1S7Z
| Structure of Ocr from Bacteriophage T7 | 分子名称: | CESIUM ION, Gene 0.3 protein | 著者 | Walkinshaw, M.D, Taylor, P, Sturrock, S.S, Atanasiu, C, Berg, T, Henderson, R.M, Edwardson, J.M, Dryden, D.T. | 登録日 | 2004-01-30 | 公開日 | 2004-02-10 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.83 Å) | 主引用文献 | Structure of Ocr from Bacteriophage T7, a Protein that Mimics B-Form DNA Mol.Cell, 9, 2002
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4FXF
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4FXJ
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3FWT
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3IS4
| Crystal structure of Leishmania mexicana pyruvate kinase (LmPYK)in complex with 1,3,6,8-pyrenetetrasulfonic acid | 分子名称: | GLYCEROL, Pyruvate kinase, pyrene-1,3,6,8-tetrasulfonic acid | 著者 | Walkinshaw, M.D, Morgan, H.P. | 登録日 | 2009-08-25 | 公開日 | 2010-03-23 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | An improved strategy for the crystallization of Leishmania mexicana pyruvate kinase Acta Crystallogr.,Sect.F, 66, 2010
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1CTX
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1A58
| CYCLOPHILIN FROM BRUGIA MALAYI | 分子名称: | CYCLOPHILIN | 著者 | Taylor, P, Page, A.P, Kontopidis, G, Husi, H, Walkinshaw, M.D. | 登録日 | 1998-02-20 | 公開日 | 1998-05-27 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | The X-ray structure of a divergent cyclophilin from the nematode parasite Brugia malayi. FEBS Lett., 425, 1998
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1BCK
| HUMAN CYCLOPHILIN A COMPLEXED WITH 2-THR CYCLOSPORIN | 分子名称: | CYCLOSPORIN C, PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A | 著者 | Mikol, V, Kallen, J, Taylor, P, Walkinshaw, M.D. | 登録日 | 1998-04-30 | 公開日 | 1998-09-16 | 最終更新日 | 2023-08-02 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | X-Ray Structures and Analysis of 11 Cyclosporin Derivatives Complexed with Cyclophilin A. J.Mol.Biol., 283, 1998
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4WJ8
| Human Pyruvate Kinase M2 Mutant C424A | 分子名称: | 1,6-di-O-phosphono-beta-D-fructofuranose, GLYCEROL, MAGNESIUM ION, ... | 著者 | Mitchell, T, Yuan, M, McNae, I, Morgan, H, Walkinshaw, M.D. | 登録日 | 2014-09-29 | 公開日 | 2015-09-30 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.87 Å) | 主引用文献 | Human Pyruvate Kinase M2 Mutant C424A To Be Published
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5OFU
| Crystal structure of Leishmania major fructose-1,6-bisphosphatase in T-state. | 分子名称: | 6-O-phosphono-beta-D-fructofuranose, ADENOSINE MONOPHOSPHATE, CHLORIDE ION, ... | 著者 | Yuan, M, Vasquez-Valdivieso, M.G, McNae, I.W, Michels, P.A.M, Fothergill-Gilmore, L.A, Walkinshaw, M.D. | 登録日 | 2017-07-11 | 公開日 | 2017-09-20 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.62 Å) | 主引用文献 | Structures of Leishmania Fructose-1,6-Bisphosphatase Reveal Species-Specific Differences in the Mechanism of Allosteric Inhibition. J. Mol. Biol., 429, 2017
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5OEY
| Crystal structure of Leishmania major fructose-1,6-bisphosphatase in holo form. | 分子名称: | CITRIC ACID, FBP protein, MANGANESE (II) ION, ... | 著者 | Yuan, M, Vasquez-Valdivieso, M.G, McNae, I.W, Michels, P.A.M, Fothergill-Gilmore, L.A, Walkinshaw, M.D. | 登録日 | 2017-07-10 | 公開日 | 2017-09-20 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structures of Leishmania Fructose-1,6-Bisphosphatase Reveal Species-Specific Differences in the Mechanism of Allosteric Inhibition. J. Mol. Biol., 429, 2017
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5OEZ
| Crystal structure of Leishmania major fructose-1,6-bisphosphatase in apo form. | 分子名称: | FBP protein | 著者 | Yuan, M, Vasquez-Valdivieso, M.G, McNae, I.W, Michels, P.A.M, Fothergill-Gilmore, L.A, Walkinshaw, M.D. | 登録日 | 2017-07-10 | 公開日 | 2017-09-20 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.41 Å) | 主引用文献 | Structures of Leishmania Fructose-1,6-Bisphosphatase Reveal Species-Specific Differences in the Mechanism of Allosteric Inhibition. J. Mol. Biol., 429, 2017
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3SRF
| Human M1 pyruvate kinase | 分子名称: | GLYCEROL, MAGNESIUM ION, PHOSPHATE ION, ... | 著者 | Morgan, H.P, O'Reilly, F, Palmer, R, McNae, I.W, Nowicki, M.W, Wear, M.A, Fothergill-Gilmore, L.A, Walkinshaw, M.D. | 登録日 | 2011-07-07 | 公開日 | 2012-08-08 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.845 Å) | 主引用文献 | Allosetric regulation of M2 pyruvate kinase. To be Published
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3SRH
| Human M2 pyruvate kinase | 分子名称: | PHOSPHATE ION, Pyruvate kinase isozymes M1/M2 | 著者 | Morgan, H.P, O'Reilly, F, Palmer, R, McNae, I.W, Nowicki, M.W, Wear, M.A, Fothergill-Gilmore, L.A, Walkinshaw, M.D. | 登録日 | 2011-07-07 | 公開日 | 2012-08-08 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Allosetric regulation of M2 pyruvate kinase. To be Published
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3SRD
