B.V, Grauwen, K, Suarez, J, Pietrak, B, Haloi, N, Yin, Y, Tresadern, G.J, Perez-Benito, L, Lindahl, E, Bottelbergs, A, Oehlrich, D, Opdenbosch, N.V, Sharma, S. | Deposit date: | 2023-05-18 | Release date: | 2024-02-14 | Method: | ELECTRON MICROSCOPY (4.32 Å) | Cite: | Cryo-EM structures of NLRP3 reveal its self-activation mechanism Nat Commun, 2024
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8SXN
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![BU of 8sxn by Molmil](/molmil-images/mine/8sxn) | Structure of NLRP3 and NEK7 complex | Descriptor: | 1-[4-(2-oxidanylpropan-2-yl)furan-2-yl]sulfonyl-3-(1,2,3,5-tetrahydro-s-indacen-4-yl)urea, ADENOSINE-5'-TRIPHOSPHATE, NACHT, ... | Authors: | Yu, X, Matico, R.E, Miller, R, Schoubroeck, B.V, Grauwen, K, Suarez, J, Pietrak, B, Haloi, N, Yin, Y, Tresadern, G.J, Perez-Benito, L, Lindahl, E, Bottelbergs, A, Oehlrich, D, Opdenbosch, N.V, Sharma, S. | Deposit date: | 2023-05-22 | Release date: | 2024-02-14 | Method: | ELECTRON MICROSCOPY (4.04 Å) | Cite: | Cryo-EM structures of NLRP3 reveal its self-activation mechanism Nat Commun, 2024
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8SWF
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![BU of 8swf by Molmil](/molmil-images/mine/8swf) | Cryo-EM structure of NLRP3 open octamer | Descriptor: | NACHT, LRR and PYD domains-containing protein 3 | Authors: | Yu, X, Matico, R.E, Miller, R, Schoubroeck, B.V, Grauwen, K, Suarez, J, Pietrak, B, Haloi, N, Yin, Y, Tresadern, G.J, Perez-Benito, L, Lindahl, E, Bottelbergs, A, Oehlrich, D, Opdenbosch, N.V, Sharma, S. | Deposit date: | 2023-05-18 | Release date: | 2024-02-14 | Method: | ELECTRON MICROSCOPY (3.39 Å) | Cite: | Cryo-EM structures of NLRP3 reveal its self-activation mechanism Nat Commun, 2024
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2BA1
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![BU of 2ba1 by Molmil](/molmil-images/mine/2ba1) | Archaeal exosome core | Descriptor: | Archaeal exosome RNA binding protein CSL4, Archaeal exosome complex exonuclease RRP41, Archaeal exosome complex exonuclease RRP42, ... | Authors: | Hopfner, K.P, Buttner, K, Wenig, K. | Deposit date: | 2005-10-13 | Release date: | 2005-11-22 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural framework for the mechanism of archaeal exosomes in RNA processing. Mol.Cell, 20, 2005
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2BA0
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![BU of 2ba0 by Molmil](/molmil-images/mine/2ba0) | Archaeal exosome core | Descriptor: | Archaeal exosome RNA binding protein RRP4, Archaeal exosome RNA binding protein RRP41, Archaeal exosome RNA binding protein RRP42 | Authors: | Buttner, K, Wenig, K, Hopfner, K.P. | Deposit date: | 2005-10-13 | Release date: | 2005-11-22 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural framework for the mechanism of archaeal exosomes in RNA processing. Mol.Cell, 20, 2005
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1OYI
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![BU of 1oyi by Molmil](/molmil-images/mine/1oyi) | Solution structure of the Z-DNA binding domain of the vaccinia virus gene E3L | Descriptor: | double-stranded RNA-binding protein | Authors: | Kahmann, J.D, Wecking, D.A, Putter, V, Lowenhaupt, K, Kim, Y.-G, Schmieder, P, Oschkinat, H, Rich, A, Schade, M. | Deposit date: | 2003-04-04 | Release date: | 2004-03-09 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | The solution structure of the N-terminal domain of E3L shows a tyrosine conformation that may explain its reduced affinity to Z-DNA in vitro. Proc.Natl.Acad.Sci.USA, 101, 2004
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1QGP
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![BU of 1qgp by Molmil](/molmil-images/mine/1qgp) | NMR STRUCTURE OF THE Z-ALPHA DOMAIN OF ADAR1, 15 STRUCTURES | Descriptor: | PROTEIN (DOUBLE STRANDED RNA ADENOSINE DEAMINASE) | Authors: | Schade, M, Turner, C.J, Kuehne, R, Schmieder, P, Lowenhaupt, K, Herbert, A, Rich, A, Oschkinat, H. | Deposit date: | 1999-05-03 | Release date: | 1999-10-19 | Last modified: | 2023-12-27 | Method: | SOLUTION NMR | Cite: | The solution structure of the Zalpha domain of the human RNA editing enzyme ADAR1 reveals a prepositioned binding surface for Z-DNA. Proc.Natl.Acad.Sci.USA, 96, 1999
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2ACJ
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![BU of 2acj by Molmil](/molmil-images/mine/2acj) | Crystal structure of the B/Z junction containing DNA bound to Z-DNA binding proteins | Descriptor: | 5'-D(*AP*CP*GP*GP*TP*TP*TP*AP*TP*GP*GP*CP*GP*CP*GP*CP*G)-3', 5'-D(*GP*TP*CP*GP*CP*GP*CP*GP*CP*CP*AP*TP*AP*AP*AP*CP*C)-3', Double-stranded RNA-specific adenosine deaminase | Authors: | Ha, S.C, Lowenhaupt, K, Rich, A, Kim, Y.-G, Kim, K.K. | Deposit date: | 2005-07-19 | Release date: | 2005-10-25 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Crystal structure of a junction between B-DNA and Z-DNA reveals two extruded bases. Nature, 437, 2005
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1SFU
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![BU of 1sfu by Molmil](/molmil-images/mine/1sfu) | Crystal structure of the viral Zalpha domain bound to left-handed Z-DNA | Descriptor: | 34L protein, 5'-D(*T*CP*GP*CP*GP*CP*G)-3' | Authors: | Ha, S.C, Van Quyen, D, Wu, C.A, Lowenhaupt, K, Rich, A, Kim, Y.G, Kim, K.K. | Deposit date: | 2004-02-20 | Release date: | 2004-08-17 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | A poxvirus protein forms a complex with left-handed Z-DNA: crystal structure of a Yatapoxvirus Zalpha bound to DNA. Proc.Natl.Acad.Sci.USA, 101, 2004
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2B2N
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![BU of 2b2n by Molmil](/molmil-images/mine/2b2n) | Structure of transcription-repair coupling factor | Descriptor: | O-ACETALDEHYDYL-HEXAETHYLENE GLYCOL, SODIUM ION, SULFATE ION, ... | Authors: | Assenmacher, N, Wenig, K, Lammens, A, Hopfner, K.-P. | Deposit date: | 2005-09-19 | Release date: | 2006-01-24 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural Basis for Transcription-coupled Repair: the N Terminus of Mfd Resembles UvrB with Degenerate ATPase Motifs J.Mol.Biol., 355, 2006
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1J75
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![BU of 1j75 by Molmil](/molmil-images/mine/1j75) | Crystal Structure of the DNA-Binding Domain Zalpha of DLM-1 Bound to Z-DNA | Descriptor: | 5'-D(*TP*CP*GP*CP*GP*CP*G)-3', Tumor Stroma and Activated Macrophage Protein DLM-1 | Authors: | Schwartz, T, Behlke, J, Lowenhaupt, K, Heinemann, U, Rich, A. | Deposit date: | 2001-05-15 | Release date: | 2001-09-01 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Structure of the DLM-1-Z-DNA complex reveals a conserved family of Z-DNA-binding proteins. Nat.Struct.Biol., 8, 2001
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6IS2
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![BU of 6is2 by Molmil](/molmil-images/mine/6is2) | |
6IS3
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![BU of 6is3 by Molmil](/molmil-images/mine/6is3) | |
6IS4
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![BU of 6is4 by Molmil](/molmil-images/mine/6is4) | |
6IS1
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![BU of 6is1 by Molmil](/molmil-images/mine/6is1) | |
8ELC
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![BU of 8elc by Molmil](/molmil-images/mine/8elc) | Human JNK2 bound to covalent inhibitor YL2056 | Descriptor: | 4-(dimethylamino)-N-{4-[(3S)-3-({4-[(8R)-2-phenylpyrazolo[1,5-a]pyridin-3-yl]pyrimidin-2-yl}amino)pyrrolidine-1-carbonyl]phenyl}butanamide, Mitogen-activated protein kinase 9 | Authors: | Li, L, Gurbani, D, Westover, K.D. | Deposit date: | 2022-09-23 | Release date: | 2023-06-28 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.072 Å) | Cite: | Development of a Covalent Inhibitor of c-Jun N-Terminal Protein Kinase (JNK) 2/3 with Selectivity over JNK1. J.Med.Chem., 66, 2023
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6LUS
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![BU of 6lus by Molmil](/molmil-images/mine/6lus) | Crystal structure of the Mengla Virus VP30 C-terminal domain | Descriptor: | Minor nucleoprotein VP30 | Authors: | Dong, S.S, Wen, K.N, Chu, H.G, Wang, C.H, Qin, X.C. | Deposit date: | 2020-01-30 | Release date: | 2020-12-02 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Crystal structure of the Mengla virus VP30 C-terminal domain. Biochem.Biophys.Res.Commun., 525, 2020
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7N8T
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![BU of 7n8t by Molmil](/molmil-images/mine/7n8t) | Crystal Structure of AMP-bound Human JNK2 | Descriptor: | ADENOSINE MONOPHOSPHATE, HEXAETHYLENE GLYCOL, Mitogen-activated protein kinase 9 | Authors: | Li, L, Gurbani, D, Westover, K.D. | Deposit date: | 2021-06-15 | Release date: | 2022-06-22 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.69 Å) | Cite: | Development of a Covalent Inhibitor of c-Jun N-Terminal Protein Kinase (JNK) 2/3 with Selectivity over JNK1. J.Med.Chem., 66, 2023
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4WA9
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![BU of 4wa9 by Molmil](/molmil-images/mine/4wa9) | |
7Q9W
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![BU of 7q9w by Molmil](/molmil-images/mine/7q9w) | Crystal structure of the C-terminal catalytic domain of Plasmodium falciparum CTP:phosphocholine cytidylyltransferase with 4-(aminomethyl)pyridin-2-amine | Descriptor: | 4-(aminomethyl)pyridin-2-amine, Cholinephosphate cytidylyltransferase, Guanidinium | Authors: | Duclovel, C, Gelin, M, Krimm, I, Cerdan, R, Guichou, J.-F. | Deposit date: | 2021-11-15 | Release date: | 2022-11-30 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystallographic screening using ultra-low-molecular-weight ligands to guide drug design of PfCCT inhibitors. To Be Published
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