| Human M2 pyruvate kinase in complex with fructose 1-6 bisphosphate and Oxalate. | 分子名称: | 1,6-di-O-phosphono-beta-D-fructofuranose, GLYCEROL, MAGNESIUM ION, ... | 著者 | Morgan, H.P, O'Reilly, F, Palmer, R, McNae, I.W, Nowicki, M.W, Wear, M.A, Fothergill-Gilmore, L.A, Walkinshaw, M.D. | 登録日 | 2011-07-07 | 公開日 | 2012-08-08 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.902 Å) | 主引用文献 | Allosetric regulation of M2 pyruvate kinase. To be Published
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3SRK
| A new class of suicide inhibitor blocks nucleotide binding to pyruvate kinase | 分子名称: | 1,2-BENZISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDE, POTASSIUM ION, Pyruvate kinase, ... | 著者 | Morgan, H.P, Walsh, M, Blackburn, E.A, Wear, M.A, Boxer, M, Shen, M, McNae, I.W, Michels, P.A.M, Auld, D.S, Fothergill-Gilmore, L.A, Walkinshaw, M.D. | 登録日 | 2011-07-07 | 公開日 | 2012-07-18 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | A new class of suicide inhibitor blocks nucleotide binding to pyruvate kinase To be Published
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1CWB
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1CWA
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2P32
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2QIJ
| Hepatitis B Capsid Protein with an N-terminal extension modelled into 8.9 A data. | 分子名称: | Core antigen | 著者 | Tan, W.S, McNae, I.W, Ho, K.L, Walkinshaw, M.D. | 登録日 | 2007-07-04 | 公開日 | 2007-12-11 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (8.9 Å) | 主引用文献 | Crystallization and X-ray analysis of the T = 4 particle of hepatitis B capsid protein with an N-terminal extension. Acta Crystallogr.,Sect.F, 63, 2007
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5LUD
| Structure of Cyclophilin A in complex with 2,3-Diaminopyridine | 分子名称: | Peptidyl-prolyl cis-trans isomerase, pyridine-2,3-diamine | 著者 | McNae, I.W, Nowicki, M.W, Blackburn, E.A, Wear, M.A, Walkinshaw, M.D. | 登録日 | 2016-09-08 | 公開日 | 2017-04-05 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | 主引用文献 | Thermo-kinetic analysis space expansion for cyclophilin-ligand interactions - identification of a new nonpeptide inhibitor using BiacoreTM T200. FEBS Open Bio, 7, 2017
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5EI3
| Co-crystal structure of eIF4E with nucleotide mimetic inhibitor. | 分子名称: | Eukaryotic translation initiation factor 4 gamma, Eukaryotic translation initiation factor 4E, SULFATE ION, ... | 著者 | Nowicki, M.W, Walkinshaw, M.D, Fischer, P.M. | 登録日 | 2015-10-29 | 公開日 | 2016-09-07 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.71 Å) | 主引用文献 | Design of nucleotide-mimetic and non-nucleotide inhibitors of the translation initiation factor eIF4E: Synthesis, structural and functional characterisation. Eur.J.Med.Chem., 124, 2016
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5EKV
| Co-crystal structure of eIF4E with nucleotide mimetic inhibitor. | 分子名称: | 3-[[(2~{R},3~{S},4~{R},5~{R})-5-(2-azanyl-7-methyl-6-oxidanylidene-1~{H}-purin-7-ium-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methylamino]-4-oxidanyl-cyclobut-3-ene-1,2-dione, Eukaryotic translation initiation factor 4E, Eukaryotic translation initiation factor 4E-binding protein 1 | 著者 | Nowicki, M.W, Walkinshaw, M.D, Fischer, P.M. | 登録日 | 2015-11-04 | 公開日 | 2016-09-07 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (3.61 Å) | 主引用文献 | Design of nucleotide-mimetic and non-nucleotide inhibitors of the translation initiation factor eIF4E: Synthesis, structural and functional characterisation. Eur.J.Med.Chem., 124, 2016
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5EHC
| Co-crystal structure of eIF4E with nucleotide mimetic inhibitor. | 分子名称: | 3-[[(2~{R},3~{S},4~{R},5~{R})-5-[2-azanyl-7-[(3-chlorophenyl)methyl]-6-oxidanylidene-1~{H}-purin-7-ium-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methylamino]-4-oxidanyl-cyclobut-3-ene-1,2-dione, Eukaryotic translation initiation factor 4 gamma 1, Eukaryotic translation initiation factor 4E | 著者 | Nowicki, M.W, Walkinshaw, M.D, Fischer, P.M. | 登録日 | 2015-10-28 | 公開日 | 2016-09-07 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Design of nucleotide-mimetic and non-nucleotide inhibitors of the translation initiation factor eIF4E: Synthesis, structural and functional characterisation. Eur.J.Med.Chem., 124, 2016
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5EIR
| Co-crystal structure of eIF4E with nucleotide mimetic inhibitor. | 分子名称: | Eukaryotic translation initiation factor 4 gamma 1, Eukaryotic translation initiation factor 4E, SULFATE ION, ... | 著者 | Nowicki, M.W, Walkinshaw, M.D, Fischer, P.M. | 登録日 | 2015-10-30 | 公開日 | 2016-09-07 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.69 Å) | 主引用文献 | Design of nucleotide-mimetic and non-nucleotide inhibitors of the translation initiation factor eIF4E: Synthesis, structural and functional characterisation. Eur.J.Med.Chem., 124, 2016
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